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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2021-4703</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-4703</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАКЛЮЧЕНИЕ СОВЕТА ЭКСПЕРТОВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERT COUNCIL OPINION</subject></subj-group></article-categories><title-group><article-title>Согласованное мнение Российских экспертов по профилактике, диагностике и лечению сердечно-сосудистой токсичности противоопухолевой терапии</article-title><trans-title-group xml:lang="en"><trans-title>Сonsensus statement of Russian experts on the prevention, diagnosis and treatment of cardiotoxicity of anticancer therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васюк</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasyuk</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">yvasyuk@yandex.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гендлин</surname><given-names>Г. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Gendlin</surname><given-names>G. E.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Емелина</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Emelina</surname><given-names>E. I.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шупенина</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shupenina</surname><given-names>E. Yu.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баллюзек</surname><given-names>М. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Ballyuzek</surname><given-names>M. F.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баринова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Barinova</surname><given-names>I. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Виценя</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vitsenya</surname><given-names>M. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдкин</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Davydkin</surname><given-names>I. L.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дундуа</surname><given-names>Д. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Dundua</surname><given-names>D. P.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дупляков</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Duplyakov</surname><given-names>D. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Затейщиков</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zateishchikov</surname><given-names>D. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Золотовская</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zolotovskaya</surname><given-names>I. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конради</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Konradi</surname><given-names>A. O.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лопатин</surname><given-names>Ю. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lopatin</surname><given-names>Yu. M.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеева</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseeva</surname><given-names>O. M.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Недогода</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nedogoda</surname><given-names>S. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Недошивин</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Nedoshivin</surname><given-names>A. O.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитин</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitin</surname><given-names>I. G.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полтавская</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Poltavskaya</surname><given-names>M. G.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потиевская</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Potievskaya</surname><given-names>V. I.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Репин</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Repin</surname><given-names>A. N.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сумин</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sumin</surname><given-names>А. N.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зотова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zotova</surname><given-names>L. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тумян</surname><given-names>Г. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tumyan</surname><given-names>G. S.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шляхто</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shlyakhto</surname><given-names>E. V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хатьков</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Khatkov</surname><given-names>I. E.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Якушин</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakushin</surname><given-names>S. S.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беленков</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Belenkov</surname><given-names>Yu. N.</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2021</year></pub-date><volume>26</volume><issue>9</issue><fpage>4703</fpage><lpage>4703</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васюк Ю.А., Гендлин Г.Е., Емелина Е.И., Шупенина Е.Ю., Баллюзек М.Ф., Баринова И.В., Виценя М.В., Давыдкин И.Л., Дундуа Д.П., Дупляков Д.В., Затейщиков Д.А., Золотовская И.А., Конради А.О., Лопатин Ю.М., Моисеева О.М., Недогода С.В., Недошивин А.О., Никитин И.Г., Полтавская М.Г., Потиевская В.И., Репин А.Н., Сумин А.Н., Зотова Г.А., Тумян Г.С., Шляхто Е.В., Хатьков И.Е., Якушин С.С., Беленков Ю.Н., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Васюк Ю.А., Гендлин Г.Е., Емелина Е.И., Шупенина Е.Ю., Баллюзек М.Ф., Баринова И.В., Виценя М.В., Давыдкин И.Л., Дундуа Д.П., Дупляков Д.В., Затейщиков Д.А., Золотовская И.А., Конради А.О., Лопатин Ю.М., Моисеева О.М., Недогода С.В., Недошивин А.О., Никитин И.Г., Полтавская М.Г., Потиевская В.И., Репин А.Н., Сумин А.Н., Зотова Г.А., Тумян Г.С., Шляхто Е.В., Хатьков И.Е., Якушин С.С., Беленков Ю.Н.</copyright-holder><copyright-holder xml:lang="en">Vasyuk Y.A., Gendlin G.E., Emelina E.I., Shupenina E.Y., Ballyuzek M.F., Barinova I.V., Vitsenya M.V., Davydkin I.L., Dundua D.P., Duplyakov D.V., Zateishchikov D.A., Zolotovskaya I.A., Konradi A.O., Lopatin Y.M., Moiseeva O.M., Nedogoda S.V., Nedoshivin A.O., Nikitin I.G., Poltavskaya M.G., Potievskaya V.I., Repin A.N., Sumin А.N., Zotova L.A., Tumyan G.S., Shlyakhto E.V., Khatkov I.E., Yakushin S.S., Belenkov Y.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/4703">https://russjcardiol.elpub.ru/jour/article/view/4703</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>химиотерапия</kwd><kwd>лучевая терапия</kwd><kwd>таргетная терапия</kwd><kwd>профилактика кардиотоксичности</kwd><kwd>лечение кардиотоксичности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chemotherapy</kwd><kwd>radiation therapy</kwd><kwd>targeted therapy</kwd><kwd>prevention of cardiotoxicity</kwd><kwd>treatment of cardiotoxicity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Eschenhagen T, Forse T, Ewer M, et al. Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur. J. Heart Fail. 2011;13(1):1-10. doi:10.1093/eurjhf/hfq213.</mixed-citation><mixed-citation xml:lang="en">Eschenhagen T, Forse T, Ewer M, et al. Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur. J. Heart Fail. 2011;13(1):1-10. doi:10.1093/eurjhf/hfq213.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Бедрицкий С.А., Ларионов В.Б., Снеговой А.В. Клинические рекомендации по кардиоваскулярной токсичности, индуцированной химиотерапией и таргетными препаратами. Москва. 2014. с.1. http://www.oncology.ru/association/clinical-guidelines/2014/14.pdf.</mixed-citation><mixed-citation xml:lang="en">Bedritsky SA, Larionova VB, Snegovoy AV. Clinical guidelines for cardiovascular toxicity induced by chemotherapy and targeted drugs. Moscow. 2014. р. 10. (In Russ.) http://www.oncology.ru/association/clinical-guidelines/2014/14.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Global WHO. Globocan 2020, all cancers [cited by 30 April, 2021]. Available from: gco.iarc.fr/today/data/factsheets/cancers/39-All-cancers-fact-sheet.pdf.</mixed-citation><mixed-citation xml:lang="en">Global WHO. Globocan 2020, all cancers [cited by 30 April, 2021]. Available from: gco.iarc.fr/today/data/factsheets/cancers/39-All-cancers-fact-sheet.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Padegimas A, Clasen S, Ky B. Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity. Trends Cardiovasc Med. 2020;30:1:22-8. doi:10.1016/j.tcm2019.01.006.</mixed-citation><mixed-citation xml:lang="en">Padegimas A, Clasen S, Ky B. Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity. Trends Cardiovasc Med. 2020;30:1:22-8. doi:10.1016/j.tcm2019.01.006.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Stiller CA. Global Burden Of Childhood Cancer: Growing, But Controllable. The Lancet Oncology. 2019;20(9):1184-5. doi:10.1016/s1470-2045(19)30163-9.</mixed-citation><mixed-citation xml:lang="en">Stiller CA. Global Burden Of Childhood Cancer: Growing, But Controllable. The Lancet Oncology. 2019;20(9):1184-5. doi:10.1016/s1470-2045(19)30163-9.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Jemal A, Ward E, Thun M. Declining death rates reflect progress against cancer [serial online]. PLoS One. 2010;5:e9584. doi:10.1371/journal.pone.0009584.</mixed-citation><mixed-citation xml:lang="en">Jemal A, Ward E, Thun M. Declining death rates reflect progress against cancer [serial online]. PLoS One. 2010;5:e9584. doi:10.1371/journal.pone.0009584.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Howlader N, Ries LAG, Mariotto AB, et al. Improved estimates of cancer-specific survival rates from population-based data. J Natl Cancer Inst. 2010;102:1584-98. doi:10.1093/jnci/djq366.</mixed-citation><mixed-citation xml:lang="en">Howlader N, Ries LAG, Mariotto AB, et al. Improved estimates of cancer-specific survival rates from population-based data. J Natl Cancer Inst. 2010;102:1584-98. doi:10.1093/jnci/djq366.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jemal A, Ward E, Hao Y, Thun M. Trends in the leading causes of death in the United States, 1970–2002. JAMA. 2005;294:1255-9. doi:10.1001/jama.294.10.1255.</mixed-citation><mixed-citation xml:lang="en">Jemal A, Ward E, Hao Y, Thun M. Trends in the leading causes of death in the United States, 1970–2002. JAMA. 2005;294:1255-9. doi:10.1001/jama.294.10.1255.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Dent S, Liu P, Brezden-Masley C, Lenihan D. Cancer and Cardiovascular Disease: The Complex Labyrinth. J Oncol. 2015;2015:516450. doi:10.1155/2015/516450.</mixed-citation><mixed-citation xml:lang="en">Dent S, Liu P, Brezden-Masley C, Lenihan D. Cancer and Cardiovascular Disease: The Complex Labyrinth. J Oncol. 2015;2015:516450. doi:10.1155/2015/516450.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bodai BI, Tuso P. Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations. Perm J. 2015;19:48-79. doi:10.7812/TPP/14-241.</mixed-citation><mixed-citation xml:lang="en">Bodai BI, Tuso P. Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations. Perm J. 2015;19:48-79. doi:10.7812/TPP/14-241.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Siegel R, DeSantis C, Virgo K, et al. Cancer treatment and survivorship statistics, 2012 CA Cancer J Clin. 2012;62:220-41. doi:10.3322/caac.21149.</mixed-citation><mixed-citation xml:lang="en">Siegel R, DeSantis C, Virgo K, et al. Cancer treatment and survivorship statistics, 2012 CA Cancer J Clin. 2012;62:220-41. doi:10.3322/caac.21149.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J, Long JB, Hurria A, et al. Incidence of heart failure or cardiomyopathy after adjuvant trastuzumab therapy for breast cancer. J Am Coll Cardiol. 2012;60:2504-12. doi:10.1016/j.jacc.2012.07.068.</mixed-citation><mixed-citation xml:lang="en">Chen J, Long JB, Hurria A, et al. Incidence of heart failure or cardiomyopathy after adjuvant trastuzumab therapy for breast cancer. J Am Coll Cardiol. 2012;60:2504-12. doi:10.1016/j.jacc.2012.07.068.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bowles EJ, Wellman R, Feigelson HS, et al. Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study. J Natl Cancer Inst. 2012;104:1293-305. doi:10.1093/jnci/djs317.</mixed-citation><mixed-citation xml:lang="en">Bowles EJ, Wellman R, Feigelson HS, et al. Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study. J Natl Cancer Inst. 2012;104:1293-305. doi:10.1093/jnci/djs317.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Aleman BM, Moser EC, Nuver J, et al. Cardiovascular disease after cancer therapy. EJC Suppl. 2014;12:18-28. doi:10.1016/j.ejcsup.2014.03.002.</mixed-citation><mixed-citation xml:lang="en">Aleman BM, Moser EC, Nuver J, et al. Cardiovascular disease after cancer therapy. EJC Suppl. 2014;12:18-28. doi:10.1016/j.ejcsup.2014.03.002.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cardinale D, Lacopo F, Cipolla CM. Cardiotoxicity of Anthracyclines. Front Cardiovasc Med. 2020;7:26. doi:10.3389/fcvm.2020.00026.</mixed-citation><mixed-citation xml:lang="en">Cardinale D, Lacopo F, Cipolla CM. Cardiotoxicity of Anthracyclines. Front Cardiovasc Med. 2020;7:26. doi:10.3389/fcvm.2020.00026.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Taunk NK, Haffty BG, Kostis JB, Goyal S. Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol. 2015;5:39. doi:10.3389/fonc.2015.00039.</mixed-citation><mixed-citation xml:lang="en">Taunk NK, Haffty BG, Kostis JB, Goyal S. Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol. 2015;5:39. doi:10.3389/fonc.2015.00039.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5-29. doi:10.3322/caac.21254.</mixed-citation><mixed-citation xml:lang="en">Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5-29. doi:10.3322/caac.21254.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ewer MS, Ewer SM. Cardiotoxicity of anticancer treatments. Nat Rev Cardiol. 2015;12(9):547-58. doi:10.1038/nrcardio.2015.65. Erratum in: Nat Rev Cardiol. 2015;12(11):620.</mixed-citation><mixed-citation xml:lang="en">Ewer MS, Ewer SM. Cardiotoxicity of anticancer treatments. Nat Rev Cardiol. 2015;12(9):547-58. doi:10.1038/nrcardio.2015.65. Erratum in: Nat Rev Cardiol. 2015;12(11):620.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ali MK, Ewer MS, Gibbs HR, et al. Late doxorubicin-associated cardiotoxicity in children. The possible role of intercurrent viral infection. Cancer.1994;74:182-8.</mixed-citation><mixed-citation xml:lang="en">Ali MK, Ewer MS, Gibbs HR, et al. Late doxorubicin-associated cardiotoxicity in children. The possible role of intercurrent viral infection. Cancer.1994;74:182-8.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hahn VS, Lenihan DJ, Ky B. Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies. J Am Heart Assoc. 2014;3(2):e000665. doi:10.1161/JAHA.113.000665.</mixed-citation><mixed-citation xml:lang="en">Hahn VS, Lenihan DJ, Ky B. Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies. J Am Heart Assoc. 2014;3(2):e000665. doi:10.1161/JAHA.113.000665.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Suter TM, Ewer MS. Cancer drugs and the heart: importance and management. Eur Heart J. 2013;34:1102-11. doi:10.1093/eurheartj/ehs181.</mixed-citation><mixed-citation xml:lang="en">Suter TM, Ewer MS. Cancer drugs and the heart: importance and management. Eur Heart J. 2013;34:1102-11. doi:10.1093/eurheartj/ehs181.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Procter M, Suter TM, de Azambuja E, et al. Longer-term assessment of trastuzumabrelated cardiac adverse events in the Herceptin Adjuvant (HERA) trial. J Clin Oncol. 2010;28:3422-8. doi: 10.1200/JCO.2009.26.0463.</mixed-citation><mixed-citation xml:lang="en">Procter M, Suter TM, de Azambuja E, et al. Longer-term assessment of trastuzumabrelated cardiac adverse events in the Herceptin Adjuvant (HERA) trial. J Clin Oncol. 2010;28:3422-8. doi: 10.1200/JCO.2009.26.0463.