COMPARATIVE EFFECTIVENESS OF THE COMBINATIONS OF DIURETICS AND DIHYDROPYRIDINE AND NONDIHYDROPYRIDINE CALCIUM ANTAGONISTS IN PATIENTS WITH ARTERIAL HYPERTENSION
Abstract
In total, 54 patients, aged 42-65 years, with Stage II arterial hypertension (AH) were examined. At baseline and 16 weeks after the treatment phase, 24-hour blood pressure monitoring (BPM) and Doppler echocardiography were performed. The patients were randomised into 2 groups: Group 1 received combined therapy with indapamide and verapamil retard, while Group 2 was administered indapamide and amlodipine. Circadian BP rhythm was normalised in 82,8% and 76,0% of the patients from Groups 1 and 2, respectively. In Group 1, combined therapy was more effective among patients with Type I left ventricular diastolic dysfunction (LVDD), non-dipper circadian BP profile, and hyperkinetic circulation type. In Group 2, the therapy was more effective among participants with Type II-III LVDD and hypokinetic circulation type.
About the Authors
B. G. Iskenderov
Пензенский медицинский институт, Пенза
Russian Federation
Russian Federation
E. V. Gridneva
Пензенский медицинский институт, Пенза
Russian Federation
Russian Federation
O. N. Sisina
Пензенский медицинский институт, Пенза
Russian Federation
Russian Federation
L. F. Burmistrova
Пензенский институт усовершенствования врачей
Russian Federation
Russian Federation
S. V. Saushkina
Пензенский медицинский институт, Пенза
Russian Federation
Russian Federation
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Review
For citations:
Iskenderov B.G., Gridneva E.V., Sisina O.N., Burmistrova L.F., Saushkina S.V. COMPARATIVE EFFECTIVENESS OF THE COMBINATIONS OF DIURETICS AND DIHYDROPYRIDINE AND NONDIHYDROPYRIDINE CALCIUM ANTAGONISTS IN PATIENTS WITH ARTERIAL HYPERTENSION. Russian Journal of Cardiology. 2010;(6):34-39. (In Russ.)
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