MICROCIRCULATION IN HEALTHY PEOPLE AND HYPERTENSIVE PATIENTS WITH DIFFERENT VARIANTS OF PERIPHERAL HEMODYNAMICS

Abstract

The study was analyzing the features of identical hemodynamic microcirculation types (HMT) in healthy people and patients with arterial hypertension (AH). In total, 80 patients with Stage II-III AH and 39 healthy men and women were included in the study. In AH patients, all HMT variants were characterised by pre-capillary vasoconstriction, to some extent compensated due to increased pulse filling of micro-vessels. Both in healthy people and AH patients, normocirculatory HMT could be regarded as the most balanced. Venous hyperemia was typical for AH patients with hyperemic HMT, due to intensified microcirculatory regulation processes. Low tissue perfusion in healthy people and AH patients with spastic HMT could be explained by advanced vascular and extravasal changes. Healthy participants with congestive HMT also had demonstrated intensification of active microcirculation control mechanisms – endothelial, neurogenic, and myogenic ones. AH patients, on the contrary, were characterised by depression of peripheral hemodynamics-regulating mechanisms. HMT analysis could facilitate identification of healthy people with higher disease risk, as well as AH patients with high risk of target organ damage and poor prognosis.