russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2014-7-eng-51-54russjcardiol-625Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯEXPERIMENTAL STUDIESIN VITRO ИМИТИРУЮЩЕЕ ИССЛЕДОВАНИЕ КОЛЬЦЕВОГО НАПРЯЖЕНИЯ МИОКАРДИАЛЬНОГО МОСТА — КОРОНАРНОЙ АРТЕРИИIN VITRO SIMULATION RESEARCH ON THE HOOP STRESS OF MYOCARDIAL BRIDGE — CORONARY ARTERYDingHaoDingHao

Shanghai

Shanghai

ShangKunShangKun

Shanghai

Shanghai

LianLanhaiLianLanhai

Shanghai

Shanghai

ZhaoLingxiZhaoLingxi

Shanghai

Shanghai

ShengLixingShengLixing

Shanghai

Shanghai

ZengYanjunZengYanjun

No. 100 PingLeYuan Beijing

No. 100 PingLeYuan, Beijing

yjzeng@bjut.edu.cnSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology; Shanghai Medical Instrumentation CollegeКитайSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology; Shanghai Medical Instrumentation CollegeChinaSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and TechnologyКитайSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and TechnologyChinaBiomechanics & Medical Information Institute, Beijing University of TechnologyКитайBiomechanics & Medical Information Institute, Beijing University of TechnologyChina20142807201407-eng5154Copyright © Ding H., Shang K., Lian L., Zhao L., Sheng L., Zeng Y., 20142014Ding H., Shang K., Lian L., Zhao L., Sheng L., Zeng Y.Ding H., Shang K., Lian L., Zhao L., Sheng L., Zeng Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/625

Предложено аналоговое устройство, которое может имитировать угнетение миокардиальным мостом стенки коронарной артерии. Устройство может быть использовано для исследования динамических изменений проксимального и дистального кольцевых напряжений. Между тем, реализуется независимое регулирование кольцевых напряжений. “Миокардиальный мост — коронарная артерия” аналоговое устройство создано для регулировки внешнего давления смоделированной коронарной артерии и угнетение уровня миокардиального моста и для записи изменений кольцевых напряжений. In vitro имитационного эксперимент указывают на то, что аномалия кольцевых стресс возникает в основном в проксимальном конце. По мере того, как уровень угнетения повышается, среднее проксимальное кольцевое напряжение и колебательного значение (максимум-минимум), соответственно, увеличивается. “Миокардиальный мост — коронарная артерия” аналоговое устройство может обеспечить метод для изучения влияния кольцевого напряжения на стенки коронарной артерии in vitro.

An analog device which can simulate myocardium bridge oppresses mural coronary artery is designed. The device can be used to research the dynamic changes of the proximal and distal hoop stresses. Meanwhile, the independent regulation of the hoop stresses is realized. The “myocardial bridge — coronary artery” analog device is built to adjust the external pressure of the simulated coronary artery and the oppression level of the myocardial bridge and to record the changes of the hoop stresses. The In vitro simulation experiment indicate that the anomaly of hoop stress mainly occurs in the proximal end. As the oppression level increases, the mean proximal hoop stress and the oscillatory value (maximum-minimum) increase obviously. The “myocardial bridge — coronary artery” analog device can provide a method to study the influence of the hoop stress on the mural coronary artery in vitro.

