The role of inflammatory theory in the pathogenesis of atrial fibrillation
https://doi.org/10.15829/1560-4071-2019-7-110-114
Abstract
Based on the data available in the literature, it is obvious that inflammation plays a significant role in the initiation, support and progression of AF. However, it is important that AF by itself is a factor provoking the development of inflammation in the atrial myocardium, which leads to the further progression of the disease according to the principle of “AF produces AF.” The question of the primacy of the development and correlations of process links is still not fully understood: does inflammation leads to fibrillation or does fibrillation leads to inflammation?
The authors analyzed the data of the world literature and tried to describe the main concepts of the inflammatory theory of AF and the practical aspects of its application.
About the Authors
K. V. Davtyan
National Research Center for Preventive Medicine
Russian Federation
Competing Interests: not
Russian Federation
Moscow
Competing Interests: not
A. A. Kalemberg
National Research Center for Preventive Medicine
Russian Federation
Competing Interests: not
Russian Federation
Moscow
Competing Interests: not
E. N. Tsareva
National Research Center for Preventive Medicine
Russian Federation
Competing Interests: not
Russian Federation
Moscow
Competing Interests: not
O. V. Blagova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Competing Interests: not
Russian Federation
Competing Interests: not
M. S. Harlap
National Research Center for Preventive Medicine
Russian Federation
Competing Interests: not
Russian Federation
Moscow
Competing Interests: not
References
1. Ha'i'ssaguerre M, Ja'i's P, Shah DC, et al. Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins. N Engl J Med. 1998;339(10):659-66. doi:10.1056/NEJM199809033391003.
2. Hakalahti A, Biancari F, Nielsen JC, et al. Radiofrequency ablation vs. antiarrhythmic drug therapy as first line treatment of symptomatic atrial fibrillation: systematic review and meta-analysis. Europace. 2015;17(3):370-8. doi:101093/europace/euu376.
3. Heeger C-H, Kuck K-H, Ouyang F. Pulmonal vene nisolation bei Vorhofflimmern. Herz. 2017;42(4):343-51. doi:10.1007/s00059-017-4565-2.
4. Frost L, Johnsen SP, Pedersen L, et al. Seasonal variation in hospital discharge diagnosis of atrial fibrillation: a population-based study. Epidemiology. 2002;13(2):211-5. doi:10.1097/00001648-200203000-00017.
5. Tsai F-C, Chang G-J, Hsu Y-J, et al. Proinflammatory gene expression in patients undergoing mitral valve surgery and maze ablation for atrial fibrillation. J Thorac Cardiovasc Surg. 2016;151(6):1673-82.e5. doi:10.1016/j.jtcvs.2015.12.003.
6. Shiroshitatakeshita A, Brundel B, Lavoie J, et al. Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs. Cardiovasc Res. 2006;69(4):865-75. doi:10.1016/j.cardiores.2005.11.028.
7. Frustaci A, Caldarulo M, Buffon A, et al. Cardiac biopsy in patients with “primary” atrial fibrillation; Histologic evidence of occult myocardial diseases. Chest. 1991;100(2):303-6. doi.org/10.1378/chest.100.2.303.
8. Gedikli O, Dogan A, Altuntas I, et al. Inflammatory markers according to types of atrial fibrillation. Int J Cardiol. 2007;120(2):193-7 doi:10.1016/j.ijcard.2006.09.015.
9. Dernellis J, Panaretou M. Relationship between C-reactive protein concentrations during glucocorticoid therapy and recurrent atrial fibrillation. European Heart Journal.2004;25:1100-107. doi:10.1016/j.ehj.2004.04.035.
10. Viviano A, Kanagasabay R, Zakkar M. Is perioperative corticosteroid administration associated with a reduced incidence of postoperative atrial fi brillation in adult cardiac surgery. Interactive CardioVascular and Thoracic Surgery. 2014;18:225-9. doi:101093/icvts/ivt486.
11. Musa H, Kaur K, O'connell R, et al. Inhibition of Platelet-Derived Growth Factor-AB Signaling Prevents Electromechanical Remodeling of Adult Atrial Myocytes that Contact Myofibroblasts. Heart Rhythm. 2013;10(7):1044-51. doi:10.1016/j.hrthm.2013.03.014.
12. Tselentakis EV, Woodford E, Chandy J, et al. Inflammation Effects on the Electrical Properties of Atrial Tissue and Inducibility of Postoperative Atrial Fibrillation. Journal of Surgical Research. 2006;135:68-75. doi:10.1016/j.jss.2006.03.024.
