ТЕОРЕТИЧЕСКОЕ ОБОСНОВАНИЕ И ПРАКТИЧЕСКИЕ АСПЕКТЫ ИСПОЛЬЗОВАНИЯ БИВАЛИРУДИНА ПРИ ЧРЕСКОЖНЫХ ВНУТРИКОРОНАРНЫХ ВМЕШАТЕЛЬСТВАХ У БОЛЬНЫХ С ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ
Аннотация
В аналитической статье представлена ключевая информация о механизме действия прямого ингибитора тромбина – бивалирудина. Обсуждаются отличия этого антикоагулянта от нефракционированного и низкомолекулярных гепаринов, фондапаринукса на уровне механизма действия, особенностей фармакокинетики и фармакодинамики. Тезисно изложены основные результаты клинических исследований с бивалирудином и позиции последнего в действующих рекомендательных документах по ведению больных с острым коронарным синдромом. Детально описаны рекомендуемые дозы бивалирудина и практические меры, призванные обеспечить эффективное и безопасное использование препарата.
Об авторе
О. В. Аверков
Городская клиническая больница № 15 им. О.М. Филатова; РУДН, Москва
Россия
доцент, заведующий кардиологическим отделением больницы № 15 имени О.М. Филатова, профессор кафедры терапии факультета повышения квалификации медицинских работников РУДН.
Россия
доцент, заведующий кардиологическим отделением больницы № 15 имени О.М. Филатова, профессор кафедры терапии факультета повышения квалификации медицинских работников РУДН.
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Рецензия
Для цитирования:
Аверков О.В. ТЕОРЕТИЧЕСКОЕ ОБОСНОВАНИЕ И ПРАКТИЧЕСКИЕ АСПЕКТЫ ИСПОЛЬЗОВАНИЯ БИВАЛИРУДИНА ПРИ ЧРЕСКОЖНЫХ ВНУТРИКОРОНАРНЫХ ВМЕШАТЕЛЬСТВАХ У БОЛЬНЫХ С ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ. Российский кардиологический журнал. 2012;(3):102-112.
For citation:
Averkov O.V. BIVALIRUDIN AND PERCUTANEOUS CORONARY INTERVENTIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME: THEORY AND PRACTICE. Russian Journal of Cardiology. 2012;(3):102-112. (In Russ.)
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