NEW EVALUATION METHOD FOR EFFICACY OF HYPOTENSIVE TREATMENT WITH ACE INHIBITORS

Abstract

The work, using Enam as an example, provides a new original evaluation method for hypotensive action of drugs. The method is based upon primary analysis of daily blood pressure monitoring data with subsequent transformation into a graphic form of BP values likelihood distribution over a plane. The authors called the image obtained in this manner hypertension areal. The authors distinguish a core and a peripheral part of hypertension areal, proposing an evaluation method for many characteristic parameters. Hypotensive action is evaluated by changes in areal square over time. Patients receiving Enam were divided into 3 groups depending on the extent of hypotensive effect, by means of a neural network. Hypotensive effect is characterized based on the proposed standpoints for each group.