russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2022-4872russjcardiol-4872Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWРоль эпикардиальной жировой ткани в развитии сердечно-сосудистых заболеванийRole of epicardial adipose tissue in the development of cardiovascular diseaseshttps://orcid.org/0000-0002-8314-9032МустафинаИ. А.MustafinaI. A.

Ирина Аликовна Мустафина — кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней, научный сотрудник НИИ кардиологии.

Уфа

Ufa

iramust@mail.ruhttps://orcid.org/0000-0001-7293-1144ИонинВ. А.IoninV. A.

Валерий Александрович Ионин — кандидат медицинских наук, доцент кафедры терапии факультетской с курсом эндокринологии, кардиологии с клиникой им. акад. Г.Ф. Ланга, старший научный сотрудник ИСССЗ НКИЦа.Санкт-Петербург

St. Petersburg

ionin.v.a@gmail.comhttps://orcid.org/0000-0001-7475-5850ДолгановА. А.DolganovA. A.

Аркадий Александрович Долганов — зав. отделением сосудистой хирургии Клиники БГМУ.

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Ufa

arkdolganov@mail.ruhttps://orcid.org/0000-0002-5527-4477ИшметовВ. Ш.IshmetovV. Sh.

Владимир Шамильевич Ишметов — доктор медицинских наук, профессор, зав. отделением рентгенохирургических методов диагностики и лечения Клиники БГМУ.

Уфа

Ufa

ishv75@mail.ruhttps://orcid.org/0000-0002-4637-4724ПушкареваА. Э.PushkarevaA. E.

Альфия Эдуардовна Пушкарева — кандидат медицинских наук, врач-кардиолог отделения сосудистой хирургии Клиники БГМУ, доцент кафедры госпитальной терапии № 1.

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Ufa

alfia.cardio@yandex.ruhttps://orcid.org/0000-0001-6915-1673ЯгудинТ. А.YagudinT. A.

Тимур Альбертович Ягудин — кандидат медицинских наук, врач, сосудистый хирург отделения сосудистой хирургии Клиники БГМУ.

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Ufa

timk7@list.ruhttps://orcid.org/0000-0002-4374-2923ДанилкоК. В.DanilkoK. V.

Ксения Владимировна Данилко — кандидат медицинских наук, старший научный сотрудник ЦНИЛ, руководитель лаборатории клеточных культур.

Уфа

Ufa

kse-danilko@yandex.ruhttps://orcid.org/0000-0003-2386-6707ЗагидуллинН. Ш.ZagidullinN Sh.

Науфаль Шамилевич Загидуллин — доктор медицинских наук, профессор, зав. кафедры пропедевтики внутренних болезней.

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Ufa

znaufal@mail.ruФГБОУ ВО Башкирский государственный медицинский университет Минздрава РоссииРоссияBashkir State Medical UniversityRussian FederationФГБОУ ВО ПСПбГМУ им. акад. И.П. Павлова Минздрава РоссииРоссияPavlov First Saint Petersburg State Medical UniversityRussian Federation202218032022271SОбразование48724872Copyright © Мустафина И.А., Ионин В.А., Долганов А.А., Ишметов В.Ш., Пушкарева А.Э., Ягудин Т.А., Данилко К.В., Загидуллин Н.Ш., 20222022Мустафина И.А., Ионин В.А., Долганов А.А., Ишметов В.Ш., Пушкарева А.Э., Ягудин Т.А., Данилко К.В., Загидуллин Н.Ш.Mustafina I.A., Ionin V.A., Dolganov A.A., Ishmetov V.S., Pushkareva A.E., Yagudin T.A., Danilko K.V., Zagidullin N.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/4872

Эпикардиальная жировая ткань (ЭЖТ) обладает уникальными свойствами благодаря особой анатомической структуре, функции терморегуляции, метаболической активности. Дисрегуляция ЭЖТ провоцирует синтез провоспалительных цитокинов, нарушения в обмене жиров, глюкозы, способствует жировой дистрофии миокарда и развитию хронической сердечной недостаточности. ЭЖТ может служить фактором риска и биомаркером сердечнососудистых заболеваний, а также является потенциальной терапевтической мишенью. Целью данного обзора было освещение данных актуальных исследований по ЭЖТ, секретируемых адипокинов, их влияние на метаболизм тканей-мишеней и систематизация взаимосвязей между ЭЖТ и сердечнососудистыми заболеваниями. В частности, освещены вопросы её функции, роль при хронической сердечной недостаточности, фибрилляции предсердий, а также прогностическое значение различных микроРНК, определяемых в ЭЖТ.

