BLOOD PRESSURE VARIABILITY AND THE CONDITION OF TARGET ORGANS IN MENOPAUSAL WOMEN

Aim. To study the correlation of arterial pressure variability on brachial artery and central arterial pressure variability with condition of target organs among menopausal women.

Material and methods. This research included 93 women of menopause age — 37 premenopausal women and 56 women at early postmenopause. The age was 49,1 (48,0; 51,0) and 53,9 (50,0; 56,0), resp. Of those 69 (74,2%) had arterial hypertension. No one received continuous antihypertension therapy. 24-hour blood pressure mon itoring with variability estimating of systolic and diastolic pressure and evaluation of arterial stiffnes was taken by oscillometric method. Daily index of arterial stiffness, ambulatory index of arterial stiffness, augmentation index and indicators of central aortal pressure were estimated. Echocardiogram was used for left ventricular remodeling estimation. Pulse wave velocity was measured by ultrasonic method. Vascular regulation of endoltelium of brachial artery was estimated by the test of reactive hyperemia. As a sign of large elastic arteries remodeling the intima-media thickness was used. All women with arterial hypertension divided into 2 groups depending on variability of arterial pressure — 16 women with high levels of systolic and dyastolic arterial pressure were in first group and 53 women with normal indicators of variability were in second group. Control group consisted of 24 women that had no arterial hypertension with normal indicators of arterial pressure variability. Results. Disordered arterial pressure was prevalent among women in early postmeno­pause. Raise of variability of arterial pressure was correlated with morphofunctional changes of the heart, structure-functional vascular changes, increase of arterial stiffeness, disturbances of endoltelial vascular regulation and subclinical kidneys damage. Conclusion. Central arterial pressure variability has no additional advantages in comparison with estimated variability of brachial artery pressure. Increased variability of arterial pressure among menopausal women can be considered as additional factor of target organ damage in early stages of climacteric.

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