INTIMA-MEDIA THICKNESS AND ADHESION MOLECULES SICAM-1 AND SVCAM-1 IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: CLINICAL AND DIAGNOSTIC VALUE
Abstract
Aim. To study the associations between the intima-media thickness (IMT) of common carotid artery and the expression of soluble adhesion molecules sICAM‑1 and sVCAM‑1 in patients with Type 2 diabetes mellitus (DM‑2). Material and methods. The study included 97 DM‑2 patients (50 men and 47 women), aged 45–70 years (mean age 52,25±5,62 years). All participants underwent in-hospital standard clinical examination, risk factor assessment, electrocardiography, and duplex ultrasound of extracranial vessels (“Vivid 3” TM device, USA; linear transducer 7,5 MHz), as well as the measurement of blood levels of soluble adhesion molecules sICAM‑1 and sVCAM‑1. Results. There was a statistically significant correlation between common carotid artery IMT and the levels of sICAM‑1 and sVCAM‑1 (р<0,05). Conclusion. The results obtained suggestthatthe levels of adhesion molecules sICAM‑1 and sVCAM‑1 could be a marker of atherosclerotic progression in DM‑2 patients.
About the Authors
S. G. Kasatkina
Astrakhan State Medical Academy, Astrakhan
Russian Federation
Russian Federation
T. N. Panova
Astrakhan State Medical Academy, Astrakhan
Russian Federation
Russian Federation
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Review
For citations:
Kasatkina S.G., Panova T.N. INTIMA-MEDIA THICKNESS AND ADHESION MOLECULES SICAM-1 AND SVCAM-1 IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: CLINICAL AND DIAGNOSTIC VALUE. Russian Journal of Cardiology. 2012;(3):47-50. (In Russ.)
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