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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2026-6893</article-id><article-id custom-type="edn" pub-id-type="custom">HHXMJA</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-6893</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ТЕХНОЛОГИИ ИСКУССТВЕННОГО ИНТЕЛЛЕКТА В КАРДИОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND TECHNOLOGIES OF ARTIFICIAL INTELLIGENCE IN CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Применение методов искусственного интеллекта в медицине: современное состояние и перспективы развития в кардиологии: обзор</article-title><trans-title-group xml:lang="en"><trans-title>Artificial intelligence application in medicine: current status and development prospects in cardiology. A review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8425-5614</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абукеримова</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Abukerimova</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Саният Касумовна Абукеримова — ординатор-кардиолог 1 года, Сургутский государственный университет; врач приемного отделения, Центр диагностики и сердечно-сосудистой хирургии </p><p>пр. Ленина, д. 1, Сургут, 628400; пр. Ленина, д. 69/1, Сургут</p></bio><bio xml:lang="en"><p>Lenin ave., 1, Surgut, 628400; Lenin ave., 69/1, Surgut,</p></bio><email xlink:type="simple">sabukerimova@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>БУ ВО Сургутский Государственный университет; &#13;
БУ Окружной кардиологический диспансер «Центр диагностики и сердечно-сосудистой хирургии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Surgut State University; &#13;
District Cardiology Dispensary "Center for Diagnostics and Cardiovascular Surgery"</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>22</day><month>04</month><year>2026</year></pub-date><volume>31</volume><issue>2S</issue><issue-title>Искусственный интеллект в медицине</issue-title><fpage>6893</fpage><lpage>6893</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Абукеримова С.К., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Абукеримова С.К.</copyright-holder><copyright-holder xml:lang="en">Abukerimova S.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/6893">https://russjcardiol.elpub.ru/jour/article/view/6893</self-uri><abstract><sec><title>Цель</title><p>Цель. Систематизация данных о применении алгоритмов машинного и глубокого обучения для диагностики, прогнозирования течения и персонализации терапии кардиологических больных.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведен систематический поиск в базах PubMed, Scopus, Web of Science, Google Scholar, eLIBRARY.RU за период 2015-2026гг. Критерии включения: оригинальные исследования, клиническая направленность, использование алгоритмов ИИ, наличие валидации модели. Процесс отбора описан в соответствии с PRISMA 2009. Из 187 идентифицированных публикаций после удаления дубликатов и скрининга в финальный анализ включена 41 работа.</p></sec><sec><title>Результаты</title><p>Результаты. Выделены пять приоритетных направлений: автоматический анализ электрокардиограмм, интерпретация эхокардиографических изображений, обработка данных компьютерной и магнитно-резонансной томографии, оценка сердечно-сосудистых рисков и персонализированный подход к лечению. Нейросетевые алгоритмы демонстрируют высокую точность, сопоставимую с экспертной оценкой. Фундаментальные модели электрокардиографии (DeepECG-SSL) достигают AUC 0,990 на внутренних тестах и 0,981-0,983 на внешних данных. Мультимодальные подходы, интегрирующие данные сетчатки и сердечно-сосудистых сигналов, показывают AUC 0,97. Первое рандомизированное исследование применения больших языковых моделей в кардиологии продемонстрировало снижение клинически значимых ошибок с 24,3% до 13,1% (p=0,033).</p></sec><sec><title>Заключение</title><p>Заключение. Искусственный интеллект становится ключевым инструментом кардиологической диагностики и прогнозирования. Российские исследователи вносят весомый вклад в это направление. Сохраняются нерешённые проблемы интерпретируемости моделей и необходимости внешней валидации.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To systematize data on the use of machine and deep learning algorithms for diagnosis, prognosis, and personalization of therapy in cardiac patients.