<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2014-5-97-100</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-79</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ОЦЕНКА ЗНАЧИМОСТИ ФАКТОРОВ РИСКА ГИПЕРТЕНЗИВНЫХ СОСТОЯНИЙ, ВЫЗВАННЫХ БЕРЕМЕННОСТЬЮ</article-title><trans-title-group xml:lang="en"><trans-title>EVALUATION OF PREGNANCY ASSOCIATED HYPERTENSIVE STATES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шахбазова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shakhbasova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м.н., доцент, научный руководитель отдела “Акушерство”</p></bio><email xlink:type="simple">shahbazova.70@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИ акушерства и гинекологии, Баку, Азербайджан.</institution><country>Азербайджан</country></aff><aff xml:lang="en"><institution>SII for Ginaecology and Obstetrics, Baky, Azerbaijan</institution><country>Azerbaijan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>05</month><year>2014</year></pub-date><volume>0</volume><issue>5</issue><fpage>97</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шахбазова Н.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Шахбазова Н.А.</copyright-holder><copyright-holder xml:lang="en">Shakhbasova N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/79">https://russjcardiol.elpub.ru/jour/article/view/79</self-uri><abstract><sec><title>Материал и методы</title><p>Материал и методы. Были изучены различные факторы риска у 120 беременных с гипертензивными состояниями, вызванными беременностью (основная группа) и 50 здоровых беременных в эти же сроки гестации (контрольная группа). У беременных оценивалось наличие или отсутствие факторов риска развития преэклампсии: возраст, паритет, гипертензивные нарушения при предшествующих беременностях, ожирение, отягощенный семейный анамнез по гипертензии, временной интервал между беременностями, бесплодие, многоплодие, экстрагенитальные заболевания. Для оценки связи между качественными признаками применялся критерий Пирсона χ2.</p></sec><sec><title>Результаты</title><p>Результаты. В ходе исследования было установлено, что при гипертензивных нарушениях наличие одного фактора риска определялось у 30 пациенток (35,3%), сочетание двух факторов риска отмечалось у 29 беременных (34,1%), трех и более — в 30,6% случаев (26 женщин). Установлено, что у 30% беременных с преэклампсией и гестационной гипертензией факторы риска отсутствуют. Наиболее значимыми факторами риска гипертензивных расстройств в период гестации являются первая беременность и наличие экстрагенитальной патологии беременной. Сочетание трех и более факторов риска является анамнестическим маркером повышенного риска развития тяжелых форм преэклампсии.</p></sec><sec><title>Заключение</title><p>Заключение. Анализ факторов риска гипертензивных расстройств, вызванных беременностью, позволяет с первого триместра гестации определить беременных в группу повышенного риска по развитию преэклампсии. Дальнейшее углубленное обследование этих женщин даст возможность начать профилактику гипертензивных расстройств с начала беременности и вести мониторинг системы гемостаза, состояния плода и улучшить исходы беременности. Отсутствие факторов риска не отрицает возможности развития преэклампсии и требует поиска других ранних, патогенетически обоснованных маркеров этой патологии.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. The main aim of current study was to investigate the significance and prevalence of the different risk factors for hypertension, caused by pregnancy. Material and methods. We evaluated different risk factors in 120 pregnant women with hypertensive states (main group) and in 50 healthy pregnant women at the same gestation period (control group). In pregnant women we evaluated the absence either presence of of pre-eclampsy risk factors: age, parity, hypertensive disorders during previous pregnancies, time gone since previous pregnancy, obesity, hypertension family anamnesis, inferlility, multiple precnancy, extragenital diseases. To calculate the relations between different qualitative signs the Pirson х used. Results. During the study it was revealed that in hypertension disorders the women had one risk factor in 30 (35,5%), two risk factors in 29 (34,1%), three and more risk factors in 26 (30,6%). It was found that in 30% of pregnants with pre-eclampsy and gestational hypertension there are no any risk factors. Most significant risk factors were first pregnancy and extragenital pathology. Combination of three and more risk factors is an anamnestic marker for higher risk of severe pre-eclampsy.</p></sec><sec><title>Conclusion</title><p>Conclusion. The analysis of hypertension risk factors in pregnant women makes evidence-based the recognition of the high-risk group for pre-eclampsy. Further detailed diagnostic investigation of these women provides the opportunity to start a prophylaxy of hypertension disorders in pregnancy and to monitor the condition of clotting system, fetus condition and to improve the outcomes of a pregnancy. Absence of the risk factors does not decline a possibility of pre-eclampsy and requires the search for additional markers that would be early and pathogenetically proven signs.