OSTEONECTIN AND SELECTED BIOMARKERS IN ATHEROSCLEROTIC OCCLUSION AND CALCINOSIS OF CORONARY ARTERIES
Abstract
Blood levels of osteonectin (a protein marker of stromal stem cells with osteogenic potential) were measured, using the method of biomagnetic protein separation with magnetic microspheres, in 45 men with coronary atherosclerosis and 45 age-matched controls without coronary heart disease. Osteonectin concentration was maximal in men with atherosclerotic stenosis (AS) and calcinosis of coronary arteries. Osteonectin levels were independently associated with several key markers of atherosclerosis, metabolic syndrome, and coronary AS and calcinosis. Therefore, osteonectin could be one of the new markers of coronary AS and calcinosis.
About the Authors
Yu. I. Ragino
Научно-исследовательский институт терапии Сибирского отделения РАМН (НИИ терапии СО РАМН)
Russian Federation
Russian Federation
E. V. Kashtanova
Научно-исследовательский институт терапии Сибирского отделения РАМН (НИИ терапии СО РАМН)
Russian Federation
Russian Federation
A. M. Chernyavsky
Новосибирский НИИ патологии кровообращения им. академика Е.Н. Мешалкина Росмедтехнологий”, Новосибирск
Russian Federation
Russian Federation
A. M. Volkov
Новосибирский НИИ патологии кровообращения им. академика Е.Н. Мешалкина Росмедтехнологий”, Новосибирск
Russian Federation
Russian Federation
Ya. V. Polonskaya
Научно-исследовательский институт терапии Сибирского отделения РАМН (НИИ терапии СО РАМН)
Russian Federation
Russian Federation
M. V. Ivanova
Научно-исследовательский институт терапии Сибирского отделения РАМН (НИИ терапии СО РАМН)
Russian Federation
Russian Federation
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Review
For citations:
Ragino Yu.I., Kashtanova E.V., Chernyavsky A.M., Volkov A.M., Polonskaya Ya.V., Ivanova M.V. OSTEONECTIN AND SELECTED BIOMARKERS IN ATHEROSCLEROTIC OCCLUSION AND CALCINOSIS OF CORONARY ARTERIES. Russian Journal of Cardiology. 2010;(4):20-23. (In Russ.)
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