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Pinder MC, Duan Z, Goodwin JS, et al. Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer. J Clin Oncol. 2007;25:3808-15.</mixed-citation><mixed-citation xml:lang="en">Pinder MC, Duan Z, Goodwin JS, et al. Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer. J Clin Oncol. 2007;25:3808-15.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Yeh ET, Tong AT, Lenihan DJ, et al. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation. 2004;109:3122-3131.</mixed-citation><mixed-citation xml:lang="en">Yeh ET, Tong AT, Lenihan DJ, et al. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation. 2004;109:3122-3131.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Armstrong GT, Kawashima T, Leisenring W, et al. Aging and risk of severe, disabling, life-threatening, and fatal events in the Childhood Cancer Survivor Study. J Clin Oncol. 2014;32:1218-27. doi:10.1200/JCO.2013.51.1055.</mixed-citation><mixed-citation xml:lang="en">Armstrong GT, Kawashima T, Leisenring W, et al. Aging and risk of severe, disabling, life-threatening, and fatal events in the Childhood Cancer Survivor Study. J Clin Oncol. 2014;32:1218-27. doi:10.1200/JCO.2013.51.1055.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Moses H3rd, Matheson DH, Cairns-Smith S, et al. The anatomy of medical research: US and international comparisons. JAMA. 2015;313:174-89. doi:10.1001/jama.2014.15939.</mixed-citation><mixed-citation xml:lang="en">Moses H3rd, Matheson DH, Cairns-Smith S, et al. The anatomy of medical research: US and international comparisons. JAMA. 2015;313:174-89. doi:10.1001/jama.2014.15939.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ferri N, Siegl P, Corsini A, et al. Drug attrition during pre-clinical and clinical development: understanding and managing drug-induced cardiotoxicity. Pharmacol Ther. 2013;138:470- 84. doi:10.1016/j.pharmthera.2013.03.005.</mixed-citation><mixed-citation xml:lang="en">Ferri N, Siegl P, Corsini A, et al. Drug attrition during pre-clinical and clinical development: understanding and managing drug-induced cardiotoxicity. Pharmacol Ther. 2013;138:470- 84. doi:10.1016/j.pharmthera.2013.03.005.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Brana I, Zamora T, Oristell G, Tabernero J. Side effects of medical cancer therapy. Cardiotoxicity. 2018;14:406. doi:10.1007/978-3-31970253-7-14.</mixed-citation><mixed-citation xml:lang="en">Brana I, Zamora T, Oristell G, Tabernero J. Side effects of medical cancer therapy. Cardiotoxicity. 2018;14:406. doi:10.1007/978-3-31970253-7-14.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Herrmann J. Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia. Nature Reviews Cardology. 2020;17(8):474-502. doi:10.1038/s41569-020-0348-1.</mixed-citation><mixed-citation xml:lang="en">Herrmann J. Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia. Nature Reviews Cardology. 2020;17(8):474-502. doi:10.1038/s41569-020-0348-1.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Araujo-Gutierrez R, Ibarra-Cortez SH, Estep JD, et al. Incidence and outcomes of cancer treatment-related cardiomyopathy among referrals for advanced heart failure. Cardiooncology. 2018;4:3. doi:10.1186/s40959-018-0029-y.</mixed-citation><mixed-citation xml:lang="en">Araujo-Gutierrez R, Ibarra-Cortez SH, Estep JD, et al. Incidence and outcomes of cancer treatment-related cardiomyopathy among referrals for advanced heart failure. Cardiooncology. 2018;4:3. doi:10.1186/s40959-018-0029-y.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Матяш М.Г., Кравчук Т.Л., Высоцкая В.В. и др. Индуцированная антрациклинами кардиотоксичность: механизмы развития и клинические проявления. Сибирский онкологический журнал. 2008;6:66-75.</mixed-citation><mixed-citation xml:lang="en">Matyash MG, Kravchuk TL, Vysotskaya VV, et al. Anthracycline-induced cardiotoxicity: mechanisms of development and clinical manifestations. Siberian Journal of Oncology. 2008;6:66-75. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Zuppinger C, Timolati F, Suter TM. Pathophysiology and diagnosis of cancer drug induced cardiomyopathy. Cardiovasc Toxicol. 2007;7:61-6. doi:10.1007/s12012-007-0016-2.</mixed-citation><mixed-citation xml:lang="en">Zuppinger C, Timolati F, Suter TM. Pathophysiology and diagnosis of cancer drug induced cardiomyopathy. Cardiovasc Toxicol. 2007;7:61-6. doi:10.1007/s12012-007-0016-2.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Шуйкова К.В., Емелина Е.И., Гендлин Г.И., Сторожаков Г.И. Кардиотоксичность современных химиотерапевтических препаратов. Атмосфера. Новости кардиологии. 2012;3:9-19.</mixed-citation><mixed-citation xml:lang="en">Shuykova KW, Emelina EI, Gendlin GE, Storozhakov GI. Cardiotoxicity of modern chemotherapeutic drugs. Atmosphere. Cardiology news. 2012;3:9-19 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Гендлин Г.Е., Емелина Е.И., Никитин И. Г., Васюк Ю.А. Современный взгляд на кардиотоксичность химиотерапии онкологических заболеваний, включающей антрациклиновые антибиотики. Российский кардиологический журнал. 2017;3:145-54. doi:10.15829/1560-4071-2017-3-145-154.</mixed-citation><mixed-citation xml:lang="en">Gendlin GE, Emelina EI, Nikitin IG, Vasyuk YA. Modern view on cardiotoxicity of chemotherapeutic in oncology including anthracyclines. Russian Journal of Cardiology. 2017;3:145-54 (In Russ.) doi:10.15829/1560-4071-2017-3-145-154.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Yeh ET, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol. 2009;53:2231-47. doi:10.1016/j.jacc.2009.02.050.</mixed-citation><mixed-citation xml:lang="en">Yeh ET, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol. 2009;53:2231-47. doi:10.1016/j.jacc.2009.02.050.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang S, Liu X, Bawa-Khalfe T, et al. Identification of the molecular basis of doxorubicininduced cardiotoxicity. Nat Med. 2012;18:1639-42. doi:10.1038/nm.2919.</mixed-citation><mixed-citation xml:lang="en">Zhang S, Liu X, Bawa-Khalfe T, et al. Identification of the molecular basis of doxorubicininduced cardiotoxicity. Nat Med. 2012;18:1639-42. doi:10.1038/nm.2919.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Minotti G, Menna P, Salvatorelli E, et al. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 2004;56(2):185-229. doi:10.1124/pr.56.2.6.</mixed-citation><mixed-citation xml:lang="en">Minotti G, Menna P, Salvatorelli E, et al. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 2004;56(2):185-229. doi:10.1124/pr.56.2.6.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Delemasure S, Vergely C, Zeller M, et al. Prévention de la cardiotoxicité des anthracyclines: approche fondamentale des mécanismes mis en jeu; relations avec les données cliniques [Preventing the cardiotoxic effects of anthracyclins. From basic concepts to clinical data]. Ann Cardiol Angeiol (Paris). 2006;55(2):104-12. French. doi:10.1016/j.ancard.2006.02.005.</mixed-citation><mixed-citation xml:lang="en">Delemasure S, Vergely C, Zeller M, et al. Prévention de la cardiotoxicité des anthracyclines: approche fondamentale des mécanismes mis en jeu; relations avec les données cliniques [Preventing the cardiotoxic effects of anthracyclins. From basic concepts to clinical data]. Ann Cardiol Angeiol (Paris). 2006;55(2):104-12. French. doi:10.1016/j.ancard.2006.02.005.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Tokarska-Schlattner M, Wallimann T, Schlattner U. Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin. C R Biol. 2006;329(9):657-68. doi:10.1016/j.crvi.2005.08.007.</mixed-citation><mixed-citation xml:lang="en">Tokarska-Schlattner M, Wallimann T, Schlattner U. Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin. C R Biol. 2006;329(9):657-68. doi:10.1016/j.crvi.2005.08.007.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Jeyaseelan R, Poizat C, Wu HY, Kedes L. Molecular mechanisms of doxorubicininduced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes. J Biol Chem. 1997;272:5828-32.</mixed-citation><mixed-citation xml:lang="en">Jeyaseelan R, Poizat C, Wu HY, Kedes L. Molecular mechanisms of doxorubicininduced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes. J Biol Chem. 1997;272:5828-32.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Pelikan PC, Weisfeldt M, Jacobus WE et al. Acute doxorubicin cardiotoxicity: functional, metabolic, and morphologic alterations in the isolated, perfused rat heart. J Cardiovasc Pharmacol. 1986;8:1058-66.</mixed-citation><mixed-citation xml:lang="en">Pelikan PC, Weisfeldt M, Jacobus WE et al. Acute doxorubicin cardiotoxicity: functional, metabolic, and morphologic alterations in the isolated, perfused rat heart. J Cardiovasc Pharmacol. 1986;8:1058-66.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Nicolay K, Aue WP, J. Seelig et al. Effects of the anti-cancer drug adriamycin on the energy metabolism of rat heart as measured by in vivo 31PNMR and implications for adriamycininduced cardiotoxicity. Biochim Biophys Acta. 1987;929:5-13.</mixed-citation><mixed-citation xml:lang="en">Nicolay K, Aue WP, J. Seelig et al. Effects of the anti-cancer drug adriamycin on the energy metabolism of rat heart as measured by in vivo 31PNMR and implications for adriamycininduced cardiotoxicity. Biochim Biophys Acta. 1987;929:5-13.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Eidenschink AB, Schroter G, Muller-Weihrich S, Stern H. Myocardial high-energy phosphate metabolism is altered after treatment with anthracycline in childhood. Cardiol Young. 2000;10:610-7.</mixed-citation><mixed-citation xml:lang="en">Eidenschink AB, Schroter G, Muller-Weihrich S, Stern H. Myocardial high-energy phosphate metabolism is altered after treatment with anthracycline in childhood. Cardiol Young. 2000;10:610-7.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Praet M, Ruysschaert JM. In-vivo and in-vitro mitochondrial membrane damages induced in mice by adriamycin and derivatives. Biochim Biophys Acta. 1993;1149:79-85.</mixed-citation><mixed-citation xml:lang="en">Praet M, Ruysschaert JM. In-vivo and in-vitro mitochondrial membrane damages induced in mice by adriamycin and derivatives. Biochim Biophys Acta. 1993;1149:79-85.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Muraoka S, Miura T. Inactivation of mitochondrial succinatede-hydrogenase by adriamycin activated by horseradish peroxidase and hydrogen peroxide. Chem Biol Interact. 2003;145:67-75.</mixed-citation><mixed-citation xml:lang="en">Muraoka S, Miura T. Inactivation of mitochondrial succinatede-hydrogenase by adriamycin activated by horseradish peroxidase and hydrogen peroxide. Chem Biol Interact. 2003;145:67-75.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou S, Starkov A, Froberg MK, et al. Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin. Cancer Res. 2001;61:771-7.</mixed-citation><mixed-citation xml:lang="en">Zhou S, Starkov A, Froberg MK, et al. Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin. Cancer Res. 2001;61:771-7.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Lopaschuk GD, Belke DD, Gamble, J et al. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta. 1994;1213:263-76.</mixed-citation><mixed-citation xml:lang="en">Lopaschuk GD, Belke DD, Gamble, J et al. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta. 1994;1213:263-76.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Bordoni A, Biagi P, Hrelia S. The impairment of essential fatty acid metabolism as a key factor in doxorubicin-induced damage in cultured rat cardiomyocytes. Biochim Biophys Acta. 1999; 1440:100-6.</mixed-citation><mixed-citation xml:lang="en">Bordoni A, Biagi P, Hrelia S. The impairment of essential fatty acid metabolism as a key factor in doxorubicin-induced damage in cultured rat cardiomyocytes. Biochim Biophys Acta. 1999; 1440:100-6.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Hong, YM, Kim HS, Yoon HR. Serum lipid and fatty acid profiles in adriamycin -treated rats after administration of L-carnitine. Pediatr Res. 2002;51:249-55.</mixed-citation><mixed-citation xml:lang="en">Hong, YM, Kim HS, Yoon HR. Serum lipid and fatty acid profiles in adriamycin -treated rats after administration of L-carnitine. Pediatr Res. 2002;51:249-55.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Wakasugi S, Fischman AJ, Babich JW, et al. Myocardial substrate utilization and left ventricular function in adriamycin cardiomyopathy. J Nucl Med. 1993;34:1529-35.</mixed-citation><mixed-citation xml:lang="en">Wakasugi S, Fischman AJ, Babich JW, et al. Myocardial substrate utilization and left ventricular function in adriamycin cardiomyopathy. J Nucl Med. 1993;34:1529-35.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Hrelia S, Fiorentin ID, Maraldi T, et al. Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytes. Biochim Biophys Acta. 2002;1567:150-6.</mixed-citation><mixed-citation xml:lang="en">Hrelia S, Fiorentin ID, Maraldi T, et al. Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytes. Biochim Biophys Acta. 2002;1567:150-6.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Васюк Ю.А., Школьник Е.Л., Несветов В.В. и др. Нарушения метаболизма миокарда на фоне химиотерапевтического лечения, а также возможности их коррекции. CardioСоматика. 2013;(4):20-4.</mixed-citation><mixed-citation xml:lang="en">Vasyuk YuA, Shkolnik EL, Nesvetov VV, et al. Disorders of myocardial metabolism against the background of chemotherapeutic treatment, as well as the possibility of their correction. CardioSomatics. 2013;(4):20-4. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Tokarska-Schlattner M, Wallimann T, Schlattner U. Multiple interference of anthracyclines with mitochondrial creatine kinases: preferential damage of the cardiac isoenzyme and its implications for drug cardiotoxicity. Mol Pharmacol. 2002;61:516-23.</mixed-citation><mixed-citation xml:lang="en">Tokarska-Schlattner M, Wallimann T, Schlattner U. Multiple interference of anthracyclines with mitochondrial creatine kinases: preferential damage of the cardiac isoenzyme and its implications for drug cardiotoxicity. Mol Pharmacol. 2002;61:516-23.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Селиверстова Д.В., Евсина О.В. Кардиотоксичность химиотерапии. Сердце: журнал для практикующих врачей. 2016;15(1):50-7. doi:10.18087/rhj.2016.2115.</mixed-citation><mixed-citation xml:lang="en">Seliverstova DV, Evsina OV. Cardiotoxicity of chemotherapy. Russian Heart Journal. 2016;15:50-7. (In Russ.) doi:10.18087/rhj.2016.2115.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">van Dalen EC, Michiels EM, Caron HN, Kremer LC. Different anthracycline derivates for reducing cardiotoxicity in cancer patients. Cochrane Database Syst Rev. 2006;4:CD005006.</mixed-citation><mixed-citation xml:lang="en">van Dalen EC, Michiels EM, Caron HN, Kremer LC. Different anthracycline derivates for reducing cardiotoxicity in cancer patients. Cochrane Database Syst Rev. 2006;4:CD005006.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Wadugu B, Kühn B. The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation. Am J Physiol Heart Circ Physiol. 2012;302:H2139-H2147. doi:10.1152/ajpheart.00063.2012.</mixed-citation><mixed-citation xml:lang="en">Wadugu B, Kühn B. The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation. Am J Physiol Heart Circ Physiol. 2012;302:H2139-H2147. doi:10.1152/ajpheart.00063.2012.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">de Korte MA, de Vries EG, Lub-de Hooge MN, et al. 111Indium-trastuzumab visualises myocardial human epidermal growth factor receptor 2 expression shortly after anthracycline treatment but not during heart failure: a clue to uncover the mechanisms of trastuzumab-related cardiotoxicity. Eur J Cancer. 2007;43:2046-51. doi:10.1016/j.ejca.2007.06.024.</mixed-citation><mixed-citation xml:lang="en">de Korte MA, de Vries EG, Lub-de Hooge MN, et al. 111Indium-trastuzumab visualises myocardial human epidermal growth factor receptor 2 expression shortly after anthracycline treatment but not during heart failure: a clue to uncover the mechanisms of trastuzumab-related cardiotoxicity. Eur J Cancer. 