THE ROLE OF TOLL-LIKE RECEPTORS POLYMORPHISM IN ATHEROSCLEROSIS COMPLICATIONS DEVELOPMENT

Aim. To reveal the association of polymorphic types of Toll-like receptor genes with myocardial infarction (MI), stroke in patients with coronary heart disease (CHD).

Material and methods. Totally 292 patients studied, with CHD and anamnesis of stroke and/or MI. The association of 8 polymorphic loci of 4 genes were studied: TLR1 (rs5743551 & rs5743611), TLR2 (rs3804099 & rs5743708), TLR4 (rs4986790 & rs4986791), TLR6 (rs3775073 & rs5743810).

Results. The association of allele C of polymorphism rs5743551 gene TLR1 is associated with higher risk of earlier CHD onset (younger than 55 y.o.). Heterozygous (A/G) genotype of polymorphism rs5743810 TLR6 is protective against the risk of earlier CHD onset (younger than 55 y.o.). Heterozygous (C/T) genotype of polymorphism rs5743551 gene TLR1 is associated with higher risk of stroke in CHD patients. The associations revealed with age, gender and cardiovascular complications by polymorphisms of TLR genes: males, having CHD, homozygous by minor allele (С/С) of polymorphism rs3804099 gene TLR2, have reduced risk of of MI development not related to age; heterozygous (C/T) genotype of polymorphism rs5743551 of gene TLR1 is associated with the increased risk of stroke in CHD patients older than 55 y.o. not depending on gender; heterozygous (T/C) genotype of polymorphism rs3775073 gene TLR6 is associated with increased risk of MI in younger than 55 y.o. patients with CHD not related to gender.

Conclusion. Some associations of polymorphic Toll-like receptors genes with the development of atherosclerosis complications (MI, stroke) in CHD are revealed.

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