References

russjcardiol

Российский кардиологический журнал

Russian Journal of Cardiology

1560-40712618-7620

«SILICEA-POLIGRAF» LLC

10.15829/1560-4071-2025-6179

EAZOZO

russjcardiol-6179

Research Article

НАРУШЕНИЯ ЛИПИДНОГО ОБМЕНА

LIPID METABOLISM DISORDERS

Гипертриглицеридемии — современное состояние вопроса. Часть I: риски, физиология и патофизиологические аспекты, классификация и проблемы диагностики

Hypertriglyceridemia — current status of the problem. Part I: risks, physiology and pathophysiological aspects, classification and diagnostic problems

https://orcid.org/0000-0002-3786-9995

Семенкин

А. А.

Semenkin

A. A.

Д.м.н., профессор, профессор кафедры внутренних болезней и семейной медицины ДПО.

Омск

Omsk

asemyonkin@mail.ru

https://orcid.org/0000-0001-5989-6233

Мешков

А. Н.

Meshkov

A. N.

Д.м.н., руководитель Института персонализированной терапии и профилактики.

Москва

Moscow

meshkov@lipidclinic.ru

https://orcid.org/0000-0002-1518-6552

Ежов

М. В.

Yezhov

M. V.

Д.м.н., г.н.с., руководитель лаборатории нарушений липидного обмена Научно-исследовательского института клинической кардиологии им. А.Л. Мясникова.

Москва

Moscow

marat_ezhov@mail.ru

ФГБОУ ВО Омский государственный медицинский университет Минздрава РоссииРоссияOmsk State Medical UniversityRussian Federation

ФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииРоссияNational Medical Research Center for Therapy and Preventive MedicineRussian Federation

ФГБУ Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова Минздрава РоссииРоссияChazov National Medical Research Center of CardiologyRussian Federation

2025

06122024

30161796179

2025

Семенкин А.А., Мешков А.Н., Ежов М.В.

Semenkin A.A., Meshkov A.N., Yezhov M.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://russjcardiol.elpub.ru/jour/article/view/6179

Многочисленные исследования демонстрируют независимую связь между повышением содержания богатых триглицеридами липопротеидов в крови и риском развития атеросклеротических сердечно-сосудистых заболеваний и острого панкреатита. В обзорной статье детально представлены физиология богатых триглицеридами липопротеинов и патофизиологические аспекты рисков, связанных с гипертриглицеридемиями (ГТГ). Приведены классификации в зависимости от этиологии, фенотипа дислипидемии и степени тяжести. Описаны подходы к диагностике ГТГ.

Numerous studies demonstrate an independent relationship between an increase in the blood content of triglyceride-rich particles and the risk of atherosclerotic cardiovascular diseases and acute pancreatitis. This review article presents in detail aspects of the pathogenesis of various types of primary and most relevant secondary hypertriglyceridemias (HTGs). Classifications are provided depending on the etiology, phenotype of dyslipidemia and severity. Approaches to HTG diagnosis are described. Special attention is paid to the potential of HTG therapy.

гипертриглицеридемиибогатые триглицеридами липопротеидыпатогенезклассификация гипертриглицеридемийдиагностика гипертриглицеридемий

hypertriglyceridemiatriglyceride-rich lipoproteinspathogenesisdiagnosticstreatment

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The authors declare that there are no conflicts of interest present.