2007;43:2046-51. doi:10.1016/j.ejca.2007.06.024.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Suter TM, Procter M, van Veldhuisen DJ, et al. Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol. 2007;25:3859-65. doi:10.1200/JCO.2006.09.1611.</mixed-citation><mixed-citation xml:lang="en">Suter TM, Procter M, van Veldhuisen DJ, et al. Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol. 2007;25:3859-65. doi:10.1200/JCO.2006.09.1611.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Herrmann J. Tyrosine kinase inhibitors and vascular toxicity: impetus for a classification system? Curr Oncol Rep. 2016;18:33. doi:10.1007/s11912-016-0514-0.</mixed-citation><mixed-citation xml:lang="en">Herrmann J. Tyrosine kinase inhibitors and vascular toxicity: impetus for a classification system? Curr Oncol Rep. 2016;18:33. doi:10.1007/s11912-016-0514-0.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Kerbel RS. Tumor angiogenesis. N Engl J Med. 2008;358(19):2039-49. doi:10.1056/NEJMra0706596.</mixed-citation><mixed-citation xml:lang="en">Kerbel RS. Tumor angiogenesis. N Engl J Med. 2008;358(19):2039-49. doi:10.1056/NEJMra0706596.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Nazer B, Hamphreys BD, Moslehi J. Effects of novel angiogenesis inhibitors for the treatment of cancer on the cardiovascular system. Circulation. 2011;124(15):1687-91. doi:10.1161/CIRCULATIONAHA.110.992230.</mixed-citation><mixed-citation xml:lang="en">Nazer B, Hamphreys BD, Moslehi J. Effects of novel angiogenesis inhibitors for the treatment of cancer on the cardiovascular system. Circulation. 2011;124(15):1687-91. doi:10.1161/CIRCULATIONAHA.110.992230.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Hayman SR, Leung N, Grande JP. Garovic VD. VEGF inhibition, hypertension and renal toxicity. Curr Oncol Rep. 2012;14(4):285-94.</mixed-citation><mixed-citation xml:lang="en">Hayman SR, Leung N, Grande JP. Garovic VD. VEGF inhibition, hypertension and renal toxicity. Curr Oncol Rep. 2012;14(4):285-94.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Kappers MN, van Esch JH, Sluiter W, et al. Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endotelin-1 levels. Hypertension. 2010;56(4):675-81. doi:10.1161/HYPERTENSIONAHA.109.149690.</mixed-citation><mixed-citation xml:lang="en">Kappers MN, van Esch JH, Sluiter W, et al. Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endotelin-1 levels. Hypertension. 2010;56(4):675-81. doi:10.1161/HYPERTENSIONAHA.109.149690.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Verdonk K, Saleh L, Lankhorst S, et al. Association studies suggest a key role for endotelin-1 in the pathogenesis of preeclampsia and the accompaying renin-angiotensinaldosterone system suppression. Hypertension. 2015;65(6):1316-23. doi:10.1161/HYPERTENSIONAHA.115.05267.</mixed-citation><mixed-citation xml:lang="en">Verdonk K, Saleh L, Lankhorst S, et al. Association studies suggest a key role for endotelin-1 in the pathogenesis of preeclampsia and the accompaying renin-angiotensinaldosterone system suppression. Hypertension. 2015;65(6):1316-23. doi:10.1161/HYPERTENSIONAHA.115.05267.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Mourad JJ, des Guetz G, Debbabi H, Levy BI. Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation. Ann Oncol. 2008;19(5):927- 34. doi:10.1093/annonc/mdm550.</mixed-citation><mixed-citation xml:lang="en">Mourad JJ, des Guetz G, Debbabi H, Levy BI. Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation. Ann Oncol. 2008;19(5):927- 34. doi:10.1093/annonc/mdm550.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Steeghs N, Gelderblom H, Roodt JO, et al. Hypertension and rarefication during treatment with telatinib, a small molecule angiogenesis inhibitor. Clin Cancer Res. 2008;14(11):3470- 6. doi:10.1158/1078-0432.ССR-07-5050.</mixed-citation><mixed-citation xml:lang="en">Steeghs N, Gelderblom H, Roodt JO, et al. Hypertension and rarefication during treatment with telatinib, a small molecule angiogenesis inhibitor. Clin Cancer Res. 2008;14(11):3470- 6. doi:10.1158/1078-0432.ССR-07-5050.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Touyz RM, Lang NN, Herrmann J, et al. Recent advances hypertension and cardiovascular toxicities with vascular endothelial growth factor inhibition. Hypertension. 2017;70(2):220- 6. doi:10.1161/HYPERTENSIONAHA.117.08856.</mixed-citation><mixed-citation xml:lang="en">Touyz RM, Lang NN, Herrmann J, et al. Recent advances hypertension and cardiovascular toxicities with vascular endothelial growth factor inhibition. Hypertension. 2017;70(2):220- 6. doi:10.1161/HYPERTENSIONAHA.117.08856.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Force T, Krause DS, Van Etten RA. Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat Rev Cancer. 2007;7:332-44. doi:10.1038/nrc2106.</mixed-citation><mixed-citation xml:lang="en">Force T, Krause DS, Van Etten RA. Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat Rev Cancer. 2007;7:332-44. doi:10.1038/nrc2106.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Alvarez A, Garcia-Albeniz X, Esteve J, et al. Cardiotoxicity of tyrosinekinase-targeting drugs. Cardiovasc Hematol Agents Med Chem. 2010;8:11-21. doi:10.2174/187152510790796192.</mixed-citation><mixed-citation xml:lang="en">Garcia-Alvarez A, Garcia-Albeniz X, Esteve J, et al. Cardiotoxicity of tyrosinekinase-targeting drugs. Cardiovasc Hematol Agents Med Chem. 2010;8:11-21. doi:10.2174/187152510790796192.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Chu TF, Rupnick MA, Kerkela R, et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 2007;370:2011-9. doi:10.1016/S0140-6736(07)61865-0.</mixed-citation><mixed-citation xml:lang="en">Chu TF, Rupnick MA, Kerkela R, et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 2007;370:2011-9. doi:10.1016/S0140-6736(07)61865-0.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Tajik R, Saadat H, Taherkhani M. Angina induced by 5-fluorouracil infusion in a patient with normal coronaries. Am Heart Hosp J. 2010;8:2E111-2. doi:10.15420/ahhj.2010.8.2.111.</mixed-citation><mixed-citation xml:lang="en">Tajik R, Saadat H, Taherkhani M. Angina induced by 5-fluorouracil infusion in a patient with normal coronaries. Am Heart Hosp J. 2010;8:2E111-2. doi:10.15420/ahhj.2010.8.2.111.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Jones RL, Ewer MS. Cardiac and cardiovascular toxicity of nonanthracycline anticancer drugs. Expert Rev Anticancer Ther. 2006;6:1249-69. doi:10.1586/14737140.6.9.1249.</mixed-citation><mixed-citation xml:lang="en">Jones RL, Ewer MS. Cardiac and cardiovascular toxicity of nonanthracycline anticancer drugs. Expert Rev Anticancer Ther. 2006;6:1249-69. doi:10.1586/14737140.6.9.1249.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Zamorano JL, Lancellotti P, Rodriguez Muñoz D, et al. 2016 ESC position paper on cancer treatment and cardiovascular toxicity developed under the auspices of the ESC committee for practice guidelines. European Heart Journal. 2016;37:2768-801. doi:10.1093/eurheartj/ehw211.</mixed-citation><mixed-citation xml:lang="en">Zamorano JL, Lancellotti P, Rodriguez Muñoz D, et al. 2016 ESC position paper on cancer treatment and cardiovascular toxicity developed under the auspices of the ESC committee for practice guidelines. European Heart Journal. 2016;37:2768-801. doi:10.1093/eurheartj/ehw211.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Jones RL, Swanton C, Ewer MS. Anthracycline cardiotoxicity. Expert Opin Drug Saf. 2006;5(6):791-809. doi:10.1517/14740338.5.6.791.</mixed-citation><mixed-citation xml:lang="en">Jones RL, Swanton C, Ewer MS. Anthracycline cardiotoxicity. Expert Opin Drug Saf. 2006;5(6):791-809. doi:10.1517/14740338.5.6.791.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Казюлин А.Н., Вельшер Л.З., Королева И.А., Кучерявый Ю.А. Кардиотоксичность при проведении химиотерапии онкологических заболеваний. Медицина критических состояний. 2010;1:62-70.</mixed-citation><mixed-citation xml:lang="en">Kazyulin AN, Velsher LZ, Koroleva IA, Kucheryavy YuA. Cardiotoxicity during chemotherapy of oncological diseases. Critical condition medicine. 2010;1:62-70. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Swain SM, Whaley FS, Ewer MS. Congestive heart failure in patients treated with doxorubicin: retrospective analysis of three trials. Cancer. 2003;97(11):2869-79. doi.10.1002/oncr.11407.</mixed-citation><mixed-citation xml:lang="en">Swain SM, Whaley FS, Ewer MS. Congestive heart failure in patients treated with doxorubicin: retrospective analysis of three trials. Cancer. 2003;97(11):2869-79. doi.10.1002/oncr.11407.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Curigliano G, Lenihan D, Fraley M, et al. Management of cardiac diseases in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol. 2020;31(2):171-90. doi:10.1016/j.annonc.2019.10.023.</mixed-citation><mixed-citation xml:lang="en">Curigliano G, Lenihan D, Fraley M, et al. Management of cardiac diseases in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol. 2020;31(2):171-90. doi:10.1016/j.annonc.2019.10.023.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Legha SS, Benjamin RS, Mackay B, et al. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann Intern Med. 1982;96:133-9.</mixed-citation><mixed-citation xml:lang="en">Legha SS, Benjamin RS, Mackay B, et al. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann Intern Med. 1982;96:133-9.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Perez EA, Suman VJ, Davidson NE, et al. Effect of doxorubicin plus cyclophosphamide on left ventricular ejection fraction in patients with breast cancer in the North Central Cancer Treatment Group N9831 Intergroup Adjuvant Trial. J Clin Oncol. 2004;22:3700-4.</mixed-citation><mixed-citation xml:lang="en">Perez EA, Suman VJ, Davidson NE, et al. Effect of doxorubicin plus cyclophosphamide on left ventricular ejection fraction in patients with breast cancer in the North Central Cancer Treatment Group N9831 Intergroup Adjuvant Trial. J Clin Oncol. 2004;22:3700-4.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Mercuro G, Cadeddu C, Piras A, et al. Early epirubicin-induced myocardial dysfunction revealed by serial tissue doppler echocardiography: correlation with inflammatory and oxidative stress markers. Oncologist. 2007;12:1124-33. doi:10.1634/theoncologist.12-9-1124.</mixed-citation><mixed-citation xml:lang="en">Mercuro G, Cadeddu C, Piras A, et al. Early epirubicin-induced myocardial dysfunction revealed by serial tissue doppler echocardiography: correlation with inflammatory and oxidative stress markers. Oncologist. 2007;12:1124-33. doi:10.1634/theoncologist.12-9-1124.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Jones LW, Haykowsky MJ, Swartz JJ, et al. Early breast cancer: therapy and cardiovascular injury. J Am Coll Cardiol. 2007;50:1435-41. doi:10.1016/j.jacc.2007.06.037.</mixed-citation><mixed-citation xml:lang="en">Jones LW, Haykowsky MJ, Swartz JJ, et al. Early breast cancer: therapy and cardiovascular injury. J Am Coll Cardiol. 2007;50:1435-41. doi:10.1016/j.jacc.2007.06.037.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Hequet O, Le QH, Moullet I, et al. Subclinical late cardiomyopathy after doxorubicin therapy for lymphoma in adults. J Clin Oncol. 2004;22:1864-71.</mixed-citation><mixed-citation xml:lang="en">Hequet O, Le QH, Moullet I, et al. Subclinical late cardiomyopathy after doxorubicin therapy for lymphoma in adults. J Clin Oncol. 2004;22:1864-71.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Fumoleau P, Roche H, Kerbrat Р, et al. Long-term cardiac toxicity after adjuvant epirubicinbased chemotherapy in early breast cancer: French Adjuvant Study Group results. Ann Oncol. 2006; 7:85-92. doi:10.1093/annonc/mdj034.</mixed-citation><mixed-citation xml:lang="en">Fumoleau P, Roche H, Kerbrat Р, et al. Long-term cardiac toxicity after adjuvant epirubicinbased chemotherapy in early breast cancer: French Adjuvant Study Group results. Ann Oncol. 2006; 7:85-92. doi:10.1093/annonc/mdj034.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Larsen CM, Mulvagh SL. Cardio-oncology: what you need to know now for clinical practice and echocardiography. Echo Res Prat. 2017;4:1:33-41. doi:10.1530/ERP-17-0013.</mixed-citation><mixed-citation xml:lang="en">Larsen CM, Mulvagh SL. Cardio-oncology: what you need to know now for clinical practice and echocardiography. Echo Res Prat. 2017;4:1:33-41. doi:10.1530/ERP-17-0013.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Lyon A, Dent S, Stanway S, et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society. Eur J Heart Fail. 2020;22(11):1945-60. doi:10.1002/ejhf.1920.</mixed-citation><mixed-citation xml:lang="en">Lyon A, Dent S, Stanway S, et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society. Eur J Heart Fail. 2020;22(11):1945-60. doi:10.1002/ejhf.1920.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Eckel RH, Jakicic JMA, Jesus JM, et al. 2013AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;129 (25Suppl2):S76-99. doi:10.1161/01.cir.0000437740.48606.dl.</mixed-citation><mixed-citation xml:lang="en">Eckel RH, Jakicic JMA, Jesus JM, et al. 2013AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;129 (25Suppl2):S76-99. doi:10.1161/01.cir.0000437740.48606.dl.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Plana J, Galderisi M, Barac A, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. European Heart Journal. Cardiovascular Imaging. 2014;15(10):1063-93. doi:10.1093/ehjci/jeu192.</mixed-citation><mixed-citation xml:lang="en">Plana J, Galderisi M, Barac A, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. European Heart Journal. Cardiovascular Imaging. 2014;15(10):1063-93. doi:10.1093/ehjci/jeu192.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Murbraech K, Wethal T, Smeland KB, et al. Valvular Dysfunction in Lymphoma Survivors Treated With Autologous Stem Cell Transplantation: A National Cross-Sectional Study. JACC Cardiovasc Imaging. 2016;9:230-9. doi:10.1016/j.jcmg.2015.06.028.</mixed-citation><mixed-citation xml:lang="en">Murbraech K, Wethal T, Smeland KB, et al. Valvular Dysfunction in Lymphoma Survivors Treated With Autologous Stem Cell Transplantation: A National Cross-Sectional Study. JACC Cardiovasc Imaging. 2016;9:230-9. doi:10.1016/j.jcmg.2015.06.028.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Epirubicin Hydrochloride for Injection [package insert]. Mayne Pharma Limited Mulgrave, VIC 3170, Australia. 2006.</mixed-citation><mixed-citation xml:lang="en">Epirubicin Hydrochloride for Injection [package insert]. Mayne Pharma Limited Mulgrave, VIC 3170, Australia. 2006.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Cyclophosphamide [package insert]. Baxter Healthcare Corporation Deerfield, IL 60015 USA. 2013.</mixed-citation><mixed-citation xml:lang="en">Cyclophosphamide [package insert]. Baxter Healthcare Corporation Deerfield, IL 60015 USA. 2013.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Quezado ZM, Wilson WH, Cunnion RE, et al. High-dose ifosfamide is associated with severe, reversible cardiac dysfunction. Ann Intern Med. 1993;118:31-6.</mixed-citation><mixed-citation xml:lang="en">Quezado ZM, Wilson WH, Cunnion RE, et al. High-dose ifosfamide is associated with severe, reversible cardiac dysfunction. Ann Intern Med. 1993;118:31-6.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Pai VB, Nahata MC. Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. Drug Saf. 2000;22:263-30.</mixed-citation><mixed-citation xml:lang="en">Pai VB, Nahata MC. Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. Drug Saf. 2000;22:263-30.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Czaykowski PM, Moore MJ, Tannock IF. High risk of vascular events in patients with urothelial transitional cell carcinoma treated with cisplatin based chemotherapy. J Urol. 1998;160:2021-4.</mixed-citation><mixed-citation xml:lang="en">Czaykowski PM, Moore MJ, Tannock IF. High risk of vascular events in patients with urothelial transitional cell carcinoma treated with cisplatin based chemotherapy. J Urol. 1998;160:2021-4.