russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2016-9-90-94russjcardiol-792Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWСИСТЕМНЫЕ КАРДИОВАСКУЛЯРНЫЕ ПОСЛЕДСТВИЯ НАРУШЕНИЙ ДЫХАНИЯ ВО ВРЕМЯ СНАSYSTEMIC CARDIOVASCULAR OUTCOMES OF SLEEP RELATED BREATHING DISORDERSКаллистовД. Ю.KallistovD. Yu.

Доктор медицинских наук,  заведующий  отделением

sleeprc@ya.ruРомановА. И.RomanovA. I.НовичковаН. И.NovichkovaN. I.

Доктор медицинских наук, профессор, руководитель отдела

РомановаЕ. А.RomanovaE. A.

Доктор медицинских наук, врач ОФД

Центр реабилитации Управления делами Президента Рф, пос. санатория имени Герцена, Московская областьРоссияCenter for Rehabilitation of the President Services, settlement of Hertsen sanatorium, Moscow RegionRussian FederationФедеральный научный центр гигиены имени Ф. Ф. Эрисмана Роспотребнадзора, МО, МытищиРоссияErisman FF Federal Scientific Center for Hygiene of Rospotrebnadzor, Moscow Region, MytishchiRussian FederationБольница с поликлиникой Управления делами Президента Рф, МоскваРоссияHospital with Outpatient care of the President services, MoscowRussian Federation201628092016099094Copyright © Каллистов Д.Ю., Романов А.И., Новичкова Н.И., Романова Е.А., 20162016Каллистов Д.Ю., Романов А.И., Новичкова Н.И., Романова Е.А.Kallistov D.Y., Romanov A.I., Novichkova N.I., Romanova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/792

Связанные со сном нарушения дыхания являются распространенными видами расстройств сна и оказывают существенное  негативное влияние на формирование и течение  ряда  соматических  заболеваний, в первую очередь  — кардиоваскулярных заболеваний и метаболических расстройств. Результаты проведенных с позиций доказательной медицины исследований свидетельствуют о наличии взаимосвязи апноэ сна и артериальной гипертензии,  ишемической болезни сердца, сердечной  недостаточности,  аритмий,  цереброваскулярных заболеваний, сахарного диабета. Включение методик диагностики и лечения расстройств сна в стандарты лечения и реабилитации пациентов с данными нозологическими формами является теоретически обоснованным и клинически значимым.

Related  to sleep  breathing  disorders  are  prevalent  kind of disordered sleep  and influence  significantly and  negatively  on  development   of  a  range   of  somatic diseases, primarily — cardiovascular  and metabolic.  Results of evidence  research witness on the relation of the sleep apnea and arterial hypertension, ischemic heart disease, heart failure, arrhythmias, cerebrovascular diseases, diabetes. Inclusion of the  methods   of  diagnostics   and  treatment  of  sleep  related   disorders   to  the standards of management and rehabilitation of patients with these nosological units is theoretically based  and clinically significant.

