HEART-TYPE FATTY ACID BINDING PROTEIN IN ACUTE CORONARY SYNDROME

Aim. To compare the serum levels of heart-type fatty acid binding protein (H-FABP), measured with immune-enzyme assay and immunochromatography express test system, in patients with acute coronary syndrome (ACS), such as myocardialinfarction (MI) and unstable angina (UA). Material and methods. The study included 250 ACS patients: 166 with MI and 84 with UA. At Days 1 and 10 of ACS, serum levels of troponin I (immune-enzyme assay), creatine kinase-MB (CK-MB; photometry), and H-FABP (quantitative measurement with immune-enzyme assay, H-FABP-IEA-BEST test system, VectorBest, Russia; qualitative measurement with immunochromatography express test system, BioTest, Russia) were assessed in all participants. Results. At Day 1, serum H-FABP levels were substantially higher in men vs. women with MI, and in men with MI vs. men with UA. This parameter significantly correlated with MI diagnosis, including Q-wave MI, with other ACS biomarkers (troponin I and CK-MB), and with selected inflammatory biomarkers. Conclusion. H-FABP is a significant, sensitive biomarker of myocardial damage and ACS development. Immunochromatography express test system produced qualitatively “positive” results even in serum H-FABP concentrations lower than 15 ng/ml.

Heart-type fatty acid binding protein (H-FABP), acute coronary syndrome, myocardial infarction, immune-enzyme assay, immunochromatography express test system H-FABP

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