THE VALUES OF MATRIX METALLOPROTEASE-9 AND TISSUE METALLOPROTEASE INHIBITOR-1 IN ACUTE MYOCARDIAL INFARCTION WITH ANEURYSM FORMATION
https://doi.org/10.15829/1560-4071-2014-7-87-90
Abstract
Aim. To study the blood levels of MMP-9 and TIMP-1 in dynamic in patients with acute transmural anterior myocardial infarction complicated by aneurysm. Material and methods. 46 patients with acute transmural anterior myocardial infarction were included into the study. The blood levels of MMP-9 and TIMP-1 were studied. Results. In 1-3 days the patients with myocardial infarction without aneurysm had a significant increase in MMP- 9 up to 229,8 ng/ml, then to 10-12th days a decrease and then increase again up to 237,3 ng/ml by 18-22th days. In patients with myocardial infarction complicated by an aneurysm at 1-3rd and 10-12th days the level of MMP-9 increased slightly, and only at 18-22th days we observed significant increases of MMP-9 up to 159,2 ng/ml. In patients with myocardial infarction without aneurysm the level of TIMP-1 gradually grew up from 1-3rd days (698,9 ng/ml) to 18-22th days (942,3 ng/ml). In patients with myocardial infarction complicated by an aneurysm at 1-3rd and 10-12th days we observed maximum values of TIMP-1, gradually decreased to 18-22th days. Conclusion. The changes found in MMP-9 and TIMP-1 levels might indicate a delay of reparation processes in patients with myocardial infarction complicated by an aneurysm.
About the Authors
A. V. Govorin
FSBI HPE Chita State Medical Academy, Chita, Russia
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
E. V. Ratsina
FSBI HPE Chita State Medical Academy, Chita, Russia
SHI City Clinical Hospital № 1, Chita, Russia
Russian Federation
Russian Federation
N. A. Sokolova
FSBI HPE Chita State Medical Academy, Chita, Russia
Russian Federation
Russian Federation
N. V. Fetisova
FSBI HPE Chita State Medical Academy, Chita, Russia
Russian Federation
Russian Federation
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Review
For citations:
Govorin A.V., Ratsina E.V., Sokolova N.A., Fetisova N.V. THE VALUES OF MATRIX METALLOPROTEASE-9 AND TISSUE METALLOPROTEASE INHIBITOR-1 IN ACUTE MYOCARDIAL INFARCTION WITH ANEURYSM FORMATION. Russian Journal of Cardiology. 2014;(7):87-90. (In Russ.) https://doi.org/10.15829/1560-4071-2014-7-87-90
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