<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2016-4-35-39</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-508</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>НЕИНВАЗИВНОЕ ИССЛЕДОВАНИЕ ПАРАМЕТРОВ КОРОНАРНОГО КРОВОТОКА У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 2 ТИПА ВО ВРЕМЯ ТЕСТОВ С ФИЗИЧЕСКОЙ НАГРУЗКОЙ</article-title><trans-title-group xml:lang="en"><trans-title>NON-INVASIVE ASSESSMENT OF CORONARY BLOOD FLOW IN PATIENTS WITH 2ND TYPE DIABETES DURING EXERCISE TEST</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загатина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagatina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">zag_angel@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Журавская</surname><given-names>Н. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhuravskaya</surname><given-names>N. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Кардиоцентр “Медика”<country>Россия</country></aff><aff xml:lang="en">“Medica” Cardiocenter<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2016</year></pub-date><volume>0</volume><issue>4</issue><issue-title>РОССИЙСКИЙ КАРДИОЛОГИЧЕСКИЙ ЖУРНАЛ</issue-title><fpage>35</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Загатина А.В., Журавская Н.Т., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Загатина А.В., Журавская Н.Т.</copyright-holder><copyright-holder xml:lang="en">Zagatina A.V., Zhuravskaya N.T.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/508">https://russjcardiol.elpub.ru/jour/article/view/508</self-uri><abstract><p>В международной литературе отсутствуют данные об изменении коронарного кровотока у пациентов с сахарным диабетом 2 типа (СД 2) во время стресс-эхокардиографии (стресс-ЭхоКГ) с физической нагрузкой (ФН).</p><sec><title>Цель</title><p>Цель. Исследовать изменения коронарного кровотока в передней межжелудочковой артерии (ПМЖА) во время стресс-ЭхоКГ с ФН у пациентов с СД с признаками и без признаков ишемической болезни сердца (ИБС).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включено 125 человек с хорошей визуализацией коронарных артерий при трансторакальном доступе. Основная группа состояла из 68 больных СД2, контрольную группу составили 57 человек, сопоставимых по полу и возрасту, без диабета и признаков ИБС. Всем пациентам выполнялась стресс-ЭхоКГ на горизонтальном велоэргометре, дополненная исследованием кровотока в ПМЖА допплерографическим методом. Пациентам с положительным тестом выполнялась коронарография.</p></sec><sec><title>Результаты</title><p>Результаты. Между подгруппами пациентов с СД и наличием ИБС и без признаков ИБС с высокой достоверностью определялась существенная разница в абсолютных значениях скоростей на пике ФН, в приросте скорости во время ФН, а также при измерении коронарного резерва (ГКР) в ПМЖА. Пациенты с СД без ИБС достоверно не отличались по вышеуказанным параметрам кровотока в ПМЖА по сравнению с контрольной группой. Пороговая величина, определяющая принадлежность пациентов к группе с ИБС или без ИБС, для ГКР была 1,7. Точность определения принадлежности к подгруппам или группе контроля данной величины была 86,2%.</p></sec><sec><title>Заключение</title><p>Заключение. Пациенты с СД без ИБС при выполнении ФН не отличаются от группы лиц без СД по параметрам коронарного кровотока. Показатель ГКР может быть использован для диагностики ИБС во время стресс-ЭхоКГ с ФН у данной категории больных.</p></sec></abstract><trans-abstract xml:lang="en"><p>There is absence of data in international publications, on the measurement of coronary flow in 2nd type diabetes patients (DM) during stress-echocardiography (SEchoCG) with physical exertion (PE).</p><sec><title>Aim</title><p>Aim. To study the changes of coronary flow in left anterior descending artery (LAD) during SEchoCG with PE in DM patients with and without signs of coronary heart disease (CHD).</p></sec><sec><title>Material and methods</title><p>Material and methods. Totally, 125 patients included, with good visualization of coronary arteries in transthoracic approach. Main group consisted of 68 DM patients, controls were 57 persons comparable by age and gender, without diabetes and CHD signs. All patients underwent SEchoCG on horizontal veloergometer, with Doppler test of blood flow in LAD. Positive stress test patients underwent then coronary angiography.</p></sec><sec><title>Results</title><p>Results. Between the subgroups with DM and CHD and non-CHD, there was highly significant difference in absolute values of velocities on the peak of PE, of velocity increase during PE, and in coronary reserve (CR) in LAD. DM patients without CHD did not significantly differ by the parameters mentioned, from the controls. Threshold value that determine relation of patients to CHD or non-CHD group, was 1,7 for CR. Test precision for subgroup relevance for this level was 86,2%.</p></sec><sec><title>Conclusion</title><p>Conclusion. DM non-CHD patients during PE do not differ from non-DM by the values of coronary flow. CR parameter can be used for CHD diagnostics during SEchoCG with PE in this category of patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>коронарный резерв</kwd><kwd>стресс-эхокардиография с физической нагрузкой</kwd><kwd>коронарные артерии</kwd><kwd>трансторакальная оценка коронарных артерий</kwd><kwd>сахарный диабет</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronary reserve</kwd><kwd>stress-echocardiography with physical exertion</kwd><kwd>coronary arteries</kwd><kwd>transthoracic assessment of coronary arteries</kwd><kwd>diabetes mellitus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hozumi T, Yoshida K, Akasaka T, et al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol. 1998;32:1251-9.</mixed-citation><mixed-citation xml:lang="en">Hozumi T, Yoshida K, Akasaka T, et al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol. 1998;32:1251-9.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Caiati C, Montaldo C, Zedda N, et al. Validation of a new noninvasive method (contrast-enhanced transthoracic second harmonic echo Doppler) for the evaluation of coronary flow reserve: comparison with intracoronary Doppler flow wire. J Am Coll Cardiol. 