Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial
https://doi.org/10.15829/1560-4071-2019-7-68-74
Abstract
Aim. To identify the features of myocardial remodeling after implantation of a dispersed allogenic biomaterial (DAB) in the subacute stage of experimental infarction and determine the role of decay products in the formation of regenerate.
Material and methods. Male rats in the control group (n=30) 5 days after coronary occlusion received physiological saline (intramyocardially), in the experimental group (n=30) — 3 mg of DAB. Myocardial tissues were examined after 7 14, 50 days from the beginning of the experiment using histological, immunohistochemical and statistical methods.
Results. In the experimental group, the cicatrix area was reduced by 1,66 times. The products of DAB biodegradation were collagen, sulfated (dermatan- and keratan sulfate), as well as non-sulfated (hyaluronic acid) glycosaminoglycans. Used DAB served as a promoter of the early proliferative phase of inflammation and had an anti-inflammatory effect. DAB particles were a chemoattractant of stem and progenitor myocardial cells in the subacute stage of myocardial infarction. It contributed to their differentiation and integration into the tissue.
Conclusion. The products of biodegradation of allogeneic biomaterial, administered intramyocardially in the subacute stage of infarction, contribute to the formation of muscular-connective tissue regenerate and effectively prevent its cicatricial devolution.
Supporting agencies: The study was conducted within the framework of the state assignment № 056-00110-18-00
About the Authors
A. I. Lebedeva
http://www.researcherid.com/rid/N-3484-2018
All-Russian Eye and Plastic Surgery Center; Bashkir State Medical University
Russian Federation
Competing Interests: not
All-Russian Eye and Plastic Surgery Center; Bashkir State Medical University
Russian Federation
Competing Interests: not
S. A. Afanasyev
Research Institute of Cardiology, National Research Medical Center
Russian Federation
Competing Interests: not
Russian Federation
Competing Interests: not
D. S. Kondratyeva
Research Institute of Cardiology, National Research Medical Center
Russian Federation
Competing Interests: not
Russian Federation
Competing Interests: not
E. M. Gareev
All-Russian Eye and Plastic Surgery Center
Competing Interests: not
Ufa
Competing Interests: not
S. A. Muslimov
All-Russian Eye and Plastic Surgery Center; Bashkir State Medical University
Russian Federation
Competing Interests: not
Russian Federation
Ufa
Competing Interests: not
S. V. Popov
Research Institute of Cardiology, National Research Medical Center
Competing Interests: not
Competing Interests: not
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Review
For citations:
Lebedeva A.I., Afanasyev S.A., Kondratyeva D.S., Gareev E.M., Muslimov S.A., Popov S.V. Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial. Russian Journal of Cardiology. 2019;(7):68-74. (In Russ.) https://doi.org/10.15829/1560-4071-2019-7-68-74
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