russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2016-8-86-91russjcardiol-771Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON THE ISSUEМОЛЕКУЛЯРНЫЕ БИОМАРКЕРЫ В ДИАГНОСТИКЕ, СТРАТИФИКАЦИИ РИСКА И ПРОГНОЗИРОВАНИИ ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТИMOLECULAR BIOMARKERS FOR DIAGNOSTICS, RISK STRATIFICATION AND PREDICTION OF CHRONIC HEART FAILUREМедведеваЕ. А.MedvedevaE. A.

к.м.н., доцент кафедры пропедевтической терапии,

Самара

Samara

elena5583@mail.ruСурковаЕ. А.SurkovaE. A.

к.м.н., доцент кафедры пропедевтической терапии, Самара;

Падуя

Samara;

Padova

lenasurkova@list.ruЛимареваЛ. В.LimarevaL. V.

д.б.н., зав. лабораторией иммунологии,

Самара

Samara

larisa-limareva@yandex.ruЩукинЮ. В.ShchukinYu. V.

профессор, д.м.н., зав. кафедрой пропедевтической терапии,

Самара

Samara

samgmu_pt@mail.ruГБОУ ВПО Самарский государственный медицинский университет Минздрава РоссииРоссияSamara State Medical University of the Ministry of HealthRussian FederationГБОУ ВПО Самарский государственный медицинский университет Минздрава России; Университет ПадуиRussian FederationSamara State Medical University of the Ministry of Health; University of PadovaRussian Federation201628082016088691Copyright © Медведева Е.А., Суркова Е.А., Лимарева Л.В., Щукин Ю.В., 20162016Медведева Е.А., Суркова Е.А., Лимарева Л.В., Щукин Ю.В.Medvedeva E.A., Surkova E.A., Limareva L.V., Shchukin Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/771

Классические проявления застойной сердечной недостаточности имеют недостаточно высокую чувствительность и специфичность, что приводит к поздней диагностике и ухудшению прогноза заболевания. Концепция молекулярных биомаркеров получила широкое развитие в последнее десятилетие. К настоящему времени описан ряд биомаркеров, отражающих различные патофизиологические процессы, формирующие звенья патогенеза хронической сердечной недостаточности. Они являются надежным, безопасным и объективным средством диагностики и стратификации риска неблагоприятных событий, дополняющим клинические и инструментальные данные и отражающим особенности механизмов развития и прогрессирования заболевания у конкретного пациента. Данный обзор посвящен обобщению имеющихся доказательных данных о роли биомаркеров в диагностике и стратификации риска.

Classic presentation of congestive heart failure do not have enough sensitivity and specificity, which lead to delayed diagnostics and worsening of the disease outcome. The concept of molecular biomarkers received broad development during past decade. Recently, a range of biomarkers has been invented, representing different pathopgysiological processes of chronic heart failure pathogenesis. These are reliable, safe and objective tool for diagnostics and stratification of adverse events risk, which adds to clinical and instrumental data and reflects the specifics of development and progression mechanisms in an exact patient. The review focuses on a synthesis of known evidence data on the role of biomarkers in diagnostics and risk stratification.

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The authors declare that there are no conflicts of interest present.