PSYCHO-EMOTIONAL STATUS, QUALITY OF LIFE, AND AUTONOMIC BALANCE IN PATIENTS WITH METABOLIC SYNDROME AND DYSPEPSIA SYNDROME

Aim. To study psycho-emotional and autonomic status, circadian blood pressure (BP) profile, and quality of life (QoL) in patients with metabolic syndrome (MS) and dyspepsia syndrome. Material and methods. We followed up 110 patients (66 women and 52 men), aged 20–60 years (mean age 47,5±2,1 years). The levels of anxiety and depression were assessed with Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale (HDRS), respectively. Personality traits were assessed with the Freiburg Personality Inventory (FPI), eating behaviour with the Dutch Questionnaire of Eating Behaviour (DQEB), and QoL with the SF-36 questionnaire (version 1). Circadian rhythms of autonomic balance, BP, and electrocardiography (ECG) parameters were assessed via the 24-hour monitoring of heart rate variability (HRV). The assessment of BP and ECG was performed with the use of “Cardio-Tens-01” device (Meditech, Hungary) and the subsequent data analysis with the “Medibase” software. Statistical analysis was performed using the Windows software Microsoft Excel 5.0 and Statistica 6.0.
Results. Affective disorders, personality disorders, and QoL disturbances were more pronounced in the patients from Group 4, who had MS and dyspepsia syndrome. The results of the 24-hour BP monitoring demonstrated that mean daytime and nighttime levels of diastolic and systolic BP for Group 2 (dyspepsia syndrome plus arterial hypertension, AH) were higher than for Group 4 (dyspepsia syndrome, obesity, and AH). Mean levels of BP variability parameters were higher for Group 4 than for Group 2. However, these differences between the groups were not statistically significant. The patients with obesity, AH, and dyspepsia syndrome (Group 4) demonstrated minimal circadian HRV dynamics, which might be due to a reduced adaptive potential in these individuals. Conclusion. The majority of the participants had substantial psycho-emotional disturbances, autonomic dysbalance (sympathetic hyperactivation), and desynchronosis, which were closely related to other parameters and more manifested in patients with the combination of MS and dyspepsia syndrome. This should be taken into account when planning and performing preventive and therapeutic interventions.

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