The role of Helicobacter pylori in cardiovascular toxicity mechanisms
https://doi.org/10.15829/1560-4071-2019-12-169-174
Abstract
Despite the long history of the concept where infection plays a significant role in cardiovascular diseases (atherosclerosis in particular), today it is relevant and represented a significant interest.
This article discusses H. pylori role in mechanisms of cardiovascular homeostasis disturbance. H. pylori involvement in atherogenic damage of arteries, and/or plaque destabilization is no doubt. This vidence is detailed in this review article.
About the Authors
A. A. AvagimyanArmenia
Yerevan
L. G. Mkrtchyan
Armenia
Yerevan
G. A. Navasardyan
Armenia
Yerevan
A. A. Gevorkyan
Armenia
Yerevan
E. A. Ananyan
Armenia
Yerevan
N. E. Pashinyan
Armenia
Yerevan
K. G. Abgaryan
Armenia
Yerevan
References
1. Navasardyan G. Textbook of fundamental pathophysiology. Yerevan State Medical University PRESS. Yerevan, RA. 2018. (In Armenian). ISBN 978-9939-65-127-9.
2. Yuan X, Wang Y, Wang M. The type IV secretion system in Helicobacter pylori. Future Microbiol. 2018;13(2):1041-54. doi:10.2217/fmb-2018-0038.
3. Itani H, McMaster W, Saleh M, et al. Activation of human T cells in hypertension: studies of humanized mice and hypertensive humans. Hypertension. 2016;68(1):123-32. doi:10.1161/HYPERTENSIONAHA.116.07237.
4. Pavlov ON. Inflammation and increasing H. pylori antibody titers in acute coronary syndrome. Russian Journal of Cardiology. 2011;(6):43-6. (In Russ.) Павлов О.Н. Связь воспаления с ростом титра антител к H. pylori при остром коронарном синдроме. Российский кардиологический журнал. 2011;(6):43-6. doi:10.15829/1560-4071-2011-6-78-82.
5. Mejias R, Lozano P, Wanisch A, et al. Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection. Sci Rep. 2019;9(1):70-4. doi:10.1038/s41598-019-43417-x.
6. Pasparakis M. Role of NF-κB in epithelial biology. Immunol Rev. 2012;246(1):346-58. doi:10.1111/j.1600-065X.2012.01109.x.
7. Park K, Byun H, Won M, et al. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. Carcinogenesis. 2007 Jan;28(1):71-80. doi:10.1093/carcin/bgl094.
8. Nina V, Ute A, Julia B, et al. Helicobacter pylori Seropositivity: Prevalence, Associations, and the Impact on Incident Metabolic Diseases/Risk Factors in the Population-Based KORA Study. Front Public Health. 2019;24(7):96-104. doi:10.3389/fpubh.2019.00096. eCollection 2019.
9. Chen L, Xu W, Lee A, et al. The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial. EBioMedicine. 2018;35(1):87-96. doi:10.1016/j.ebiom.2018.08.028.
10. Avagimyan A. The novel visibility of myocarditis. From pathology to treatment. Aristotle Biomed J. 2019:1(1):32-47.
11. Masahiro K, Junya Tanaka, Nobuhiro A, et al. Helicobacter pylori Promotes the Production of Thymic Stromal Lymphopoietin by Gastric Epithelial Cells and Induces Dendritic Cell-Mediated Inflammatory Th2 Responses. Infect Immun. 2010;78(1):108-14. doi:10.1128/IAI.00762-09.
12. Xu Y, Huang D, Lü S, et al. Mechanical features of endothelium regulate cell adhesive molecule-induced calcium response in neutrophils. APL Bioeng. 2019;28(1):104-22. doi:10.1063/1.5045115.
13. Zaph C, Troy E, Taylor, et al. Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis. Nature 2007;446(4):552-6.
14. Francisco V, Ruiz-Fernández C, Pino J et al. Adipokines: linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol. 2019;52(9):16-9. doi:10.1016/j.bcp.2019.03.030.
15. Tay M, Lim S, Leong Y, et al. Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia. Front Immunol. 2019;27(10):5705. doi:10.3389/fimmu.2019.00575.
16. Ilze B, Guo S, Petri T. Mast cells as effectors in atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;35(2):265-71. doi:10.1161/ATVBAHA.114.303570.
17. Hamed S, Amine N, Galal G, et al. Vascular risks and complications in diabetes mellitus: the role of helicobacter pylori infection. J Stroke Cerebrovasc Dis. 2008;17(2):86-94. doi:10.1016/j.jstrokecerebrovasdis.2007.10.006.