расстройства снаапноэартериальная гипертензияИБсаритмиицереброваскулярные заболеваниядиабетстандартыsleep disordersapneaarterial hypertensionCHDarrhythmiascerebrovascular diseasesdiabetesstandardsReferencesRich J, Raviv A, Raviv N, Brietzke SE. All-Cause Mortality and Obstructive Sleep Apnea Severity Revisited. Otolaryngol Head Neck Surg 2012 vol. 147 no. 3 583-587Rich J, Raviv A, Raviv N, Brietzke SE. All-Cause Mortality and Obstructive Sleep Apnea Severity Revisited. Otolaryngol Head Neck Surg 2012 vol. 147 no. 3 583-587American Sleep Disorders Association. International Classification of Sleep Disorders, revised: Diagnostic and coding manuals. Rochester, MN. // American Sleep Disorders Association.- 2005.American Sleep Disorders Association. International Classification of Sleep Disorders, revised: Diagnostic and coding manuals. Rochester, MN. // American Sleep Disorders Association.- 2005.Lévy P, Ryan S, Oldenburg O, Parati G. Sleep apnoea and the heart. Eur Respir Rev September 1, 2013 vol. 22 no. 129 333-352Lévy P, Ryan S, Oldenburg O, Parati G. Sleep apnoea and the heart. Eur Respir Rev September 1, 2013 vol. 22 no. 129 333-352Федеральный закон Российской Федерации от 21 ноября 2011 г. N 323-ФЗ "Об основах охраны здоровья граждан в Российской Федерации".Федеральный закон Российской Федерации от 21 ноября 2011 г. N 323-ФЗ "Об основах охраны здоровья граждан в Российской Федерации".Guilleminault C, Eldridge FL, Simmons FB, Dement WC. Sleep apnea syndrome: can it induce hemodynamic changes? // West J Med.- 1975.-Vol.123.- P.7-16.Guilleminault C, Eldridge FL, Simmons FB, Dement WC. Sleep apnea syndrome: can it induce hemodynamic changes? // West J Med.- 1975.-Vol.123.- P.7-16.Cano-Pumarega I, Durán-Cantolla J, Aizpuru F, Miranda-Serrano E, Rubio R, Martínez-Null C, de Miguel J, Egea C, Cancelo L, Alvarez A, Fernández-Bolaños M, Barbé F. Obstructive sleep apnea and systemic hypertension: longitudinal study in the general population: the Vitoria Sleep Cohort. Am J Respir Crit Care Med. 2011;184:1299–1304.Cano-Pumarega I, Durán-Cantolla J, Aizpuru F, Miranda-Serrano E, Rubio R, Martínez-Null C, de Miguel J, Egea C, Cancelo L, Alvarez A, Fernández-Bolaños M, Barbé F. Obstructive sleep apnea and systemic hypertension: longitudinal study in the general population: the Vitoria Sleep Cohort. Am J Respir Crit Care Med. 2011;184:1299–1304.Marin JM, Agusti A, Villar I, Forner M, Nieto D, Carrizo SJ, Barbé F, Vicente E, Wei Y, Nieto FJ, Jelic S. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA. 2012;307:2169–2176.Marin JM, Agusti A, Villar I, Forner M, Nieto D, Carrizo SJ, Barbé F, Vicente E, Wei Y, Nieto FJ, Jelic S. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA. 2012;307:2169–2176.Pedrosa RP, Drager LF, Gonzaga CC, Sousa MG, de Paula LK, Amaro AC, Amodeo C, Bortolotto LA, Krieger EM, Bradley TD, Lorenzi-Filho G. Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension. Hypertension. 2011;58:811–817.Pedrosa RP, Drager LF, Gonzaga CC, Sousa MG, de Paula LK, Amaro AC, Amodeo C, Bortolotto LA, Krieger EM, Bradley TD, Lorenzi-Filho G. Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension. Hypertension. 2011;58:811–817.Konecny T, Kara T, Somers VK. Obstructive Sleep Apnea and Hypertension: An Update. Hypertension 2014;63:203-209.Konecny T, Kara T, Somers VK. Obstructive Sleep Apnea and Hypertension: An Update. Hypertension 2014;63:203-209.Freet CS, Stoner JF, Tang X. Baroreflex and chemoreflex controls of sympathetic activity following intermittent hypoxia. Auton Neurosci. 