</p></sec><sec><title>Material and methods</title><p>Material and methods. A systematic search of PubMed, Scopus, Web of Science, Google Scholar, and eLIBRARY.RU was conducted for the period 2015-2026. Inclusion criteria included original studies, clinical focus, use of AI algorithms, and model validation. The selection process was described in accordance with PRISMA 2009. Of the 187 identified publications, 41 were included in the final analysis after duplicate removal and screening.</p></sec><sec><title>Results</title><p>Results. Five priority areas were identified: automated electrocardiogram analysis, echocardiographic image interpretation, computed tomography and magnetic resonance imaging data processing, cardiovascular risk assessment, and personalized treatment approaches. Neural network algorithms demonstrate high accuracy, comparable to expert judgment. Fundamental electrocardiography models (DeepECG-SSL) achieve an AUC of 0,990 on internal tests and 0,981-0,983 on external data. Multimodal approaches integrating retinal and cardiovascular data show an AUC of 0,97. The first randomized trial of large-scale language models in cardiology demonstrated a reduction in clinically significant errors from 24,3% to 13,1% (p=0,033).</p></sec><sec><title>Conclusion</title><p>Conclusion. Artificial intelligence is becoming a key tool in cardiac diagnostics and prognosis. Russian researchers are making a significant contribution to this field. Unresolved issues remain regarding model interpretability and the need for external validation.</p></sec><sec><title> </title><p> </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>искусственный интеллект</kwd><kwd>нейронные сети</kwd><kwd>электрокардиография</kwd><kwd>эхокардиография</kwd><kwd>прогнозирование рисков</kwd><kwd>персонализированная терапия.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>artificial intelligence</kwd><kwd>machine learning</kwd><kwd>neural networks</kwd><kwd>cardiology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Krittanawong C, Zhang H, Wang Z, et al. Artificial intelligence in precision cardiovascular medicine. J Am Coll Cardiol. 2017;69(21):2657-64. doi:10.1016/j.jacc.2017.03.571.</mixed-citation><mixed-citation xml:lang="en">Krittanawong C, Zhang H, Wang Z, et al. Artificial intelligence in precision cardiovascular medicine. J Am Coll Cardiol. 2017;69(21):2657-64. doi:10.1016/j.jacc.2017.03.571.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Topol EJ. High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25(1):44-56. doi:10.1038/s41591-018-0300-7.</mixed-citation><mixed-citation xml:lang="en">Topol EJ. High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25(1):44-56. doi:10.1038/s41591-018-0300-7.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Holzinger A, Langs G, Denk H, et al. Causability and explainability of artificial intelligence in medicine. Wiley Interdiscip Rev Data Min Knowl Discov. 2019;9(4):e1312. doi:10.1002/widm.1312.</mixed-citation><mixed-citation xml:lang="en">Holzinger A, Langs G, Denk H, et al. Causability and explainability of artificial intelligence in medicine. Wiley Interdiscip Rev Data Min Knowl Discov. 2019;9(4):e1312. doi:10.1002/widm.1312.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kelly CJ, Karthikesalingam A, Suleyman M, et al. Key challenges for delivering clinical impact with artificial intelligence. BMC Med. 2019;17(1):195. doi:10.1186/s12916-019-1426-2.</mixed-citation><mixed-citation xml:lang="en">Kelly CJ, Karthikesalingam A, Suleyman M, et al. Key challenges for delivering clinical impact with artificial intelligence. BMC Med. 2019;17(1):195. doi:10.1186/s12916-019-1426-2.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">London AJ. Artificial intelligence and black-box medical decisions: accuracy versus explainability. Hastings Cent Rep. 2019;49(1):15-21. doi:10.1002/hast.973.</mixed-citation><mixed-citation xml:lang="en">London AJ. Artificial intelligence and black-box medical decisions: accuracy versus explainability. Hastings Cent Rep. 2019;49(1):15-21. doi:10.1002/hast.973.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Attia ZI, Kapa S, Lopez-Jimenez F, et al. Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram. Nat Med. 2019;25(1):70-4. doi:10.1038/s41591-018-0240-2.</mixed-citation><mixed-citation xml:lang="en">Attia ZI, Kapa S, Lopez-Jimenez F, et al. Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram. Nat Med. 2019;25(1):70-4. doi:10.1038/s41591-018-0240-2.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hannun AY, Rajpurkar P, Haghpanahi M, et al. Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network. Nat Med. 2019;25(1):65-9. doi:10.1038/s41591-018-0268-3.</mixed-citation><mixed-citation xml:lang="en">Hannun AY, Rajpurkar P, Haghpanahi M, et al. Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network. Nat Med. 2019;25(1):65-9. doi:10.1038/s41591-018-0268-3.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ribeiro AH, Ribeiro MH, Paixão GMM, et al. Automatic diagnosis of the 12-lead ECG using a deep neural network. Nat Commun. 2020;11(1):1760. doi:10.1038/s41467-020-15432-4.</mixed-citation><mixed-citation xml:lang="en">Ribeiro AH, Ribeiro MH, Paixão GMM, et al. Automatic diagnosis of the 12-lead ECG using a deep neural network. Nat Commun. 2020;11(1):1760. doi:10.1038/s41467-020-15432-4.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu H, Cheng C, Yin H, et al. Automatic multilabel electrocardiogram diagnosis of heart rhythm or conduction abnormalities with deep learning: a cohort study. Lancet Digit Health. 2020;2:e348-e357. doi:10.1016/S2589-7500(20)30107-2.</mixed-citation><mixed-citation xml:lang="en">Zhu H, Cheng C, Yin H, et al. Automatic multilabel electrocardiogram diagnosis of heart rhythm or conduction abnormalities with deep learning: a cohort study. Lancet Digit Health. 2020;2:e348-e357. doi:10.1016/S2589-7500(20)30107-2.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Alusi MA, Friedman SF, Kany S, et al. A deep learning digital biomarker to detect hypertension and stratify cardiovascular risk from the electrocardiogram. NPJ Digit Med. 2025;8(1):120. doi:10.1038/s41746-025-01491-8.</mixed-citation><mixed-citation xml:lang="en">Al-Alusi MA, Friedman SF, Kany S, et al. A deep learning digital biomarker to detect hypertension and stratify cardiovascular risk from the electrocardiogram. NPJ Digit Med. 2025;8(1):120. doi:10.1038/s41746-025-01491-8.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Raghunath S, Pfeifer JM, Ulloa-Cerna AE, et al. Deep neural networks can predict new-onset atrial fibrillation from the 12-lead ECG and help identify those at risk of atrial fibrillation-related stroke. Circulation. 2021;143(13):1287-98. doi:10.1161/CIRCULATIONAHA.120.047829.</mixed-citation><mixed-citation xml:lang="en">Raghunath S, Pfeifer JM, Ulloa-Cerna AE, et al. Deep neural networks can predict new-onset atrial fibrillation from the 12-lead ECG and help identify those at risk of atrial fibrillation-related stroke. Circulation. 2021;143(13):1287-98. doi:10.1161/CIRCULATIONAHA.120.047829.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Attia ZI, Noseworthy PA, Lopez-Jimenez F, et al. An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction. Lancet. 2019;394(10201):861-7. doi:10.1016/S0140-6736(19)31721-0.</mixed-citation><mixed-citation xml:lang="en">Attia ZI, Noseworthy PA, Lopez-Jimenez F, et al. An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction. Lancet. 2019;394(10201):861-7. doi:10.1016/S0140-6736(19)31721-0.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Денисова Е. А., Кордюкова А. А., Шевяков Д. О. Применение искусственного интеллекта в анализе данных электрокардиографа сверхвысокого разрешения. Научное приборостроение. 2025;35(4):72-8.</mixed-citation><mixed-citation xml:lang="en">Denisova EA, Kordyukova AA, Shevyakov DO. Application of artificial intelligence in the analysis of data from an ultra-high resolution electrocardiograph. Nauchnoe Priborostroenie. 2025;35(4):72-8. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Мсукар С., Давыдов Р. В. Разработка нейронной сети для отслеживания негативных изменений в сердечно-сосудистой системе человека на основе сигналов пульсовых волн. Учёные записки физического факультета Московского университета. 2025;(6):2560701.</mixed-citation><mixed-citation xml:lang="en">Msukar S, Davydov RV. Development of a neural network for monitoring negative changes in the human cardiovascular system based on pulse wave signals. Uchenye Zapiski Fizicheskogo Fakulteta Moskovskogo Universiteta. 2025;(6):2560701. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nolin-Lapalme A, Sowa A, Delfrate J, et al. Foundation models for electrocardiogram interpretation: clinical implications. Eur Heart J. 2026;47(4):312-25. doi:10.1093/eurheartj/ehaf1119.