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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2014-1-107-110</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>НУЖЕН ЛИ КОНТРОЛЬ ЧСС ПРИ ЛЕЧЕНИИ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ?</article-title><trans-title-group xml:lang="en"><trans-title>WHETHER CONTROL OF THE HEAT RATE IN THE TREATMENT OF HYPERTENSION?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Недогода</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nedogoda</surname><given-names>S . V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>профессор, заведующий кафедрой терапии и эндокринологии</p></bio><email xlink:type="simple">nedogodasv@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Волгоградский государственный медицинский университет,  Волгоград, Россия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University, Volgograd, Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>01</month><year>2014</year></pub-date><volume>0</volume><issue>1</issue><fpage>107</fpage><lpage>110</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Недогода С.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Недогода С.В.</copyright-holder><copyright-holder xml:lang="en">Nedogoda S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/6">https://russjcardiol.elpub.ru/jour/article/view/6</self-uri><abstract><p>В данном литературном обзоре говорится о значении контроля за частотой сердечных сокращений при выборе и назначении адекватной гипотензивной терапии.</p></abstract><trans-abstract xml:lang="en"><p>In this literature review indicates the importance of monitoring the heart rate in the selection and prescription of adequate antihypertensive therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>частота сердечных сокращений</kwd><kwd>артериальное давление</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart rate</kwd><kwd>blood pressure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">S halnova SA, Deev AD, Oganov RG. Factors influencing cardiovascular mortality in russian population. Cardiovascular Therapy and Prevention, 2005, 4 (1): 4–9. Russian (Шальнова С . А ., Деев А . Д., Оганов Р. Г. Факторы, влияющие на смертность от сердечно-сосудистых заболеваний в российской популяции. Кардиоваскулярная терапия и профилактика, 2005; 4 (1): 4–9).</mixed-citation><mixed-citation xml:lang="en">S halnova SA, Deev AD, Oganov RG. Factors influencing cardiovascular mortality in russian population. Cardiovascular Therapy and Prevention, 2005, 4 (1): 4–9. Russian (Шальнова С . А ., Деев А . Д., Оганов Р. Г. Факторы, влияющие на смертность от сердечно-сосудистых заболеваний в российской популяции. Кардиоваскулярная терапия и профилактика, 2005; 4 (1): 4–9).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Empana JP, et al. Paris Prospective Study III: a study of novel heart rate parameters, baroreflex sensitivity and risk of sudden death. European journal of epidemiology 2011; 26 (11):887–92.</mixed-citation><mixed-citation xml:lang="en">Empana JP, et al. Paris Prospective Study III: a study of novel heart rate parameters, baroreflex sensitivity and risk of sudden death. European journal of epidemiology 2011; 26 (11):887–92.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Palatini P, et al. Resting heart rate as a predictor of body weight gain in the early stage of hypertension. Obesity 2011; 19 (3):618–23.</mixed-citation><mixed-citation xml:lang="en">Palatini P, et al. Resting heart rate as a predictor of body weight gain in the early stage of hypertension. Obesity 2011; 19 (3):618–23.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Tardif JC, et al. Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina. European heart journal 2005; 26 (23):2529–36.</mixed-citation><mixed-citation xml:lang="en">Tardif JC, et al. Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina. European heart journal 2005; 26 (23):2529–36.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">S alles GF, Cardoso CRL, Fonseca LL, et al. Prognostic Significance of Baseline Heart Rate and Its Interaction With Beta-Blocker Use in Resistant Hypertension: A Cohort Study. Am. J. H ypertens. 