Epicardial adipose tissue (EAT) has unique properties due to its special anatomical structure, thermoregulation, and metabolic activity. Dysregulated EAT provokes the synthesis of pro-inflammatory cytokines, disorders in the metabolism of fats and glucose, as well as contributes to fatty degeneration of the myocardium and heart failure development. EAT may serve as a risk factor and biomarker for cardiovascular diseases, and is also a potential therapeutic target. The purpose of this review was to highlight current research data on EAT, secreted adipokines, their effect on target tissue metabolism, and to systematize the relationship between EAT and cardiovascular diseases. In particular, its function, role in heart failure, atrial fibrillation, as well as the prognostic value of various microRNAs determined in EAT are highlighted.

эпикардиальная жировая тканьсердечно-сосудистый рискадипокинымикроРНКepicardial adipose tissuecardiovascular riskadipokinesmicroRNAИсследование выполнено за счет гранта Российского научного фонда № 21-75-00065The study was supported by a grant from the Russian Science Foundation № 21-75-00065ReferencesIacobellis G, Willens HJ. Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr. 2009;22(12):1311-9; quiz 1417-8. doi:10.1016/j.echo.2009.10.013.Iacobellis G, Willens HJ. Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr. 2009;22(12):1311-9; quiz 1417-8. doi:10.1016/j.echo.2009.10.013.Baker AR, Silva NF, Quinn DW, et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol. 2006;5:1. doi:10.1186/1475-2840-5-1.Baker AR, Silva NF, Quinn DW, et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol. 2006;5:1. doi:10.1186/1475-2840-5-1.Berg G, Miksztowicz V, Morales C, et al. Epicardial Adipose Tissue in Cardiovascular Disease. Adv Exp Med Biol. 2019;1127:131-43. doi:10.1007/978-3-030-11488-6_9.Berg G, Miksztowicz V, Morales C, et al. Epicardial Adipose Tissue in Cardiovascular Disease. Adv Exp Med Biol. 2019;1127:131-43. doi:10.1007/978-3-030-11488-6_9.Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med. 2005;2(10):536-43. doi:10.1038/ncpcardio0319.Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med. 2005;2(10):536-43. doi:10.1038/ncpcardio0319.Achari AE, Jain SK. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int J Mol Sci. 2017;18(6):1321. doi:10.3390/ijms18061321.Achari AE, Jain SK. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int J Mol Sci. 2017;18(6):1321. doi:10.3390/ijms18061321.Wu Q, Chen Y, Chen S, et al. Correlation between adiponectin, chemerin, vascular endothelial growth factor and epicardial fat volume in patients with coronary artery disease. Exp Ther Med. 2020;19(2):1095-102. doi:10.3892/etm.2019.8299.Wu Q, Chen Y, Chen S, et al. Correlation between adiponectin, chemerin, vascular endothelial growth factor and epicardial fat volume in patients with coronary artery disease. Exp Ther Med. 2020;19(2):1095-102. doi:10.3892/etm.2019.8299.Mazurek T, Zhang L, Zalewski A, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003;108(20):2460-6. doi:10.1161/01.CIR.0000099542.57313.C5.Mazurek T, Zhang L, Zalewski A, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003;108(20):2460-6. doi:10.1161/01.CIR.0000099542.57313.C5.Baker AR, Harte AL, Howell N, et al. Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease. J Clin Endocrinol Metab. 2009;94(1):261-7. doi:10.1210/jc.2007-2579.Baker AR, Harte AL, Howell N, et al. Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease. J Clin Endocrinol Metab. 