</mixed-citation><mixed-citation xml:lang="en">Nolin-Lapalme A, Sowa A, Delfrate J, et al. Foundation models for electrocardiogram interpretation: clinical implications. Eur Heart J. 2026;47(4):312-25. doi:10.1093/eurheartj/ehaf1119.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Murthy VL, Patel CJ. The paradoxical challenge of high-value medical artificial intelligence. NEJM AI. 2026;3(2). doi:10.1056/aip2501364.</mixed-citation><mixed-citation xml:lang="en">Murthy VL, Patel CJ. The paradoxical challenge of high-value medical artificial intelligence. NEJM AI. 2026;3(2). doi:10.1056/aip2501364.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ouyang D, He B, Ghorbani A, et al. Video-based AI for beat-to-beat assessment of cardiac function. Nature. 2020;580(7802):252-6. doi:10.1038/s41586-020-2145-8.</mixed-citation><mixed-citation xml:lang="en">Ouyang D, He B, Ghorbani A, et al. Video-based AI for beat-to-beat assessment of cardiac function. Nature. 2020;580(7802):252-6. doi:10.1038/s41586-020-2145-8.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J, Gajjala S, Agrawal P, et al. Fully Automated Echocardiogram Interpretation in Clinical Practice. Circulation. 2018;138(16):1623-35. doi:10.1161/CIRCULATIONAHA.118.034338.</mixed-citation><mixed-citation xml:lang="en">Zhang J, Gajjala S, Agrawal P, et al. Fully Automated Echocardiogram Interpretation in Clinical Practice. Circulation. 2018;138(16):1623-35. doi:10.1161/CIRCULATIONAHA.118.034338.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Salte IM, Østvik A, Smistad E, et al. Artificial intelligence for automatic measurement of left ventricular strain in echocardiography. JACC Cardiovasc Imaging. 2021;14(10):1918-28. doi:10.1016/j.jcmg.2021.04.018.</mixed-citation><mixed-citation xml:lang="en">Salte IM, Østvik A, Smistad E, et al. Artificial intelligence for automatic measurement of left ventricular strain in echocardiography. JACC Cardiovasc Imaging. 2021;14(10):1918-28. doi:10.1016/j.jcmg.2021.04.018.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Tromp J, Seekings PJ, Hung CL, et al. Automated interpretation of systolic and diastolic function on the echocardiogram: a multicohort study. The Lancet Digit Health. 2022;4(1):e46-e54. doi:10.1016/S2589-7500(21)00235-1.</mixed-citation><mixed-citation xml:lang="en">Tromp J, Seekings PJ, Hung CL, et al. Automated interpretation of systolic and diastolic function on the echocardiogram: a multicohort study. The Lancet Digit Health. 2022;4(1):e46-e54. doi:10.1016/S2589-7500(21)00235-1.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Malagila Raphael Y, Monkam P, Qi S, et al. Deep generative models in echocardiography: a scoping review of trends and future perspectives. Measurement Science and Technology. 2026;37(4):042001. doi:10.1088/1361-6501/ae319b.</mixed-citation><mixed-citation xml:lang="en">Malagila Raphael Y, Monkam P, Qi S, et al. Deep generative models in echocardiography: a scoping review of trends and future perspectives. Measurement Science and Technology. 2026;37(4):042001. doi:10.1088/1361-6501/ae319b.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kusunose K, Haga A, Inoue M, et al. Clinically feasible and accurate view classification of echocardiographic images using deep learning. Biomolecules. 2020;10(5):685. doi:10.3390/biom10050665.</mixed-citation><mixed-citation xml:lang="en">Kusunose K, Haga A, Inoue M, et al. Clinically feasible and accurate view classification of echocardiographic images using deep learning. Biomolecules. 2020;10(5):685. doi:10.3390/biom10050665.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Guan H, Liu M. Domain adaptation for medical image analysis: a survey. IEEE Trans Biomed Eng. 2021;69(3):1173-85. doi:10.1109/TBME.2021.3117407.</mixed-citation><mixed-citation xml:lang="en">Guan H, Liu M. Domain adaptation for medical image analysis: a survey. IEEE Trans Biomed Eng. 2021;69(3):1173-85. doi:10.1109/TBME.2021.3117407.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bai W, Sinclair M, Tarroni G, et al. Automated cardiovascular magnetic resonance image analysis with fully convolutional networks. J Cardiovasc Magn Reson. 2018;20(1):65. doi:10.1186/s12968-018-0471-x.