THE SIGNIFICANCE OF OSTEOPONTINE AND MATRIX METALLOPROTEASE-9 IN THORACAL AORTA ANEURYSM DEVELOPMENT
https://doi.org/10.15829/1560-4071-2015-7-73-77
Abstract
Aim. To evaluate the significance of osteopontine and MMP-9 in the development of thoracal aorta aneurysm in patients with tricuspid (TAV) and bicuspid (BAV) aorta valve. Material and methods. Totally 94 patients included with the dilation of thoracal aorta for more than 40 mm, and 50 patients without aorta pathology, that were the comparison group. All patients underwent echocardiographic study by Vivid 7 (GE, USA) device by standard protocol. The osteopontine concentration and MMP-9 were measured in blood serum with manual plate immune-enzyme assay. Results. The concentration of MMP-9 in blood serum of the patients with aorta pathology and TAV did not differ significantly with the value in comparison group. Otherwise, in IHD the concentration of MMP-9 was significantly higher than in patients without aorta pathology (164,9±76,6 ng/ml and 106,8±82,7 ng/ml, respectively, p<0,01) and closely correlated with the Valsalva sinuses diameters (r=0,302, р=0,007). Comparative analysis of the osteopontine serum concentration did not show differences in the subgroups studied.
Conclusion. The positive correlation revealed of the aorta diameter and concentration of MMP-9 in blood serum of the patients with BAV confirms not only the differences in the pathogenesis of thoracal aorta aneurysm in TAV and BAV, but makes it possible to think on the usage of MMP-9 as biomarker of thoracal aorta dilatation.
About the Authors
O. B. Irtyuga
North-Western Federal Medical Research Center of the Healthcare Ministry, Saint-Petersburg
Russian Federation
Competing Interests: Кандидат медицинских наук, ведущий научный сотрудник НИЛ кардиомиопатий
Russian Federation
Competing Interests: Кандидат медицинских наук, ведущий научный сотрудник НИЛ кардиомиопатий
T. A. Druzhkova
North-Western Federal Medical Research Center of the Healthcare Ministry, Saint-Petersburg
Russian Federation
Russian Federation
N. D. Gavrilyuk
North-Western Federal Medical Research Center of the Healthcare Ministry, Saint-Petersburg
Russian Federation
Russian Federation
D. S. Krivonosov
North-Western Federal Medical Research Center of the Healthcare Ministry, Saint-Petersburg
Russian Federation
Russian Federation
V. E. Uspensky
North-Western Federal Medical Research Center of the Healthcare Ministry, Saint-Petersburg
Russian Federation
Russian Federation
O. M. Moiseeva
North-Western Federal Medical Research Center of the Healthcare Ministry, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Irtyuga O.B., Druzhkova T.A., Gavrilyuk N.D., Krivonosov D.S., Uspensky V.E., Moiseeva O.M. THE SIGNIFICANCE OF OSTEOPONTINE AND MATRIX METALLOPROTEASE-9 IN THORACAL AORTA ANEURYSM DEVELOPMENT. Russian Journal of Cardiology. 2015;(7):73-77. (In Russ.) https://doi.org/10.15829/1560-4071-2015-7-73-77
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