russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2023-5297russjcardiol-5297Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWПрименение омега-3 полиненасыщенных жирных кислот в профилактике послеоперационной фибрилляции предсердий при проведении открытой операции на сердце: систематический обзор и метаанализOmega-3 polyunsaturated fatty acids in the prevention of postoperative atrial fibrillation in open heart surgery: a systematic review and meta-analysishttps://orcid.org/0000-0001-9351-6177РубаненкоО. А.RubanenkoO. A.

Рубаненко Олеся Анатольевна — доктор медицинских наук, доцент кафедры госпитальной терапии с курсами поликлинической терапии и трансфузиологии

Самара

Samara

olesya.rubanenko@gmail.comhttps://orcid.org/0000-0002-3996-4689РубаненкоА. О.RubanenkoA. O.

Рубаненко Анатолий Олегович — кандидат медицинских наук, доцент кафедры пропедевтической терапии

Самара

Samara

anatolii.rubanenko@gmail.comhttps://orcid.org/0000-0002-4318-4247ДавыдкинИ. Л.DavydkinI. L.

Давыдкин Игорь Леонидович — доктор медицинских наук, профессор, проректор по научной работе, заведующий кафедрой госпитальной терапии с курсами поликлинической терапии и трансфузиологии

Самара

Samara

dagi2006@rambler.ruФГБОУ ВО СамГМУ Минздрава РоссииРоссияSamara State Medical UniversityRussian Federation202325012023281SОбразование52975297Copyright © Рубаненко О.А., Рубаненко А.О., Давыдкин И.Л., 20232023Рубаненко О.А., Рубаненко А.О., Давыдкин И.Л.Rubanenko O.A., Rubanenko A.O., Davydkin I.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/5297Цель

Цель. Оценить данные литературы об эффективности применения омега-3 полиненасыщенных жирных кислот (ПНЖК) в профилактике послеоперационной фибрилляции предсердий (ПОФП) при проведении планового кардиохирургического вмешательства, включая коронарное шунтирование на работающем сердце или в условиях искусственного кровообращения и/или протезирование и/или пластику клапанов сердца.

Материал и методы

Материал и методы. Поиск исследований осуществлялся с помощью базы данных PubMed и Google Scholar с 2005г по 31.01.2022г. Из первоначально идентифицированных результатов поиска проведен анализ 19 статей. Дизайн статей соответствовал рандомизированным клиническим исследованиям. В качестве интервенционного воздействия были выбраны омега-3 ПНЖК. Исследования должны были включать в качестве конечной точки оценку новых случаев ПОФП в раннем периоде после открытой операции на сердце.

Результаты

Результаты. В метаанализ было включено 15 исследований, насчитывающих 3980 пациентов, из них принимающих омега-3 ПНЖК 1992 (50,0%) больных. ПОФП возникла у 587 (29,5%) пациентов на омега-3 ПНЖК и 679 (34,2%) пациентов на стандартной терапии (отношение рисков 0,8, 0,68-0,93, р=0,004). Отмечается разброс размера эффектов для пациентов с ПОФП в представленных рандомизированных клинических исследований относительно оси центральной тенденции и неоднородность исследований при немалом количестве включенных пациентов (I2=51%, р=0,01).

Заключение

Заключение. Проведенный нами систематический обзор и метаанализ показали эффективность применения омега-3 ПНЖК в профилактике ПОФП при проведении открытой операции на сердце.

Aim

Aim. To evaluate the literature data on the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in the prevention of postoperative atrial fibrillation (POAF) in elective cardiac surgery, including onor off-pump coronary artery bypass grafting and/or valve replacement and/or repair.

Material and methods

Material and methods. The search for studies was carried out using the PubMed database and Google Scholar from 2005 to January 31, 2022. From the initially identified search results, 19 articles were analyzed. The design of articles corresponded to randomized clinical trials. Omega-3 PUFAs was selected as an interventional effect. The studies were to include, as an end point, the assessment of new POAF cases in the early period after open heart surgery.

Results

Results. The meta-analysis included 15 studies with 3980 patients, of which 1992 (50,0%) patients took omega-3 PUFAs. POAF occurred in 587 (29,5%) patients receiving omega-3 PUFAs and 679 (34,2%) patients on standard therapy (hazard ratio, 0,8, 0,68-0,93, p=0,004). There is a variation in effect size for POAF patients in the presented randomized clinical trials relative to the axis of the central trend and heterogeneity of studies with a significant number of patients included (I2=51%, p=0,01).

Conclusion

Conclusion. Our systematic review and meta-analysis showed the effectiveness of omega-3 PUFAs in the prevention of POAF during open heart surgery.

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The authors declare that there are no conflicts of interest present.