2013;174:8–14.Freet CS, Stoner JF, Tang X. Baroreflex and chemoreflex controls of sympathetic activity following intermittent hypoxia. Auton Neurosci. 2013;174:8–14.Capone C, Faraco G, Coleman C, Young CN, et al. Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension. 2012;60:106–113.Capone C, Faraco G, Coleman C, Young CN, et al. Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension. 2012;60:106–113.Reichmuth KJ, Dopp JM, Barczi SR, et al. Impaired vascular regulation in patients with obstructive sleep apnea: effects of continuous positive airway pressure treatment. Am J Respir Crit Care Med 2009; 180: 1143–1150.Reichmuth KJ, Dopp JM, Barczi SR, et al. Impaired vascular regulation in patients with obstructive sleep apnea: effects of continuous positive airway pressure treatment. Am J Respir Crit Care Med 2009; 180: 1143–1150.Montesi SB, Edwards BA, Malhotra A, et al. The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med. 2012;8:587–596.Montesi SB, Edwards BA, Malhotra A, et al. The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med. 2012;8:587–596.Lévy P, McNicholas WT. Sleep apnoea and hypertension: time for recommendations. ERJ March 1, 2013 vol. 41 no. 3 505-506Lévy P, McNicholas WT. Sleep apnoea and hypertension: time for recommendations. ERJ March 1, 2013 vol. 41 no. 3 505-506Parati G, Lombardi C, Hedner J, et.al. Position paper on the management of patients with obstructive sleep apnea and hypertension: Joint recommendations by the European Society of Hypertension, by the European Respiratory Society and by the members of European COST (COoperation in Scientific and Technological Research) ACTION B26 on obstructive sleep apnea. J Hypertens. 2012;30:633–646.Parati G, Lombardi C, Hedner J, et.al. Position paper on the management of patients with obstructive sleep apnea and hypertension: Joint recommendations by the European Society of Hypertension, by the European Respiratory Society and by the members of European COST (COoperation in Scientific and Technological Research) ACTION B26 on obstructive sleep apnea. J Hypertens. 2012;30:633–646.Drager LF, Polotsky VY, Lorenzi-Filho G. Obstructive Sleep Apnea: An Emerging Risk Factor for Atherosclerosis. Chest, Aug 2011; 140: 534 - 542.Drager LF, Polotsky VY, Lorenzi-Filho G. Obstructive Sleep Apnea: An Emerging Risk Factor for Atherosclerosis. Chest, Aug 2011; 140: 534 - 542.Nakashima H, Henmi T, Minami K, et al. Obstructive sleep apnoea increases the incidence of morning peak of onset in acute myocardial infarctionNakashima H, Henmi T, Minami K, et al. Obstructive sleep apnoea increases the incidence of morning peak of onset in acute myocardial infarctionEuropean Heart Journal: Acute Cardiovascular Care, Jun 2013; 2: 153 - 158.European Heart Journal: Acute Cardiovascular Care, Jun 2013; 2: 153 - 158.Gottlieb DJ, Yenokyan G, Newman AB, et.al. Prospective Study of Obstructive Sleep Apnea and Incident Coronary Heart Disease and Heart Failure. The Sleep Heart Health Study. Circulation. 2010; 122: 352-360Gottlieb DJ, Yenokyan G, Newman AB, et.al. Prospective Study of Obstructive Sleep Apnea and Incident Coronary Heart Disease and Heart Failure. The Sleep Heart Health Study. Circulation. 2010; 122: 352-360Kent BD, Garvey JF, Ryan S. Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study. ERJ November 1, 2013 vol. 42 no. 5 1263-1270.Kent BD, Garvey JF, Ryan S. Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study. ERJ November 1, 2013 vol. 42 no. 5 1263-1270.Kadohira T, Kobayashi Y, Iwata Y. Coronary Artery Endothelial Dysfunction Associated With Sleep Apnea. Angiology, 2011 vol. 62 no. 5 397-400.Kadohira T, Kobayashi Y, Iwata Y. Coronary Artery Endothelial Dysfunction Associated With Sleep Apnea. Angiology, 2011 vol. 62 no. 5 397-400.Yamauchi M, Tamaki S, Tomoda K, et al. Evidence for activation of nuclear factor kB in obstructive sleep apnea. Sleep Breath 2006; 10: 189–193.Yamauchi M, Tamaki S, Tomoda K, et al. Evidence for activation of nuclear factor kB in obstructive sleep apnea. Sleep Breath 2006; 10: 189–193.Jelic S, Padeletti M, Kawut SM, et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation 2008; 117: 2270–2278.Jelic S, Padeletti M, Kawut SM, et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation 2008; 117: 2270–2278.Testelmans D, Tamisier R, Barone-Rochette G, Baguet JP, Roux-Lombard P, Pépin JL, Lévy P. Profile of circulating cytokines: impact of OSA, obesity and acute cardiovascular events. Cytokine. 2013;62:210–216.Testelmans D, Tamisier R, Barone-Rochette G, Baguet JP, Roux-Lombard P, Pépin JL, Lévy P. Profile of circulating cytokines: impact of OSA, obesity and acute cardiovascular events. Cytokine. 2013;62:210–216.Thunstrom E, Glantz H, Fu M, et. al Obstructive sleep apnea is associated with increased inflammatory activity in non-obese patients with coronary artery disease; a cross sectional study Eur Heart J 2013: 34: 5521Thunstrom E, Glantz H, Fu M, et. al Obstructive sleep apnea is associated with increased inflammatory activity in non-obese patients with coronary artery disease; a cross sectional study Eur Heart J 2013: 34: 5521von Känel R, Natarajan L, Ancoli-Israel S, Mills PJ, Loredo JS, Dimsdale JE. Day/night rhythm of hemostatic factors in obstructive sleep apnea. Sleep. 2010;33:371–377.von Känel R, Natarajan L, Ancoli-Israel S, Mills PJ, Loredo JS, Dimsdale JE. Day/night rhythm of hemostatic factors in obstructive sleep apnea. Sleep. 2010;33:371–377.Kasai T, Floras LS, Bradley TD. Sleep Apnea and Cardiovascular Disease: A Bidirectional Relationship. Circulation. 2012; 126: 1495-1510Kasai T, Floras LS, Bradley TD. Sleep Apnea and Cardiovascular Disease: A Bidirectional Relationship. Circulation. 2012; 126: 1495-1510Konecny T, Brady PA, Orban M, et al. Interactions between sleep disordered breathing and atrial fibrillation in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2010;105:1597–1602.Konecny T, Brady PA, Orban M, et al. Interactions between sleep disordered breathing and atrial fibrillation in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2010;105:1597–1602.Neilan T.G., Farhad H, Dodson JA, et al. Effect of Sleep Apnea and Continuous Positive Airway Pressure on Cardiac Structure and Recurrence of Atrial Fibrillation. JAHA, Dec 2013; 2: e000421.Neilan T.G., Farhad H, Dodson JA, et al. Effect of Sleep Apnea and Continuous Positive Airway Pressure on Cardiac Structure and Recurrence of Atrial Fibrillation. JAHA, Dec 2013; 2: e000421.Lu Z, Nie L, He B, et al. Increase in vulnerability of atrial fibrillation in an acute intermittent hypoxia model: importance of autonomic imbalance. Auton Neurosci. 2013;177:148–153.Lu Z, Nie L, He B, et al. Increase in vulnerability of atrial fibrillation in an acute intermittent hypoxia model: importance of autonomic imbalance. Auton Neurosci. 