Preview

Russian Journal of Cardiology

Advanced search

Spirapril effects on heart remodeling in patients with mild to moderate arterial hypertension

Abstract

In total, 62patients with mild to moderate arterial hypertension underwent echocardiography and Doppler cardiography. For 12 weeks, all participants received spirapril, 6 mg/d. Spirapril therapy was associated with reduced left ventricular hypertrophy and pathological heart remodeling type number.

About the Authors

M. M. Beraya
Московская медицинская академия им. И. М. Сеченова
Russian Federation


V. V. Petriy
Московская медицинская академия им. И. М. Сеченова
Russian Federation


V. I. Buvaltsev
Московская медицинская академия им. И. М. Сеченова
Russian Federation


N. G. Sergushkina
Московская медицинская академия им. И. М. Сеченова
Russian Federation


V. I. Makolkin
Московская медицинская академия им. И. М. Сеченова
Russian Federation


References

1. Devereux R.B., Agabiti-Rosei E., Dahlof В. Regression of left ventricular hypertrophy as asurrogate end-point for morbid events in antihypertensive treatment trials. J Hypertens 1996, 14: S95-101.

2. Folkow B. Physiological aspects of primary hypertension. Physiol. Rev. 1982, 62: 347-504.

3. Guitard C., Sassano P. Placebo-controlled comparison of spirapril at 6 mg/day in mild vere essential hypertensio. Ibid. 61-68.

4. Lagagh G. Cardiac patophysiology and its heterogenety in patients with established hypertensive diasease. Am. J. Med. 1988; 84: 3-11.

5. Muiesan M.I., Salvetti M., Rizonni D. Association of change in left ventricular mass with prognosis during long-term antihypertensive treatment. J. Hypertens 1995, 13: 1091-1097.

6. Regression of cardiovascular structurial changes by antihypertensive treatment. Hypertension 1984, 6: 150-157.

7. Roman O., Bunout D., Prats H. Efficacy and safety of spirapril a new ACE ingibitor. A long term study on hypertensive patients. J. Hypertens. 1994; 12: 165.

8. Safar M.E., Laurent S.L., Bouthier J.D. Effect of converting enzyme ingnbitors on hypertensive lage arteries in humans. J. Hypertens. 1986; 5: S285-289.

9. Vedecchia P., Schfflaci G., Borgioni C. Prognostic significance of serial changes in left ventricular mass in essential hypertension//Circulation 1998; 97: 48-54.


Review

For citations:


Beraya M.M., Petriy V.V., Buvaltsev V.I., Sergushkina N.G., Makolkin V.I. Spirapril effects on heart remodeling in patients with mild to moderate arterial hypertension. Russian Journal of Cardiology. 2007;(1):45-47. (In Russ.)

Views: 295


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)