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Yanamandra U, Gupta S, Khadwal A, Malhotra P. Melphalan-induced cardiotoxicity: ventricular arrhythmias. BMJ Case Rep. 2016;2016:bcr2016218652. doi:10.1136/bcr2016-218652.</mixed-citation><mixed-citation xml:lang="en">Yanamandra U, Gupta S, Khadwal A, Malhotra P. Melphalan-induced cardiotoxicity: ventricular arrhythmias. BMJ Case Rep. 2016;2016:bcr2016218652. doi:10.1136/bcr2016-218652.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Meyer CC, Calis KA, Burke LB, et al. Symptomatic cardiotoxicity associated with 5-fluorouracil. Pharmacotherapy. 1997;17:729-36.</mixed-citation><mixed-citation xml:lang="en">Meyer CC, Calis KA, Burke LB, et al. Symptomatic cardiotoxicity associated with 5-fluorouracil. Pharmacotherapy. 1997;17:729-36.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Sasson Z, Morgan CD, Wang B, et al. 5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation. Can J Cardiol. 1994;10:861-4.</mixed-citation><mixed-citation xml:lang="en">Sasson Z, Morgan CD, Wang B, et al. 5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation. Can J Cardiol. 1994;10:861-4.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Killu A, Madhavan M, Prasad K, Prasad A. 5-fluorouracil induced pericarditis. BMJ Case Rep. 2011;2011:bcr0220113883. doi:10.1136/bcr.02.2011.3883.</mixed-citation><mixed-citation xml:lang="en">Killu A, Madhavan M, Prasad K, Prasad A. 5-fluorouracil induced pericarditis. BMJ Case Rep. 2011;2011:bcr0220113883. doi:10.1136/bcr.02.2011.3883.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Van Cutsem E, Hoff PM, Blum JL, et al. Incidence of cardiotoxicity with the oral fluoropyrimidine capecitabine is typical of that reported with 5-fluorouracil. Ann Oncol. 2002;13:484-5.</mixed-citation><mixed-citation xml:lang="en">Van Cutsem E, Hoff PM, Blum JL, et al. Incidence of cardiotoxicity with the oral fluoropyrimidine capecitabine is typical of that reported with 5-fluorouracil. Ann Oncol. 2002;13:484-5.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Hussein MA, Gundacker H, Head DR, et al. Cyclophosphamide followed by fludarabine for untreated chronic lymphocytic leukemia: a phase II SWOG TRIAL 9706. Leukemia 2005;19:1880-6.</mixed-citation><mixed-citation xml:lang="en">Hussein MA, Gundacker H, Head DR, et al. Cyclophosphamide followed by fludarabine for untreated chronic lymphocytic leukemia: a phase II SWOG TRIAL 9706. Leukemia 2005;19:1880-6.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Decitabine (Dacogen) [package insert]. MGI PHARMA, INC., Bloomington, MN 55437. 2006.</mixed-citation><mixed-citation xml:lang="en">Decitabine (Dacogen) [package insert]. MGI PHARMA, INC., Bloomington, MN 55437. 2006.</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Martin M, Pienkowski T, Mackey J, et al. Adjuvant docetaxel for node-positive breast cancer. N Engl J Med. 2005;352:2302-13. doi:10.1056/NEJMoa043681.</mixed-citation><mixed-citation xml:lang="en">Martin M, Pienkowski T, Mackey J, et al. Adjuvant docetaxel for node-positive breast cancer. N Engl J Med. 2005;352:2302-13. doi:10.1056/NEJMoa043681.</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Rowinsky EK, McGuire WP, Guarnieri T, et al. Cardiac disturbances during the administration of taxol. J Clin Oncol. 1991;9:1704-12.</mixed-citation><mixed-citation xml:lang="en">Rowinsky EK, McGuire WP, Guarnieri T, et al. Cardiac disturbances during the administration of taxol. J Clin Oncol. 1991;9:1704-12.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Arbuck SG, Strauss H, Rowinsky E, et al. A reassessment of cardiac toxicity associated with Taxol. J Natl Cancer Inst Monogr. 1993;(15):117-30.</mixed-citation><mixed-citation xml:lang="en">Arbuck SG, Strauss H, Rowinsky E, et al. A reassessment of cardiac toxicity associated with Taxol. J Natl Cancer Inst Monogr. 1993;(15):117-30.</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Subar M, Muggia FM. Apparent myocardial ischemia associated with vinblastine administration. Cancer Treat Rep. 1986;70:690-1.</mixed-citation><mixed-citation xml:lang="en">Subar M, Muggia FM. Apparent myocardial ischemia associated with vinblastine administration. Cancer Treat Rep. 1986;70:690-1.</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Vinblastine [package insert]. Bedford Laboratories, Bedford, Ohio 44146. 2012.</mixed-citation><mixed-citation xml:lang="en">Vinblastine [package insert]. Bedford Laboratories, Bedford, Ohio 44146. 2012.</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Rituximab [package insert]. Genentech, Inc. A Member of the Roche Group,1 DNA Way, South San Francisco, CA. 2010.</mixed-citation><mixed-citation xml:lang="en">Rituximab [package insert]. Genentech, Inc. A Member of the Roche Group,1 DNA Way, South San Francisco, CA. 2010.</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Ofatumumab (Arzerra) [package insert]. GlaxoSmithKline Research Triangle Park, NC 27709. 2009.</mixed-citation><mixed-citation xml:lang="en">Ofatumumab (Arzerra) [package insert]. GlaxoSmithKline Research Triangle Park, NC 27709. 2009.</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Alemtuzumab (Campath) [package insert]. Millennium and ILEX Partners, LP Cambridge, MA 02142. 2001.</mixed-citation><mixed-citation xml:lang="en">Alemtuzumab (Campath) [package insert]. Millennium and ILEX Partners, LP Cambridge, MA 02142. 2001.</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Chen MH, Kerkela R, Force T. Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation. 2008;118(1):84-95. doi:10.1161/CIRCULATIONAHA.108.776831.</mixed-citation><mixed-citation xml:lang="en">Chen MH, Kerkela R, Force T. Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation. 2008;118(1):84-95. doi:10.1161/CIRCULATIONAHA.108.776831.</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Li W, Croce K, Steensma DP, et al. Vascular and Metabolic Implications of Novel Targeted Cancer Therapies: Focus on Kinase Inhibitors. J Am Coll Cardiol. 2015; 66(10):1160-78. doi:10.1016/j.jacc.2015.07.025.</mixed-citation><mixed-citation xml:lang="en">Li W, Croce K, Steensma DP, et al. Vascular and Metabolic Implications of Novel Targeted Cancer Therapies: Focus on Kinase Inhibitors. J Am Coll Cardiol. 2015; 66(10):1160-78. doi:10.1016/j.jacc.2015.07.025.</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">Pertuzumab (Perjeta) [package insert]. Genentech, Inc. A Member of the Roche Group, 1 DNA Way, South San Francisco, CA. 2012.</mixed-citation><mixed-citation xml:lang="en">Pertuzumab (Perjeta) [package insert]. Genentech, Inc. A Member of the Roche Group, 1 DNA Way, South San Francisco, CA. 2012.</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Trastuzumab (Herceptin) [package insert]. Genentech, Inc. 1 DNA Way, South San Francisco, CA. 2010.</mixed-citation><mixed-citation xml:lang="en">Trastuzumab (Herceptin) [package insert]. Genentech, Inc. 1 DNA Way, South San Francisco, CA. 2010.</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344:783-92.</mixed-citation><mixed-citation xml:lang="en">Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344:783-92.</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med. 2012;367(18):1694-703. doi:10.1056/NEJMoa1210093.</mixed-citation><mixed-citation xml:lang="en">Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med. 2012;367(18):1694-703. doi:10.1056/NEJMoa1210093.</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">Bronte E, Bronte G, Novo G et al. What links BRAF to the heart function? New insights from the cardiotoxicity of BRAF inhibitors in cancer treatment. Oncotarget. 2015;6(34):35589- 601. doi:10.18632/oncotarget.5853.</mixed-citation><mixed-citation xml:lang="en">Bronte E, Bronte G, Novo G et al. What links BRAF to the heart function? New insights from the cardiotoxicity of BRAF inhibitors in cancer treatment. Oncotarget. 2015;6(34):35589- 601. doi:10.18632/oncotarget.5853.</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">Moslehi JJ, Deininger M. Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia. J Clin Oncol. 2015;33(35):4210-8. doi:10.1200/JCO.2015.62.4718.</mixed-citation><mixed-citation xml:lang="en">Moslehi JJ, Deininger M. Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia. J Clin Oncol. 2015;33(35):4210-8. doi:10.1200/JCO.2015.62.4718.</mixed-citation></citation-alternatives></ref><ref id="cit117"><label>117</label><citation-alternatives><mixed-citation xml:lang="ru">Perez EA, Koehler M, Byrne J, et al. Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc 2008;83(6):679-86. doi:10.4065/83.6.679.</mixed-citation><mixed-citation xml:lang="en">Perez EA, Koehler M, Byrne J, et al. Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc 2008;83(6):679-86. doi:10.4065/83.6.679.</mixed-citation></citation-alternatives></ref><ref id="cit118"><label>118</label><citation-alternatives><mixed-citation xml:lang="ru">Battisti NML, Tong D, Ring A, Smith I. Long-term outcome with targeted therapy in advanced/metastatic HER2-positive breast cancer: The Royal Marsden experience. Breast Cancer Res Treat. 2019;178(2):401-8. doi:10.1007/s10549-019-05406-6.</mixed-citation><mixed-citation xml:lang="en">Battisti NML, Tong D, Ring A, Smith I. Long-term outcome with targeted therapy in advanced/metastatic HER2-positive breast cancer: The Royal Marsden experience. Breast Cancer Res Treat. 2019;178(2):401-8. doi:10.1007/s10549-019-05406-6.</mixed-citation></citation-alternatives></ref><ref id="cit119"><label>119</label><citation-alternatives><mixed-citation xml:lang="ru">Motzer RJ, Hutson TE, Cella D, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med. 2013;22;369(8):722-31. doi:10.1056/NEJMoa1303989.</mixed-citation><mixed-citation xml:lang="en">Motzer RJ, Hutson TE, Cella D, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med. 2013;22;369(8):722-31. doi:10.1056/NEJMoa1303989.</mixed-citation></citation-alternatives></ref><ref id="cit120"><label>120</label><citation-alternatives><mixed-citation xml:lang="ru">Cortes JE, Kim DW, Pinilla-Ibarz J, et al. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med. 2013;369(19):1783-96. doi:10.1056/NEJMoa1306494.</mixed-citation><mixed-citation xml:lang="en">Cortes JE, Kim DW, Pinilla-Ibarz J, et al. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med. 2013;369(19):1783-96. doi:10.1056/NEJMoa1306494.</mixed-citation></citation-alternatives></ref><ref id="cit121"><label>121</label><citation-alternatives><mixed-citation xml:lang="ru">Sudasena D, Balanescu DV, Donisan T, et al. Fulminant Vascular and Cardiac Toxicity Associated with Tyrosine Kinase Inhibitor Sorafenib. Cardiovasc Toxicol. 2019;19(4):382-7. doi:10.1007/s12012-018-9499-2.</mixed-citation><mixed-citation xml:lang="en">Sudasena D, Balanescu DV, Donisan T, et al. Fulminant Vascular and Cardiac Toxicity Associated with Tyrosine Kinase Inhibitor Sorafenib. Cardiovasc Toxicol. 2019;19(4):382-7. doi:10.1007/s12012-018-9499-2.</mixed-citation></citation-alternatives></ref><ref id="cit122"><label>122</label><citation-alternatives><mixed-citation xml:lang="ru">Abdel-Rahman O, Fouad M. Risk of cardiovascular toxicities in patients with solid tumors treated with sorafenib: an updated systematic review and meta-analysis. Future Oncol. 2014;10(12):1981-92. doi:10.2217/fon.14.42.</mixed-citation><mixed-citation xml:lang="en">Abdel-Rahman O, Fouad M. Risk of cardiovascular toxicities in patients with solid tumors treated with sorafenib: an updated systematic review and meta-analysis. Future Oncol. 2014;10(12):1981-92. doi:10.2217/fon.14.42.</mixed-citation></citation-alternatives></ref><ref id="cit123"><label>123</label><citation-alternatives><mixed-citation xml:lang="ru">Pantaleo MA, Mandrioli A, Saponara M, et al. Development of coronary artery stenosis in a patient with metastatic renal cell carcinoma treated with sorafenib. BMC Cancer. 2012;12:231. doi:10.1186/1471-2407-12-231.</mixed-citation><mixed-citation xml:lang="en">Pantaleo MA, Mandrioli A, Saponara M, et al. Development of coronary artery stenosis in a patient with metastatic renal cell carcinoma treated with sorafenib. BMC Cancer. 2012;12:231. doi:10.1186/1471-2407-12-231.</mixed-citation></citation-alternatives></ref><ref id="cit124"><label>124</label><citation-alternatives><mixed-citation xml:lang="ru">Flaherty KT, Robert C, Hersey P, et al. Improved survival with MEK inhibition in BRAFmutated melanoma. N Engl J Med. 2012;367(2):107-14. doi:10.1056/NEJMoa1203421.</mixed-citation><mixed-citation xml:lang="en">Flaherty KT, Robert C, Hersey P, et al. Improved survival with MEK inhibition in BRAFmutated melanoma. N Engl J Med. 2012;367(2):107-14. doi:10.1056/NEJMoa1203421.</mixed-citation></citation-alternatives></ref><ref id="cit125"><label>125</label><citation-alternatives><mixed-citation xml:lang="ru">Axitinib (Inlyta) [package insert]. Pfizer Labs, Division of Pfizer Inc, New York, NY 10017, USA. 2012.</mixed-citation><mixed-citation xml:lang="en">Axitinib (Inlyta) [package insert]. Pfizer Labs, Division of Pfizer Inc, New York, NY 10017, USA. 2012.</mixed-citation></citation-alternatives></ref><ref id="cit126"><label>126</label><citation-alternatives><mixed-citation xml:lang="ru">Nilotinib (Tasigna) [package insert]. Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936, USA. 2010.</mixed-citation><mixed-citation xml:lang="en">Nilotinib (Tasigna) [package insert]. Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936, USA. 2010.</mixed-citation></citation-alternatives></ref><ref id="cit127"><label>127</label><citation-alternatives><mixed-citation xml:lang="ru">Ibrutinib (Ibruvica) [package insert]. Pharmacyclics, Inc. Sunnyvale, CA USA 94085, 2015.</mixed-citation><mixed-citation xml:lang="en">Ibrutinib (Ibruvica) [package insert]. Pharmacyclics, Inc. Sunnyvale, CA USA 94085, 2015.</mixed-citation></citation-alternatives></ref><ref id="cit128"><label>128</label><citation-alternatives><mixed-citation xml:lang="ru">Ganatra S, Majithia A, Shah S. Challenges in ibrutinib associated atrial fibrillation. J Am Coll Cardiol. 2017;11:2308.</mixed-citation><mixed-citation xml:lang="en">Ganatra S, Majithia A, Shah S. Challenges in ibrutinib associated atrial fibrillation. J Am Coll Cardiol. 2017;11:2308.</mixed-citation></citation-alternatives></ref><ref id="cit129"><label>129</label><citation-alternatives><mixed-citation xml:lang="ru">Santoni M, Guerra F, Conti A, et al. Incidence and risk of cardiotoxicity in cancer patients treated with targeted therapies. Cancer Treat Rev. 2017;59:123-31. doi:10.1016/j.ctrv.2017.07.006.</mixed-citation><mixed-citation xml:lang="en">Santoni M, Guerra F, Conti A, et al. Incidence and risk of cardiotoxicity in cancer patients treated with targeted therapies. Cancer Treat Rev. 2017;59:123-31. doi:10.1016/j.ctrv.2017.07.006.</mixed-citation></citation-alternatives></ref><ref id="cit130"><label>130</label><citation-alternatives><mixed-citation xml:lang="ru">Regorafenib (Stivarga) [package insert]. Bayer HealthCare Pharmaceuticals Inc., Wayne, NJ 07470, USA. 2012.</mixed-citation><mixed-citation xml:lang="en">Regorafenib (Stivarga) [package insert]. Bayer HealthCare Pharmaceuticals Inc., Wayne, NJ 07470, USA. 2012.</mixed-citation></citation-alternatives></ref><ref id="cit131"><label>131</label><citation-alternatives><mixed-citation xml:lang="ru">Imatinib [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. 2001.</mixed-citation><mixed-citation xml:lang="en">Imatinib [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. 2001.</mixed-citation></citation-alternatives></ref><ref id="cit132"><label>132</label><citation-alternatives><mixed-citation xml:lang="ru">Ziv-aflibercept (Zaltrap) [package insert]. Sanofi-aventis U.S. LLC, Bridgewater, NJ 08807, USA. 2012.</mixed-citation><mixed-citation xml:lang="en">Ziv-aflibercept (Zaltrap) [package insert]. Sanofi-aventis U.S. LLC, Bridgewater, NJ 08807, USA. 2012.</mixed-citation></citation-alternatives></ref><ref id="cit133"><label>133</label><citation-alternatives><mixed-citation xml:lang="ru">Cabozantinib (Cambometyx) [package insert]. Exelixis, Inc. South San Francisco, CA 94080 USA. 2016.