PREVALENCE OF INSULIN RESISTANCE AND ITS ASSOCIATION WITH METABOLIC SYNDROME COMPONENTS IN ADOLESCENTS: POPULATION STUDY RESULTS
Abstract
Aim. To study the blood levels of insulin and glucose, to assess the prevalence of insulin resistance (IR), and to investigate the association between IR and the components of metabolic syndrome (MS) in a population sample of adolescents aged 14–17 years. Material and methods. A representative sample of Novosibirsk City adolescents, aged 14–17 years, was examined (n=667). The examination included the standard questionnaire survey, blood pressure (BP) measurement, anthropometry, and the assessment of serum levels of lipids, insulin, and glucose. Hyperinsulinemia (HI) was diagnosed if basal insulin levels were ≥15 μIU/ml, while fasting hyperglycaemia (FHG) was registered if fasting glucose levels were ≥5,6 mmol/l. IR was diagnosed if HOMA index was >3,7. Results. In Novosibirsk adolescents, the prevalence of IR reached 11,8% (13,4% in boys and 10,5% in girls). FHG was registered in 2% of boys and 0,8% of girls; the prevalence of HI was 22,5% and 21%, respectively. The presence of IR was associated with higher values of waist circumference, BP, blood triglycerides, body mass index, and lower levels of high-density lipoprotein cholesterol. The 90% percentile of HOMA distribution in this adolescent population sample was 4,1 (4,7 in boys and 3,7 in girls). Conclusion. The study results justify the need for a regular monitoring of carbohydrate metabolism markers in adolescents.
About the Authors
L. G. Zavyalova
Institute of Internal Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk
Russian Federation
Russian Federation
D. V. Denisova
Institute of Internal Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk
Russian Federation
Russian Federation
Yu. I. Ragino
Institute of Internal Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk
Russian Federation
Russian Federation
O. N. Poteryaeva
Institute of Internal Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk
Russian Federation
Russian Federation
M. V. Ivanova
Institute of Internal Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk
Russian Federation
Russian Federation
References
1. Oganov R. G., Mamedova M. N. School for the diagnosis and treatment of metabolic syndrome. M.: Medical Book, 2007; 64 p. Russian (Оганов Р. Г., Мамедова М. Н. Школа по диагностике и лечению метаболического синдрома. М.: Медицинская книга, 2007; 64 с.).
2. Cook S., Weitzman M., Avinger P. et al. Prevalence of a metabolic syndrome phenotype in adolescents; Finding from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch. Pediatric. Adolesc. Med., 2003; 157:821–27.
3. Caceres M., Teran C. G., Medina R. et al. Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity. BMC Pediatrics, 2008; 8:31–6.
4. Keskin M., Kurtoglu S., Kendirci M. et al. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics, 2005; 115:500–3.
5. McAuley K. A., Mann J. I., Chase J. G. et al. HOMA-Satisfactory for the time being. J. Diabetes Care, 2007; 30 (9):2411–13.
6. Roitberg G. E., Ushakova T. I., Dorosh G. V. Role of insulin resistance in the diagnosis of metabolic syndrome. Cardiology, 2004; 1:94–101. Russian (Ройтберг Г. Е., Ушакова Т. И., Дорош Ж. В. Роль инсулинорезистентности в диагностике метаболического синдрома. Кардиология, 2004; 1:94–101).
7. Monzillo L. U., Hamdy O. Evalution of insulin sensitivity in clinical practice and in research setting. Nutrition, 2003; 61 (12):397–412.
8. Valerio G., Licenziati M. R., Iannuzzi A. et al. Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr. Metabol. Cardiovasc. Dis., 2006; 16:279–84.
9. Zimmet P., Alberti K. G., Kaufman F. et al. IDF Consensus Group. The metabolic syndrome in children and adolescents – an IDF consensus report. Pediatric Diabetes, 2007; 8 (5):299–306.
10. Williams D. E., Cadwell B. L., Cheng Y. J. et al. Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents. Pediatrics, 2005; 116:1122–26.
11. Plotnikova I. V., Suslova T. E., Zheltonogova N. M. et al. The markers of the metabolic syndrome in adolescents with hypertension. Pediatria, 2007; 86 (3):39–43. Russian (Плотникова И. В., Суслова Т. Е., Желтоногова Н. М. и др. Маркеры метаболического синдрома у подростков с артериальной гипертензией. Педиатрия, 2007; 86 (3):39–43).
12. Hirschler V., Aranda C., Calcagno M. L. et al. Can waist circumference identify children with the metabolic syndrome? Arch. Pediatr. Adolesc. Med., 2005; 159:740–4.
Review
For citations:
Zavyalova L.G., Denisova D.V., Ragino Yu.I., Poteryaeva O.N., Ivanova M.V. PREVALENCE OF INSULIN RESISTANCE AND ITS ASSOCIATION WITH METABOLIC SYNDROME COMPONENTS IN ADOLESCENTS: POPULATION STUDY RESULTS. Russian Journal of Cardiology. 2012;(4):37-42. (In Russ.)
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