стенка коронарной артериимиокардиальный мостгемодинамикакольцевое напряжениеmural coronary arterymyocardial bridgehemodynamichoop stressShanghai Education Committee scientific research innovation projects (13YZ148) and national project cultivation fund of USSTReferencesMoses JW, Leon MB, Popma JJ, et al. Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery [J] N Engl J Med 2003; 349:1315–23.Moses JW, Leon MB, Popma JJ, et al. Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery [J] N Engl J Med 2003; 349:1315–23.Park DW, Park SW, Park KH, et al. Frequency of and risk factors for stent thrombosis after drug-eluting stent implantation during long-term follow-up [J]. Am J Cardiol 2006;98:352–6.Park DW, Park SW, Park KH, et al. Frequency of and risk factors for stent thrombosis after drug-eluting stent implantation during long-term follow-up [J]. Am J Cardiol 2006;98:352–6.McFadden EP, Stabile E, Regar E, et al. Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy [J]. Lancet 2004; 364:1519–21.McFadden EP, Stabile E, Regar E, et al. Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy [J]. Lancet 2004; 364:1519–21.Cheng GC, Loree HM, Kamm RD, et al. Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation [J]. Circulation. 1993; 87: 1179–87.Cheng GC, Loree HM, Kamm RD, et al. Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation [J]. Circulation. 1993; 87: 1179–87.Ohayon J, Dubreuil O, Tracqui P, et al. Influence of residual stress/strain on the biomechanical stability of vulnerable coronary plaques: potential impact for evaluating the risk of plaque rupture [J]. AJP –Heart and circulatory physiology, 2007, 293 (3): 1987–96.Ohayon J, Dubreuil O, Tracqui P, et al. Influence of residual stress/strain on the biomechanical stability of vulnerable coronary plaques: potential impact for evaluating the risk of plaque rupture [J]. AJP –Heart and circulatory physiology, 2007, 293 (3): 1987–96.Cardamone L, Valent n A, Eberth JF, et al. Origin of axial prestretch and residual stress in arteries [J]. Biomechanics and Modeling in Mechanobiology, 2009,8 (6): 431–46.Cardamone L, Valent n A, Eberth JF, et al. Origin of axial prestretch and residual stress in arteries [J]. Biomechanics and Modeling in Mechanobiology, 2009,8 (6): 431–46.Alastrue V, Pena E, Martinez MA, Doblare M. Assessing the use of the “opening angle method” to enforce residual stresses in patient-specific arteries [J]. Ann Biomed Eng 2007, 35: 1821–37.Alastrue V, Pena E, Martinez MA, Doblare M. Assessing the use of the “opening angle method” to enforce residual stresses in patient-specific arteries [J]. Ann Biomed Eng 2007, 35: 1821–37.Azeloglu EU, Albro MB, Thimmappa VA, et al. Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta [J]. Am J Physiol 2008, 294: 1197–205.Azeloglu EU, Albro MB, Thimmappa VA, et al. Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta [J]. Am J Physiol 2008, 294: 1197–205.Naruse K, Sokabe M. Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells [J]. Am J Physiol, 1993, 264: 797–805.Naruse K, Sokabe M. Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells [J]. Am J Physiol, 1993, 264: 797–805.Xu Zhilun. An Introduction to theory of elasticity [M].Beijing: People’s Education Press. 1982:87–9.Xu Zhilun. An Introduction to theory of elasticity [M].Beijing: People’s Education Press. 1982:87–9.Hu xuqu, Qin kairong, Wu hao, et al. Simulation of arterial pulsatile fluid shear stress and circumferential stress using a silicone tube flow chamber system [J].Journal of Medical Biomechanics, 2006, 21 (2): 94–9.Hu xuqu, Qin kairong, Wu hao, et al. Simulation of arterial pulsatile fluid shear stress and circumferential stress using a silicone tube flow chamber system [J].Journal of Medical Biomechanics, 2006, 21 (2): 94–9.Yao tai, Wu Bowei. Physiology [M]. (sixth edition). Beijin: People’s Medical Publishing House, 2003:93–104.Yao tai, Wu Bowei. Physiology [M]. (sixth edition). Beijin: People’s Medical Publishing House, 2003:93–104.Guohui Z, Junbo G. Clinical Analysis of Coronary Myocardial Bridge [J].Chinese Journal of Interventional Cardiology, 2002, 10 (1): 54–6.Guohui Z, Junbo G. Clinical Analysis of Coronary Myocardial Bridge [J].Chinese Journal of Interventional Cardiology, 2002, 10 (1): 54–6.Möhlenkamp S, Hort W, Junbo G, et al. Update on Myocardial Bridging [J]. Circulation. 