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>гестационная гипертензия</kwd><kwd>преэклампсия</kwd><kwd>факторы риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>gestational hypertension</kwd><kwd>pre-eclampsy</kwd><kwd>risk factors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Royal College of Obstetricians and Gynaecologists. THE MANAGEMENT OF SEVERE PREECLAMPSIYA/ECLAMP-SIYA. Guideline 10, RCOG Press, March 2006.</mixed-citation><mixed-citation xml:lang="en">Royal College of Obstetricians and Gynaecologists. THE MANAGEMENT OF SEVERE PREECLAMPSIYA/ECLAMP-SIYA. Guideline 10, RCOG Press, March 2006.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ounningham FG, Leveno KJ, Bloom SL, et al. Hypertensive disorders in pregnancy. 22 ed. New York, 2005: 761-808.</mixed-citation><mixed-citation xml:lang="en">Ounningham FG, Leveno KJ, Bloom SL, et al. Hypertensive disorders in pregnancy. 22 ed. New York, 2005: 761-808.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">The Society of Obstetricians and Gynaecologists of Canada. Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy. Journal of Obstetrics and Gynaecology Canada 2008; Volume 30, Number 3, Supplement 1, March.</mixed-citation><mixed-citation xml:lang="en">The Society of Obstetricians and Gynaecologists of Canada. Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy. Journal of Obstetrics and Gynaecology Canada 2008; Volume 30, Number 3, Supplement 1, March.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Facchinetti F, Marozio L, Frusca T, et al. Maternal thrombophilia and the risk of recurrence of preeclampsia. Am J Obstet Gynecol. 2009 Jan; 200 (1): 46.e1-5. Epub 2008 Oct 9.</mixed-citation><mixed-citation xml:lang="en">Facchinetti F, Marozio L, Frusca T, et al. Maternal thrombophilia and the risk of recurrence of preeclampsia. Am J Obstet Gynecol. 2009 Jan; 200 (1): 46.e1-5. Epub 2008 Oct 9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Romundstad PR, Magnussen EB, Smith GD, et al. Hypertension in pregnancy and later cardiovascular risk: common antecedents? J Circulation. 2010; Aug 3; 122 (5): 478-87.</mixed-citation><mixed-citation xml:lang="en">Romundstad PR, Magnussen EB, Smith GD, et al. Hypertension in pregnancy and later cardiovascular risk: common antecedents? J Circulation. 2010; Aug 3; 122 (5): 478-87.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Magnussek EB. Prepregnancy cardiovascular risk as predictors of preeclampsia: population based cohort study. BMJ. 2007; 335: 978-86.</mixed-citation><mixed-citation xml:lang="en">Magnussek EB. Prepregnancy cardiovascular risk as predictors of preeclampsia: population based cohort study. BMJ. 2007; 335: 978-86.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Vikse BE, Hallan S, Bostad L, et al. Previous preeclampsia and risk for progression of</mixed-citation><mixed-citation xml:lang="en">Vikse BE, Hallan S, Bostad L, et al. Previous preeclampsia and risk for progression of</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">biopsy-verified kidney disease to end-stage renal disease. J Nephrol Dial Transplant. 2010; Oct; 25 (10): 3289-96.</mixed-citation><mixed-citation xml:lang="en">biopsy-verified kidney disease to end-stage renal disease. J Nephrol Dial Transplant. 2010; Oct; 25 (10): 3289-96.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bussen S. Influence of the vascular endothelial growth, factor on the development of severe pre-eclampsia or HELLP syndrome. Arch. Gynecol Obstet. 2010; Oct 13: 24-32.</mixed-citation><mixed-citation xml:lang="en">Bussen S. Influence of the vascular endothelial growth, factor on the development of severe pre-eclampsia or HELLP syndrome. Arch. Gynecol Obstet. 2010; Oct 13: 24-32.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Drost JT, Maas AH, van Eyck J, et al. Preeclampsia as a female-specific risk factor for chronic hypertension. J. Circulation. 20104 Aug 10; 122 (6): 579-584.</mixed-citation><mixed-citation xml:lang="en">Drost JT, Maas AH, van Eyck J, et al. Preeclampsia as a female-specific risk factor for chronic hypertension. J. Circulation. 20104 Aug 10; 122 (6): 579-584.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hertig A, Liere P. New markers in preeclampsia. Clin. Chim. Acta. 2010; Nov 11; 411 (21-22): 1591-5.</mixed-citation><mixed-citation xml:lang="en">Hertig A, Liere P. New markers in preeclampsia. Clin. Chim. Acta. 2010; Nov 11; 411 (21-22): 1591-5.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lorquet S, Pequeux C, Munaut C, et al. Aetiology and physiopathology of pre-eclampsia and related forms. J Acta Clin. Belg. 2010; Jul-Aug; 65 (4): 237-241.</mixed-citation><mixed-citation xml:lang="en">Lorquet S, Pequeux C, Munaut C, et al. Aetiology and physiopathology of pre-eclampsia and related forms. J Acta Clin. Belg. 2010; Jul-Aug; 65 (4): 237-241.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mao D, Che J, Li K, et al. Association of homocysteine, asymmetric dimethylargi-nine, and nitric oxide with preeclampsia. Arch. Gynecol. Obstet. 2010; Oct; 282 (4): 371-5.</mixed-citation><mixed-citation xml:lang="en">Mao D, Che J, Li K, et al. Association of homocysteine, asymmetric dimethylargi-nine, and nitric oxide with preeclampsia. Arch. Gynecol. Obstet. 2010; Oct; 282 (4): 371-5.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Duckitt K. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ 2005; Mar. 12; 330:565.</mixed-citation><mixed-citation xml:lang="en">Duckitt K. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ 2005; Mar. 12; 330:565.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