</mixed-citation><mixed-citation xml:lang="en">Cabozantinib (Cambometyx) [package insert]. Exelixis, Inc. South San Francisco, CA 94080 USA. 2016.</mixed-citation></citation-alternatives></ref><ref id="cit134"><label>134</label><citation-alternatives><mixed-citation xml:lang="ru">Mak IT, Kramer JH, Chmielinska JJ, et al. EGFR-TKI, erlotinib, causes hypomagnesemia, oxidative stress, and cardiac dysfunction: attenuation by NK-1 receptor blockade. J Cardiovasc Pharmacol. 2015;65:54-61. doi:10.1097/FJC.0000000000000163.</mixed-citation><mixed-citation xml:lang="en">Mak IT, Kramer JH, Chmielinska JJ, et al. EGFR-TKI, erlotinib, causes hypomagnesemia, oxidative stress, and cardiac dysfunction: attenuation by NK-1 receptor blockade. J Cardiovasc Pharmacol. 2015;65:54-61. doi:10.1097/FJC.0000000000000163.</mixed-citation></citation-alternatives></ref><ref id="cit135"><label>135</label><citation-alternatives><mixed-citation xml:lang="ru">Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960-6. doi:10.1200/JCO.2006.07.9525.</mixed-citation><mixed-citation xml:lang="en">Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960-6. doi:10.1200/JCO.2006.07.9525.</mixed-citation></citation-alternatives></ref><ref id="cit136"><label>136</label><citation-alternatives><mixed-citation xml:lang="ru">Erlotinib (Tarceva) [package insert]. OSI Pharmaceuticals Inc., Melville, NY 11747, USA. 2010.</mixed-citation><mixed-citation xml:lang="en">Erlotinib (Tarceva) [package insert]. OSI Pharmaceuticals Inc., Melville, NY 11747, USA. 2010.</mixed-citation></citation-alternatives></ref><ref id="cit137"><label>137</label><citation-alternatives><mixed-citation xml:lang="ru">Tang XM, Chen H, Liu Y et al. The cardiotoxicity of cetuximab as single therapy in Chinese chemotherapy-refractory metastatic colorectal cancer patients. Medicine (Baltimore). 2017;96:e5946. doi:10.1097/MD.0000000000005946.</mixed-citation><mixed-citation xml:lang="en">Tang XM, Chen H, Liu Y et al. The cardiotoxicity of cetuximab as single therapy in Chinese chemotherapy-refractory metastatic colorectal cancer patients. Medicine (Baltimore). 2017;96:e5946. doi:10.1097/MD.0000000000005946.</mixed-citation></citation-alternatives></ref><ref id="cit138"><label>138</label><citation-alternatives><mixed-citation xml:lang="ru">Ceritinib (Zykadia) [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. 2017.</mixed-citation><mixed-citation xml:lang="en">Ceritinib (Zykadia) [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. 2017.</mixed-citation></citation-alternatives></ref><ref id="cit139"><label>139</label><citation-alternatives><mixed-citation xml:lang="ru">Crizotinib (Xalkori) [package insert]. Pfizer Labs, Division of Pfizer Inc, New York, NY 10017, USA 2012.</mixed-citation><mixed-citation xml:lang="en">Crizotinib (Xalkori) [package insert]. Pfizer Labs, Division of Pfizer Inc, New York, NY 10017, USA 2012.</mixed-citation></citation-alternatives></ref><ref id="cit140"><label>140</label><citation-alternatives><mixed-citation xml:lang="ru">Vemurafenib (Zelboraf) [package insert]. Genentech USA, Inc., A Member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA. 2016.</mixed-citation><mixed-citation xml:lang="en">Vemurafenib (Zelboraf) [package insert]. Genentech USA, Inc., A Member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA. 2016.</mixed-citation></citation-alternatives></ref><ref id="cit141"><label>141</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson DB, Balko JM, Compton ML et al. Fulminant Myocarditis with Combination Immune Checkpoint Blockade. N Engl J Med. 2016;375:1749-55. doi:10.1056/NEJMoa1609214.</mixed-citation><mixed-citation xml:lang="en">Johnson DB, Balko JM, Compton ML et al. Fulminant Myocarditis with Combination Immune Checkpoint Blockade. N Engl J Med. 2016;375:1749-55. doi:10.1056/NEJMoa1609214.</mixed-citation></citation-alternatives></ref><ref id="cit142"><label>142</label><citation-alternatives><mixed-citation xml:lang="ru">Mahmood SS, Fradely MG, Cohen JV, et al. Myocarditis in patients treated with immune checkpoint inhibitors. J Am Coll Cardiol. 2018;71(16):1755-64. doi:10.1016/j.jacc.2018.02.037.</mixed-citation><mixed-citation xml:lang="en">Mahmood SS, Fradely MG, Cohen JV, et al. Myocarditis in patients treated with immune checkpoint inhibitors. J Am Coll Cardiol. 2018;71(16):1755-64. doi:10.1016/j.jacc.2018.02.037.</mixed-citation></citation-alternatives></ref><ref id="cit143"><label>143</label><citation-alternatives><mixed-citation xml:lang="ru">Ganatra S, Neilan TG. Immune Checkpoint Inhibitor Associated Myocarditis. Oncologist. 2018 Aug;23(8):879-86. doi:10.1634/theoncologist.2018-0130.</mixed-citation><mixed-citation xml:lang="en">Ganatra S, Neilan TG. Immune Checkpoint Inhibitor Associated Myocarditis. Oncologist. 2018 Aug;23(8):879-86. doi:10.1634/theoncologist.2018-0130.</mixed-citation></citation-alternatives></ref><ref id="cit144"><label>144</label><citation-alternatives><mixed-citation xml:lang="ru">Bortezomib [package insert]. Millennium Pharmaceuticals Inc., 40 Landsdowne Street, Cambridge, MA 02139, USA. 2014.</mixed-citation><mixed-citation xml:lang="en">Bortezomib [package insert]. Millennium Pharmaceuticals Inc., 40 Landsdowne Street, Cambridge, MA 02139, USA. 2014.</mixed-citation></citation-alternatives></ref><ref id="cit145"><label>145</label><citation-alternatives><mixed-citation xml:lang="ru">Zangari M, Fink L, Zhan F, Tricot G. Low venous thromboembolic risk with bortezomib in multiple myeloma and potential protective effect with thalidomide/lenalidomide-based therapy: review of data from phase 3 trials and studies of novel combination regimens. Clin Lymphoma Myeloma Leuk. 2011;11:228-36. doi:10.1016/j.clml.2011.03.006.</mixed-citation><mixed-citation xml:lang="en">Zangari M, Fink L, Zhan F, Tricot G. Low venous thromboembolic risk with bortezomib in multiple myeloma and potential protective effect with thalidomide/lenalidomide-based therapy: review of data from phase 3 trials and studies of novel combination regimens. Clin Lymphoma Myeloma Leuk. 2011;11:228-36. doi:10.1016/j.clml.2011.03.006.</mixed-citation></citation-alternatives></ref><ref id="cit146"><label>146</label><citation-alternatives><mixed-citation xml:lang="ru">Siegel D, Martin T, Nooka A et al. Integrated safety profile of single-agent carfilzomib: experience from 526 patients enrolled in 4 phase II clinical studies. Haematologica. 2013;98:1753-61. doi:10.3324/haematol.2013.089334.</mixed-citation><mixed-citation xml:lang="en">Siegel D, Martin T, Nooka A et al. Integrated safety profile of single-agent carfilzomib: experience from 526 patients enrolled in 4 phase II clinical studies. Haematologica. 2013;98:1753-61. doi:10.3324/haematol.2013.089334.</mixed-citation></citation-alternatives></ref><ref id="cit147"><label>147</label><citation-alternatives><mixed-citation xml:lang="ru">Stewart AK, Rajkumar SV, Dimopoulos MA, et al. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. N Engl J Med. 2015;372:142-52. doi:10.1056/NEJMoa1411321.</mixed-citation><mixed-citation xml:lang="en">Stewart AK, Rajkumar SV, Dimopoulos MA, et al. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. N Engl J Med. 2015;372:142-52. doi:10.1056/NEJMoa1411321.</mixed-citation></citation-alternatives></ref><ref id="cit148"><label>148</label><citation-alternatives><mixed-citation xml:lang="ru">Everolimus [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA 2010.</mixed-citation><mixed-citation xml:lang="en">Everolimus [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA 2010.</mixed-citation></citation-alternatives></ref><ref id="cit149"><label>149</label><citation-alternatives><mixed-citation xml:lang="ru">Temsirolimus (Torisel) [package insert]. Wyeth Pharmaceuticals Inc, Philadelphia, PA 19101, USA. 2015.</mixed-citation><mixed-citation xml:lang="en">Temsirolimus (Torisel) [package insert]. Wyeth Pharmaceuticals Inc, Philadelphia, PA 19101, USA. 2015.</mixed-citation></citation-alternatives></ref><ref id="cit150"><label>150</label><citation-alternatives><mixed-citation xml:lang="ru">Lenalidomide (Revlimid) [package insert]. Celgene Corporation, Summit, NJ 07901, USA. 2017.</mixed-citation><mixed-citation xml:lang="en">Lenalidomide (Revlimid) [package insert]. Celgene Corporation, Summit, NJ 07901, USA. 2017.</mixed-citation></citation-alternatives></ref><ref id="cit151"><label>151</label><citation-alternatives><mixed-citation xml:lang="ru">Thalidomide [package insert]. In. Summit, NJ 07901, USA: Celgene Corporation 2014.</mixed-citation><mixed-citation xml:lang="en">Thalidomide [package insert]. In. Summit, NJ 07901, USA: Celgene Corporation 2014.</mixed-citation></citation-alternatives></ref><ref id="cit152"><label>152</label><citation-alternatives><mixed-citation xml:lang="ru">Pomalidomide [package insert]. Celgene Corporation, Summit, NJ 07901, USA. 2013.</mixed-citation><mixed-citation xml:lang="en">Pomalidomide [package insert]. Celgene Corporation, Summit, NJ 07901, USA. 2013.</mixed-citation></citation-alternatives></ref><ref id="cit153"><label>153</label><citation-alternatives><mixed-citation xml:lang="ru">Mann BS, Johnson JR, Cohen MH et al. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist. 2007;12:1247-52. doi:10.1634/theoncologist.12-10-1247.</mixed-citation><mixed-citation xml:lang="en">Mann BS, Johnson JR, Cohen MH et al. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist. 2007;12:1247-52. doi:10.1634/theoncologist.12-10-1247.</mixed-citation></citation-alternatives></ref><ref id="cit154"><label>154</label><citation-alternatives><mixed-citation xml:lang="ru">Belinostat (Beleodaq) [package insert]. Spectrum Pharmaceuticals, Inc., Irvine, CA 92618, USA. 2014.</mixed-citation><mixed-citation xml:lang="en">Belinostat (Beleodaq) [package insert]. Spectrum Pharmaceuticals, Inc., Irvine, CA 92618, USA. 2014.</mixed-citation></citation-alternatives></ref><ref id="cit155"><label>155</label><citation-alternatives><mixed-citation xml:lang="ru">Tamoxifen [package insert]. In. Wilmington, Delaware 19850, USA: AstraZeneca Pharmaceuticals LP 2004.</mixed-citation><mixed-citation xml:lang="en">Tamoxifen [package insert]. In. Wilmington, Delaware 19850, USA: AstraZeneca Pharmaceuticals LP 2004.</mixed-citation></citation-alternatives></ref><ref id="cit156"><label>156</label><citation-alternatives><mixed-citation xml:lang="ru">Toremifene [package insert]. In. Mephis, TN 38103, USA: GTx, Inc. 2011.</mixed-citation><mixed-citation xml:lang="en">Toremifene [package insert]. In. Mephis, TN 38103, USA: GTx, Inc. 2011.</mixed-citation></citation-alternatives></ref><ref id="cit157"><label>157</label><citation-alternatives><mixed-citation xml:lang="ru">Anastrozole (Arimidex) [package insert]. In. Wilmington, DE 19850, USA: AstraZeneca Pharmaceuticals LP 2009.</mixed-citation><mixed-citation xml:lang="en">Anastrozole (Arimidex) [package insert]. In. Wilmington, DE 19850, USA: AstraZeneca Pharmaceuticals LP 2009.</mixed-citation></citation-alternatives></ref><ref id="cit158"><label>158</label><citation-alternatives><mixed-citation xml:lang="ru">Letrozole (femara) [package insert]. In. East Hanover, New Jersey, 07936, USA: Novartis Pharmaceuticals Corporation 2014.</mixed-citation><mixed-citation xml:lang="en">Letrozole (femara) [package insert]. In. East Hanover, New Jersey, 07936, USA: Novartis Pharmaceuticals Corporation 2014.</mixed-citation></citation-alternatives></ref><ref id="cit159"><label>159</label><citation-alternatives><mixed-citation xml:lang="ru">Exemestane (Aromasin) [package insert]. In. NY 10017, USA: Pharmacia &amp; Upjohn Co., Division of Pfizer Inc, NY 2011.</mixed-citation><mixed-citation xml:lang="en">Exemestane (Aromasin) [package insert]. In. NY 10017, USA: Pharmacia &amp; Upjohn Co., Division of Pfizer Inc, NY 2011.</mixed-citation></citation-alternatives></ref><ref id="cit160"><label>160</label><citation-alternatives><mixed-citation xml:lang="ru">Goserelin (Zoladex) [package insert]. In. Wilmington, DE 19850, USA: AstraZeneca Pharmaceuticals LP 2015.</mixed-citation><mixed-citation xml:lang="en">Goserelin (Zoladex) [package insert]. In. Wilmington, DE 19850, USA: AstraZeneca Pharmaceuticals LP 2015.</mixed-citation></citation-alternatives></ref><ref id="cit161"><label>161</label><citation-alternatives><mixed-citation xml:lang="ru">Leuprolide (Lupron) [package insert]. In. North Chicago, IL 60064, USA: AbbVie Inc. 2014.</mixed-citation><mixed-citation xml:lang="en">Leuprolide (Lupron) [package insert]. In. North Chicago, IL 60064, USA: AbbVie Inc. 2014.</mixed-citation></citation-alternatives></ref><ref id="cit162"><label>162</label><citation-alternatives><mixed-citation xml:lang="ru">Flutamide [package insert]. Schering Corp., Kenilworth, NJ 07033, USA. 2001.</mixed-citation><mixed-citation xml:lang="en">Flutamide [package insert]. Schering Corp., Kenilworth, NJ 07033, USA. 2001.</mixed-citation></citation-alternatives></ref><ref id="cit163"><label>163</label><citation-alternatives><mixed-citation xml:lang="ru">Bicalutamide [package insert]. AstraZeneca Pharmaceuticals LP, Wilmington, DE 19850, USA. 2015.</mixed-citation><mixed-citation xml:lang="en">Bicalutamide [package insert]. AstraZeneca Pharmaceuticals LP, Wilmington, DE 19850, USA. 2015.</mixed-citation></citation-alternatives></ref><ref id="cit164"><label>164</label><citation-alternatives><mixed-citation xml:lang="ru">Nilutamide [package insert]. ANI Pharmaceuticals, Inc., Baudette, MN 56623, USA. 2015.</mixed-citation><mixed-citation xml:lang="en">Nilutamide [package insert]. ANI Pharmaceuticals, Inc., Baudette, MN 56623, USA. 2015.</mixed-citation></citation-alternatives></ref><ref id="cit165"><label>165</label><citation-alternatives><mixed-citation xml:lang="ru">Tisagenlecleucel (Kymriah) [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. 2017.</mixed-citation><mixed-citation xml:lang="en">Tisagenlecleucel (Kymriah) [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. 2017.</mixed-citation></citation-alternatives></ref><ref id="cit166"><label>166</label><citation-alternatives><mixed-citation xml:lang="ru">Axicabtagene ciloleucel (Yescarta) [package insert]. Kite Pharma, Inc., Santa Monica, CA 90404, USA. 2017.</mixed-citation><mixed-citation xml:lang="en">Axicabtagene ciloleucel (Yescarta) [package insert]. Kite Pharma, Inc., Santa Monica, CA 90404, USA. 2017.</mixed-citation></citation-alternatives></ref><ref id="cit167"><label>167</label><citation-alternatives><mixed-citation xml:lang="ru">Ribociclib (Kisqali) [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. 2017.</mixed-citation><mixed-citation xml:lang="en">Ribociclib (Kisqali) [package insert]. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. 2017.</mixed-citation></citation-alternatives></ref><ref id="cit168"><label>168</label><citation-alternatives><mixed-citation xml:lang="ru">Didagelos M, Boutis A, Diamantopoulos N, et al. Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor. Hippokratia. 2013;17:187-8.</mixed-citation><mixed-citation xml:lang="en">Didagelos M, Boutis A, Diamantopoulos N, et al. Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor. Hippokratia. 2013;17:187-8.</mixed-citation></citation-alternatives></ref><ref id="cit169"><label>169</label><citation-alternatives><mixed-citation xml:lang="ru">Vogelzang NJ, Frenning DH, Kennedy BJ. Coronary artery disease after treatment with bleomycin and vinblastine. Cancer Treat Rep. 1980;64:1159-60.</mixed-citation><mixed-citation xml:lang="en">Vogelzang NJ, Frenning DH, Kennedy BJ. Coronary artery disease after treatment with bleomycin and vinblastine. Cancer Treat Rep. 1980;64:1159-60.</mixed-citation></citation-alternatives></ref><ref id="cit170"><label>170</label><citation-alternatives><mixed-citation xml:lang="ru">Simbre IV, Adams MJ, Deshpande SS, et al. Cardiomyopathy Caused by Antineoplastic Therapies. Curr Treat Options Cardiovasc Med. 2001;3:93-505.</mixed-citation><mixed-citation xml:lang="en">Simbre IV, Adams MJ, Deshpande SS, et al. Cardiomyopathy Caused by Antineoplastic Therapies. Curr Treat Options Cardiovasc Med. 2001;3:93-505.