1999;34:1193-200.</mixed-citation><mixed-citation xml:lang="en">Caiati C, Montaldo C, Zedda N, et al. Validation of a new noninvasive method (contrast-enhanced transthoracic second harmonic echo Doppler) for the evaluation of coronary flow reserve: comparison with intracoronary Doppler flow wire. J Am Coll Cardiol. 1999;34:1193-200.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">De Simone L, Caso P, Severino S, et al. Reduction of coronary flow reserve non-invasively determined by transthoracic Doppler echocardiography as a predictor of left anterior descending coronary artery stenosis. Ital Heart J. 2000;1:289-94.</mixed-citation><mixed-citation xml:lang="en">De Simone L, Caso P, Severino S, et al. Reduction of coronary flow reserve non-invasively determined by transthoracic Doppler echocardiography as a predictor of left anterior descending coronary artery stenosis. Ital Heart J. 2000;1:289-94.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rigo F, Sicari R, Gherardi S, et al. The additive prognostic value of wall motion abnormalities and coronary flow reserve during dipyridamole stress echo. Eur Heart J. 2008;29:79-88.</mixed-citation><mixed-citation xml:lang="en">Rigo F, Sicari R, Gherardi S, et al. The additive prognostic value of wall motion abnormalities and coronary flow reserve during dipyridamole stress echo. Eur Heart J. 2008;29:79-88.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Boshchenko AA, Vrublevskiy AV. Coronary flow reserve for major coronary artery significant stenosis diagnostics: a transthoracic ultrasound study. Circulation Pathology and Cardiac Surgery. 2010;4:104-6. Russian. (Бощенко А.А., Врублевский А.В. Коронарный резерв в диагностике гемодинамически значимых стенозов магистральных коронарных артерий: трансторакальное ультразвуковое исследование. Патология кровообращения и кардиохирургия. 2010;4:104-6.)</mixed-citation><mixed-citation xml:lang="en">Boshchenko AA, Vrublevskiy AV. Coronary flow reserve for major coronary artery significant stenosis diagnostics: a transthoracic ultrasound study. Circulation Pathology and Cardiac Surgery. 2010;4:104-6. Russian. (Бощенко А.А., Врублевский А.В. Коронарный резерв в диагностике гемодинамически значимых стенозов магистральных коронарных артерий: трансторакальное ультразвуковое исследование. Патология кровообращения и кардиохирургия. 2010;4:104-6.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Nemes A, Forster T, Geleijnse ML, et al. Prognostic role of aortic atherosclerosis and coronary flow reserve in patients with suspected coronary artery disease. Int J Cardiol. 2008;131: 45-50.</mixed-citation><mixed-citation xml:lang="en">Nemes A, Forster T, Geleijnse ML, et al. Prognostic role of aortic atherosclerosis and coronary flow reserve in patients with suspected coronary artery disease. Int J Cardiol. 2008;131: 45-50.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sicari R, Nihoyannopoulos P, Evangelista A, et al. European Association of Echocardiography. Stress echocardiography expert consensus statement: European Association of Echocardiography (EAE) (a registered branch of the ESC). Eur J Echocardiogr. 2008; 9: 415-37.</mixed-citation><mixed-citation xml:lang="en">Sicari R, Nihoyannopoulos P, Evangelista A, et al. European Association of Echocardiography. Stress echocardiography expert consensus statement: European Association of Echocardiography (EAE) (a registered branch of the ESC). Eur J Echocardiogr. 2008; 9: 415-37.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zagatina A, Zhuravskaya N. Transthoracic detection of coronary flow in left and right coronary descending arteries during supine bicycle stress echocardiography. Coron Artery Dis. 2012; 23: 337-47.</mixed-citation><mixed-citation xml:lang="en">Zagatina A, Zhuravskaya N. Transthoracic detection of coronary flow in left and right coronary descending arteries during supine bicycle stress echocardiography. Coron Artery Dis. 2012; 23: 337-47.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Galderisi M, Rigo F, Gherardi S, Cortigiani L, et al. The impact of aging and atherosclerotic risk factors on transthoracic coronary flow reserve in subjects with normal coronary angiography. Cardiovasc Ultrasound. 2012;10:20.</mixed-citation><mixed-citation xml:lang="en">Galderisi M, Rigo F, Gherardi S, Cortigiani L, et al. The impact of aging and atherosclerotic risk factors on transthoracic coronary flow reserve in subjects with normal coronary angiography. Cardiovasc Ultrasound. 2012;10:20.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Prior JO, Quiñones MJ, Hernandez-Pampaloni M,et al. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation. 2005;111:2291-8.</mixed-citation><mixed-citation xml:lang="en">Prior JO, Quiñones MJ, Hernandez-Pampaloni M,et al. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation. 2005;111:2291-8.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Task Force Members, Montalescot G, Sechtem U, Achenbach S, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34:2949-3003.</mixed-citation><mixed-citation xml:lang="en">Task Force Members, Montalescot G, Sechtem U, Achenbach S, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34:2949-3003.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kawata T, Daimon M, Hasegawa R, et al. Prognostic value of coronary flow reserve assessed by transthoracic Doppler echocardiography on long-term outcome in asymptomatic patients with type 2 diabetes without overt coronary artery disease. Cardiovasc Diabetol. 2013;12:121.</mixed-citation><mixed-citation xml:lang="en">Kawata T, Daimon M, Hasegawa R, et al. Prognostic value of coronary flow reserve assessed by transthoracic Doppler echocardiography on long-term outcome in asymptomatic patients with type 2 diabetes without overt coronary artery disease. Cardiovasc Diabetol. 2013;12:121.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
