AGE AND ARTERIAL STRUCTURE AND FUNCTION IN MEN WITH ARTERIAL HYPERTENSION AND LIPID METABOLISM DISTURBANCES
Abstract
Aim. To assess arterial structure and function in men with arterial hypertension (AH) combined with dyslipidemia and obesity, in comparison to men with AH and normal body weight.Material and methods. The study included 205 men with the combination of AH, dyslipidemia, and obesity, as well as 42 men with AH and normal body weight. All participants (age 20–71 years) underwent ultrasound examination and oscillometry. Results. Men with disturbed lipid metabolism demonstrated a tendency towards the increase in intima-media thickness (IMT) of common carotid artery (CCA), starting from the age of 45 years. Endothelial dysfunction, manifested as reduced endothelium-dependent vasodilatation, manifested from the age of 35–38 years. These changes occurred, on average, 15 years earlier than in AH patients without dyslipidemia and obesity. Among men with AH and disturbed lipid metabolism, CCA IMT values strongly correlated with age, body mass index, waist circumference, peak systolic blood flow velocity, cholesterol levels, and pulse wave velocity.Conclusion. Obesity and dyslipidemia are not only strong predictors of cardiovascular risk, but also aetiological factors of vascular pathology.
References
1. Celermajer DS, Sorensen КЕ, Gooch VM, et al. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 2004, 340: 1111–5.
2. Ward K., Sparrow D., Landsberg L. et al. Influence of insulin sympathetic nervous system activity and obesity on BP: the normative aging study. J. Hypertens. 2006, 14 (3): 301–8.
3. Bond MG., Barnes RW., Riley WA. et al. High-ressolution B- mode ultrasound scanning methods in the atherosclerosis risk in communities study. Neuro imaging 2005; 1: 68–73.
4. U. S. Physical activity health: a report of the surgeon general. Atlanta: US Department of Health and Human Services, CDC, National Center for Disease Control and Prevention 2005.
5. Takahashi K, Miura S, Mori – Abe A et al. Impact of menopause on the augmentation of arterial stilness with aging. Gynecol. Obstet. Invest. 2005; 60 (3): 162–6.
6. Cassano P., Segal M., Vokovas P. et al. Body fat distribution, blood pressure and hypertension: a prospective cohort study of men in the normative aging study. Ann. Epidemiol. 2004, 01: 33–48.
7. Deng L. Y., Schiffrin F. L., Larochelle P. Morphology of resistance arteries of DOCA-salt hypertensives rats. Amer. J. Physiol. 2005; 262: 1782–7.
8. Drexler H. Endothelial dysfunction: clinical implications. Prog. Cardiovascular Dis. 2004; 39: 287–324.
9. Juonala M, Kuhunen M et al. Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: The Cardiovascular Risk in Young Finns Study. Еur Heart J. 2007; 12.
10. Kawamoto R., Tomita H., Oka Y. et al. Assotiation between risk factors and carotid enlargement. Inter. Med.-2006; 45 (8): 503–9.
11. Bonadonna R. C., Groop L., Kraemer N. et al. Obesity and insulin resistance in humans: a dose-response study. Metabolism 2003; 39(5): 452–9.
12. Lusher TF. Receptor-mediated endothelial vascular regulation. Arzneimittelforschung 2004; 44: ЗА: 418–9.
13. Virmani R., Avolio A. P., Mergner W. J. et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. Am. J. Pathol. 2004; 139: 1119–29.
Review
For citations:
Petrosov S.L. AGE AND ARTERIAL STRUCTURE AND FUNCTION IN MEN WITH ARTERIAL HYPERTENSION AND LIPID METABOLISM DISTURBANCES. Russian Journal of Cardiology. 2012;(6):29-33. (In Russ.)
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