Unspecific resistance in patients with coronary heart disease and extrasystolia

Abstract

Various parameters of unspecific resistance (peripheral blood leucogram, erythrocyte sedimentation rate, integral leucocyte indices, adaptation reaction types, phagocytosis) were assessed in 60 coronary heart disease patients with stable angina, functional status I-IV, and extrasystolia of different prognostic value (benign, malignant). Comparing to healthy controls, among patiens with CHD and extrasystolia, per cent of eosinophils and stick-nuclear neutrophils was elevated, per cent of segment-nuclear granulocytes decreased, neutrophil/monocyte ratio, neutrophil shift, phagocytosis number and index increased. In contrast with « benign» extrasystolia patients, individuals with prognostically « malignant» extrasystoles had unspecific resistance characterised by reduced absolute leucocyte number, per cent of segment-nuclear granulocytes, increased per cent of lymphocytes, leucocytes, lymphocyte-granulocyte general indices, index of lymphocytes/ESR, and decreased intoxication index, leucocyte shift, neutrophil/lymphocyte ratio. Among adaptation reactions in patients with « malignant» extrasystolia, hyperactivation was the most prevalent variant. NBT-test results were decreased.