13. Ryu K, Li L, Khrestian CM, et al. Effects of sterile pericarditis on connexins 40 and 43 in the atria: correlation with abnormal conduction and atrial arrhythmias. Am J Physiol Hear Circ Physiol. 2007; 293:1231-41. doi:10.1152/ajpheart.00607.2006.
14. Sawaya SE, Rajawat YS, Rami TG, et al. Downregulation of connexin40 and increased prevalence of atrial arrhythmias in transgenic mice with cardiac-restricted overexpression of tumor necrosis factor. Am J Physiol Hear Circ Physiol. 2007;292:1561-7. doi:101152/ajpheart.00285.2006.
15. Liew R, Khairunnisa K, Gu Y, et al. Role of tumor necrosis factor-а in the pathogenesis of atrial fibrosis and development of an arrhythmogenic substrate. Circ J. 2013;77(5):1171-9. doi:10.1253/circj.CJ-12-1155.
16. Li YY, Feng YQ, Kadokami T, et al. Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by antitumor necrosis factor alpha therapy. Proc Natl Acad Sci USA. 2000;97(23): 12746-51. doi:10.1073/pnas.97.23.12746.
17. Liao C-H, Akazawa H, Tamagawa M, et al. Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts. J Clin Invest. 2010;120. doi:10.1172/JCI39942.
18. Burstein B, Libby E, Calderone A, et al. Differential Behaviors of Atrial Versus Ventricular Fibroblasts A Potential Role for Platelet-Derived Growth Factor in Atrial-Ventricular Remodeling Differences. Circulation. 2008; 117:1630-41. doi: 10.1161/CIRCULATIONAHA.107.748053.
19. Luan Y, Guo Y, Li S, et al. Interleukin-18 among atrial fibrillation patients in the absence of structural heart disease. Europace. 2010;12(12):1713-8. doi:10.1093/europace/euq321.
20. Psychari SN, Apostolou TS, Sinos L, et al. Relation of elevated C-reactive protein and interleukin-6 levels to left atrial size and duration of episodes in patients with atrial fibrillation. Am J Cardiol. 2005;95(6):764-7. doi:10.1016/j.amjcard.2004.11.032.
21. Roldan V, Marin F, Diaz J, et al. High sensitivity cardiac troponin T and interleukin-6 predict adverse cardiovascular events and mortality in anticoagulated patients with atrial fibrillation. J Thromb Haemost. 2012;10(8):1500-7. doi:10.1111/j.1538-7836.2012.04812.x.
22. Lip GYH, Patel J V., Hughes E, et al. High-Sensitivity C-Reactive Protein and Soluble CD40 Ligand as Indices of Inflammation and Platelet Activation in 880 Patients With Nonvalvular Atrial Fibrillation. Stroke. 2007;38(4):1229-37. doi:10.1161/01.STR.0000260090.90508.3e.
23. Nakamura Y, Nakamura K, Fukushima-Kusano K, et al. Tissue factor expression in atrial endothelia associated with nonvalvular atrial fibrillation: possible involvement in intracardiac thrombogenesis. Thrombosis Research. 2003;111:137-42. doi:10.1016/S0049-3848(03)00405-5.
24. Lu T-F, Lin T-M, Tsao Y-J, et al. Plasma Asymmetric Dimethylarginine and Adverse Events in Patients with Atrial Fibrillation Referred for Coronary Angiogram. PLoS One. 2013;8(8):71675. doi:10.1371/journal.pone.0071675.
25. Roldan V, Marin F, Muina B, et al. Atrial Fibrillation Plasma von Willebrand Factor Levels Are an Independent Risk Factor for Adverse Events Including Mortality and Major Bleeding in Anticoagulated Atrial Fibrillation Patients. JAC. 2011;57:2496-504. doi: 10.1016/j.jacc.2010.12.033.
26. Fukuchi M, Watanabe J, Kumagai K, et al. Increased von Willebrand Factor in the Endocardium as a Local Predisposing Factor for Thrombogenesis in Overloaded Human Atrial Appendage. JACC. 2001;5:1436-42. doi:10.1016/S0735-1097(01)01125-1.
27. Conway DSG, Buggins P, Hughes E, et al. Relation of Interleukin-6, C-Reactive Protein, and the Prothrombotic State to Transesophageal Echocardiographic Findings in Atrial Fibrillation. Am J Cardiol. 2004;93. doi:10.1016/j.amjcard.2004.02.032.
Review
For citations:
Davtyan K.V., Kalemberg A.A., Tsareva E.N., Blagova O.V., Harlap M.S. The role of inflammatory theory in the pathogenesis of atrial fibrillation. Russian Journal of Cardiology. 2019;(7):110-114. (In Russ.) https://doi.org/10.15829/1560-4071-2019-7-110-114
Views:
1077
Email this article 