russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2014-4-ENG-66-67russjcardiol-613Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCLINICAL CASESВАЗОСПАЗМ КОРОНАРНЫХ АРТЕРИЙ СРЕДНЕГО ТИПА I ВАРИАНТ KOUNIS СИНДРОМА: СЕРИЯ СЛУЧАЕВ У МУЖЧИН. ВАЖНЫ ЛИ ГЕНДЕРНЫЕ РАЗЛИЧИЯ?CORONARY ARTERY VASOSPASM SECONDARY TO TYPE I VARIANT KOUNIS SYNDROME: A CASE SERIES OF MEN. IS THE GENDER DIFFERENCES IMPORTANT?KocasCuneytKocasCuneyt

MD, Istanbul University Institute of Cardiology, Department of Cardiology, Cardiologist, Instructor; Haseki, Aksaray 34350, Istanbul/Turkey, Tel: +90 505 938 35 27, Fax: +90 216 469 37 96

cuneytkocas@hotmail.comAykanAhmet CagriAykanAhmet CagriAbaciOkayAbaciOkayCetinkalGokhanCetinkalGokhanArslanSukruArslanSukruYildizMustafaYildizMustafaDepartment of Cardiology, Istanbul University Cardiology Institute, IstanbulDepartment of Cardiology, Kartal Kosuyolu Educational and Reseach Hospital, Istanbul, Turkey20142804201404-ENG6667Copyright © Kocas C., Aykan A.C., Abaci O., Cetinkal G., Arslan S., Yildiz M., 20142014Kocas C., Aykan A.C., Abaci O., Cetinkal G., Arslan S., Yildiz M.Kocas C., Aykan A.C., Abaci O., Cetinkal G., Arslan S., Yildiz M.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/613

Kounis-синдром является известной причиной острого коронарного синдрома и сообщается о более 100 случаях заболевания при аллергических реакциях на различные препараты, укусы животных и насекомых, даже на стенты с лекарственным покрытием и эндоваскулярные устройства. В этой статье мы докладываем о пяти пациентах с синдром Kounis, по отношению к различным лекарствам. Главная характеристика больных приведена в Таблице 1. Все они были мужчинами, и их возраст от 18 до 35 лет. У всех пациентов представлен инфаркт миокарда с подъемом ST. Коронарная ангиография выявила у всех больных нормальные коронарные артерии. Из истории аллергического воздействия, электрокардиографических, лабораторных (Общий IgE и уровни триптазы) и ангиографических данных, был поставлен диагноз синдрома Kounis типа I для всех пациентов, которых лечили перорально антигистаминными препаратами и преднизолоном. Несмотря на то, что синдром Kounis типа I не связан с факторами риска атеросклероза и ИБС, все пациенты в отчетах, и многие пациенты, описанные в литературе, являются мужчинами. Гендерные различия синдрома Kounis должны быть изучены в ходе дальнейших исследований.

Kounis syndrome is a well-known cause of acute coronary syndrome and more than 100 cases are reported with allergic reactions to various drugs, animal and insect bites, even with drug eluting stents and endovascular devices. In this paper we report five-patients with Kounis syndrome related to different drugs. The main characteristic of patients is given in Table 1. All of them were male and their age was from 18 to 35. All patients presented with ST- elevation myocardial infarction. Coronary angiography was performed in all patients and revealed normal coronary arteries. From history of allergic exposure, electrocardiographic, laboratory (Total IgE and tryptase levels) and angiographic findings the diagnosis was Kounis syndrome type I for all patients and was treated with oral antihistamines and prednisolone. Despite Type 1 KS is not associated with atherosclerotic risk factors and CAD all patients in or report and many patients in literature are male. Gender differences in KS should be investigated in further studies.

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The authors declare that there are no conflicts of interest present.