2013; 26:218–26.</mixed-citation><mixed-citation xml:lang="en">S alles GF, Cardoso CRL, Fonseca LL, et al. Prognostic Significance of Baseline Heart Rate and Its Interaction With Beta-Blocker Use in Resistant Hypertension: A Cohort Study. Am. J. H ypertens. 2013; 26:218–26.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, De Backer G, Dominiczak A, et al. Guidelines for the Management of Arterial Hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. H ypertens. 2007; 25:1105–87.</mixed-citation><mixed-citation xml:lang="en">Mancia G, De Backer G, Dominiczak A, et al. Guidelines for the Management of Arterial Hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. H ypertens. 2007; 25:1105–87.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Palatini P, Mos L, Santonastaso M, et al. Resting heart rate as a predictor of body weight gain in the early stage of hypertension. Obesity. 2011; 19:618–23.</mixed-citation><mixed-citation xml:lang="en">Palatini P, Mos L, Santonastaso M, et al. Resting heart rate as a predictor of body weight gain in the early stage of hypertension. Obesity. 2011; 19:618–23.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Shigetoh Y, et al. Higher heart rate may predispose to obesity and diabetes mellitus: 20-year prospective study in a general population. American journal of hypertension. 2008; 22 (2):151–5.</mixed-citation><mixed-citation xml:lang="en">Shigetoh Y, et al. Higher heart rate may predispose to obesity and diabetes mellitus: 20-year prospective study in a general population. American journal of hypertension. 2008; 22 (2):151–5.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Custodis F, Shirmer SH, Baumhakel M, et al. Vascular pathophysiology in response to increased heart rate. J. Am. Coll. Cardiol. 2010; 56:1973–83.</mixed-citation><mixed-citation xml:lang="en">Custodis F, Shirmer SH, Baumhakel M, et al. Vascular pathophysiology in response to increased heart rate. J. Am. Coll. Cardiol. 2010; 56:1973–83.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Diaz A, Bourassa MG, Guertin M–C, et al. Long-term prognostic value of resting heart rate in patients with suspected of proven coronary artery disease. Eur. Heart J. 2005; 26:967–74.</mixed-citation><mixed-citation xml:lang="en">Diaz A, Bourassa MG, Guertin M–C, et al. Long-term prognostic value of resting heart rate in patients with suspected of proven coronary artery disease. Eur. Heart J. 2005; 26:967–74.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Reule S, Drawz PE. Heart Rate and Blood Pressure: Any Possible Implications for Management of Hypertension? Current hypertension reports. 2012; 14 (6):478–84.</mixed-citation><mixed-citation xml:lang="en">Reule S, Drawz PE. Heart Rate and Blood Pressure: Any Possible Implications for Management of Hypertension? Current hypertension reports. 2012; 14 (6):478–84.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kobalava ZhD. Clinical and prognostic significance of elevated heart rate and its correction in arterial hypertension. RMJ 2013: 27:1334–42. Russian (Кобалава Ж. Д. Клинико-прогностическое значение повышенной частоты сердечных сокращений и ее коррекции при артериальной гипертонии. РМЖ 2013: 27:1334–42).</mixed-citation><mixed-citation xml:lang="en">Kobalava ZhD. Clinical and prognostic significance of elevated heart rate and its correction in arterial hypertension. RMJ 2013: 27:1334–42. Russian (Кобалава Ж. Д. Клинико-прогностическое значение повышенной частоты сердечных сокращений и ее коррекции при артериальной гипертонии. РМЖ 2013: 27:1334–42).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">King DE, Everett CJ, Mainous AG, et al. Long-term prognostic value of resting heart rate in subjects with prehypertension. Am. J. H ypertens. 2006; 19:796–800.</mixed-citation><mixed-citation xml:lang="en">King DE, Everett CJ, Mainous AG, et al. Long-term prognostic value of resting heart rate in subjects with prehypertension. Am. J. H ypertens. 2006; 19:796–800.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cooney MT, et al. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women. American heart journal. 