THE ROLE OF OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION IN DIASTOLIC CHRONIC HEART FAILURE PATIENTS OF VARIOUS AGE GROUPS

Abstract

Recently, the diastolic heart function has been studied no less than the systolic function. Age-related changes in cardiovascular system determine many features of chronic heart failure (CHF) in patients of advanced age. Due to the present lack of information, it is important to study oxidative stress and to assess the role of age-related changes on endothelial dysfunction in diastolic CHF. To study the levels of oxidative stress markers and endothelial function in diastolic CHF patients from various age groups. In total, 146 men aged 31-75 years were examined, with restrictive type of diastolic CHF of various aetiology, and NYHA class II-III. All participants were divided into two groups by their age. The control group included 30 healthy volunteers. The levels of malonic dialdehyde (MDA), diene conjugates (DC), catalase (CAT), as well as laboratory markers of endothelial dysfunction (TNF-alpha, IL-1-beta, MAU, C-reactive protein, and NO), were measured. The older patients with diastolic CHF demonstrated higher serum levels of MAU, TNF-alpha, and lower concentration of NO. Therefore, they had more severe endothelial dysfunction and free-radical stress activation (higher MDA and DC levels, lower CAT concentration), comparing to the younger patients. This could explain more severe clinical course of CHF and adverse prognosis in elder patient groups.