2009;94(1):261-7. doi:10.1210/jc.2007-2579.Gruzdeva OV, Akbasheva OE, Dyleva YA, et al. Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease. Bull Exp Biol Med. 2017;163(5):608-11. doi:10.1007/s10517-017-3860-5.Gruzdeva OV, Akbasheva OE, Dyleva YA, et al. Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease. Bull Exp Biol Med. 2017;163(5):608-11. doi:10.1007/s10517-017-3860-5.Guglielmo M, Lin A, Dey D, et al. Epicardial fat and coronary artery disease: Role of cardiac imaging. Atherosclerosis. 2021;321:30-8. doi:10.1016/j.atherosclerosis.2021.02.008.Guglielmo M, Lin A, Dey D, et al. Epicardial fat and coronary artery disease: Role of cardiac imaging. Atherosclerosis. 2021;321:30-8. doi:10.1016/j.atherosclerosis.2021.02.008.Natale F, Tedesco MA, Mocerino R, et al. Visceral adiposity and arterial stiffness: echocardiographic epicardial fat thickness reflects, better than waist circumference, carotid arterial stiffness in a large population of hypertensives. Eur J Echocardiogr. 2009;10(4):549-55. doi:10.1093/ejechocard/jep002.Natale F, Tedesco MA, Mocerino R, et al. Visceral adiposity and arterial stiffness: echocardiographic epicardial fat thickness reflects, better than waist circumference, carotid arterial stiffness in a large population of hypertensives. Eur J Echocardiogr. 2009;10(4):549-55. doi:10.1093/ejechocard/jep002.Forouzandeh F, Chang SM, Muhyieddeen K, et al. Does quantifying epicardial and intrathoracic fat with noncontrast computed tomography improve risk stratification beyond calcium scoring alone? Circ Cardiovasc Imaging. 2013;6(1):58-66. doi:10.1161/CIRCIMAGING.112.976316.Forouzandeh F, Chang SM, Muhyieddeen K, et al. Does quantifying epicardial and intrathoracic fat with noncontrast computed tomography improve risk stratification beyond calcium scoring alone? Circ Cardiovasc Imaging. 2013;6(1):58-66. doi:10.1161/CIRCIMAGING.112.976316.Sato F, Maeda N, Yamada T, et al. Association of Epicardial, Visceral, and Subcutaneous Fat With Cardiometabolic Diseases. Circ J. 2018;82(2):502-8. doi:10.1253/circj.CJ-17-0820.Sato F, Maeda N, Yamada T, et al. Association of Epicardial, Visceral, and Subcutaneous Fat With Cardiometabolic Diseases. Circ J. 2018;82(2):502-8. doi:10.1253/circj.CJ-17-0820.Отт А.В., Чумакова Г.А. Эпикардиальное ожирение как один из основных критериевметаболически тучного фенотипа ожирения ипредикторов субклинического атеросклероза. Комплексные проблемы сердечно-сосудистых заболеваний. 2018;7(1):21-8. doi:10.17802/2306-1278-2018-7-1-21-28.Ott AV, Chumakova GA. Epicardial obesity as one of the basic criteria for metabolically unhealthy obesity phenotype and the predictor of subclinical atherosclerosis. Complex Issues of Cardiovascular Diseases. 2018;7(1):21-8. (In Russ.) doi:10.17802/2306-1278-2018-7-1-21-28.Rostamzadeh A, Khademvatani K, Seyed Mohammadzadeh MH, et al. Association of epicardial fat thickness assessed by echocardiography with the severity of coronary artery disease. J Cardiovasc Thorac Res. 2020;12(2):114-9. doi:10.34172/jcvtr.2020.19.Rostamzadeh A, Khademvatani K, Seyed Mohammadzadeh MH, et al. Association of epicardial fat thickness assessed by echocardiography with the severity of coronary artery disease. J Cardiovasc Thorac Res. 2020;12(2):114-9. doi:10.34172/jcvtr.2020.19.Nerlekar N, Brown AJ, Muthalaly RG, et al. Association of Epicardial Adipose Tissue and High-Risk Plaque Characteristics: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2017;6(8):e006379. doi:10.1161/JAHA.117.006379.Nerlekar N, Brown AJ, Muthalaly RG, et al. Association of Epicardial Adipose Tissue and High-Risk Plaque Characteristics: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2017;6(8):e006379. doi:10.1161/JAHA.117.006379.