2010; 159 (4):612–9. e3.</mixed-citation><mixed-citation xml:lang="en">Cooney MT, et al. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women. American heart journal. 2010; 159 (4):612–9. e3.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue T, Iseki K, Iseki C, et al. Higher heart rate predicts the risk of developing hypertension in a normotensive screened cohort. Circ. J. 2007; 71:1755–60.</mixed-citation><mixed-citation xml:lang="en">Inoue T, Iseki K, Iseki C, et al. Higher heart rate predicts the risk of developing hypertension in a normotensive screened cohort. Circ. J. 2007; 71:1755–60.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cuspidi C, et al. Ambulatory heart rate and target organ damage in never-treated essential hypertensives. Journal of human hypertension. 2007; 22 (2):89–95.</mixed-citation><mixed-citation xml:lang="en">Cuspidi C, et al. Ambulatory heart rate and target organ damage in never-treated essential hypertensives. Journal of human hypertension. 2007; 22 (2):89–95.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">García-García Á, et al. Office and 24-hour heart rate and target organ damage in hypertensive patients. BMC Cardiovascular Disorders. 2012; 12 (1):19.</mixed-citation><mixed-citation xml:lang="en">García-García Á, et al. Office and 24-hour heart rate and target organ damage in hypertensive patients. BMC Cardiovascular Disorders. 2012; 12 (1):19.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hartaigh BO, Bosch JA, Carroll D, et al. Evidence of a synergistic association between heart rate, inflammation, and cardiovascular mortality in patients undergoing coronary angiography. Eur Heart J. 2013;34:932–41.</mixed-citation><mixed-citation xml:lang="en">Hartaigh BO, Bosch JA, Carroll D, et al. Evidence of a synergistic association between heart rate, inflammation, and cardiovascular mortality in patients undergoing coronary angiography. Eur Heart J. 2013;34:932–41.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Facila L, Pallares V, Peset A, et al. Twenty-four-hour ambulatory heart rate and organ damage in primary hypertension. Blood. Press. 2010; 19:104–9.</mixed-citation><mixed-citation xml:lang="en">Facila L, Pallares V, Peset A, et al. Twenty-four-hour ambulatory heart rate and organ damage in primary hypertension. Blood. Press. 2010; 19:104–9.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Júnior IFF, et al. Resting heart rate as a predictor of metabolic dysfunctions in obese children and adolescents. BMC pediatrics. 2012; 12 (1):5.</mixed-citation><mixed-citation xml:lang="en">Júnior IFF, et al. Resting heart rate as a predictor of metabolic dysfunctions in obese children and adolescents. BMC pediatrics. 2012; 12 (1):5.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Rogowski O, et al. Elevated resting heart rate is associated with the metabolic syndrome. Cardiovasc Diabetol. 2009; 8 (55):327–31.</mixed-citation><mixed-citation xml:lang="en">Rogowski O, et al. Elevated resting heart rate is associated with the metabolic syndrome. Cardiovasc Diabetol. 2009; 8 (55):327–31.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Chu CY, et al. Heart Rate Significantly Influences the Relationship between Atrial Fibrillation and Arterial Stiffness. International journal of medical sciences. 2013; 10 (10):1295.</mixed-citation><mixed-citation xml:lang="en">Chu CY, et al. Heart Rate Significantly Influences the Relationship between Atrial Fibrillation and Arterial Stiffness. International journal of medical sciences. 2013; 10 (10):1295.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Park BJ, et al. Association between resting heart rate and arterial stiffness in Korean adults. Archives of Cardiovascular Diseases. 2010; 103 (4):246–52.</mixed-citation><mixed-citation xml:lang="en">Park BJ, et al. Association between resting heart rate and arterial stiffness in Korean adults. Archives of Cardiovascular Diseases. 2010; 103 (4):246–52.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Fox K, Borer JS, Camm J, et al. The Heart Rate Working Group. Resting heart rate in cardiovascular disease. J. Am. Coll. Cardiol. 