Key mechanisms of the relationship between vitamin D and cardiovascular disease
https://doi.org/10.15829/1560-4071-2022-4602
Abstract
Recent research indicates that vitamin D does indeed have a wide range of biological effects beyond its regulating function of bone and mineral homeostasis. Vitamin D deficiency is associated with leading predictors of cardiovascular risk, such as obesity, hypertension, and type 2 diabetes. In addition, it plays a role in the disease progression and worsening of the prognosis in patients with left ventricular hypertrophy, coronary artery disease, heart failure, and chronic kidney disease. An analysis was made of studies aimed at evaluating the efficacy and safety of vitamin D therapy in order to reduce the risk of cardiovascular pathologies, as well as improve the clinical course and outcomes in patients with existing metabolic disorders and cardiovascular diseases.
About the Author
Yu. S. SytayaRussian Federation
Moscow
Competing Interests:
none
References
1. Marino R, Misra M. Extra-Skeletal Effects of Vitamin D. Nutrients. 2019;11(7):1460. doi:10.3390/nu11071460.
2. Guo J, Cockcroft JR, Elwood PC, et al. Vitamin D intake and risk of CVD and all-cause mortality: evidence from the Caerphilly Prospective Cohort Study. Public Health Nutr. 20(15):2744-53. doi:10.1017/S1368980017001732.
3. Gouni-Berthold I, Berthold HK. Vitamin D and Vascular Disease. Curr Vasc Pharmacol. 2021;19(3):250-68. doi:10.2174/1570161118666200317151955.
4. Wang Y, Zhang Y, Wei J, et al. Vitamin D for inflammation biomarkers in coronary artery disease: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020;99(31):e21407. doi:10.1097/MD.0000000000021407.
5. de la Guía-Galipienso F, Martínez-Ferran M, Vallecillo N, et al. Vitamin D and cardiovascular health. Clin Nutr. 2021;40(5):2946-57. doi:10.1016/j.clnu.2020.12.025.
6. Orkaby AR, Djousse L, Manson JE. Vitamin D supplements and prevention of cardiovascular disease. Curr Opin Cardiol. 2019;34(6):700-5. doi:10.1097/HCO.0000000000000675.
7. Rai V, Agrawal DK. Role of Vitamin D in Cardiovascular Diseases. Endocrinol Metab Clin North Am. 2017;46(4):1039-59. doi:10.1016/j.ecl.2017.07.009.
8. Sizar O, Khare S, Goyal A, et al. Vitamin D Deficiency. 2021. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.
9. Saponaro F, Saba A, Zucchi R. An Update on Vitamin D Metabolism. Int J Mol Sci. 2020;21(18):6573. doi:10.3390/ijms21186573.
10. Izzo M, Carrizzo A, Izzo C, et al. Vitamin D: Not Just Bone Metabolism but a Key Player in Cardiovascular Diseases. Life (Basel). 2021;11(5):452. doi:10.3390/life11050452.
11. Jamali N, Sorenson CM, Sheibani N. Vitamin D and regulation of vascular cell function. Am J Physiol Heart Circ Physiol. 2018;314(4):H753-H765. doi:10.1152/ajpheart.00319.2017.
12. Matsui MS. Vitamin D Update [published online ahead of print, 2020 Oct 14]. Curr Dermatol Rep. 2020;1-8. doi:10.1007/s13671-020-00315-0.
13. Zittermann A, Trummer C, Theiler-Schwetz V, et al. Vitamin D and Cardiovascular Disease: An Updated Narrative Review. Int J Mol Sci. 2021;22(6):2896. doi:10.3390/ijms22062896.
14. Latic N, Erben RG. Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure. Int J Mol Sci. 2020;21(18):6483. doi:10.3390/ijms21186483.
15. Zittermann A, Berthold HK, Pilz S. The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2021;75(6):980-7. doi:10.1038/s41430-020-00725-0.
16. Reznik EV, Nikitin IG. Mineral and bone disorders in chronic heart failure. Kardiologiia. 2018;58(S2):42-62. (In Russ.) doi:10.18087/cardio.2429.
17. Kowalówka M, Główka AK, Karaźniewicz-Łada M, et al. Clinical Significance of Analysis of Vitamin D Status in Various Diseases. Nutrients. 2020;12(9):2788. doi:10.3390/nu12092788.
18. Krishna SM. Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation. Int J Mol Sci. 2019;20(19):4907. doi:10.3390/ijms20194907.
19. Beketova NA, Kosheleva OV, Vrzhesinskaya OA, et al. Supply of vitamins for patients with type 2 diabetes and obesity in the autumn. Cardiovascular Therapy and Prevention. 2019;18(1):95-101. (In Russ.) doi:10.15829/1728-8800-2019-1-95-101.
20. Stepanova AP, Karonova TL, Bystrova AA, et al. Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development. Diabetes Mellitus. 2018;21(4):301-6. (In Russ.) doi:10.14341/DM9583.
21. Stepanova AP, Karonova TL. The effect of vitamin D therapy on inflammatory markers in patients with type 2 diabetes mellitus and diabetic peripheral polyneuropathy. Diabetes Mellitus. 2019;22(5):417-27. (In Russ.) doi:10.14341/DM10316.