Полякова Е.А., Колодина Д.А., Мирошникова В.В. и др. Экспрессия гена лептина в эпикардиальной жировой ткани у мужчин с ишемической болезнью сердца. Артериальная гипертензия. 2019;6(3):25-35.Polyakova EA, Kolodina DA, Miroshnikova VV, et al. Leptin gene expression in epicardial adipose tissue in males with coronary heart disease. Arterial hypertension. 2019;6(3):25-35. (In Russ.)Mahabadi AA, Berg MH, Lehmann N, et al. Association of epicardial fat with cardiovascular risk factors and incident myocardial infarction in the general population: the Heinz Nixdorf Recall Study. J Am Coll Cardiol. 2013;61(13):1388-95. doi:10.1016/j.jacc.2012.11.062.Mahabadi AA, Berg MH, Lehmann N, et al. Association of epicardial fat with cardiovascular risk factors and incident myocardial infarction in the general population: the Heinz Nixdorf Recall Study. J Am Coll Cardiol. 2013;61(13):1388-95. doi:10.1016/j.jacc.2012.11.062.Nakanishi K, Fukuda S, Tanaka A, et al. Persistent epicardial adipose tissue accumulation is associated with coronary plaque vulnerability and future acute coronary syndrome in non-obese subjects with coronary artery disease. Atherosclerosis. 2014;237(1):353- 60. doi:10.1016/j.atherosclerosis.2014.09.015.Nakanishi K, Fukuda S, Tanaka A, et al. Persistent epicardial adipose tissue accumulation is associated with coronary plaque vulnerability and future acute coronary syndrome in non-obese subjects with coronary artery disease. Atherosclerosis. 2014;237(1):353- 60. doi:10.1016/j.atherosclerosis.2014.09.015.Kunita E, Yamamoto H, Kitagawa T, et al. Prognostic value of coronary artery calcium and epicardial adipose tissue assessed by non-contrast cardiac computed tomography. Atherosclerosis. 2014;233(2):447-53. doi:10.1016/j.atherosclerosis.2014.01.038.Kunita E, Yamamoto H, Kitagawa T, et al. Prognostic value of coronary artery calcium and epicardial adipose tissue assessed by non-contrast cardiac computed tomography. Atherosclerosis. 2014;233(2):447-53. doi:10.1016/j.atherosclerosis.2014.01.038.Gitsioudis G, Schmahl C, Missiou A, et al. Epicardial Adipose Tissue Is Associated with Plaque Burden and Composition and Provides Incremental Value for the Prediction of Cardiac Outcome. A Clinical Cardiac Computed Tomography Angiography Study. PLoS One. 2016;11(5):e0155120. doi:10.1371/journal.pone.0155120.Gitsioudis G, Schmahl C, Missiou A, et al. Epicardial Adipose Tissue Is Associated with Plaque Burden and Composition and Provides Incremental Value for the Prediction of Cardiac Outcome. A Clinical Cardiac Computed Tomography Angiography Study. PLoS One. 2016;11(5):e0155120. doi:10.1371/journal.pone.0155120.Mahabadi AA, Balcer B, Dykun I, et al. Cardiac computed tomography-derived epicardial fat volume and attenuation independently distinguish patients with and without myocardial infarction. PLoS One. 2017;12(8):e0183514. doi:10.1371/journal.pone.0183514.Mahabadi AA, Balcer B, Dykun I, et al. Cardiac computed tomography-derived epicardial fat volume and attenuation independently distinguish patients with and without myocardial infarction. PLoS One. 2017;12(8):e0183514. doi:10.1371/journal.pone.0183514.Goeller M, Achenbach S, Marwan M, et al. Epicardial adipose tissue density and volume are related to subclinical atherosclerosis, inflammation and major adverse cardiac events in asymptomatic subjects. J Cardiovasc Comput Tomogr. 