russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2021-4807russjcardiol-4807Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWЭмпаглифлозин: путь от контроля гликемии к снижению сердечно-сосудистой смертности и госпитализаций по причине сердечной недостаточностиEmpagliflozin: a path from glycemic control to reduced cardiovascular mortality and heart failure-related hospitalizationshttps://orcid.org/0000-0002-7760-0763ХасановН. Р.KhasanovN. R.

Доктор медицинских наук, профессор, заведующий кафедрой пропедевтики внутренних болезней.

Казань.

Kazan.

ybzp@mail.ruКазанский ГМУ Минздрава РоссииРоссияKazan State Medical UniversityRussian Federation202110122021264SОбразование48074807Copyright © Хасанов Н.Р., 20222022Хасанов Н.Р.Khasanov N.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/4807

В исследованиях EMPA-REG OUTCOME, CANVAS и DECLARE-TIMI 58 у пациентов с сахарным диабетом 2 типа и установленными сердечно-сосудистыми заболеваниями или факторами сердечно-сосудистого риска на фоне ингибиторов натрий-глюкозного котранспортера 2 типа (иНГЛТ2) по сравнению с плацебо было продемонстрировано снижение риска неблагоприятных сердечно-сосудистых осложнений и развития или ухудшения течения хронической сердечной недостаточности без учащения случаев гипогликемии. К настоящему времени описаны различные механизмы действия иНГЛТ2, которые рассматриваются с позиции их влияния на течение и прогноз хронической сердечной недостаточности. В исследовании EMPEROR-Reduced в группе пациентов, получавших эмпаглифлозин, было показано значительное снижение риска смерти от сердечно-сосудистых причин и госпитализаций по поводу сердечной недостаточности, независимо от наличия сахарного диабета 2 типа.

In the EMPA-REG OUTCOME, CANVAS and DECLARE-TIMI 58 studies, in patients with type 2 diabetes and established cardiovascular diseases or risk factors, a decrease in the risk of cardiovascular events and development or worsening of heart failure course without an increase in hypoglycemia incidence was revealed in those receiving sodium-glucose co-transporter-2 (SGLT2) inhibitors compared with placebo. To date, various mechanisms of action of SGLT2 inhibitors have been described, which are considered from the standpoint of their influence on the course and prognosis of heart failure. In the EMPEROR-Reduced study in the group of patients receiving empagliflozin, a significant reduction in the risk of cardiovascular death and hospitalizations for heart failure, regardless of the type 2 diabetes presence, was revealed.

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The authors declare that there are no conflicts of interest present.