2007; 50:823–30.</mixed-citation><mixed-citation xml:lang="en">Fox K, Borer JS, Camm J, et al. The Heart Rate Working Group. Resting heart rate in cardiovascular disease. J. Am. Coll. Cardiol. 2007; 50:823–30.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Giannoglou GD, Chatzizisis YS, Zamboulis C, et al. Elevated heart rate and atherosclerosis: an overview of the pathogenetic mechanisms. Int. J. Cardiol. 2008; 126:302–12.</mixed-citation><mixed-citation xml:lang="en">Giannoglou GD, Chatzizisis YS, Zamboulis C, et al. Elevated heart rate and atherosclerosis: an overview of the pathogenetic mechanisms. Int. J. Cardiol. 2008; 126:302–12.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue T, Iseki K, Iseki C, et al. Heart rate as a risk factor for developing chronic kidney disease: longitudinal analysis of a screened cohort. Clin. Exp. Nephrol. 2009; 13:487–93.</mixed-citation><mixed-citation xml:lang="en">Inoue T, Iseki K, Iseki C, et al. Heart rate as a risk factor for developing chronic kidney disease: longitudinal analysis of a screened cohort. Clin. Exp. Nephrol. 2009; 13:487–93.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Bohm M, Reil JC, Danchin N, et al. Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH. J. H ypertens. 2008; 26:18–25.</mixed-citation><mixed-citation xml:lang="en">Bohm M, Reil JC, Danchin N, et al. Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH. J. H ypertens. 2008; 26:18–25.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Julius S, Palatini P, Kjeldsen S, et al. Tachycardia predicts cardiovascular events in the VALUE trial. American Society of Hypertension 2010 Scientific Meeting; May 1–4, 2010. New York, NY. Abstract LB-OR-01.</mixed-citation><mixed-citation xml:lang="en">Julius S, Palatini P, Kjeldsen S, et al. Tachycardia predicts cardiovascular events in the VALUE trial. American Society of Hypertension 2010 Scientific Meeting; May 1–4, 2010. New York, NY. Abstract LB-OR-01.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Palatini P. Role of elevated heart rate in the development of cardiovascular disease in hypertension. Hypertension. 2011; 58 (5):745–50.</mixed-citation><mixed-citation xml:lang="en">Palatini P. Role of elevated heart rate in the development of cardiovascular disease in hypertension. Hypertension. 2011; 58 (5):745–50.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Borer JS. Heart rate: from risk marker to risk factor in coronary artery disease. Medicographia. 2009; 31:349–55.</mixed-citation><mixed-citation xml:lang="en">Borer JS. Heart rate: from risk marker to risk factor in coronary artery disease. Medicographia. 2009; 31:349–55.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Poulter NR, et al. Baseline heart rate, antihypertensive treatment, and prevention of cardiovascular outcomes in ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial). Journal of the American College of Cardiology. 2009; 54 (13):1154–61.</mixed-citation><mixed-citation xml:lang="en">Poulter NR, et al. Baseline heart rate, antihypertensive treatment, and prevention of cardiovascular outcomes in ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial). Journal of the American College of Cardiology. 2009; 54 (13):1154–61.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rambihar S, Gao P, Teo K, et al. Heart rate is associated with increased risk of major cardiovascular events, cardiovascular and all-cause death in patients with stable chronic cardiovascular disease: an analysis of ONTARGET/TRANSCEND. Circulation. 2010; 122: A12667</mixed-citation><mixed-citation xml:lang="en">Rambihar S, Gao P, Teo K, et al. Heart rate is associated with increased risk of major cardiovascular events, cardiovascular and all-cause death in patients with stable chronic cardiovascular disease: an analysis of ONTARGET/TRANSCEND. Circulation. 2010; 122: A12667</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kolloch R, Legler UF, Champion A, et al. Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the International Verapamil -SR/trandolapril STudy (INVEST). Eur. Heart J. 2008; 29:1327–34.</mixed-citation><mixed-citation xml:lang="en">Kolloch R, Legler UF, Champion A, et al. Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the International Verapamil -SR/trandolapril STudy (INVEST). Eur. Heart J. 2008; 29:1327–34.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Palatini P. Is there benefit of cardiac slowing drugs in the treatment of hypertensive patients with elevated heart rate? Eur. Heart J. 2008; 29:1218–20.</mixed-citation><mixed-citation xml:lang="en">Palatini P. Is there benefit of cardiac slowing drugs in the treatment of hypertensive patients with elevated heart rate? Eur. Heart J. 2008; 29:1218–20.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Bramlage P, et al. A global perspective on blood pressure treatment and control in a referred cohort of hypertensive patients. The Journal of Clinical Hypertension. 2010; 12 (9):666–77.</mixed-citation><mixed-citation xml:lang="en">Bramlage P, et al. A global perspective on blood pressure treatment and control in a referred cohort of hypertensive patients. The Journal of Clinical Hypertension. 2010; 12 (9):666–77.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Bangalore S, Sawhney S, Messerli FH. Relation of beta-blocker-induced heart rate lowering and cardioprotection in hypertension. J. Am. Coll. Cardiol. 2008; 52:1482–9.</mixed-citation><mixed-citation xml:lang="en">Bangalore S, Sawhney S, Messerli FH. Relation of beta-blocker-induced heart rate lowering and cardioprotection in hypertension. J. Am. Coll. Cardiol. 2008; 52:1482–9.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Rogowski O, et al. Heart rate and microinflammation in men: a relevant atherothrombotic link. Heart. 2007; 93 (8):940–4.</mixed-citation><mixed-citation xml:lang="en">Rogowski O, et al. Heart rate and microinflammation in men: a relevant atherothrombotic link. Heart. 2007; 93 (8):940–4.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Mulder P, Barbier S, Chagraoui A, et al. Long-term heart rate reduction induced by the selective If current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation. 2004; 109:1674–9.</mixed-citation><mixed-citation xml:lang="en">Mulder P, Barbier S, Chagraoui A, et al. Long-term heart rate reduction induced by the selective If current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation. 2004; 109:1674–9.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">S aladini F, Benetti E, Mos L, et al. Evolution of parameters of arterial distensibility in a cohort of young-to-middle-age hypertensive subjects. J. H ypertens. 2010; 28: e176.</mixed-citation><mixed-citation xml:lang="en">S aladini F, Benetti E, Mos L, et al. Evolution of parameters of arterial distensibility in a cohort of young-to-middle-age hypertensive subjects. J. H ypertens. 2010; 28: e176.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Tomiyama H, Hashimoto H, Tanaka H, et al. baPWV/cfPWV Collaboration Group. Synergistic relationship between changes in the pulse wave velocity and changes in the heart rate in middle-aged Japanese adults: a prospective study. J. H ypertens. 2010; 28:687–94.</mixed-citation><mixed-citation xml:lang="en">Tomiyama H, Hashimoto H, Tanaka H, et al. baPWV/cfPWV Collaboration Group. Synergistic relationship between changes in the pulse wave velocity and changes in the heart rate in middle-aged Japanese adults: a prospective study. J. H ypertens. 2010; 28:687–94.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kobalava ZhD, Kijakbajev GK, Homitskaya JuV. The Results of the Russia supervisory multicenter non-interventional research ATHENA “AchievemenT of goal resting HEart rate on β-blockers in patients with stable angiNA and hypertension in routine practice”. Kardiologija 2013; 7: 13–23. Russian (Кобалава Ж. Д., Киякбаев Г. К ., Хомицкая Ю. В. Результаты Российского наблюдательного многоцентрового неинтервенционного исследования ATHENA “AchievemenT of goal resting HEart rate on β-blockers in patients with stable angiNA and hypertension in routine practice”. Кардиология 2013; 7:13–23).