2018;12(1):67-73. doi:10.1016/j.jcct.2017.11.007.Goeller M, Achenbach S, Marwan M, et al. Epicardial adipose tissue density and volume are related to subclinical atherosclerosis, inflammation and major adverse cardiac events in asymptomatic subjects. J Cardiovasc Comput Tomogr. 2018;12(1):67-73. doi:10.1016/j.jcct.2017.11.007.Morales-Portano JD, Peraza-Zaldivar JÁ, Suárez-Cuenca JA, et al. Echocardiographic measurements of epicardial adipose tissue and comparative ability to predict adverse cardiovascular outcomes in patients with coronary artery disease. Int J Cardiovasc Imaging. 2018;34(9):1429-37. doi:10.1007/s10554-018-1360-y.Morales-Portano JD, Peraza-Zaldivar JÁ, Suárez-Cuenca JA, et al. Echocardiographic measurements of epicardial adipose tissue and comparative ability to predict adverse cardiovascular outcomes in patients with coronary artery disease. Int J Cardiovasc Imaging. 2018;34(9):1429-37. doi:10.1007/s10554-018-1360-y.Полякова Е.А., Беркович О.А., Баранова Е. И. Прогностическое значение толщины эпикардиальной жировой ткани у больных ишемической болезнью сердца, перенесших реваскуляризацию миокарда. Кардиология. 2020;60(3):4-13. doi:10.18087/cardio.2020.3.n874.Polyakova EA, Berkovich OA, Baranova EI. Prognostic value of epicardial fat thickness in coronary heart disease patients after myocardial revascularization. Kardiologiia. 2020;60(3):4-13. (In Russ.) doi:10.18087/cardio.2020.3.n874.Topuz M, Dogan A. The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries. Kardiol Pol. 2017;75(3):196-203. doi:10.5603/KP.a2016.0139.Topuz M, Dogan A. The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries. Kardiol Pol. 2017;75(3):196-203. doi:10.5603/KP.a2016.0139.Karason K, Jamaly S. Heart failure development in obesity: mechanistic pathways. Eur Heart J. 2020;41(36):3485. doi:10.1093/eurheartj/ehaa422.Karason K, Jamaly S. Heart failure development in obesity: mechanistic pathways. Eur Heart J. 2020;41(36):3485. doi:10.1093/eurheartj/ehaa422.Nyawo TA, Dludla PV, Mazibuko-Mbeje SE, et al. A systematic review exploring the significance of measuring epicardial fat thickness in correlation to B-type natriuretic peptide levels as prognostic and diagnostic markers in patients with or at risk of heart failure. Heart Fail Rev. 2021. doi:10.1007/s10741-021-10160-3.Nyawo TA, Dludla PV, Mazibuko-Mbeje SE, et al. A systematic review exploring the significance of measuring epicardial fat thickness in correlation to B-type natriuretic peptide levels as prognostic and diagnostic markers in patients with or at risk of heart failure. Heart Fail Rev. 2021. doi:10.1007/s10741-021-10160-3.Malavazos AE, Di Leo G, Secchi F, et al. Relation of echocardiographic epicardial fat thickness and myocardial fat. Am J Cardiol. 2010;105(12):1831-5. doi:10.1016/j.amjcard.2010.01.368.Malavazos AE, Di Leo G, Secchi F, et al. Relation of echocardiographic epicardial fat thickness and myocardial fat. Am J Cardiol. 2010;105(12):1831-5. doi:10.1016/j.amjcard.2010.01.368.Gaeta M, Bandera F, Tassinari F, et al. Is epicardial fat depot associated with atrial fibrillation? A systematic review and meta-analysis. Europace. 2017;19(5):747-52.doi:10.1093/europace/euw398.Gaeta M, Bandera F, Tassinari F, et al. Is epicardial fat depot associated with atrial fibrillation? A systematic review and meta-analysis. Europace. 2017;19(5):747-52.doi:10.1093/europace/euw398.Zghaib T, Ipek EG, Zahid S, et al. Association of left atrial epicardial adipose tissue with electrogram bipolar voltage and fractionation: Electrophysiologic substrates for atrial fibrillation. Heart Rhythm. 