22. Yankouvskaya LV, Snezhitskiy VA, Mamedov MN. Effect of Cholecalciferol and Diuretics as Components of Combination Antihypertensive Therapy on Plasma Renin Activity and Endothelial Function in Patients With Arterial Hypertension. Kardiologiia. 2017;57(8):34-9. (In Russ.) doi:10.18087/cardio.2017.8.10015.
23. Sentsova TB, Vorozhko IV, Chernyak OO, et al. Characteristics of the Renin-AngiotensinAldosterone System in Carriers of Polymorphic Variants of the VDR Gene With Arterial Hypertension and Obesity. Kardiologiia. 2018;58(8):45-9. (In Russ.) doi:10.18087/cardio. 2018.8.10142.
24. Pérez-Hernández N, Aptilon-Duque G, Nostroza-Hernández MC, et al. Vitamin D and its effects on cardiovascular diseases: a comprehensive review. Korean J Intern Med. 2016;31(6):1018-29. doi:10.3904/kjim.2015.224.
25. Karonova TL, Andreeva AT, Zlotnikova EK, et al. Vitamin D deficiency and hypertension: what is in common? Arterial’naya Gipertenziya. 2017;23(4):275-81. (In Russ.) doi:10.18705/1607-419X-2017-23-4-275-281.
26. Bogachev RS, Mikhailova LV, Shytova ES, et al. Vitamin D deficiency in patients with acute coronary syndrome. Complex Issues of Cardiovascular Diseases. 2019;8(2):12-20. (In Russ.) doi:10.17802/2306-1278-2019-8-2-12-20.
27. Legarth C, Grimm D, Krüger M, et al. Potential Beneficial Effects of Vitamin D in Coronary Artery Disease. Nutrients. 2019;12(1):99. doi:10.3390/nu12010099.
28. Aljefree NM, Lee P, Ahmed F. Knowledge and attitudes about vitamin D, and behaviors related to vitamin D in adults with and without coronary heart disease in Saudi Arabia. BMC Public Health. 2017;17(1):266. doi:10.1186/s12889-017-4183-1.
29. Cubbon RM, Lowry JE, Drozd M, et al. Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure. Eur J Nutr. 2019;58(6):2535-43. doi:10.1007/s00394-018-1806-y.
30. Banerjee D, Jha V. Vitamin D and Cardiovascular Complications of CKD: What’s Next? Clin J Am Soc Nephrol. 2019;14(6):932-4. doi:10.2215/CJN.12581018.
31. Lim K, Hamano T, Thadhani R. Vitamin D and Calcimimetics in Cardiovascular Disease. Semin Nephrol. 2018;38(3):251-66. doi:10.1016/j.semnephrol.2018.02.005.
32. Song JY, Shen TC, Hou YC, et al. Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease. Int J Mol Sci. 2020;21(17):6294. doi:10.3390/ijms21176294.
33. Cianciolo G, Cappuccilli M, Tondolo F, et al. Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients. Nutrients. 2021;13(5):1453. doi:10.3390/nu13051453.
34. Scragg R, Stewart AW, Waayer D, et al. Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study: A Randomized Clinical Trial. JAMA Cardiol. 2017;2(6):608-16. doi:10.1001/jamacardio.2017.0175.
35. Manson JE, Bassuk SS, Buring JE, et al. Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and updated meta-analyses of relevant vitamin D trials. J Steroid Biochem Mol Biol. 2020;198:105522.
36. Zhang D, Cheng C, Wang Y, et al. Effect of Vitamin D on Blood Pressure and Hypertension in the General Population: An Update Meta-Analysis of Cohort Studies and Randomized Controlled Trials. Prev Chronic Dis. 2020;17:E03. doi:10.5888/pcd17.190307.
37. Angellotti E, D’Alessio D, Dawson-Hughes B, et al. Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes. Clin Nutr. 2019;38(5):2449-53. doi:10.1016/j.clnu.2018.10.003.
38. Rodriguez AJ, Mousa A, Ebeling PR, et al. Effects of vitamin D supplementation on inflammatory markers in heart failure: a systematic review and meta-analysis of randomized controlled trials. Sci Rep. 2018;8(1):1169. doi:10.1038/s41598-018-19708-0.
39. Hao Y, Chen Y. Vitamin D levels and vitamin D receptor variants are associated with chronic heart failure in Chinese patients. J Clin Lab Anal. 2019;33(4):e22847. doi:10.1002/ jcla.22847.
40. Buleu FN, Luca CT, Tudor A, et al. Correlations between Vascular Stiffness Indicators, OPG, and 25-OH Vitamin D3 Status in Heart Failure Patients. Medicina (Kaunas). 2019;55(6):309. doi:10.3390/medicina55060309.
41. Gluba-Brzózka A, Franczyk B, Ciałkowska-Rysz A, et al. Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. Nutrients. 2018;10(6):709. doi:10.3390/nu10060709.
42. Borgi L, McMullan C, Wohlhueter A, et al. Effect of Vitamin D on Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Trial. Am J Hypertens. 2017;30(2):1249. doi:10.1093/ajh/hpw135.
Supplementary files
Review
For citations:
Sytaya Yu.S. Key mechanisms of the relationship between vitamin D and cardiovascular disease. Russian Journal of Cardiology. 2022;27(1):4602. (In Russ.) https://doi.org/10.15829/1560-4071-2022-4602