Efficacy and tolerance of Arifam in patients with arterial hypertension over 55 years old: main results of the observational program ARBALET
https://doi.org/10.15829/1560-4071-2018-12-64-74
Abstract
Aim. To assess the effectiveness and safety of therapy with fixed combination of amlodipine/indapamide (Arifam) in outpatients with arterial hypertension (AH) over 55 years old.
Material and methods. We included 2217 patients in the observation — 692 (31%) men and 1521 (69%) women. Changes in the course of 3-month therapy of systolic and diastolic blood pressure (BP), the frequency of achievement of target BP levels (<140/90 mm Hg), responder rate during the clinical and ambulatory blood pressure measurement were evaluated and.
Results. With the use of Arifam fixed combination 89,81% of patients achieved target BP level by the 3rd month of treatment, 73,77% of patients achieved positive response in 2 weeks, 94,88% of patients — after 1 month. According to the selfcontrol data, the target BP level (<135/85 mm Hg) was achieved in 79,47% of patients. The number of patients with pulse BP <60 mm Hg increased after 3 months of treatment to 81,97%. Also 48 (2,17%) patients discontinued participation; 6 (0,28%) patients — due to the development of adverse events.
Conclusion. The ARBALET program has demonstrated high efficacy and tolerance of using Arifam fixed combination in outpatients over 55 years old with hypertension.
About the Authors
Zh. D. Kobalava
The Peoples’ Friendship University of Russia
Moscow
Moscow
V. V. Tolkacheva
The Peoples’ Friendship University of Russia
Russian Federation
Moscow
Russian Federation
Moscow
N. Kh. Bagmanova
The Peoples’ Friendship University of Russia
Moscow
Moscow
E. R. Khasanova
The Peoples’ Friendship University of Russia
Moscow
Moscow
References
1. Kobalava ZhD, Shavarova EK. Clinical features of arterial hypertension in the elderly and senile age and the rationale for using the combination of amlodipine/indapamide-retard. Kardiologiia. 2017;57(8):60-70. (In Russ.) doi: 10.18087/cardio.2017.8.10020
2. Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA. 2010;303:2043. doi:10.12691/ajhr-1-1-2.
3. Aronow WS, Fleg JL, Pepine CJ, et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation. 2011;123(21):2434506. doi:10.1161/CIR.0b013e31821daaf6.
4. Kobalava ZhD, Kotovskaya YuV, Aseeva OA, et al. Clinicodemographic characteristics of various variants of arterial hypertension in elderly patients (according to the results of the Russian scientific and practical program ARGUS). Therapeutic archive. 2002;2:47-51. (In Russ.)
5. Nilsson PM, Olsen MH, Laurent S. Early Vascular Aging (EVA): New Directions in Cardiovascular Protection. Elsevier. 2015,343 p. ISBN: 978-0-12-801387-8.
6. Franklin SS, Pio JR, Wong ND, et al. Predictors of new-onset diastolic and systolic hypertension: the Framingham Heart Study. Circulation. 2005;111:1121-7. doi:10.1161/01. CIR.0000157159.39889.EC.
7. Falaschetti E, Mindell J, Knott C, et al. Hypertension management in England: a serial cross-sectional study from 1994 to 2011. Lancet. 2014;383:1912-9. doi:10.1016/S01406736(14)60688-7.
8. Kobalava ZD, Kotovskaya YuV, Moiseev VS. Arterial hypertension. The keys to diagnosis and treatment. M.: GEOTAR-Media. 2009. р. 864 (In Russ.) ISBN 978-5-9704-1026-4.
9. Alderman MH, Cohen HW, Sealey JE, et al. Pressor responses to antihypertensive drug types. Am J Hypertens. 2010;23(9):1033-37. doi:10.1038/ajh.2010.114.
10. Kobalava ZhD, Shavarova EK, Padaryan SS. Fixed combination of amlodipine/indapamideretard in the treatment of uncontrolled hypertension in subjects over 55 years old. Arterial hypertension. 2018;12. In print. (In Russ.)
11. Mancia G, Fagard R, Narkiewicz K, et al. Task Force Members. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013;31:1281-357. doi:10.1093/eurheartj/eht151.
12. ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71:e127-e248. doi:10.1161/HYP.0000000000000065.
13. 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal. 2018;39:3021-104. doi:10.1093/eurheartj/ehy339.
14. Russian society of arterial hypertension/Russian society of cardiology. Diagnosis and treatment of arterial hypertension. Russian guidelines. Systemic Hypertension. 2010;3:526. (In Russ.)
15. NICE guidelines. Hypertension: Clinical management of primary hypertension in adults [CG127]. Published August 2011. Updated 2016. https://www.nice.org.uk/guidance/cg127/chapter/Introduction.
16. Staessen JA, Fagard R, Thijs L, et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet. 1997;350:757.
17. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA. 1991;265:3255. doi:10.7326/ACPJC1991-115-3-065.
18. Lindholm LH, Hansson L, Dahlöf B, et al. The Swedish Trial in old patients with hypertension-2 (STOP-hypertension-2): a progress report. Blood Press. 1996 Sep;5;(5):300-4. doi:10.3109/08037059609078063.
19. Rimoldi SF, Messerli FH, Chavez P, et al. Efficacy and Safety of Calcium Channel Blocker/Diuretics Combination Therapy in Hypertensive Patients: A Meta-Analysis. J Clin Hypertens. 2015;17:193-9. doi:10.1111/jch.12462.
20. Hanon O, Boully C, Caillard L, et al. Treatment of Hypertensive Patients With Diabetes and Microalbuminuria With Combination Indapamide SR/Amlodipine: Retrospective Analysis of NESTOR. Am J Hypertens. 2015;28(8):1064-7. doi:10.1093/ajh/hpu297.
21. Jadhav U, Hiremath J, Namjoshi DJ, et al. Blood Pressure Control with a SinglePill Combination of Indapamide Sustained-Release and Amlodipine in Patients with Hypertension: The EFFICIENT Study. PLoS ONE 2014;9(4):e92955. doi:10.1371/journal.pone.0092955.
22. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension. 2010;55(2):399407. doi:10.1161/HYPERTENSIONAHA.109.139816.
23. Corrao G, Nicotra F, Parodi A, et al. Cardiovascular protection by initial and subsequent combination of antihypertensive drugs in daily life practice. Hypertension. 2011;58(4):56672. doi:10.1161/HYPERTENSIONAHA.111.177592.
24. Egan BM, Bandyopadhyay D, Shaftman SR, et al. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension. 2012;59(6):1124-31. doi:10.1161/HYPERTENSIONAHA.112.194167.
25. Gradman AH, Parisé H, Lefebvre P, et al. Initial combination therapy reduces the risk of cardiovascular events in hypertensive patients: a matched cohort study. Hypertension. 2013;61(2):309-18. doi:10.1161/HYPERTENSIONAHA.112.201566.
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For citations:
Kobalava Zh.D., Tolkacheva V.V., Bagmanova N.Kh., Khasanova E.R. Efficacy and tolerance of Arifam in patients with arterial hypertension over 55 years old: main results of the observational program ARBALET. Russian Journal of Cardiology. 2018;(12):64-74. (In Russ.) https://doi.org/10.15829/1560-4071-2018-12-64-74
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