</mixed-citation><mixed-citation xml:lang="en">Bai W, Sinclair M, Tarroni G, et al. Automated cardiovascular magnetic resonance image analysis with fully convolutional networks. J Cardiovasc Magn Reson. 2018;20(1):65. doi:10.1186/s12968-018-0471-x.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Pirruccello JP, Bick A, Wang M, et al. Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy. Nat Commun. 2020;11(1):2254. doi:10.1038/s41467-020-15823-7.</mixed-citation><mixed-citation xml:lang="en">Pirruccello JP, Bick A, Wang M, et al. Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy. Nat Commun. 2020;11(1):2254. doi:10.1038/s41467-020-15823-7.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Максимова А. С., Саматов Д. С., Листратов А. И. и др. Применение радиомического анализа и алгоритмов машинного обучения для выявления постинфарктного кардиосклероза у пациентов с ишемической кардиомиопатией по данным магнитно-резонансной томографии сердца без контрастирования. Российский кардиологический журнал. 2025;30(12):6428. doi:10.1 5829/1560-4071-2025-6428.</mixed-citation><mixed-citation xml:lang="en">Maksimova AS, Samatov DS, Listratov AI, et al. Using radiomics analysis and machine learning algorithms to detect post-infarction cardiosclerosis in patients with ischemic cardiomyopathy based on non-contrast cardiac magnetic resonance imaging. Russian Journal of Cardiology. 2025;30(12):6428. (In Russ.) doi:10.1 5829/1560-4071-2025-6428.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Poplin R, Varadarajan AV, Blumer K, et al. Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning. Nat Biomed Eng. 2018;2(3):158-64. doi:10.1038/s41551-018-0195-0.</mixed-citation><mixed-citation xml:lang="en">Poplin R, Varadarajan AV, Blumer K, et al. Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning. Nat Biomed Eng. 2018;2(3):158-64. doi:10.1038/s41551-018-0195-0.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Weng SF, Reps J, Kai J, et al. Can machine-learning improve cardiovascular risk prediction using routine clinical data? PLoS One. 2017;12(4):e0174944. doi:10.1371/journal.pone.0174944.</mixed-citation><mixed-citation xml:lang="en">Weng SF, Reps J, Kai J, et al. Can machine-learning improve cardiovascular risk prediction using routine clinical data? PLoS One. 2017;12(4):e0174944. doi:10.1371/journal.pone.0174944.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Bhagawati M, Gupta S, Paul S, et al. Attention-based hybrid deep learning models and its scientific validation for cardiovascular disease risk stratification. Biomed Signal Process Control. 2025;108:107824. doi:10.1016/j.bspc.2025.107824.</mixed-citation><mixed-citation xml:lang="en">Bhagawati M, Gupta S, Paul S, et al. Attention-based hybrid deep learning models and its scientific validation for cardiovascular disease risk stratification. Biomed Signal Process Control. 2025;108:107824. doi:10.1016/j.bspc.2025.107824.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Sathya K, Magesh G. Multimodal deep learning for cardiovascular risk stratification: integrating retinal biomarkers and cardiovascular signals for enhanced heart attack prediction. IEEE Access. 2025;13:99672-99689. doi:10.1109/ACCESS.2025.3577064.</mixed-citation><mixed-citation xml:lang="en">Sathya K, Magesh G. Multimodal deep learning for cardiovascular risk stratification: integrating retinal biomarkers and cardiovascular signals for enhanced heart attack prediction. IEEE Access. 2025;13:99672-99689. doi:10.1109/ACCESS.2025.3577064.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Veldhuizen GP, Lenz T, Cifci D, et al. Deep learning can predict cardiovascular events from liver imaging. JHEP Rep. 2025;7(8):101427. doi:10.1016/j.jhepr.2025.101427.</mixed-citation><mixed-citation xml:lang="en">Veldhuizen GP, Lenz T, Cifci D, et al. Deep learning can predict cardiovascular events from liver imaging. JHEP Rep. 2025;7(8):101427. doi:10.1016/j.jhepr.2025.101427.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Mahdavi M, Kazemnejad A, Asosheh A, et al. Development and validation of an artificial intelligence-based model for cardiovascular disease prediction using longitudinal data. BMC Med Inform Decis Mak. 2025;25(1):447. doi:10.1186/s12911-025-03280-5.</mixed-citation><mixed-citation xml:lang="en">Mahdavi M, Kazemnejad A, Asosheh A, et al. Development and validation of an artificial intelligence-based model for cardiovascular disease prediction using longitudinal data. BMC Med Inform Decis Mak. 2025;25(1):447. doi:10.1186/s12911-025-03280-5.