2002, 106: 2616–22.Möhlenkamp S, Hort W, Junbo G, et al. Update on Myocardial Bridging [J]. Circulation. 2002, 106: 2616–22.Kalaria VG, Koradia N, Breall JA. Myocardial Bridge: a Clinical Review [J]. Catheterization and Cardiovascular Interventions 2002, 57:552–6.Kalaria VG, Koradia N, Breall JA. Myocardial Bridge: a Clinical Review [J]. Catheterization and Cardiovascular Interventions 2002, 57:552–6.Ishii T, Asuwa N, Masuda S, et al. The effects of a myocardial bridge on coronary atherosclerosis and ischaemia [J]. The Journal of Pathology,1998,185 (1):4–9.Ishii T, Asuwa N, Masuda S, et al. The effects of a myocardial bridge on coronary atherosclerosis and ischaemia [J]. The Journal of Pathology,1998,185 (1):4–9.Jun Y, Tao G. Study on the normal value of Blood Viscosity [J]. Chinese Journal of Hemorheology, 1998, 8 (1): 69.Jun Y, Tao G. Study on the normal value of Blood Viscosity [J]. Chinese Journal of Hemorheology, 1998, 8 (1): 69.Junbo G, Erbel R, Görge G, et al. High wall shear stress proximal to myocardial bridging and atherosclerosis: intracoronary ultrasound and pressure measurements [J]. Br Heart J, 1995, 73: 462–5.Junbo G, Erbel R, Görge G, et al. High wall shear stress proximal to myocardial bridging and atherosclerosis: intracoronary ultrasound and pressure measurements [J]. Br Heart J, 1995, 73: 462–5.Ding H, Chen Z, Shen L, et al. Heart Pump System in “Heart — Mural coronary artery — Myocardial Bridge” Simulative Device [J]. Australasian Physical & Engineering Sciences in Medicine, 2009, 32 (2): 105–11.Ding H, Chen Z, Shen L, et al. Heart Pump System in “Heart — Mural coronary artery — Myocardial Bridge” Simulative Device [J]. Australasian Physical & Engineering Sciences in Medicine, 2009, 32 (2): 105–11.Ning-fu W, Pan hao, Tong Guo-xin. The evaluation on stent implantation efficacy of myocardial bridge and severe atherosclerosis lesions in the segments proximal to the myocardial bridge [J].Chinese Journal of Cardiology, 2005, 33 (8): 684–6.Ning-fu W, Pan hao, Tong Guo-xin. The evaluation on stent implantation efficacy of myocardial bridge and severe atherosclerosis lesions in the segments proximal to the myocardial bridge [J].Chinese Journal of Cardiology, 2005, 33 (8): 684–6.Ishikawa Y, Akasaka Y, Ito K, et al. Significance of anatomical properties of myocardial bridge on atherosclerosis evolution in the left anteriordescending coronary artery [J], Atherosclerosis 2006,186: 380–9.Ishikawa Y, Akasaka Y, Ito K, et al. Significance of anatomical properties of myocardial bridge on atherosclerosis evolution in the left anteriordescending coronary artery [J], Atherosclerosis 2006,186: 380–9.Duygu H, Zoghi M, Nalbantgil S, et al. Myocardial bridge: a bridge to atherosclerosis [J]. Anadolu Kardiyol Derg 2007;7:12–6.Duygu H, Zoghi M, Nalbantgil S, et al. Myocardial bridge: a bridge to atherosclerosis [J]. Anadolu Kardiyol Derg 2007;7:12–6.Li-song L, Qi H, Bei-lei P. Relationship between coronary atherosclerosis and aortic pulse pressure in patients with primary hypertension [J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2007, 11 (8): 1567–9.Li-song L, Qi H, Bei-lei P. Relationship between coronary atherosclerosis and aortic pulse pressure in patients with primary hypertension [J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2007, 11 (8): 1567–9.Jankowski P, Kawecka-Jaszcz K, Czarnecka D, et al. Pulsatile but Not Steady Component of Blood Pressure Predicts Cardiovascular Events in Coronary Patients [J]. Hypertension. 2008;51:848–55.Jankowski P, Kawecka-Jaszcz K, Czarnecka D, et al. Pulsatile but Not Steady Component of Blood Pressure Predicts Cardiovascular Events in Coronary Patients [J]. Hypertension. 2008;51:848–55.Sipahi I, Tuzcu EM, Schoenhagen P, et al. Effects of Normal, Pre-Hypertensive, and Hypertensive Blood Pressure Levels on Progression of Coronary Atherosclerosis [J], J Am Coll Cardiol. 2006;48 (4):833–8.Sipahi I, Tuzcu EM, Schoenhagen P, et al. Effects of Normal, Pre-Hypertensive, and Hypertensive Blood Pressure Levels on Progression of Coronary Atherosclerosis [J], J Am Coll Cardiol. 2006;48 (4):833–8.

The authors declare that there are no conflicts of interest present.