russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2022-5228russjcardiol-5228Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWКлеточная гетерогенность и клональный гемопоэз клеток иммунной системы при атеросклерозеCellular heterogeneity and clonal hematopoiesis of immune system cells in atherosclerosishttps://orcid.org/0000-0003-3226-1750СлепцовА. А.SleptsovA. A.

Слепцов Алексей Анатольевич — кандидат медицинских наук, научный сотрудник лаборатории популяционной генетики

634050 г. Томск ул. Набережной реки Ушайки, 10

Tomsk

alexei.sleptcov@medgenetics.ruНаучно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наукРоссияResearch Institute of Medical Genetics, Tomsk National Research Medical CenterRussian Federation202221092022271052285228Copyright © Слепцов А.А., 20222022Слепцов А.А.Sleptsov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/5228

Недавние исследования в области секвенирования РНК единичных клеток улучшили понимание структуры субпопуляции иммунных клеток при атеросклерозе. С помощью новых технологий выявлены новые субпопуляции иммунных клеток, участвующих в атеросклерозе. Кроме того, появился относительно распространенный и сильный фактор сердечно-сосудистого риска: клональный гемопоэз с неопределенным потенциалом, возникающий в результате накопления соматических мутаций в течение жизни с формированием популяций мутантных клонов циркулирующих лейкоцитов. Лица с таким состоянием имеют высокий риск сердечно-сосудистых осложнений, таких как инфаркт миокарда и инсульт, вне зависимости от традиционных факторов риска. В данном обзоре освещаются последние данные в области исследования клеточной гетерогенности клеток иммунной системы при атеросклерозе, а также роль клонального гемопоэза в его развитии.

Recent studies in single cell RNA sequencing have improved understanding of the structure of the immune cell subpopulation in atherosclerosis. With the help of novel technologies, new subpopulations of immune cells involved in atherosclerosis have been identified. In addition, a following relatively common and strong cardiovascular risk factor has emerged: clonal hematopoiesis of indeterminate potential resulting from the accumulation of somatic mutations during life with the appearance of populations of mutant leukocyte clones. Individuals with this condition are at high risk for cardiovascular complications such as myocardial infarction and stroke, regardless of conventional risk factors. This review highlights the latest data on the study of cellular heterogeneity of immune system cells in atherosclerosis, as well as the role of clonal hematopoiesis in its development.

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The authors declare that there are no conflicts of interest present.