2013;177:148–153.Oldenburg O, Lamp B, Faber L, Teschler H, Horstkotte D, Topfer V. Sleep-disordered breathing in patients with symptomatic heart failure: a contemporary study of prevalence in and characteristics of 700 patients. Eur J Heart Fail 2007;9: 251–257.Oldenburg O, Lamp B, Faber L, Teschler H, Horstkotte D, Topfer V. Sleep-disordered breathing in patients with symptomatic heart failure: a contemporary study of prevalence in and characteristics of 700 patients. Eur J Heart Fail 2007;9: 251–257.Simon R, Chirakalwasan N, Teerapraipruk B. Severity of Obstructive Sleep Apnea in Patients With and Without Cardiovascular-Related Diseases. Respir Care, Sep 2012; 57: 1476 - 1482.Simon R, Chirakalwasan N, Teerapraipruk B. Severity of Obstructive Sleep Apnea in Patients With and Without Cardiovascular-Related Diseases. Respir Care, Sep 2012; 57: 1476 - 1482.Gottlieb JD, Schwartz AR, Marshall J, et.al. Hypoxia, Not the Frequency of Sleep Apnea, Induces Acute Hemodynamic Stress in Patients With Chronic Heart Failure. J. Am. Coll. Cardiol., 2009; 54: 1706 - 1712.Gottlieb JD, Schwartz AR, Marshall J, et.al. Hypoxia, Not the Frequency of Sleep Apnea, Induces Acute Hemodynamic Stress in Patients With Chronic Heart Failure. J. Am. Coll. Cardiol., 2009; 54: 1706 - 1712.Kim SH, Cho GY, Shin C, Lim HE, Kim YH, Song WH, Shim WJ, Ahn JC. Impact of obstructive sleep apnea on left ventricular diastolic function. Am J Cardiol. 2008;101:1663–1668Kim SH, Cho GY, Shin C, Lim HE, Kim YH, Song WH, Shim WJ, Ahn JC. Impact of obstructive sleep apnea on left ventricular diastolic function. Am J Cardiol. 2008;101:1663–1668Jilek C, Krenn M, Sebah D, Obermeier R, Braune A, Kehl V, Schroll S, Montalvan S, Riegger GA, Pfeifer M, Arzt M. Prognostic impact of sleep disordered breathing and its treatment in heart failure: an observational study. Eur J Heart Fail 2011;13:68–75Jilek C, Krenn M, Sebah D, Obermeier R, Braune A, Kehl V, Schroll S, Montalvan S, Riegger GA, Pfeifer M, Arzt M. Prognostic impact of sleep disordered breathing and its treatment in heart failure: an observational study. Eur J Heart Fail 2011;13:68–75Bonsignore MR, Bore AL, Machan E, Grunstein R. Sleep apnoea and metabolic dysfunction. Eur Respir Rev 2013; 22: 353–364Bonsignore MR, Bore AL, Machan E, Grunstein R. Sleep apnoea and metabolic dysfunction. Eur Respir Rev 2013; 22: 353–364Botros N, Concato J, Mohsenin V, et al. Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med 2009; 122: 1122–1127.Botros N, Concato J, Mohsenin V, et al. Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med 2009; 122: 1122–1127.Pamidi S, Wroblewski K, Broussard J, et al. Obstructive sleep apnea in young lean men: Impact on insulin sensitivity and secretion. Diabetes Care 2012; 35: 2384–2389.Pamidi S, Wroblewski K, Broussard J, et al. Obstructive sleep apnea in young lean men: Impact on insulin sensitivity and secretion. Diabetes Care 2012; 35: 2384–2389.Buxton OM, Pavlova M, Reid EW, et al. Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes. 2010;59:2126–2133.Buxton OM, Pavlova M, Reid EW, et al. Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes. 2010;59:2126–2133.Lam JC, Lam B, Yao TJ, et al. A randomized controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea. ERJ 2010;1:138-145.Lam JC, Lam B, Yao TJ, et al. A randomized controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea. ERJ 2010;1:138-145.Phillips CL, Yee BJ, Marshall NS, Liu PY, Sullivan DR, Grunstein RR. Continuous positive airway pressure reduces postprandial lipidemia in obstructive sleep apnea: a randomized, placebo-controlled crossover trial. Am J Respir Crit Care Med. 2011;184:355–361.Phillips CL, Yee BJ, Marshall NS, Liu PY, Sullivan DR, Grunstein RR. Continuous positive airway pressure reduces postprandial lipidemia in obstructive sleep apnea: a randomized, placebo-controlled crossover trial. Am J Respir Crit Care Med. 2011;184:355–361.Bassetti CL, Milanova M, Gugger M. Sleep-Disordered Breathing and Acute Ischemic Stroke: Diagnosis, Risk Factors, Treatment, Evolution, and Long-Term Clinical Outcome. Stroke. 