russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2024-6190ETEEFSrussjcardiol-6190Research ArticleКЛИНИКА И ФАРМАКОТЕРАПИЯCLINIC AND PHARMACOTHERAPYВ поисках оптимальной антигипертензивной комбинации. Фокус на азилсартана медоксомил/хлорталидонLooking for an optimal antihypertensive combination. Focus on azilsartan medoxomil/chlorthalidonehttps://orcid.org/0000-0001-6515-3882СмирноваМ. Д.SmirnovaM. D.

Д. м. н., с. н. с. отдела амбулаторных лечебно-диагностических технологий НИИ клинической кардиологии им. А.Л. Мясникова.

Москва

Moscow

naliya1@yandex.ruhttps://orcid.org/0000-0002-3321-2902ФофановаТ. В.FofanovaT. V.

Д.м.н., с.н.с. отдела амбулаторных лечебно-диагностических технологий НИИ клинической кардиологии им. А.Л. Мясникова.

Москва

Moscow

t.fofanova@yandex.ruhttps://orcid.org/0000-0003-4369-1393АгеевФ. Т.AgeyevF. T.

Д.м.н., профессор, г.н.с. отдела амбулаторных лечебно-диагностических технологий НИИ клинической кардиологии им. А.Л. Мясникова.

Москва

Moscow

ftageev@gmail.comФГБУ Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова Минздрава РоссииРоссияChazov National Medical Research Center for CardiologyRussian Federation202429112024291261906190Copyright © Смирнова М.Д., Фофанова Т.В., Агеев Ф.Т., 20252025Смирнова М.Д., Фофанова Т.В., Агеев Ф.Т.Smirnova M.D., Fofanova T.V., Ageyev F.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/6190

В статье проведен анализ данных клинических исследований, посвященных эффективности и безопасности комбинированного гипотензивного препарата азилсартана медоксомил/хлорталидон и его компонентов. По данным анализируемых источников как отдельные его компоненты, так и их комбинация доказали свою эффективность и безопасность у больных с артериальной гипертензией, в т.ч. с коморбидной патологией. Азилсартана медоксомил продемонстрировал большую эффективность при сопоставимой безопасности в плане снижения артериального давления, как офисного, так и амбулаторного, по сравнению с кандесартаном, валсартаном, олмесартаном. Хлорталидон показал большую гипотензивную эффективность в сравнении с гидрохлоротиазидом и доказал свой протективный эффект в плане снижения сердечно-сосудистого риска. Комбинация азилсартана медоксомил/хлорталидон, в свою очередь, доказала свою безопасность и большую гипотензивную эффективность по сравнению как с комбинацией олмесартана медоксомил/гидрохлоротиазид, так и азилсартана медоксомил/гидрохлоротиазид.

The article analyzes data from clinical studies on the efficacy and safety of azilsartan medoxomil/chlorthalidone combination and its components. According to the analyzed sources, both individual components and their combination have proven their efficacy and safety in patients with hypertension, including those with comorbid pathology. Azilsartan medoxomil demonstrated greater efficacy with comparable safety in terms of lowering blood pressure, both office and ambulatory, compared to candesartan, valsartan, olmesartan. Chlorthalidone showed greater hypotensive efficacy compared to hydrochlorothiazide and proved its protective effect in cardiovascular risk reduction. The combination of azilsartan medoxomil/chlorthalidone, in turn, has proven its safety and greater hypotensive efficacy compared to both the combination of olmesartan medoxomil/hydrochlorothiazide and azilsartan medoxomil/hydrochlorothiazide.

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The authors declare that there are no conflicts of interest present.