ADIPONECTIN AND ATHEROSCLEROTIC REMODELLING OF CAROTID ARTERIES
Abstract
The associations between adiponectin levels and atherosclerotic remodelling of carotid arteries were investigated in 50 patients with coronary heart disease. Among patients with increased adiponectin levels, carotid atherosclerosis was less severe (significantly lower mean values of total plaque volume), while arterial wall elasticity was higher (lower mean values of arterial stiffness, Icompl), compared to individuals with lower adiponectin concentrations.
About the Authors
O. P. ShevchenkoRussian Federation
A. O. Shevchenko
Russian Federation
E. V. Shin
Russian Federation
M. V. Tulikov
Russian Federation
Yu. S. Slesareva
Russian Federation
L. M. Ginsburg
Russian Federation
References
1. Delaigle AM, Jonas JC, Bauche IB, et al. Induction of adiponectin in skeletal muscle by inflammatory cytokines: in vivo and in vitro studies. Endocrinology. 2004; 145: 5589–5597.
2. Ferrante G. et al. Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study Eur Heart J (2008) 29(15): 1922-1923.
3. George J, Patal S, Wexler D, et al. Circulating adiponectin concentrations in patients with congestive heart failure. Heart. 2006; 92: 1420–1424.
4. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev. 2005; 26: 439–451.
5. Karbowska J, Kochan Z. Role of adiponectin in the regulation of carbohydrate and lipid metabolism. J Physiol Pharmacol. 2006; 57: 103–113.
6. Kintscher U. Does adiponectin resistance exist in chronic heart failure? Eur Heart J. 2007; 28: 1676–1677.
7. Kistorp C, Faber J, Galatius S, et al. Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure. Circulation. 2005; 112: 1756–1762.
8. Lyon CJ, Law RE, Hsueh WA. Minireview: adiposity, inflammation, and atherogenesis. Endocrinology. 2003; 144: 2195–2200.
9. McEntegart MB, Awede B, Petrie MC, et al. Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide. Eur Heart J. 2007; 28: 829–835.
10. Norrelund H, Wiggers H, Halbirk M, et al. Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure. J Intern Med. 2006; 260: 11–21.
11. Pineiro R, Iglesias MJ, Gallego R, et al. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett. 2005; 579: 5163–5169.
12. Skurk C, Wittchen F, Suckau L, et al. Description of a local cardiac adiponectin system and its deregulation in dilated cardiomyopathy. Eur Heart J. 2008; 29: 1168–1180.
13. Tamura T, Furukawa Y, Taniguchi R, et al. Serum adiponectin level as an independent predictor of mortality in patients with congestive heart failure. Circ J. 2007; 71: 623–630.
14. Tanaka T, Tsutamoto T, Sakai H, et al. Effect of atrial natriuretic peptide on adiponectin in patients with heart failure. Eur J Heart Fail. 2008; 10: 360–366.
15. Tsutamoto T, Tanaka T, Sakai H, et al. Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure. Eur Heart J. 2007; 28: 1723–1730.
Review
For citations:
Shevchenko O.P., Shevchenko A.O., Shin E.V., Tulikov M.V., Slesareva Yu.S., Ginsburg L.M. ADIPONECTIN AND ATHEROSCLEROTIC REMODELLING OF CAROTID ARTERIES. Russian Journal of Cardiology. 2011;(4):38-41. (In Russ.)