russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2014-7-eng-23-27russjcardiol-618Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESВЛИЯНИЕ РАННЕГО РЕМОДЕЛИРОВАНИЯ ЛЕВОГО ЖЕЛУДОЧКА ПРИ ИЗМЕНЕНИЯХ QTC У ВЫСОКОКВАЛИФИЦИРОВАННЫХ НЕПОЛОВОЗРЕЛЫХ ФУТБОЛИСТОВTHE INFLUENCE OF EARLY LEFT VENTRICLE REMODELING OVER QTC CHANGES IN HIGHLY TRAINED PREADOLESCENT FOOTBALLERSZdravkovicMarijaZdravkovicMarija

Dr, Assistant Professor, MD, PhD, FESC,

Белград

Dr, Assistant Professor, MD, PhD, FESC, 

Belgrade

sekcija.kardioloska@gmail.comMilovanovicBranislavMilovanovicBranislav

Белград

Belgrade

KrotinMirjanaKrotinMirjana

Белград

Belgrade

DimnkovicSinisaDimnkovicSinisa

Белград

Belgrade

LovicDraganLovicDragan

Nis

FilipovicBrankaFilipovicBranka

Белград

Belgrade

MarkovicOliveraMarkovicOlivera

Белград

Belgrade

ZdravkovicDarkoZdravkovicDarko

Белград

Belgrade

PrijicSergejPrijicSergej

Белград

Belgrade

VukomanovicVladimirVukomanovicVladimir

Белград

Belgrade

KoracevicGoranKoracevicGoran

Nis

SoldatovicIvanSoldatovicIvan

Белград

Belgrade

AcimovicTijanaAcimovicTijana

Белград

Belgrade

DizdarevicIvanaDizdarevicIvana

Белград

Belgrade

MazicSanjaMazicSanja

Nis

University Hospital Medical Center Bezanijska Kosa, Faculty of Medicine, University of BelgradeЧехословакияUniversity Hospital Medical Center Bezanijska Kosa, Faculty of Medicine, University of BelgradeCzechoslovakiaClinic for Internal Medicine Intermedica, НисЧехословакияClinic for Internal Medicine IntermedicaCzechoslovakiaInstitute for Child and Mother Care “Vukan Cupic”, Dept. of Cardiology, Faculty of Medicine, University of BelgradeЧехословакияInstitute for Child and Mother Care “Vukan Cupic”, Dept. of Cardiology, Faculty of Medicine, University of BelgradeCzechoslovakiaClinic for Cardiology, Faculty of Medicine, University of Nis, НисЧехословакияClinic for Cardiology, Faculty of Medicine, University of NisCzechoslovakiaInstitute for Medical Statistics, Faculty of Medicine, University of BelgradeЧехословакияInstitute for Medical Statistics, Faculty of Medicine, University of BelgradeCzechoslovakiaInstitute for Physiology, Faculty of Medicine, University of BelgradeЧехословакияInstitute for Physiology, Faculty of Medicine, University of BelgradeCzechoslovakiaClinical Center of Serbia, Faculty of Medicine, University of BelgradeЧехословакияClinical Center of Serbia, Faculty of Medicine, University of BelgradeCzechoslovakia20142807201407-eng2327Copyright © Zdravkovic M., Milovanovic B., Krotin M., Dimnkovic S., Lovic D., Filipovic B., Markovic O., Zdravkovic D., Prijic S., Vukomanovic V., Koracevic G., Soldatovic I., Acimovic T., Dizdarevic I., Mazic S., 20142014Zdravkovic M., Milovanovic B., Krotin M., Dimnkovic S., Lovic D., Filipovic B., Markovic O., Zdravkovic D., Prijic S., Vukomanovic V., Koracevic G., Soldatovic I., Acimovic T., Dizdarevic I., Mazic S.Zdravkovic M., Milovanovic B., Krotin M., Dimnkovic S., Lovic D., Filipovic B., Markovic O., Zdravkovic D., Prijic S., Vukomanovic V., Koracevic G., Soldatovic I., Acimovic T., Dizdarevic I., Mazic S.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/618Цель

Цель. Для оценки корреляции между ремоделированием левого желудочка, индуцированной физическими нагрузками, и продолжительностью QTc у неполовозрелых профессиональных футболистов.

Материал и методы

Материал и методы. Девяносто четыре высококвалифицированных футболистов мужского пола (средний возраст 12,85±0,84), тренирующихся в Сербской Футбольной Лиге (по крайней мере, 7 учебных часов в неделю) и 47 по возрасту здоровых мужчин были включены в исследование. Основные критерии оценки: они были обследованы с помощью ЭКГ и ЭхоКГ в местном кардиологическом центре. Исследуемые в контрольной группе вели малоподвижный образ жизни (менее 2 учебных часа в неделю). Значения QTc и размеры левого желудочка сравнивались у этих двух групп.

Результаты

Результаты. Нормальные значения интервала QTc были зарегистрированы у всех участников. Значения QTc у спортсменов были значительно выше, по сравнению с не-спортсменами (419,89±13,07 мс vs 399,78±13,27 мс) (p<0,001). Интервал QTc имел сильную положительную корреляцию к дилатации левого предсердия, дилатации ЛЖ, ЛЖ массы и индексу массы ЛЖ. Не было никакой корреляции между интервалом QTc и толщиной стенки ЛЖ, но имелась корреляция между интервалом QTc, длительностью и специфичностью индекса массы ЛЖ (LVM/BSA 1,5 and LVM/h 2.7).

Заключение

Заключение. Удлинение интервала QTc присутствует в ранней стадии ремоделирование сердца спортсмена и, следовательно, удлинение QTc может быть ранним ЭКГ-маркером физиологического ремоделирования ЛЖ у молодых неполовозрелых футболистов, без каких-либо других стандартных ЭКГ и эхокардиографических признаков ранней гипертрофии ЛЖ. Это может быть объяснено различной формой ремоделирования ЛЖ в половозрелый период, когда увеличение толщины стенки ЛЖ невозможно определить визуально и предоминантная характеристика является увеличением ЛЖ.

Aim

Aim. To assess the correlation between left ventricle remodeling induced by physical training with QTc duration in preadolescent professional football players.

Material and methods

Material and methods. Ninety-four highly trained male footballers (mean aged 12,85±0,84) competing in the Serbian Football League (at least 7 training hours/ week) and 47 age-matched healthy male controls were enrolled in the study. Main outcome measures: They were screened by ECG and echocardiography at a tertiary referral cardio center. The control group had sedentary life style (less than 2 training hours/week). QTc values and left ventricle dimensions were compared in these two groups.

Results

Results. In all participants, normal values of QTc interval were registered. Mean QTc in athletes was significantly higher compared to non-athletes (419,89±13,07 msec vs 399,78±13,27 msec) (p<0,001). QTc interval had strong positive correlation to left atrium dilatation, LV dilatation, LV mass and LV mass index. There was no correlation between QTc interval and LV wall thickness, but there were correlations between QTc interval duration and specific LV mass indexes (LVM/BSA 1,5 and LVM/h 2.7).

Conclusion

Conclusion. QTc interval prolongation is present in early stage of athlete’s heart remodeling, hence QTc prolongation could be the early ECG marker of physiological LV remodeling in young preadolescent footballers, without any other standard ECG and echocardiographic signs of early LV hypertrophy. This could be explained by a different pattern of left ventricle remodeling in preadolescent period, where LV wall thickness increase cannot usually be seen and the predominant characteristic is left ventricle dilatation.

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The authors declare that there are no conflicts of interest present.