18. Paul G, Sreyoshi F. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015;14:6. doi:10.1186/1475-2891-14-6.
19. Mędrek M, Chojnacki J, Smigielski J et al. Changes in the lipid profile of patients with asymptomatic and symptomatic helicobacter pylori infection. Wiad Lek. 2018;71(8):1467-73.
20. Choi J, Lim S, Han Y, et al. Association between Helicobacter pylori infection and arterial stiffness: Results from a large cross-sectional study. PLoS One. 2019;14(8):16-23. doi:10.1371/journal.pone.0221643.
21. Gomez L, Garcia L, Patino M, et al. Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial. Cardiovasc Diabetol. 2016;15(1):148. doi:10.1186/s12933-016-0465-7.
22. Yang S, Xia Y, Luo X, et al. Exosomal CagA derived from Helicobacter pylori-infected gastric epithelial cells induces macrophage foam cell formation and promotes atherosclerosis. J Mol Cell Cardiol. 2019;135(3):40-51. doi:10.1016/j.yjmcc.2019.07.011.
23. Kowalski M. Helicobacter pylori (H. pylori) infection in coronary artery disease: influence of H. pylori eradication on coronary artery lumen after percutaneous transluminal coronary angioplasty. The detection of H. pylori specific DNA in human coronary atherosclerotic plaque. J Physiol Pharmacol. 2001;52(1):3-31.
24. Shan J, Bai X, Han L, et al. Association between atherosclerosis and gastric biomarkers concerning Helicobacter pylori infection in a Chinese healthy population. Exp Gerontol. 2018;112(2):97-102. doi:10.1016/j.exger.2018.09.009.
25. Pantea M, Negovan A, Voidãzan S, et al. Statins and gastroduodenal endoscopic lesions: A case-control study. Medicine (Baltimore). 2018;97(50):13-25. doi:10.1097/MD.0000000000013579.
26. Stone A, Mendall M, Kaski J. Effect of treatment for Chlamydia pneumoniae and Helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes: South Thames Trial of Antibiotics in Myocardial Infarction and Unstable Angina (STAMINA). Circulation. 2002;106(10):1219-23.
27. Feng L, Deng C, Li Y. Assessment of the Relationship between Carotid Intima-Media Thickening and Early-Stage Diabetic Kidney Disease Coupled with Helicobacter pylori Infection. Dis Markers. 2018:201(1):37-93. doi:10.1155/2018/3793768.
28. Lee M, Baek H, Park J, et al. Current Helicobacter pylori infection is significantly associated with subclinical coronary atherosclerosis in healthy subjects: A cross-sectional study. PLoS One. 2018 Mar 2;13(3):e0193646. doi:10.1371/journal.pone.0193646.
29. He C, Yang Z, Lu N. Helicobacter pylori-an infectious risk factor for atherosclerosis? J Atheroscler Thromb. 2014;21(12):1229-42. Epub 2014 Oct 24.
30. Karadag Z, Sehitoglu T, Cure M, et al. Helicobacter pylori can be related to carotid intimamedia thickness, epicardial adipose tissue thickness and serum neutrophil gelatinaseassociated lipocalin (NGAL) levels. Bratisl Lek Listy. 2018;119(5):302-7. doi:10.4149/BLL_2018_057.
31. Avagimyan A, Ananyan E, Djndoyan Z, Navasardyan G. The modern visibility of atherosclerosis development. Med News Armenia J. 2019;78(1):3-29. (In Russ.)
32. Xu Z, Li J, Wang H, et al. Helicobacter pylori infection and atherosclerosis: is there a causal relationship? Eur J Clin Microbiol Infect Dis. 2017;36(12):2293-301. doi:10.1007/s10096017-3054-0.
33. Mkrtchyan L. A textbook of atherosclerosis. Yerevan State Medical University PRESS. Yerevan, RA. 2019. (In Armenian). ISBN 978-9939-65-140-8.
34. Johansen H, Norgaard A, Andersen L, et al. Cross-reactive antigens shared by Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Haemophilus influenzae may cause false-positive titers of antibody to H. pylori. Clin Diagn Lab Immunol. 1995;2(2):149-55.
Review
For citations:
Avagimyan A.A., Mkrtchyan L.G., Navasardyan G.A., Gevorkyan A.A., Ananyan E.A., Pashinyan N.E., Abgaryan K.G. The role of Helicobacter pylori in cardiovascular toxicity mechanisms. Russian Journal of Cardiology. 2019;(12):169-174. (In Russ.) https://doi.org/10.15829/1560-4071-2019-12-169-174