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THE PLACE OF NEBIVOLOL IN RATIONAL THERAPY OF CONGESTIVE HEART FAILURE

https://doi.org/10.15829/1560-4071-2014-9-72-76

Abstract

The prevalence of congestive heart failure (CHF) is growing further with age, and 65% of the sufferers are in the age group from 65 to 80 y.o. Despite success in CHF treatment, mean year mortality is about 6%, and mortality of those with clinically salient CHF reaches 12%. To increase duration of life it is important to prescribe efficient drug therapy, that must include beta-adrenoblockers (BAB), especially in CHF with low ejection fraction (EF) of the left ventricle (LV). Taken into account the results of SENIORS and NEMESIDA, in the year 2013 Nebivolol was included to the National Guidelines on diagnostics and treatment of CHF (IVth review). Benefits on Nebivolol are super-selectivity, vasodilation due to NO release, ability to decrease central aortal pressure, good tolerability and low risk of side effects, especially in patients with concomitant diseases. Nebivolol is effective in coronary heart disease (CHD) and arterial hypertension (AH).

About the Author

A. B. Khadzegova
Moscow State Medical and Stomatological University, Moscow, Russia.
Russian Federation


References

1. Fomin IV. Arterial hypertension in the Russian Federation — the last 10 years. What's next? Heart. 2007; 6 (3):1-6. Russian (Фомин И. В. Артериальная гипертония в Российской Федерации — последние 10 лет. Что дальше? Сердце. 2007; 6 (3): 1-6).

2. Belenkov YuN, Fomin IV, Mareev VY et al. The prevalence of chronic heart failure in the European part of the Russian Federation — data EPOHA-HSN (part 2). Journal of cardiac failure. 2006;7 (3):3-7. Russian (Беленков Ю. Н., Фомин И. В., Мареев В.Ю. и др. Распространенность хронической сердечной недостаточности в Европейской части Российской Федерации — данные ЭПОХА-ХСН (часть 2). Журнал сердечная недостаточность. 2006; 7 (3): 3-7).

3. Danielyan MO. Prognosis and treatment of chronic heart failure (data 20-year follow-up). Abstract. dis. Moscow. 2001. Russian (Даниелян М. О. Прогноз и лечение хронической сердечной недостаточности (данные 20-летнего наблюдения). Автореф. дис. канд. мед. наук. Москва. 2001).

4. National Guidelines OSSN, RCO and RNMOT for the diagnosis and treatment of chronic heart failure (fourth revision). Journal of cardiac failure 2013;81 (7):379-472. Russian (Национальные рекомендации ОССН, РКО и РНМОТ по диагностике и лечению ХСН (четвертый пересмотр). Журнал сердечная недостаточность 2013;81 (7):379-472).

5. Brixius K, Bundkirchen A, Bolck B, et al. Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium. Brit.J. Pharmacol., 2001;133:1330-8.

6. Bundkirchen A, Brixius K, Bolck B, et al. B1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H] CGP 12.177 and [125I] iodocyanopindolol bimding studies.— Europ.J.Pharmacol., 2003; 460:19-26.

7. Bubnova MG. Pleiotropic effects superselective b1-blocker nebivolol in the treatment of arterial hypertension and its complications. Consilium Medicum 2004: 3-10. Russian (Бубнова М. Г. Плейотропные эффекты суперселективного М-блокатора небиволола при лечении артериальной гипертонии и ее осложнений. Consilium Medicum 2004: 3-10).

8. Flather M. D., Shibata M. C., Coats A., J., et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J. 2005; 26 (3):215-25.

9. Moen MD, Wagstaff AJ. Nebivolol. A review of its use in the management of hypertension and chronic heart failure.— Drugs, 2006; 66 (10): 1-21.

10. Ambrosio G, et al. B-blockade with nebivolol for prevention of acute ischaemic events in elderly patients with heart failure. Heart, 2011; 97 (3): 209-14.

11. Gao Y et al. Nebivolol induces endothelium-dependent relaxations of canine coronary arteries. J Cardiovasc Pharm 1991; 17:964-9.

12. Vandeplassche G, et al. Cytoprotective effect of Nebivolol. Drug Invest 1991;3 (Suppl 1):134-6.

13. Edes I, Gasior Z, Wita K. Effects of Nebivolol on left ventricular function in elderly patients with chronic heart failure: results of the ENECA study. Eur J Heart Fail 2005; 7 (4):631-9.

14. Wisenbaugh T, et al. Long-term (3 month) effects of new/3-blocker (Nebivolol) on cardiac performance in dilated cardiomyopathy. J Am Coi/Cardiol 1993;21:1094-100.

15. Cherchia A, et al. Antianginal and antiischemic activity of Nebivolol in stable angina of effort. Drug Invest 1991; (3) Suppl.1:86-98.

16. Czuriga I, Riecansky I, Bodnar J, et al. Comparison of the new cardioselective beta-blocker Nebivolol with bisoprolol in hypertension: the Nebivolol, Bisoprolol Multicenter Study (NEBIS). Cardiovasc Drug Ther 2003; 17 (3):257-63.

17. Boydak B, Nalbantgil S, Fici F, et al. A randomized comparison of the effects of nebivolol and atenolol with and without chlorthalidone on the sexual function of hypertensive men. Clin. Drug. Invest. 2005; 25 (6): 409-16.


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For citations:


Khadzegova A.B. THE PLACE OF NEBIVOLOL IN RATIONAL THERAPY OF CONGESTIVE HEART FAILURE. Russian Journal of Cardiology. 2014;(9):72-76. (In Russ.) https://doi.org/10.15829/1560-4071-2014-9-72-76

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ISSN 1560-4071 (Print)
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