2006; 37: 967-972Bassetti CL, Milanova M, Gugger M. Sleep-Disordered Breathing and Acute Ischemic Stroke: Diagnosis, Risk Factors, Treatment, Evolution, and Long-Term Clinical Outcome. Stroke. 2006; 37: 967-972Redline S, Yenokyan G, Gottlieb DJ, et.al. Obstructive Sleep Apnea–Hypopnea and Incident Stroke: The Sleep Heart Health Study. Am. J. Respir. Crit. Care Med., 2010; 182: 269 - 277.Redline S, Yenokyan G, Gottlieb DJ, et.al. Obstructive Sleep Apnea–Hypopnea and Incident Stroke: The Sleep Heart Health Study. Am. J. Respir. Crit. Care Med., 2010; 182: 269 - 277.Chan W, Coutts SB, Hanly P. Sleep Apnea in Patients with Transient Ischemic Attack and Minor Stroke. Opportunity for Risk Reduction of Recurrent Stroke? Stroke 2010Chan W, Coutts SB, Hanly P. Sleep Apnea in Patients with Transient Ischemic Attack and Minor Stroke. Opportunity for Risk Reduction of Recurrent Stroke? Stroke 2010Morgan BJ, Reichmuth KJ, Peppard PE, et.al. Effects of Sleep-disordered Breathing on Cerebrovascular Regulation. A Population-based Study . Am J Respir Crit Care Med 2009; Vol 182.: 1445–1452Morgan BJ, Reichmuth KJ, Peppard PE, et.al. Effects of Sleep-disordered Breathing on Cerebrovascular Regulation. A Population-based Study . Am J Respir Crit Care Med 2009; Vol 182.: 1445–1452Martinez-Garsia МА, Soler-Cataluna JJ, et.al. Continuous Positive Airway Pressure Reduces Mortality in Patients with Ischemic Stroke and Obstructive Sleep Apnea. A 5-year Follow Up Study. Am J Respir Crit Care Med. 2009; Vol. 180: pp-36-41.Martinez-Garsia МА, Soler-Cataluna JJ, et.al. Continuous Positive Airway Pressure Reduces Mortality in Patients with Ischemic Stroke and Obstructive Sleep Apnea. A 5-year Follow Up Study. Am J Respir Crit Care Med. 2009; Vol. 180: pp-36-41.Tsivgoulis G, и соавт. Safety and Tolerability of Early Noninvasive Ventilatory Correction Using Bilevel Positive Airway Pressure in Acute Ischemic Stroke. Stroke. 2011; 42: 1030-1034Tsivgoulis G, и соавт. Safety and Tolerability of Early Noninvasive Ventilatory Correction Using Bilevel Positive Airway Pressure in Acute Ischemic Stroke. Stroke. 2011; 42: 1030-1034Ryan СМ, Bayley М, Green R, Murray BJ, Bradley TD. Influence of Continuous Positive Airway Pressure on Outcomes of Rehabilitation in Stroke Patients With Obstructive Sleep Apnea. Stroke, Apr 2011; 42: 1062 - 1067.Ryan СМ, Bayley М, Green R, Murray BJ, Bradley TD. Influence of Continuous Positive Airway Pressure on Outcomes of Rehabilitation in Stroke Patients With Obstructive Sleep Apnea. Stroke, Apr 2011; 42: 1062 - 1067.Ronksley PE, Hemmelgarn BR, Tsai WH. Comorbidity and healthcare costs in patients with obstructive sleep apnoea. Breathe, 2011; 8: 95 - 104.Ronksley PE, Hemmelgarn BR, Tsai WH. Comorbidity and healthcare costs in patients with obstructive sleep apnoea. Breathe, 2011; 8: 95 - 104.Jennum Р, Ibsen R, Kjellberg J. Social consequences of sleep disordered breathing on patients and their partners: a controlled national study. ERJ January 1, 2014 vol. 43 no. 1 134-144Jennum Р, Ibsen R, Kjellberg J. Social consequences of sleep disordered breathing on patients and their partners: a controlled national study. ERJ January 1, 2014 vol. 43 no. 1 134-144

The authors declare that there are no conflicts of interest present.