ТЕЛОМЕРЫ И АРТЕРИАЛЬНАЯ ГИПЕРТОНИЯ: ПАТОФИЗИОЛОГИЯ И КЛИНИЧЕСКИЕ ПЕРСПЕКТИВЫ
https://doi.org/10.15829/1560-4071-2014-6-77-84
Аннотация
Старение — основной фактор риска артериальной гипертонии (АГ) и сердечно-сосудистых заболеваний. Естественное старение при нормальном АД сопровождается параллельными структурными и функциональными изменениями в крупных артериях (ригидность), миокарде (гипертрофия) и процессах расслабления и наполнения сердечной мышцы (диастолическая дисфункция). При АГ эти изменения начинаются раньше, прогрессируют с возрастом быстрее, наблюдаются при старении с нормальным давлением и при АГ в любом возрасте. Длина теломер — особых концевых структур хромосом соматических клеток — зависит от возраста и укорачивается по мере старения. Данный обзор посвящен современным представлениям о роли теломер как биологических индикаторов старения для понимания патофизиологии эссенциальной АГ как синдрома ускоренного старения сердечно-сосудистой системы.
Об авторах
Ж. Д. Кобалава
ФПК МР Российский университет дружбы народов, Москва, Россия
Россия
д. м.н., профессор, зав.кафедрой пропедевтики внутренних болезней медицинского факультета РУДН, зав. кафедрой внутренних болезней, кардиологии и клинической фармакологии ФПК МР РУДН
Россия
д. м.н., профессор, зав.кафедрой пропедевтики внутренних болезней медицинского факультета РУДН, зав. кафедрой внутренних болезней, кардиологии и клинической фармакологии ФПК МР РУДН
Ю. В. Котовская
ФПК МР Российский университет дружбы народов, Москва, Россия
Россия
д. м.н., профессор кафедры пропедевтики внутренних болезней медицинского факультета РУДН, профессор кафедры внутренних болезней, кардиологии и клинической фармакологии ФПК МР РУДН
Россия
д. м.н., профессор кафедры пропедевтики внутренних болезней медицинского факультета РУДН, профессор кафедры внутренних болезней, кардиологии и клинической фармакологии ФПК МР РУДН
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Рецензия
Для цитирования:
Кобалава Ж.Д., Котовская Ю.В. ТЕЛОМЕРЫ И АРТЕРИАЛЬНАЯ ГИПЕРТОНИЯ: ПАТОФИЗИОЛОГИЯ И КЛИНИЧЕСКИЕ ПЕРСПЕКТИВЫ. Российский кардиологический журнал. 2014;(6):77-84. https://doi.org/10.15829/1560-4071-2014-6-77-84
For citation:
Kobalava J.D., Kotovskaya Yu.V. TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVES. Russian Journal of Cardiology. 2014;(6):77-84. (In Russ.) https://doi.org/10.15829/1560-4071-2014-6-77-84
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