Oxidative stress and endothelial dysfunction correction with ACE inhibitor therapy in patients with myocardial infarction and Type 2 diabetes mellitus
Abstract
In total, 25 patients with acute myocardial infarction (MI) and 25 patients with MI and Type 2 diabetes mellitus (DM-2) received an ACE inhibitor zofenopril (zocardis) for 6 months, as a part of their basis therapy. Lipid peroxidation and antioxidant system dynamics, endogenous cytoprotective mechanisms - NO and HSP70 stress proteins - were assessed during first 24 hours after hospitalization, as well as 1 and 6 months after MI. Long-term zofenopril therapy was associated with reduced levels of free-radical lipid peroxidation, due to protective antioxidant enzyme activation and increase in serum total antioxidant activity. The medication also improved the parameters ofprotective HSP70 system and endothelial function.
About the Authors
V. S. Zadionchenko
Московский государственный медико-стоматологический университет
Russian Federation
Russian Federation
K. S. Leksina
Московский государственный медико-стоматологический университет
Russian Federation
Russian Federation
N. Yu. Timofeeva
Московский государственный медико-стоматологический университет
Russian Federation
Russian Federation
G. G. Shekhyan
Московский государственный медико-стоматологический университет
Russian Federation
Russian Federation
M. A. Mironova
Московский государственный медико-стоматологический университет
Russian Federation
Russian Federation
T. M. Terekhova
Московский государственный медико-стоматологический университет
Russian Federation
Russian Federation
References
1. Зенков Н.К., Ланкин В.З., Меньщикова Е.Б. Окислительный стресс. Биохимический и патофизиологические аспекты. Москва: МАИК «Наука/Интерпериодика», 2001; 343 с.
2. Ланкин В.З., Тихазе А.К., Беленков Ю.Н. Антиоксиданты в комплексной терапии атеросклероза: PRO ET CONTRA (Пособие для врачей). Москва: РКНПК МЗ РФ, 2006; 78-1.
3. Ланкин В.З., Тихазе А.К., Беленков Ю.Н. Свободнорадикальные процессы при заболеваниях сердечно-сосудистой системы//Кардиология. 2000; 40(7): 486-1.
4. Величковский Б.Т. Свободнорадикальное окисление как звено срочной и долговременной адаптации организма к факторам окружающей среды//Вестник РАМН. 2001, №5, С. 455-1.
5. Дедов И.И., Александров А.А. Диабетическое сердце: Causa Magna//Сердце. 2004; 1(3): 58.
6. Панченко Е.П. Ишемическая болезнь сердца и сахарный диабет -коварный тандем//Сердце. 2004; 1(3): 91-2.
7. Borghi C. et al. Double-blind comparison between Zofenopril and lisinopril in patients with acute myocardial infarction: Results of the Survival of Myocardial Infarction Long-term Evaluation-2 (SMILE-2) study//Am Heart J 2003; 145: 808-7.
8. De Nigris Fet al. Chronic treatment with sulfhydryl angiotensinconverting enzyme inhibitors reduces susceptibility of plasma LDL to «in vitro» oxidation, formation of oxidation-specific epitopes in the arterial wall, and atherogenesis in apolipoprotein E knockout mice//Int J Cardiol. 2001; 81(23-): 1071-5;
9. Flak T.A., Goldman W.E. Autotoxicity of nitric oxide in airway disease//Am. J. Respir Crit. care Med. 1996. Vol. 154. P 2022-06.
10. Flather M.D., Yisuf S., Kober L. et al. Long-term ACE-inhibitor therapy in heart failure or left-ventricular dysfunction: a systemic overview of data from individual patients//Lancet 2000; 355: 15751 -581.
11. Haffner S.M., Lehto S., Ronnemaa T. et al. Mortality from coronary heart disease in subjects with type 2 diabetes and nondiabetic subjects with and without prior myocardial infarction//N. Engl. J. Med.1998; 339: 2292-34.
12. Melchior T. Kober L., Madsen C.R. et al. Accelerating impact of diabetes mellitus on mortality in the years following an acute myocardial infarction. TRACE Study Group. Trandolapril Cardiac Evaluation//Eur Heart J. 2000; 21: 19371-943.
13. Scribner A.W. et al.: The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress//Eur J. Pharmacol 2003; 482: 959-9.
14. Timmis A.D. Diabetic Heart disease: clinical considerations//Heart 2001; 85: 4634-69.
15. Torp-Pedersen C., Rask-Madsen C., Gustafsson I. et al. Diabetes mellitus and cardiovascular risk: just another risk factor?//Eur
16. Heart J. 2003; 5(suppl. F.): F23-F32.
17. Timmis A.D. Diabetic heart disease: clinical considerations//Heart. 2001; 85: 4634-69.
Review
For citations:
Zadionchenko V.S., Leksina K.S., Timofeeva N.Yu., Shekhyan G.G., Mironova M.A., Terekhova T.M. Oxidative stress and endothelial dysfunction correction with ACE inhibitor therapy in patients with myocardial infarction and Type 2 diabetes mellitus. Russian Journal of Cardiology. 2008;(5):40-45. (In Russ.)
Views:
334
Email this article 