</mixed-citation></citation-alternatives></ref><ref id="cit171"><label>171</label><citation-alternatives><mixed-citation xml:lang="ru">Kathirgamanathan K, Angaran P, Lazo-Langner A, Gula LJ. Cardiac conduction block at multiple levels caused by arsenic trioxide therapy. Can J Cardiol. 2013;29:130.e5-6. doi:10.1016/j.cjca.2012.04.004.</mixed-citation><mixed-citation xml:lang="en">Kathirgamanathan K, Angaran P, Lazo-Langner A, Gula LJ. Cardiac conduction block at multiple levels caused by arsenic trioxide therapy. Can J Cardiol. 2013;29:130.e5-6. doi:10.1016/j.cjca.2012.04.004.</mixed-citation></citation-alternatives></ref><ref id="cit172"><label>172</label><citation-alternatives><mixed-citation xml:lang="ru">Popat S, Smith IE. Therapy insight: anthracyclines and trastuzumab-the optimal managemtnt of cardiotoxic side effects. Nat.Clin.Prac. Oncol. 2008;5:6,324-35. doi:101038/ncponc1090.</mixed-citation><mixed-citation xml:lang="en">Popat S, Smith IE. Therapy insight: anthracyclines and trastuzumab-the optimal managemtnt of cardiotoxic side effects. Nat.Clin.Prac. Oncol. 2008;5:6,324-35. doi:101038/ncponc1090.</mixed-citation></citation-alternatives></ref><ref id="cit173"><label>173</label><citation-alternatives><mixed-citation xml:lang="ru">McGovan JV, Chung R, Mauluk A, et al. Anthracycline Chemotherapy and Cardiotoxicity. Cardiovasc Drugs Ther. 2017;31(1):63-75. doi:10107/s10557-16-6711-0.</mixed-citation><mixed-citation xml:lang="en">McGovan JV, Chung R, Mauluk A, et al. Anthracycline Chemotherapy and Cardiotoxicity. Cardiovasc Drugs Ther. 2017;31(1):63-75. doi:10107/s10557-16-6711-0.</mixed-citation></citation-alternatives></ref><ref id="cit174"><label>174</label><citation-alternatives><mixed-citation xml:lang="ru">Mousavi N, Tan TC, Ali M, et al. Echocardiographic parameters of left ventricular size and function as predictors of symptomatic heart failure in patients with a left ventricular ejection fraction of 50-59% treated with anthracyclines. Eur Heart J Cardiovasc Imaging. 2015;16(9):977-84. doi:10.1093/ehjci/jev113.</mixed-citation><mixed-citation xml:lang="en">Mousavi N, Tan TC, Ali M, et al. Echocardiographic parameters of left ventricular size and function as predictors of symptomatic heart failure in patients with a left ventricular ejection fraction of 50-59% treated with anthracyclines. Eur Heart J Cardiovasc Imaging. 2015;16(9):977-84. doi:10.1093/ehjci/jev113.</mixed-citation></citation-alternatives></ref><ref id="cit175"><label>175</label><citation-alternatives><mixed-citation xml:lang="ru">Fei HW, Ali MT, Tan TC, et al. Left Ventricular Global Longitudinal Strain in HER-2 + Breast Cancer Patients Treated with Anthracyclines and Trastuzumab Who Develop Cardiotoxicity Is Associated with Subsequent Recovery of Left Ventricular Ejection Fraction. Echocardiography. 2016;33(4):519-26. doi:10.1111/echo.13168.</mixed-citation><mixed-citation xml:lang="en">Fei HW, Ali MT, Tan TC, et al. Left Ventricular Global Longitudinal Strain in HER-2 + Breast Cancer Patients Treated with Anthracyclines and Trastuzumab Who Develop Cardiotoxicity Is Associated with Subsequent Recovery of Left Ventricular Ejection Fraction. Echocardiography. 2016;33(4):519-26. doi:10.1111/echo.13168.</mixed-citation></citation-alternatives></ref><ref id="cit176"><label>176</label><citation-alternatives><mixed-citation xml:lang="ru">Васюк Ю.А., Ющук Е.Н., Несветов В.В. Кардиоонкология: новый вызов нашего времени. Сердечно-сосудистые осложнения противоопухолевого лечения. М.: Клинмедконсалтинг; 2019. c. 100.</mixed-citation><mixed-citation xml:lang="en">Vasyuk YuA, Yushchuk EN, Nesvetov VV. Cardioncology: a new challenge of our time. Cardiovascular complications of antitumor treatment. M.: Klinmedconsulting; 2019. p. 100. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit177"><label>177</label><citation-alternatives><mixed-citation xml:lang="ru">Lange SA, Jung J, Jaeck A, et al. Subclinical Myocardial Impairment Occurred in Septal and Anterior LV Wall Segments After Anthracycline Embedded Chemotherapy and did not Worsen During Adjuvant Trastuzumab Treatment in Breast Cancer Patients. Cardiovasc Toxicol. 2016;16(2):193-206. doi:10.1007/s12012-015-9328-9.</mixed-citation><mixed-citation xml:lang="en">Lange SA, Jung J, Jaeck A, et al. Subclinical Myocardial Impairment Occurred in Septal and Anterior LV Wall Segments After Anthracycline Embedded Chemotherapy and did not Worsen During Adjuvant Trastuzumab Treatment in Breast Cancer Patients. Cardiovasc Toxicol. 2016;16(2):193-206. doi:10.1007/s12012-015-9328-9.</mixed-citation></citation-alternatives></ref><ref id="cit178"><label>178</label><citation-alternatives><mixed-citation xml:lang="ru">Boyd A, Stoodley P, Richards D, et al. Anthracyclines induce early changes in left ventricular systolic and diastolic function: A single centre study. PLoS One. 2017;13;12(4):e0175544. doi:10.1371/journal.pone.0175544.</mixed-citation><mixed-citation xml:lang="en">Boyd A, Stoodley P, Richards D, et al. Anthracyclines induce early changes in left ventricular systolic and diastolic function: A single centre study. PLoS One. 2017;13;12(4):e0175544. doi:10.1371/journal.pone.0175544.</mixed-citation></citation-alternatives></ref><ref id="cit179"><label>179</label><citation-alternatives><mixed-citation xml:lang="ru">Ho E, Brown A, Barrett P, et al. Subclinical anthracycline and trastuzumab-induced cardiotoxicity in the long-term follow-up of asymptomatic breast cancer survivors: a speckle tracking echocardiographic study. Heart. 2010;96(9):701-7. doi:10.1136/hrt.2009.173997.</mixed-citation><mixed-citation xml:lang="en">Ho E, Brown A, Barrett P, et al. Subclinical anthracycline and trastuzumab-induced cardiotoxicity in the long-term follow-up of asymptomatic breast cancer survivors: a speckle tracking echocardiographic study. Heart. 2010;96(9):701-7. doi:10.1136/hrt.2009.173997.</mixed-citation></citation-alternatives></ref><ref id="cit180"><label>180</label><citation-alternatives><mixed-citation xml:lang="ru">Serrano JM, González I, Del Castillo S, et al. Diastolic Dysfunction Following AnthracyclineBased Chemotherapy in Breast Cancer Patients: Incidence and Predictors. Oncologist. 2015;20(8):864-72. doi:10.1634/theoncologist.2014-0500.</mixed-citation><mixed-citation xml:lang="en">Serrano JM, González I, Del Castillo S, et al. Diastolic Dysfunction Following AnthracyclineBased Chemotherapy in Breast Cancer Patients: Incidence and Predictors. Oncologist. 2015;20(8):864-72. doi:10.1634/theoncologist.2014-0500.</mixed-citation></citation-alternatives></ref><ref id="cit181"><label>181</label><citation-alternatives><mixed-citation xml:lang="ru">Yu AF, Ho AY, Braunstein LZ, et al. Assessment of Early Radiation-Induced Changes in Left Ventricular Function by Myocardial Strain Imaging After Breast Radiation Therapy. J Am Soc Echocardiogr. 2019;32(4):521-8. doi:10.1016/j.echo.2018.12.009.</mixed-citation><mixed-citation xml:lang="en">Yu AF, Ho AY, Braunstein LZ, et al. Assessment of Early Radiation-Induced Changes in Left Ventricular Function by Myocardial Strain Imaging After Breast Radiation Therapy. J Am Soc Echocardiogr. 2019;32(4):521-8. doi:10.1016/j.echo.2018.12.009.</mixed-citation></citation-alternatives></ref><ref id="cit182"><label>182</label><citation-alternatives><mixed-citation xml:lang="ru">Вельшер Л.З., Казюлин А.Н., Королева А.Н. Кардиотоксичность при химиотерапии рака молочной железы по данным ретроспективного мультицентрового “случай-контроль” исследования. Вестник хирургии им. И.И. Грекова. 2010;169(4):17-21.</mixed-citation><mixed-citation xml:lang="en">Welsher LZ, Kazyulin AN, Koroleva AN. Cardiotoxicity in breast cancer chemotherapy according to the data of a retrospective multicenter “case-control” study. Bulletin of Surgery named after I.I. Grekov. 2010;169(4):17-21. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit183"><label>183</label><citation-alternatives><mixed-citation xml:lang="ru">Song L, Brezden-Masley C, Ramanan V, et al. Serial Measurements of Left Ventricular Systolic and Diastolic Function by Cardiac Magnetic Resonance Imaging in Patients with Early Stage Breast Cancer on Trastuzumab. Am J Cardiol. 2019;1;123(7):1173-9. doi:10.1016/j.amjcard.2018.12.046.</mixed-citation><mixed-citation xml:lang="en">Song L, Brezden-Masley C, Ramanan V, et al. Serial Measurements of Left Ventricular Systolic and Diastolic Function by Cardiac Magnetic Resonance Imaging in Patients with Early Stage Breast Cancer on Trastuzumab. Am J Cardiol. 2019;1;123(7):1173-9. doi:10.1016/j.amjcard.2018.12.046.</mixed-citation></citation-alternatives></ref><ref id="cit184"><label>184</label><citation-alternatives><mixed-citation xml:lang="ru">Lancellotti PN, Komo VT, Badano LP, et al. 2013 Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr. 2013;26(9):1013-32. doi:10.1016/j.echo.2013.07.005. Erratum in: J Am Soc Echocardiogr. 2013;26(11):1305.</mixed-citation><mixed-citation xml:lang="en">Lancellotti PN, Komo VT, Badano LP, et al. 2013 Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr. 2013;26(9):1013-32. doi:10.1016/j.echo.2013.07.005. Erratum in: J Am Soc Echocardiogr. 2013;26(11):1305.</mixed-citation></citation-alternatives></ref><ref id="cit185"><label>185</label><citation-alternatives><mixed-citation xml:lang="ru">Cardinale D, Colombo A, Lamantia G, et al. Anthracycline-induced cardiomyopathy clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol. 2010;55:213-20. doi:10.1016/j.jacc.2009.03.095.</mixed-citation><mixed-citation xml:lang="en">Cardinale D, Colombo A, Lamantia G, et al. Anthracycline-induced cardiomyopathy clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol. 2010;55:213-20. doi:10.1016/j.jacc.2009.03.095.</mixed-citation></citation-alternatives></ref><ref id="cit186"><label>186</label><citation-alternatives><mixed-citation xml:lang="ru">Ewer MS, Ali MK, Mackay B, et al. A comparison of cardiac biopsy grades and ejection fraction estimations in patients receiving Adriamycin. J Clin Oncol. 1984;2(2):112-7. doi:10.1200/JCO.1984.2.2.112.</mixed-citation><mixed-citation xml:lang="en">Ewer MS, Ali MK, Mackay B, et al. A comparison of cardiac biopsy grades and ejection fraction estimations in patients receiving Adriamycin. J Clin Oncol. 1984;2(2):112-7. doi:10.1200/JCO.1984.2.2.112.</mixed-citation></citation-alternatives></ref><ref id="cit187"><label>187</label><citation-alternatives><mixed-citation xml:lang="ru">Solomon SD, Anavekar N, Skali H, et al. Influence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients. Circulation. 2005;112:3738-44.</mixed-citation><mixed-citation xml:lang="en">Solomon SD, Anavekar N, Skali H, et al. Influence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients. Circulation. 2005;112:3738-44.</mixed-citation></citation-alternatives></ref><ref id="cit188"><label>188</label><citation-alternatives><mixed-citation xml:lang="ru">Takigiku K, Takeuchi M, Izumi C, et al; JUSTICE investigators. Normal range of left ventricular 2-dimensional strain: Japanese Ultrasound Speckle Tracking of the Left Ventricle (JUSTICE) study. Circ J. 2012;76(11):2623-32. doi:10.1253/circj.cj-12-0264.</mixed-citation><mixed-citation xml:lang="en">Takigiku K, Takeuchi M, Izumi C, et al; JUSTICE investigators. Normal range of left ventricular 2-dimensional strain: Japanese Ultrasound Speckle Tracking of the Left Ventricle (JUSTICE) study. Circ J. 2012;76(11):2623-32. doi:10.1253/circj.cj-12-0264.</mixed-citation></citation-alternatives></ref><ref id="cit189"><label>189</label><citation-alternatives><mixed-citation xml:lang="ru">Negishi K, Negishi T, Hare JL, et al. Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity. J Am Soc Echocardiogr. 2013;26:493-8. doi:10.1016/j.echo.2013.02.008.</mixed-citation><mixed-citation xml:lang="en">Negishi K, Negishi T, Hare JL, et al. Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity. J Am Soc Echocardiogr. 2013;26:493-8. doi:10.1016/j.echo.2013.02.008.</mixed-citation></citation-alternatives></ref><ref id="cit190"><label>190</label><citation-alternatives><mixed-citation xml:lang="ru">Thavendiranathan P, Poulin F, Lim KD, et al. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol. 2014;63:2751-68. doi:10.1016/j.jacc.2014.01.073.</mixed-citation><mixed-citation xml:lang="en">Thavendiranathan P, Poulin F, Lim KD, et al. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol. 2014;63:2751-68. doi:10.1016/j.jacc.2014.01.073.</mixed-citation></citation-alternatives></ref><ref id="cit191"><label>191</label><citation-alternatives><mixed-citation xml:lang="ru">Australian Government, National Health and Medical Research Council, Department of Industry. Tasmanian Study of Echocardiographic detection of Left ventricular dysfunction (TAS-ELF). Available from: www.australianclinicaltrials.gov.au/node/1716.</mixed-citation><mixed-citation xml:lang="en">Australian Government, National Health and Medical Research Council, Department of Industry. Tasmanian Study of Echocardiographic detection of Left ventricular dysfunction (TAS-ELF). Available from: www.australianclinicaltrials.gov.au/node/1716.</mixed-citation></citation-alternatives></ref><ref id="cit192"><label>192</label><citation-alternatives><mixed-citation xml:lang="ru">Nabati M, Janbabai G, Esmailian J, Yazdani J. Effect of Rosuvastatin in Preventing Chemotherapy-Induced Cardiotoxicity in Women With Breast Cancer: A Randomized, Single-Blind, Placebo-Controlled Trial. J Cardiovasc Pharmacol Ther. 2019;24(3):233-41. doi:10.1177/1074248418821721.</mixed-citation><mixed-citation xml:lang="en">Nabati M, Janbabai G, Esmailian J, Yazdani J. Effect of Rosuvastatin in Preventing Chemotherapy-Induced Cardiotoxicity in Women With Breast Cancer: A Randomized, Single-Blind, Placebo-Controlled Trial. J Cardiovasc Pharmacol Ther. 2019;24(3):233-41. doi:10.1177/1074248418821721.</mixed-citation></citation-alternatives></ref><ref id="cit193"><label>193</label><citation-alternatives><mixed-citation xml:lang="ru">Sawaya H, Sebag IA, Plana JC, et al. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. Am J Cardiol. 2011;107:1375-80. doi:10.1016/j.amjcard.2011.01.006.</mixed-citation><mixed-citation xml:lang="en">Sawaya H, Sebag IA, Plana JC, et al. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. Am J Cardiol. 2011;107:1375-80. doi:10.1016/j.amjcard.2011.01.006.</mixed-citation></citation-alternatives></ref><ref id="cit194"><label>194</label><citation-alternatives><mixed-citation xml:lang="ru">Sawaya H, Sebag IA, Plana JC, et al. Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients treated with Anthracyclines, Taxanes and Trastuzumab. Circ Cardiovasc Imaging. 2012;5(5):596-603. doi:10.1161/CIRCIMAGING.112.973321.</mixed-citation><mixed-citation xml:lang="en">Sawaya H, Sebag IA, Plana JC, et al. Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients treated with Anthracyclines, Taxanes and Trastuzumab. Circ Cardiovasc Imaging. 2012;5(5):596-603. doi:10.1161/CIRCIMAGING.112.973321.</mixed-citation></citation-alternatives></ref><ref id="cit195"><label>195</label><citation-alternatives><mixed-citation xml:lang="ru">Cadeddu C, Piras A, Mantovani G, et al. Protective effects of the angiotensin II receptor blocker telmisartan on epirubicini-induced inflammation, oxidative stress, and early ventricular impairment. Am Heart J. 2010;160(3):487.e1-7. doi:10.1016/j.ahj.2010.05.037.</mixed-citation><mixed-citation xml:lang="en">Cadeddu C, Piras A, Mantovani G, et al. Protective effects of the angiotensin II receptor blocker telmisartan on epirubicini-induced inflammation, oxidative stress, and early ventricular impairment. Am Heart J. 2010;160(3):487.e1-7. doi:10.1016/j.ahj.2010.05.037.</mixed-citation></citation-alternatives></ref><ref id="cit196"><label>196</label><citation-alternatives><mixed-citation xml:lang="ru">Berk BC, Fujiwara K, Lehoux S. ECM remodeling in hypertensive heart disease. J Clin Invest. 2007;117(3):568-75. doi:10.1172/JCI31044.</mixed-citation><mixed-citation xml:lang="en">Berk BC, Fujiwara K, Lehoux S. ECM remodeling in hypertensive heart disease. J Clin Invest. 