</mixed-citation><mixed-citation xml:lang="en">Kobalava ZhD, Kijakbajev GK, Homitskaya JuV. The Results of the Russia supervisory multicenter non-interventional research ATHENA “AchievemenT of goal resting HEart rate on β-blockers in patients with stable angiNA and hypertension in routine practice”. Kardiologija 2013; 7: 13–23. Russian (Кобалава Ж. Д., Киякбаев Г. К ., Хомицкая Ю. В. Результаты Российского наблюдательного многоцентрового неинтервенционного исследования ATHENA “AchievemenT of goal resting HEart rate on β-blockers in patients with stable angiNA and hypertension in routine practice”. Кардиология 2013; 7:13–23).</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kampus P, Serg M, Kals J, et al. Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness. Hypertens. 2011; 57:1122–8.</mixed-citation><mixed-citation xml:lang="en">Kampus P, Serg M, Kals J, et al. Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness. Hypertens. 2011; 57:1122–8.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Polonia J, Barbosa L, Silva JA, et al. Different patterns of peripheral versus central blood pressure in hypertensive patients treated with β-blockers either with or without vasodilator properties or with angiotensin receptor blockers. Blood Press. Monit. 2010; 15:235–9.</mixed-citation><mixed-citation xml:lang="en">Polonia J, Barbosa L, Silva JA, et al. Different patterns of peripheral versus central blood pressure in hypertensive patients treated with β-blockers either with or without vasodilator properties or with angiotensin receptor blockers. Blood Press. Monit. 2010; 15:235–9.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Mahmud A, Feely J. β-Blockers reduce aortic stiffness in hypertension but nebivolol, not atenolol, reduces wave reflection. Am. J. H ypertens. 2008; 21:663–7.</mixed-citation><mixed-citation xml:lang="en">Mahmud A, Feely J. β-Blockers reduce aortic stiffness in hypertension but nebivolol, not atenolol, reduces wave reflection. Am. J. H ypertens. 2008; 21:663–7.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">S hah NK, Smith SM, Nichols WW, et al. Carvedilol reduces aortic wave reflection and improves left ventricular/vascular coupling: a comparison with atenolol (CENTRAL Study). J. Clin. Hypertens. 2011; 13:917–24.</mixed-citation><mixed-citation xml:lang="en">S hah NK, Smith SM, Nichols WW, et al. Carvedilol reduces aortic wave reflection and improves left ventricular/vascular coupling: a comparison with atenolol (CENTRAL Study). J. Clin. Hypertens. 2011; 13:917–24.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Orlova JaА, Mikhailov GV, Хежева FM, et al. The Influence of the bisoprolol therapy on indices of peripheral and central blood pressure, stiffness of the arteries, diastolic left ventricular function and quality of life in patients with arterial hypertension (study KLJuCh). Serdze 2012; 6:342–50. Russian (Орлова Я . А ., Михайлов Г. В., Хежева Ф. М . и др. Влияние терапии бисопрололом на поКазатели периферического и центрального артериаЛьного давления, жесткость артерий, диастолическуЮ функцию левого желудочка и каЧество жизни у больных артериальной гипертонией (исследование КЛЮЧ). Сердце 2012; 6:342–50).</mixed-citation><mixed-citation xml:lang="en">Orlova JaА, Mikhailov GV, Хежева FM, et al. The Influence of the bisoprolol therapy on indices of peripheral and central blood pressure, stiffness of the arteries, diastolic left ventricular function and quality of life in patients with arterial hypertension (study KLJuCh). Serdze 2012; 6:342–50. Russian (Орлова Я . А ., Михайлов Г. В., Хежева Ф. М . и др. Влияние терапии бисопрололом на поКазатели периферического и центрального артериаЛьного давления, жесткость артерий, диастолическуЮ функцию левого желудочка и каЧество жизни у больных артериальной гипертонией (исследование КЛЮЧ). Сердце 2012; 6:342–50).</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Rana R, Patil A. Efficacy and safety of bisoprolol plus amlodipine fixed dose combination in essential hypertension. Indian Pract 2008; 61: 225–34.</mixed-citation><mixed-citation xml:lang="en">Rana R, Patil A. Efficacy and safety of bisoprolol plus amlodipine fixed dose combination in essential hypertension. Indian Pract 2008; 61: 225–34.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