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Alaa AM, Bolton T, Di Angelantonio E, et al. Cardiovascular disease risk prediction using automated machine learning: A prospective study of 423,604 UK Biobank participants. PLoS One. 2019;14(5):e0213653. doi:10.1371/journal.pone.0213653.</mixed-citation><mixed-citation xml:lang="en">Alaa AM, Bolton T, Di Angelantonio E, et al. Cardiovascular disease risk prediction using automated machine learning: A prospective study of 423,604 UK Biobank participants. PLoS One. 2019;14(5):e0213653. doi:10.1371/journal.pone.0213653.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kakadiaris IA, Vrigkas M, Yen AA, et al. Machine learning outperforms ACC/AHA CVD risk calculator in MESA. J Am Heart Assoc. 2018;7(22):e009476. doi:10.1161/JAHA.118.009476.</mixed-citation><mixed-citation xml:lang="en">Kakadiaris IA, Vrigkas M, Yen AA, et al. Machine learning outperforms ACC/AHA CVD risk calculator in MESA. J Am Heart Assoc. 2018;7(22):e009476. doi:10.1161/JAHA.118.009476.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">van Osta N, van Loon T, Lumens J. Individual hearts: computational models for improved management of cardiovascular disease. Heart. 2025. Epub ahead of print. doi:10.1136/heartjnl-2024-324177.</mixed-citation><mixed-citation xml:lang="en">van Osta N, van Loon T, Lumens J. Individual hearts: computational models for improved management of cardiovascular disease. Heart. 2025. Epub ahead of print. doi:10.1136/heartjnl-2024-324177.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Tasmurzayev N, Amangeldy B, Imanbek B, et al. Digital cardiovascular twins, AI agents, and sensor data: a narrative review from system architecture to proactive heart health. Sensors (Basel). 2025;25(17):5272. doi:10.3390/s25175272.</mixed-citation><mixed-citation xml:lang="en">Tasmurzayev N, Amangeldy B, Imanbek B, et al. Digital cardiovascular twins, AI agents, and sensor data: a narrative review from system architecture to proactive heart health. Sensors (Basel). 2025;25(17):5272. doi:10.3390/s25175272.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Niederer SA, Lumens J, Trayanova NA. Computational models in cardiology. Nat Rev Cardiol. 2019;16(2):100-11. doi:10.1038/s41569-018-0104-y.</mixed-citation><mixed-citation xml:lang="en">Niederer SA, Lumens J, Trayanova NA. Computational models in cardiology. Nat Rev Cardiol. 2019;16(2):100-11. doi:10.1038/s41569-018-0104-y.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">O’Sullivan JW, Palepu A, Saab K, et al. A large language model for complex cardiology care. Nat Med. 2026;32(4):616-23. doi:10.1038/s41591-025-04190-9.</mixed-citation><mixed-citation xml:lang="en">O’Sullivan JW, Palepu A, Saab K, et al. A large language model for complex cardiology care. Nat Med. 2026;32(4):616-23. doi:10.1038/s41591-025-04190-9.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Price WN, Cohen IG. Privacy in the age of medical big data. Nat Med. 2019;25(1):37-43. doi:10.1038/s41591-018-0272-7.</mixed-citation><mixed-citation xml:lang="en">Price WN, Cohen IG. Privacy in the age of medical big data. Nat Med. 2019;25(1):37-43. doi:10.1038/s41591-018-0272-7.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Gerke S, Minssen T, Cohen G. Ethical and legal challenges of artificial intelligence-driven healthcare. In: Artificial Intelligence in Healthcare. London: Academic Press; 2020. p.295336. doi:10.1016/B978-0-12-818438-7.00012-5.</mixed-citation><mixed-citation xml:lang="en">Gerke S, Minssen T, Cohen G. Ethical and legal challenges of artificial intelligence-driven healthcare. In: Artificial Intelligence in Healthcare. London: Academic Press; 2020. p.295336. doi:10.1016/B978-0-12-818438-7.00012-5.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Dunn J, Coravos A, Fanarjian M, et al. Remote digital health technologies for improving the care of people with respiratory disorders. Lancet Digit Health. 2024;6(3):e178-e188. doi:10.1016/S2589-7500(23)00248-0.</mixed-citation><mixed-citation xml:lang="en">Dunn J, Coravos A, Fanarjian M, et al. Remote digital health technologies for improving the care of people with respiratory disorders. Lancet Digit Health. 2024;6(3):e178-e188. doi:10.1016/S2589-7500(23)00248-0.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