2016;13(12):2333-9. doi:10.1016/j.hrthm.2016.08.030.Zghaib T, Ipek EG, Zahid S, et al. Association of left atrial epicardial adipose tissue with electrogram bipolar voltage and fractionation: Electrophysiologic substrates for atrial fibrillation. Heart Rhythm. 2016;13(12):2333-9. doi:10.1016/j.hrthm.2016.08.030.Balcioğlu AS, Çiçek D, Akinci S, et al. Arrhythmogenic evidence for epicardial adipose tissue: heart rate variability and turbulence are influenced by epicardial fat thickness. Pacing Clin Electrophysiol. 2015;38(1):99-106. doi:10.1111/pace.12512.Balcioğlu AS, Çiçek D, Akinci S, et al. Arrhythmogenic evidence for epicardial adipose tissue: heart rate variability and turbulence are influenced by epicardial fat thickness. Pacing Clin Electrophysiol. 2015;38(1):99-106. doi:10.1111/pace.12512.van Woerden G, Gorter TM, Westenbrink BD, et al. Epicardial fat in heart failure patients with mid-range and preserved ejection fraction. Eur J Heart Fail. 2018;20(11):1559-66. doi:10.1002/ejhf.1283.van Woerden G, Gorter TM, Westenbrink BD, et al. Epicardial fat in heart failure patients with mid-range and preserved ejection fraction. Eur J Heart Fail. 2018;20(11):1559-66. doi:10.1002/ejhf.1283.Заславская Е. Л., Ионин В.А., Нифонтов С.Е. и др. Эпикардиальная жировая ткань и трансформирующий фактор роста бета1 — факторы риска фибрилляции предсердий у пациентов с метаболическим синдромом? Артериальная гипертензия. 2018;24(3):281-92. doi:10.18705/1607-419X-2018-24-3-281-292.Zaslavskaya EL, Ionin VA, Nifontov SE, et al. Are epicardial adipose tissue and transforming growth factor beta1 risk factors of atrial fibrillation in patients with metabolic syndrome? Arterial Hypertension. 2018;24(3):281-92. (In Russ.) doi:10.18705/1607-419X-2018-24-3-281-292.Голухова Е.З., Громова О.И., Булаева Н.И. и др. Эпикардиальный жир и фибрилляция предсердий: роль профиброгенных медиаторов. Кардиология. 2018;58(7):59-65. doi:10.18087/cardio.2018.7.10145.Golukhova EZ, Gromova OI, Bulaeva NI, et al. Epicardial fat and atrial fibrillation: the role of profibrinogenic mediators. Cardiology. 2018;58(7):59-65. (In Russ.) doi:10.18087/cardio.2018.7.10145.Ионин В.А., Листопад О.В., Нифонтов С.Е. и др. Роль галектина-3 и эпикардиального жира в развитии фибрилляции предсердий у пациентов при метаболическом синдроме. Ученые записки СПбГМУ имени академика И.П. Павлова. 2015;22(1):43-6. doi:10.24884/1607-4181-2015-22-1-43-46.Ionin VA, Listopad OV, Nifontov SE, et al. Role of galectin 3 and epicardial fat thickness in the development of atrial fibrillation in patients with metabolic syndrome. The Scientific Notes of the Pavlov University. 2015;22(1):43-6. (In Russ.) doi:10.24884/1607-4181-2015-22-1-43-46.Kogo H, Sezai A, Osaka S, et al. Does Epicardial Adipose Tissue Influence Postoperative Atrial Fibrillation? Ann Thorac Cardiovasc Surg. 2019;25(3):149-57. doi:10.5761/atcs.oa.18-00212.Kogo H, Sezai A, Osaka S, et al. Does Epicardial Adipose Tissue Influence Postoperative Atrial Fibrillation? Ann Thorac Cardiovasc Surg. 2019;25(3):149-57. doi:10.5761/atcs.oa.18-00212.Gunturk EE, Topuz M, Serhatlioğlu F, et al. Echocardiographically Measured Epicardial Fat Predicts New-onset Atrial Fibrillation after Cardiac Surgery. Braz J Cardiovasc Surg. 2020;35(3):339-45. doi:10.21470/1678-9741-2019-0388.Gunturk EE, Topuz M, Serhatlioğlu F, et al. Echocardiographically Measured Epicardial Fat Predicts New-onset Atrial Fibrillation after Cardiac Surgery. Braz J Cardiovasc Surg. 2020;35(3):339-45. doi:10.21470/1678-9741-2019-0388.Sepehri Shamloo A, Dagres N, Dinov B, et al. Is epicardial fat tissue associated with atrial fibrillation recurrence after ablation? A systematic review and meta-analysis. Int J Cardiol Heart Vasc. 2019;22:132-8. doi:10.1016/j.ijcha.2019.01.003.Sepehri Shamloo A, Dagres N, Dinov B, et al. Is epicardial fat tissue associated with atrial fibrillation recurrence after ablation? A systematic review and meta-analysis. Int J Cardiol Heart Vasc. 2019;22:132-8. doi:10.1016/j.ijcha.2019.01.003.Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11(9):597-610. doi:10.1038/nrg2843.Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11(9):597-610. doi:10.1038/nrg2843.de Gonzalo-Calvo D, Vilades D, Martínez-Camblor P, et al. Plasma microRNA Profiling Reveals Novel Biomarkers of Epicardial Adipose Tissue: A Multidetector Computed Tomography Study. J Clin Med. 2019;8(6):780. doi:10.3390/jcm8060780.de Gonzalo-Calvo D, Vilades D, Martínez-Camblor P, et al. Plasma microRNA Profiling Reveals Novel Biomarkers of Epicardial Adipose Tissue: A Multidetector Computed Tomography Study. J Clin Med. 2019;8(6):780. doi:10.3390/jcm8060780.Tran KV, Majka J, Sanghai S, et al. Micro-RNAs Are Related to Epicardial Adipose Tissue in Participants With Atrial Fibrillation: Data From the MiRhythm Study. Front Cardiovasc Med. 2019;6:115. doi:10.3389/fcvm.2019.00115.Tran KV, Majka J, Sanghai S, et al. Micro-RNAs Are Related to Epicardial Adipose Tissue in Participants With Atrial Fibrillation: Data From the MiRhythm Study. Front Cardiovasc Med. 2019;6:115. doi:10.3389/fcvm.2019.00115.Vacca M, Di Eusanio M, Cariello M, et al. Integrative miRNA and whole-genome analyses of epicardial adipose tissue in patients with coronary atherosclerosis. Cardiovasc Res. 2016 Feb 1;109(2):228-39. doi:10.1093/cvr/cvv266.Vacca M, Di Eusanio M, Cariello M, et al. Integrative miRNA and whole-genome analyses of epicardial adipose tissue in patients with coronary atherosclerosis. Cardiovasc Res. 2016 Feb 1;109(2):228-39. doi:10.1093/cvr/cvv266.Liu Y, Fu W, Lu M, et al. Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM. Biomed Res Int. 2016;2016:1629236. doi:10.1155/2016/1629236.Liu Y, Fu W, Lu M, et al. Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM. Biomed Res Int. 2016;2016:1629236. doi:10.1155/2016/1629236.Blumensatt M, Fahlbusch P, Hilgers R, et al. Secretory products from epicardial adipose tissue from patients with type 2 diabetes impair mitochondrial β-oxidation in cardiomyocytes via activation of the cardiac renin-angiotensin system and induction of miR208a. Basic Res Cardiol. 2017;112(1):2. doi:10.1007/s00395-016-0591-0.Blumensatt M, Fahlbusch P, Hilgers R, et al. Secretory products from epicardial adipose tissue from patients with type 2 diabetes impair mitochondrial β-oxidation in cardiomyocytes via activation of the cardiac renin-angiotensin system and induction of miR208a. Basic Res Cardiol. 2017;112(1):2. doi:10.1007/s00395-016-0591-0.Marí-Alexandre J, Barceló-Molina M, Sanz-Sánchez J, et al. Thickness and an Altered miRNA Expression in the Epicardial Adipose Tissue Is Associated With Coronary Heart Disease in Sudden Death Victims. Rev Esp Cardiol (Engl Ed). 2019;72(1):30-9. doi:10.1016/j.rec.2017.12.007.Marí-Alexandre J, Barceló-Molina M, Sanz-Sánchez J, et al. Thickness and an Altered miRNA Expression in the Epicardial Adipose Tissue Is Associated With Coronary Heart Disease in Sudden Death Victims. Rev Esp Cardiol (Engl Ed). 2019;72(1):30-9. doi:10.1016/j.rec.2017.12.007.

The authors declare that there are no conflicts of interest present.