Endothelial function in young men with essential hypertension
Abstract
The aim of the study was to evaluate the association between markers of endothelial function and arterial hypertension (AH). We measured the plasma level of nitrite and nitrate and flow-mediated vasodilatation of the brachial artery (endothelium dependent) in 148 men with AH and 32 healthy men in age 18-24 years. The low level of nitrite was found in 140 patients with AH compared with control group (odds ratio 29, 2; 95 %CI [9, 6-92, 1]). Flow-mediated vasodilatation of the brachial artery was measured in 126 men with AH and it was impaired in 66 men (70,2 % ) (odds ratio 7, 1; 95 %CI [2, 6-19. 7]). There is no significant difference between groups in endothelium independent vasodilatation to nitroglycerin. Endothelial dysfunction was documented in patients with and without left ventricular hypertrophy. Logistic regression analysis using AH as a dependent variable revealed a statistically significant association with nitrite (p=0, 02), flow-mediated vasodilatation (p=0, 046) and genetically predisposition to arterial hypertension.
About the Authors
G. R. Yanovskaya
Государственная медицинская академия
Russian Federation
Russian Federation
V. V. Belov
Государственная медицинская академия
Russian Federation
Russian Federation
A. A. Bolotov
Государственная медицинская академия
Russian Federation
Russian Federation
References
1. Park J.B., Schiffrin E.L. Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension.//J. Hypertens. 2001. № 19. P. 921-930.
2. Хаютин В.М. Механорецепция эндотелия артериальных сосудов и механизмы защиты от развития гипертонической болезни.//Кардиология. 1996. № 7. С. 41-46.
3. Гогин Е.Е. Гипертоническая болезнь. М., 1997. 399 с.
4. Cockroft J.R., Chowenczyk P.J., Benjamin N., Ritter J.M. Preserved endothelium-dependent vasodilatation in patient with essential hypertension.//N. Engl. J. Med. 1994. № 330. P. 1036-1040.
5. Балахонова Т.В., Погорелова О.А., Алиджанова Х.Г. и др. Неинвазивное определение функции эндотелия у больных гипертонической болезнью в сочетании с гиперхолестеринемией.//Тер. арх. 1998. № 4. С. 15-19.
6. Потемкина Р.А., Глазунов И.С., Камардина Т.В. и др. Руководство по проведению изучения поведенческих факторов неинфекционных заболеваний. М., 2002. 60 с.
7. Devereux R.B., Reicheck N. Echocardiographic determination of left ventricular mass in man.//Circulation. 1977. № 55. P. 613-618.
8. Liu J., Roman M., Pini R., et al. Prediction of mortality risk by different methods of indexation for left ventricular mass.//J. Am. Coll. Cardiol. 1997. № 29. P. 641-657.
9. Canau A., Devereux R.B., Roman M.J., et al. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension.//J. Am. Coll. Cardiol. 1992. № 19. P. 1550-1558.
10. Celermajer D.S., Sorensen K.E., Gooch V.M., et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis.//Lancet. 1992. № 340. P. 1111-1115.
11. Емченко Н.Л., Цыганенко О.И., Ковалевская Т.В. Универсальный метод определения нитратов в биосредах организма.//Клин. лаб. диагностика. 1994. № 6. C. 19 -20.
12. Lauer Т., Preik M., Rassat Т., et al. Plasma nitrite rather than nitrate reflects regionals endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action [Электронный ресурс]:PNAS, 2001. Режим доступа:http://www.pnas.org/cgi/doi/10.1073/pnas.221381098
Review
For citations:
Yanovskaya G.R., Belov V.V., Bolotov A.A. Endothelial function in young men with essential hypertension. Russian Journal of Cardiology. 2004;(3):21-25. (In Russ.)
Views:
494
Email this article 