2007;117(3):568-75. doi:10.1172/JCI31044.</mixed-citation></citation-alternatives></ref><ref id="cit197"><label>197</label><citation-alternatives><mixed-citation xml:lang="ru">Mondillo S, Galderisi M, Mele D, et al. Echocardiography Study Group of the Italian Society of Cardiology. Speckle-tracking echocardiography: A new technique for assessing myocardial function. J Ultrasound Med. 2011;30:71-83. doi:10.7863/jum.2011.30.1.71.</mixed-citation><mixed-citation xml:lang="en">Mondillo S, Galderisi M, Mele D, et al. Echocardiography Study Group of the Italian Society of Cardiology. Speckle-tracking echocardiography: A new technique for assessing myocardial function. J Ultrasound Med. 2011;30:71-83. doi:10.7863/jum.2011.30.1.71.</mixed-citation></citation-alternatives></ref><ref id="cit198"><label>198</label><citation-alternatives><mixed-citation xml:lang="ru">Tian M, Nishijima Y, Asp ML, et al. Cardiac alterations in cancer-induced cachexia in mice. Int J Oncol. 2010;37:347-53. doi:10.3892/ijo_00000683.</mixed-citation><mixed-citation xml:lang="en">Tian M, Nishijima Y, Asp ML, et al. Cardiac alterations in cancer-induced cachexia in mice. Int J Oncol. 2010;37:347-53. doi:10.3892/ijo_00000683.</mixed-citation></citation-alternatives></ref><ref id="cit199"><label>199</label><citation-alternatives><mixed-citation xml:lang="ru">Negishi K, Negishi T, Haluska BA, et al. Use of speckle strain to assess left ventricular responses to cardiotoxic chemotherapy and cardioprotection. Eur Heart J Cardiovasc Imaging. 2014;15(3):324-31. doi:10.1093/ehjci/jet159.</mixed-citation><mixed-citation xml:lang="en">Negishi K, Negishi T, Haluska BA, et al. Use of speckle strain to assess left ventricular responses to cardiotoxic chemotherapy and cardioprotection. Eur Heart J Cardiovasc Imaging. 2014;15(3):324-31. doi:10.1093/ehjci/jet159.</mixed-citation></citation-alternatives></ref><ref id="cit200"><label>200</label><citation-alternatives><mixed-citation xml:lang="ru">Stoodley PW, Richards DA, Hui R, et al. Two dimensional myocardial strain imaging detects changes in left ventricular systolic function immediately after anthracycline chemotherapy. Eur J Echocardiogr. 2011;12(12):945-52. doi:10.1093/ejechocard/jer187.</mixed-citation><mixed-citation xml:lang="en">Stoodley PW, Richards DA, Hui R, et al. Two dimensional myocardial strain imaging detects changes in left ventricular systolic function immediately after anthracycline chemotherapy. Eur J Echocardiogr. 2011;12(12):945-52. doi:10.1093/ejechocard/jer187.</mixed-citation></citation-alternatives></ref><ref id="cit201"><label>201</label><citation-alternatives><mixed-citation xml:lang="ru">Song FY, Shi J, Guo Y, et al. Assessment of biventricular systolic strain derived from the two-dimensional and three-dimensional speckle tracking echocardiography in lymphoma patients after anthracycline therapy. Int J Cardiovasc Imaging. 2017;33(6):857-68. doi:10.1007/s10554-017-1082-6.</mixed-citation><mixed-citation xml:lang="en">Song FY, Shi J, Guo Y, et al. Assessment of biventricular systolic strain derived from the two-dimensional and three-dimensional speckle tracking echocardiography in lymphoma patients after anthracycline therapy. Int J Cardiovasc Imaging. 2017;33(6):857-68. doi:10.1007/s10554-017-1082-6.</mixed-citation></citation-alternatives></ref><ref id="cit202"><label>202</label><citation-alternatives><mixed-citation xml:lang="ru">Florescu M, Magda LS, Enescu OA, et al. Early detection of epirubicin-induced cardiotoxicity in patients with breast cancer. J Am Soc Echocardiogr. 2014;27(1):83-92. doi:10.1016/j.echo.2013.10.008.</mixed-citation><mixed-citation xml:lang="en">Florescu M, Magda LS, Enescu OA, et al. Early detection of epirubicin-induced cardiotoxicity in patients with breast cancer. J Am Soc Echocardiogr. 2014;27(1):83-92. doi:10.1016/j.echo.2013.10.008.</mixed-citation></citation-alternatives></ref><ref id="cit203"><label>203</label><citation-alternatives><mixed-citation xml:lang="ru">Motoki H, Koyama J, Nakazawa H, et al. Torsion analysis in the early detection of anthracycline-mediated cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2012;13(1):95- 103. doi:10.1093/ejechocard/jer172.</mixed-citation><mixed-citation xml:lang="en">Motoki H, Koyama J, Nakazawa H, et al. Torsion analysis in the early detection of anthracycline-mediated cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2012;13(1):95- 103. doi:10.1093/ejechocard/jer172.</mixed-citation></citation-alternatives></ref><ref id="cit204"><label>204</label><citation-alternatives><mixed-citation xml:lang="ru">Mornoş C, Manolis AJ, Cozma D, et al. The value of left ventricular global longitudinal strain assessed by three-dimensional strain imaging in the early detection of anthracyclinemediated cardiotoxicity. Hellenic J Cardiol. 2014;55(3):235-44.</mixed-citation><mixed-citation xml:lang="en">Mornoş C, Manolis AJ, Cozma D, et al. The value of left ventricular global longitudinal strain assessed by three-dimensional strain imaging in the early detection of anthracyclinemediated cardiotoxicity. Hellenic J Cardiol. 2014;55(3):235-44.</mixed-citation></citation-alternatives></ref><ref id="cit205"><label>205</label><citation-alternatives><mixed-citation xml:lang="ru">Li VW, Liu AP, So EK, et al. Two- and three-dimensional myocardial strain imaging in the interrogation of sex differences in cardiac mechanics of long-term survivors of childhood cancers. Int J Cardiovasc Imaging. 2019;35(6):999-1007. doi:10.1007/s10554-019-01573-1.</mixed-citation><mixed-citation xml:lang="en">Li VW, Liu AP, So EK, et al. Two- and three-dimensional myocardial strain imaging in the interrogation of sex differences in cardiac mechanics of long-term survivors of childhood cancers. Int J Cardiovasc Imaging. 2019;35(6):999-1007. doi:10.1007/s10554-019-01573-1.</mixed-citation></citation-alternatives></ref><ref id="cit206"><label>206</label><citation-alternatives><mixed-citation xml:lang="ru">Erven K, Florian A, Slagmolen P, et al. Subclinical cardiotoxicity detected by strain rate imaging up to 14 months after breast radiation therapy. Int J Radiat Oncol Biol Phys. 2013;85(5):1172-8. doi:10.1016/j.ijrobp.2012.09.022.</mixed-citation><mixed-citation xml:lang="en">Erven K, Florian A, Slagmolen P, et al. Subclinical cardiotoxicity detected by strain rate imaging up to 14 months after breast radiation therapy. Int J Radiat Oncol Biol Phys. 2013;85(5):1172-8. doi:10.1016/j.ijrobp.2012.09.022.</mixed-citation></citation-alternatives></ref><ref id="cit207"><label>207</label><citation-alternatives><mixed-citation xml:lang="ru">Tuohinen SS, Skyttä T, Poutanen T, et al. Radiotherapy-induced global and regional differences in early-stage left-sided versus right-sided breast cancer patients: speckle tracking echocardiography study. Int J Cardiovasc Imaging. 2017;33(4):463-72. doi:10.1007/s10554-016-1021-y.</mixed-citation><mixed-citation xml:lang="en">Tuohinen SS, Skyttä T, Poutanen T, et al. Radiotherapy-induced global and regional differences in early-stage left-sided versus right-sided breast cancer patients: speckle tracking echocardiography study. Int J Cardiovasc Imaging. 2017;33(4):463-72. doi:10.1007/s10554-016-1021-y.</mixed-citation></citation-alternatives></ref><ref id="cit208"><label>208</label><citation-alternatives><mixed-citation xml:lang="ru">Cuppone F, Bria E, Verma S, et al. Do adjuvant aromstase inhibitirs increase the cardiovascular risk in poctmenopausal women with early breast cancer? Meta-analysis of randomized trials. Cancer. 2008;112:260-72.</mixed-citation><mixed-citation xml:lang="en">Cuppone F, Bria E, Verma S, et al. Do adjuvant aromstase inhibitirs increase the cardiovascular risk in poctmenopausal women with early breast cancer? Meta-analysis of randomized trials. Cancer. 2008;112:260-72.</mixed-citation></citation-alternatives></ref><ref id="cit209"><label>209</label><citation-alternatives><mixed-citation xml:lang="ru">de Geus-Oei L-F, Mavinkurve-Groothuis AMC, Bellersen L, et al. Scintigraphic techniques for early detection of cancer treatment-induced cardiotoxicity. Journal of Nuclear Medicine. 2011;52(4):560-71. doi:10.2967/jnumed.110.082784.</mixed-citation><mixed-citation xml:lang="en">de Geus-Oei L-F, Mavinkurve-Groothuis AMC, Bellersen L, et al. Scintigraphic techniques for early detection of cancer treatment-induced cardiotoxicity. Journal of Nuclear Medicine. 2011;52(4):560-71. doi:10.2967/jnumed.110.082784.</mixed-citation></citation-alternatives></ref><ref id="cit210"><label>210</label><citation-alternatives><mixed-citation xml:lang="ru">Nakata T, Nakajima K, Yamashina S, et al. A pooled analysis of multicenter cohort studies of (123) I-mIBG imaging of sympathetic innervation for assessment of long-term prognosis in heart failure. JACC Cardiovasc Imaging. 2013;6(7):772-84. doi:10.1016/j.jcmg.2013.02.007.</mixed-citation><mixed-citation xml:lang="en">Nakata T, Nakajima K, Yamashina S, et al. A pooled analysis of multicenter cohort studies of (123) I-mIBG imaging of sympathetic innervation for assessment of long-term prognosis in heart failure. JACC Cardiovasc Imaging. 2013;6(7):772-84. doi:10.1016/j.jcmg.2013.02.007.</mixed-citation></citation-alternatives></ref><ref id="cit211"><label>211</label><citation-alternatives><mixed-citation xml:lang="ru">Panjrath GS, Jain D. Monitoring chemotherapyinduced cardiotoxicity: role of cardiac nuclear imaging. Journal of Nuclear Cardiology. 2006;13 (3):415-26.</mixed-citation><mixed-citation xml:lang="en">Panjrath GS, Jain D. Monitoring chemotherapyinduced cardiotoxicity: role of cardiac nuclear imaging. Journal of Nuclear Cardiology. 2006;13 (3):415-26.</mixed-citation></citation-alternatives></ref><ref id="cit212"><label>212</label><citation-alternatives><mixed-citation xml:lang="ru">Wakasugi S, Fischman AJ, Babich JW, et al. Metaiodobenzylguanidine: evaluation of its potential as a tracer for monitoring doxorubicin cardiomyopathy. J Nucl Med. 1993;34(8):1283-6.</mixed-citation><mixed-citation xml:lang="en">Wakasugi S, Fischman AJ, Babich JW, et al. Metaiodobenzylguanidine: evaluation of its potential as a tracer for monitoring doxorubicin cardiomyopathy. J Nucl Med. 1993;34(8):1283-6.</mixed-citation></citation-alternatives></ref><ref id="cit213"><label>213</label><citation-alternatives><mixed-citation xml:lang="ru">Jeon TJ, Lee JD, Ha JW, et al. Evaluation of cardiac adrenergic neuronal damage in rats with doxorubicin-induced cardiomyopathy using iodine-131 MIBG autoradiography and PGP 9.5 immunohistochemistry. Eur J Nucl Med. 2000;27(6):686-93.</mixed-citation><mixed-citation xml:lang="en">Jeon TJ, Lee JD, Ha JW, et al. Evaluation of cardiac adrenergic neuronal damage in rats with doxorubicin-induced cardiomyopathy using iodine-131 MIBG autoradiography and PGP 9.5 immunohistochemistry. Eur J Nucl Med. 2000;27(6):686-93.</mixed-citation></citation-alternatives></ref><ref id="cit214"><label>214</label><citation-alternatives><mixed-citation xml:lang="ru">Niitsu N, Yamazaki J, Umeda M. Clinical usefulness of 123I-BMIPP (beta-methyl iodophenyl pentadecanoic (acid) myocardial SPECT in patients with hematological malignancies with adriamycininduced cardiomyopathy. Gan To Kagaku Ryoho. 1996;23(13):1793-7.</mixed-citation><mixed-citation xml:lang="en">Niitsu N, Yamazaki J, Umeda M. Clinical usefulness of 123I-BMIPP (beta-methyl iodophenyl pentadecanoic (acid) myocardial SPECT in patients with hematological malignancies with adriamycininduced cardiomyopathy. Gan To Kagaku Ryoho. 1996;23(13):1793-7.</mixed-citation></citation-alternatives></ref><ref id="cit215"><label>215</label><citation-alternatives><mixed-citation xml:lang="ru">Pennell DJ, Sechtem UP, Higgins CB, et al. Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. J Cardiovasc Magn Reson. 2004;6:727-65.</mixed-citation><mixed-citation xml:lang="en">Pennell DJ, Sechtem UP, Higgins CB, et al. Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. J Cardiovasc Magn Reson. 2004;6:727-65.</mixed-citation></citation-alternatives></ref><ref id="cit216"><label>216</label><citation-alternatives><mixed-citation xml:lang="ru">Armstrong AC, Gidding S, Gjesdal O, et al. LV mass assessed by echocardiography and CMR, cardiovascular outcomes, and medical practice. JACC Cardiovasc Imaging. 2012;5:837-48. doi:10.1016/j.jcmg.2012.06.003.</mixed-citation><mixed-citation xml:lang="en">Armstrong AC, Gidding S, Gjesdal O, et al. LV mass assessed by echocardiography and CMR, cardiovascular outcomes, and medical practice. JACC Cardiovasc Imaging. 2012;5:837-48. doi:10.1016/j.jcmg.2012.06.003.</mixed-citation></citation-alternatives></ref><ref id="cit217"><label>217</label><citation-alternatives><mixed-citation xml:lang="ru">Thavendiranathan P, Wintersperger BJ, Flamm SD, Marwick TH. Cardiac MRI in the assessment of cardiac injury and toxicity from cancer chemotherapy a systematic review. Circulation: Cardiovascular Imaging. 2013;6(6):1080-91. doi:10.1161/CIRCIMAGING.113.000899.</mixed-citation><mixed-citation xml:lang="en">Thavendiranathan P, Wintersperger BJ, Flamm SD, Marwick TH. Cardiac MRI in the assessment of cardiac injury and toxicity from cancer chemotherapy a systematic review. Circulation: Cardiovascular Imaging. 2013;6(6):1080-91. doi:10.1161/CIRCIMAGING.113.000899.</mixed-citation></citation-alternatives></ref><ref id="cit218"><label>218</label><citation-alternatives><mixed-citation xml:lang="ru">Wassmuth R, Lentzsch S, Erdbruegger U, et al. Subclinical cardiotoxic effects of anthracyclines as assessed by magnetic resonance imaging — a pilot study. The American Heart Journal. 2001;141(6):1007-13.</mixed-citation><mixed-citation xml:lang="en">Wassmuth R, Lentzsch S, Erdbruegger U, et al. Subclinical cardiotoxic effects of anthracyclines as assessed by magnetic resonance imaging — a pilot study. The American Heart Journal. 2001;141(6):1007-13.</mixed-citation></citation-alternatives></ref><ref id="cit219"><label>219</label><citation-alternatives><mixed-citation xml:lang="ru">Fallah-Rad N, Lytwyn M, Fang T, et al. Delayed contrast enhancement cardiac magnetic resonance imaging in trastuzumab induced cardiomyopathy. Journal of Cardiovascular Magnetic Resonance. 2008;10(8):729-40. doi:10.1186/1532-429X-10-5.</mixed-citation><mixed-citation xml:lang="en">Fallah-Rad N, Lytwyn M, Fang T, et al. Delayed contrast enhancement cardiac magnetic resonance imaging in trastuzumab induced cardiomyopathy. Journal of Cardiovascular Magnetic Resonance. 2008;10(8):729-40. doi:10.1186/1532-429X-10-5.</mixed-citation></citation-alternatives></ref><ref id="cit220"><label>220</label><citation-alternatives><mixed-citation xml:lang="ru">Drafts BC, Twomley KM, D’Agostino RJr, et al. Low to moderate dose anthracyclinebased chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. Journal of the American College of Cardiology: Cardiovascular Imaging. 2013;6(8):877-85. doi:10.1016/j.jcmg.2012.11.017.</mixed-citation><mixed-citation xml:lang="en">Drafts BC, Twomley KM, D’Agostino RJr, et al. Low to moderate dose anthracyclinebased chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. Journal of the American College of Cardiology: Cardiovascular Imaging. 2013;6(8):877-85. doi:10.1016/j.jcmg.2012.11.017.</mixed-citation></citation-alternatives></ref><ref id="cit221"><label>221</label><citation-alternatives><mixed-citation xml:lang="ru">Armstrong GT, Plana JC, Zhang N, et al. Screening adult survivors of childhood cancer for cardiomyopathy: comparison of echocardiography and cardiac magnetic resonance imaging. Journal of Clinical Oncology. 2012; 30(23):2876-84. doi:10.1200/JCO.2011.40.3584.</mixed-citation><mixed-citation xml:lang="en">Armstrong GT, Plana JC, Zhang N, et al. Screening adult survivors of childhood cancer for cardiomyopathy: comparison of echocardiography and cardiac magnetic resonance imaging. Journal of Clinical Oncology. 2012; 30(23):2876-84. doi:10.1200/JCO.2011.40.3584.</mixed-citation></citation-alternatives></ref><ref id="cit222"><label>222</label><citation-alternatives><mixed-citation xml:lang="ru">Cardinale D, Sandri MT, Colombo A, et al. Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. Circulation. 2004;109:2749-54. doi:10.1161/01.CIR.0000130926.51766.CC.</mixed-citation><mixed-citation xml:lang="en">Cardinale D, Sandri MT, Colombo A, et al. Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. Circulation. 2004;109:2749-54. doi:10.1161/01.CIR.0000130926.51766.CC.</mixed-citation></citation-alternatives></ref><ref id="cit223"><label>223</label><citation-alternatives><mixed-citation xml:lang="ru">Cardinale D, Caruso V, Cipolla CM. The breast cancer patient in the cardiooncology unit. Review. J Thorac Dis. 2018;10(Suppl 35):S4306-S4322. doi:10.21037/jtd.2018.10.06.</mixed-citation><mixed-citation xml:lang="en">Cardinale D, Caruso V, Cipolla CM. The breast cancer patient in the cardiooncology unit. Review. J Thorac Dis. 2018;10(Suppl 35):S4306-S4322. doi:10.21037/jtd.2018.10.06.</mixed-citation></citation-alternatives></ref><ref id="cit224"><label>224</label><citation-alternatives><mixed-citation xml:lang="ru">Ky B, Putt M, Sawaya H, et al. Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab. J Am Coll Cardiol. 2014;63(8):809. doi:10.1016/j.jacc.2013.10.061.</mixed-citation><mixed-citation xml:lang="en">Ky B, Putt M, Sawaya H, et al. Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab. J Am Coll Cardiol. 2014;63(8):809. doi:10.1016/j.jacc.2013.10.061.</mixed-citation></citation-alternatives></ref><ref id="cit225"><label>225</label><citation-alternatives><mixed-citation xml:lang="ru">Liu FT Hsu DK, Zuberi RI, et al. Expressionand function of galectin-3, a beta-galactosidebinding lectin, in humanmonocytes andmacrophages. Am J Pathol. 1995;147(4):1016-28.</mixed-citation><mixed-citation xml:lang="en">Liu FT Hsu DK, Zuberi RI, et al. Expressionand function of galectin-3, a beta-galactosidebinding lectin, in humanmonocytes andmacrophages. Am J Pathol. 1995;147(4):1016-28.</mixed-citation></citation-alternatives></ref><ref id="cit226"><label>226</label><citation-alternatives><mixed-citation xml:lang="ru">Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev. 2009;230(1):160-71. doi:10.1111/j.1600-065X.2009.00794.x.</mixed-citation><mixed-citation xml:lang="en">Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev. 2009;230(1):160-71. doi:10.1111/j.1600-065X.2009.00794.x.</mixed-citation></citation-alternatives></ref><ref id="cit227"><label>227</label><citation-alternatives><mixed-citation xml:lang="ru">Carrasco-Sanchez FJ, Aramburu-Bodas O, Salamanca-Bautista P, et al Predictive value of serum galectin-3 levels in patients with acute heart failure with preserved ejection fraction. Int J Cardiol. 2013;169(3):177-82. doi:10.1016/j.ijcard.2013.08.081.</mixed-citation><mixed-citation xml:lang="en">Carrasco-Sanchez FJ, Aramburu-Bodas O, Salamanca-Bautista P, et al Predictive value of serum galectin-3 levels in patients with acute heart failure with preserved ejection fraction. Int J Cardiol. 2013;169(3):177-82. doi:10.1016/j.ijcard.2013.08.081.</mixed-citation></citation-alternatives></ref><ref id="cit228"><label>228</label><citation-alternatives><mixed-citation xml:lang="ru">Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol. 2005;77(5):598-625. doi:10.1189/jlb.1204697.</mixed-citation><mixed-citation xml:lang="en">Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol. 2005;77(5):598-625. doi:10.1189/jlb.1204697.</mixed-citation></citation-alternatives></ref><ref id="cit229"><label>229</label><citation-alternatives><mixed-citation xml:lang="ru">Baldus S, Heitzer T, Eiserich JP, et al. Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion. Free Radic Biol Med. 2004;37:902-11. doi:10.1016/j.freeradbiomed.2004.06.003.</mixed-citation><mixed-citation xml:lang="en">Baldus S, Heitzer T, Eiserich JP, et al. Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion. Free Radic Biol Med. 2004;37:902-11. doi:10.1016/j.freeradbiomed.2004.06.003.</mixed-citation></citation-alternatives></ref><ref id="cit230"><label>230</label><citation-alternatives><mixed-citation xml:lang="ru">Daugherty A, Dunn JL, Rateri DL, Heinecke JW. Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J Clin Invest. 1994;94(1):437-44.</mixed-citation><mixed-citation xml:lang="en">Daugherty A, Dunn JL, Rateri DL, Heinecke JW. Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J Clin Invest. 1994;94(1):437-44.</mixed-citation></citation-alternatives></ref><ref id="cit231"><label>231</label><citation-alternatives><mixed-citation xml:lang="ru">Rehman SU, Mueller T, Januzzi JL. Characteristics of the novel interleukin family biomarker ST2 in patients with acute heart failure. J. Am. Coll. Cardiol. 2008;52(18):1458-65. doi:10.1016/j.jacc.2008.07.042.</mixed-citation><mixed-citation xml:lang="en">Rehman SU, Mueller T, Januzzi JL. Characteristics of the novel interleukin family biomarker ST2 in patients with acute heart failure. J. Am. Coll. Cardiol. 2008;52(18):1458-65. doi:10.1016/j.jacc.2008.07.042.</mixed-citation></citation-alternatives></ref><ref id="cit232"><label>232</label><citation-alternatives><mixed-citation xml:lang="ru">Shah RV, Januzzi JL Jr. ST2: a novel remodeling biomarker in acute and chronic heart failure. Curr Heart Fail Rep. 2010;7(1):9-14. doi:10.1007/s11897-010-0005-9.</mixed-citation><mixed-citation xml:lang="en">Shah RV, Januzzi JL Jr. ST2: a novel remodeling biomarker in acute and chronic heart failure. Curr Heart Fail Rep. 2010;7(1):9-14. doi:10.1007/s11897-010-0005-9.</mixed-citation></citation-alternatives></ref><ref id="cit233"><label>233</label><citation-alternatives><mixed-citation xml:lang="ru">Чазова И.Е., Виценя М.В., Агеев Ф.Т. и др. Сердечно-сосудистые осложнения противоопухолевой терапии. Москва, М. Гарант, 2019. c. 225.</mixed-citation><mixed-citation xml:lang="en">Chazova IE, Vitsenya MV, Ageev FT, et al. Cardiovascular complications of antitumor therapy. Moscow, M. Garant, 2019. p. 225. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit234"><label>234</label><citation-alternatives><mixed-citation xml:lang="ru">Pacciarini MA, Barbieri B, Colombo T, et al. Distribution and antitumor activity of adriamicin given in a high-dose and a repeated low-dose schedule to mice. Cancer Treat Rep. 1978;62:791-800.</mixed-citation><mixed-citation xml:lang="en">Pacciarini MA, Barbieri B, Colombo T, et al. Distribution and antitumor activity of adriamicin given in a high-dose and a repeated low-dose schedule to mice. Cancer Treat Rep. 1978;62:791-800.</mixed-citation></citation-alternatives></ref><ref id="cit235"><label>235</label><citation-alternatives><mixed-citation xml:lang="ru">Scott JM, Khacoo A, Mackey JR, et al. Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlyng mechanisms. Circulation. 2011;124:642-50. doi:10.1161/CIRCULATIONAHA.111.021774.</mixed-citation><mixed-citation xml:lang="en">Scott JM, Khacoo A, Mackey JR, et al. Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlyng mechanisms. Circulation. 2011;124:642-50. doi:10.1161/CIRCULATIONAHA.111.021774.</mixed-citation></citation-alternatives></ref><ref id="cit236"><label>236</label><citation-alternatives><mixed-citation xml:lang="ru">Kalam K, Marwick TH. Role cardioprotective therapy or prevention of cardiotoxisity with chemotherapy: a systematic review and meta-analisis. Eur J Cancer. 2013;49:2900-9. doi:10.1016/j.ejca.2013.04.030.</mixed-citation><mixed-citation xml:lang="en">Kalam K, Marwick TH. Role cardioprotective therapy or prevention of cardiotoxisity with chemotherapy: a systematic review and meta-analisis. Eur J Cancer. 2013;49:2900-9. doi:10.1016/j.ejca.2013.04.030.</mixed-citation></citation-alternatives></ref><ref id="cit237"><label>237</label><citation-alternatives><mixed-citation xml:lang="ru">U.S. Food and Drug Administration. Drug Safety and Availability. FDA statement and dexrazoxan. Jul 20, 2011. Available at: http: www.fda/Drugs/DrugSafety/ucm263729.htm</mixed-citation><mixed-citation xml:lang="en">U.S. Food and Drug Administration. Drug Safety and Availability. FDA statement and dexrazoxan. Jul 20, 2011. Available at: http: www.fda/Drugs/DrugSafety/ucm263729.htm</mixed-citation></citation-alternatives></ref><ref id="cit238"><label>238</label><citation-alternatives><mixed-citation xml:lang="ru">Lyu YL, Kerrigan JE, Lin SP, et al. Topoisomerase II IIβ mediated DNA Double-strand breaks: Implications in doxorubicin cardiotoxisity and prevention by dexrazoxsane. Cancer Res. 2007;67:8839-46. doi:10.1158/0008-5472.CAN-07-1649.</mixed-citation><mixed-citation xml:lang="en">Lyu YL, Kerrigan JE, Lin SP, et al. Topoisomerase II IIβ mediated DNA Double-strand breaks: Implications in doxorubicin cardiotoxisity and prevention by dexrazoxsane. Cancer Res. 2007;67:8839-46. doi:10.1158/0008-5472.CAN-07-1649.</mixed-citation></citation-alternatives></ref><ref id="cit239"><label>239</label><citation-alternatives><mixed-citation xml:lang="ru">Vejpongsa P, Yeh ETH. Prevention of anthracycline-Induced cardiotoxisity challenges and opportunities. J Am Coll Cardiol. 2014;64:938-45. doi:10.1016/j.jacc.2014.06.1167.</mixed-citation><mixed-citation xml:lang="en">Vejpongsa P, Yeh ETH. Prevention of anthracycline-Induced cardiotoxisity challenges and opportunities. J Am Coll Cardiol. 2014;64:938-45. doi:10.1016/j.jacc.2014.06.1167.</mixed-citation></citation-alternatives></ref><ref id="cit240"><label>240</label><citation-alternatives><mixed-citation xml:lang="ru">Swain SM, Whaley FS, Gerber MC et al. Cardioprotection with dexrazoxsane for doxorubicin-containing therapy in advanced breast cancer. J Clin Oncol. 1997;15:1318-32.</mixed-citation><mixed-citation xml:lang="en">Swain SM, Whaley FS, Gerber MC et al. Cardioprotection with dexrazoxsane for doxorubicin-containing therapy in advanced breast cancer. J Clin Oncol. 1997;15:1318-32.</mixed-citation></citation-alternatives></ref><ref id="cit241"><label>241</label><citation-alternatives><mixed-citation xml:lang="ru">Raimondi S, Botteri E, Munzone E, et al. Use of beta-blockers, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and breast cancer survival: systematic review and meta-analysis. Int J Cancer. 2016;139:212-19. doi:10.1002/ijc.30062.</mixed-citation><mixed-citation xml:lang="en">Raimondi S, Botteri E, Munzone E, et al. Use of beta-blockers, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and breast cancer survival: systematic review and meta-analysis. Int J Cancer. 2016;139:212-19. doi:10.1002/ijc.30062.</mixed-citation></citation-alternatives></ref><ref id="cit242"><label>242</label><citation-alternatives><mixed-citation xml:lang="ru">Asanuma H, Minamino T, Sanada S, et al. Beta-adrenoreceptor blocker carvedilol provides cardioprotection via an adrenosine-dependent mechanism in ischemic canine hearts. Circulation. 2004;109:2773-9. doi:10.1161/01.CIR.0000130917.12959.04.</mixed-citation><mixed-citation xml:lang="en">Asanuma H, Minamino T, Sanada S, et al. Beta-adrenoreceptor blocker carvedilol provides cardioprotection via an adrenosine-dependent mechanism in ischemic canine hearts. Circulation. 2004;109:2773-9. doi:10.1161/01.CIR.0000130917.12959.04.</mixed-citation></citation-alternatives></ref><ref id="cit243"><label>243</label><citation-alternatives><mixed-citation xml:lang="ru">Kim AM, Tilley DG, Chen J, et al. Beta- blocker alprenolol and carvedilol stimulate betaarrestine-mediated EGFR transactivation. Proc Natl Acad Sci USA. 2008;105:1455-60. doi:10.1073/pnas.0804745105.</mixed-citation><mixed-citation xml:lang="en">Kim AM, Tilley DG, Chen J, et al. Beta- blocker alprenolol and carvedilol stimulate betaarrestine-mediated EGFR transactivation. Proc Natl Acad Sci USA. 2008;105:1455-60. doi:10.1073/pnas.0804745105.</mixed-citation></citation-alternatives></ref><ref id="cit244"><label>244</label><citation-alternatives><mixed-citation xml:lang="ru">Oliveria PJ, Bjork JA, Santos MS, et al. Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity. Toxicol Appl Pharmacol. 2004;200:159-68. doi:10.1016/j.taap.2004.04.005.</mixed-citation><mixed-citation xml:lang="en">Oliveria PJ, Bjork JA, Santos MS, et al. Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity. Toxicol Appl Pharmacol. 2004;200:159-68. doi:10.1016/j.taap.2004.04.005.</mixed-citation></citation-alternatives></ref><ref id="cit245"><label>245</label><citation-alternatives><mixed-citation xml:lang="ru">Kalay N, Basar E, Ozdogru I, et al. Protective effects of carvedilol against anthracyclineinduced cardiomyopathy. J Am Coll Cardiol. 2006;48:2258-62. doi:10.1016/j.jacc.2006.07.052.</mixed-citation><mixed-citation xml:lang="en">Kalay N, Basar E, Ozdogru I, et al. Protective effects of carvedilol against anthracyclineinduced cardiomyopathy. J Am Coll Cardiol. 2006;48:2258-62. doi:10.1016/j.jacc.2006.07.052.</mixed-citation></citation-alternatives></ref><ref id="cit246"><label>246</label><citation-alternatives><mixed-citation xml:lang="ru">El-Shitany NA, Tolba OA, El-Shanshory MR, El-Hawary EE. Protective effect of carvedilol on adriamycin-induced left ventricular dysfunction in children with acute lymphoblastic leukemia. J Card Fail. 2012;18(8):607-13. doi:10.1016/j.cardfail.2012.06.416.</mixed-citation><mixed-citation xml:lang="en">El-Shitany NA, Tolba OA, El-Shanshory MR, El-Hawary EE. Protective effect of carvedilol on adriamycin-induced left ventricular dysfunction in children with acute lymphoblastic leukemia. J Card Fail. 2012;18(8):607-13. doi:10.1016/j.cardfail.2012.06.416.</mixed-citation></citation-alternatives></ref><ref id="cit247"><label>247</label><citation-alternatives><mixed-citation xml:lang="ru">Avila VS, Ayub-Ferreira SM, de Barros Wanderley MR, et al. Carvedilol for prevention of chemotherapy-related cardiotoxicity: The CECCY trial. J Am Coll Cardiol. 2018;71:2281- 90. doi:10.1016/j.jacc.2018.02.049.</mixed-citation><mixed-citation xml:lang="en">Avila VS, Ayub-Ferreira SM, de Barros Wanderley MR, et al. Carvedilol for prevention of chemotherapy-related cardiotoxicity: The CECCY trial. J Am Coll Cardiol. 2018;71:2281- 90. doi:10.1016/j.jacc.2018.02.049.</mixed-citation></citation-alternatives></ref><ref id="cit248"><label>248</label><citation-alternatives><mixed-citation xml:lang="ru">Kaya MG, Ozkan M, Gunebakmaz O, et al. Protective effects of nebivolol against anthracycline- induced cardiomyophaty: a randomized control study. Int J Cardiol. 2013;167:2306-10. doi:10.1016/j.ijcard.2012.06.023.</mixed-citation><mixed-citation xml:lang="en">Kaya MG, Ozkan M, Gunebakmaz O, et al. Protective effects of nebivolol against anthracycline- induced cardiomyophaty: a randomized control study. Int J Cardiol. 2013;167:2306-10. doi:10.1016/j.ijcard.2012.06.023.</mixed-citation></citation-alternatives></ref><ref id="cit249"><label>249</label><citation-alternatives><mixed-citation xml:lang="ru">Georgakopoulos P, Roussou P, Matsakas E, et al. Cardioprotective effects of metoprolol and enalapril in doxorubicin-treated lymphoma patients: a prospective, parallele-group, randomized controlled study with 36-month follow-up. Am J Hematol. 2010;85:894-6. doi:10.1002/ajh.21840.</mixed-citation><mixed-citation xml:lang="en">Georgakopoulos P, Roussou P, Matsakas E, et al. Cardioprotective effects of metoprolol and enalapril in doxorubicin-treated lymphoma patients: a prospective, parallele-group, randomized controlled study with 36-month follow-up. Am J Hematol. 2010;85:894-6. doi:10.1002/ajh.21840.</mixed-citation></citation-alternatives></ref><ref id="cit250"><label>250</label><citation-alternatives><mixed-citation xml:lang="ru">Gulaty G, Heck SL, Ree AH, et al. Prevention of cardiac dysfunction during adjvant breast cancer therapy (PRADA): 2x2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol. Eur Heart J. 2016;37:1671-80. doi:10.1093/eurheartj/ehw022.</mixed-citation><mixed-citation xml:lang="en">Gulaty G, Heck SL, Ree AH, et al. Prevention of cardiac dysfunction during adjvant breast cancer therapy (PRADA): 2x2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol. Eur Heart J. 2016;37:1671-80. doi:10.1093/eurheartj/ehw022.</mixed-citation></citation-alternatives></ref><ref id="cit251"><label>251</label><citation-alternatives><mixed-citation xml:lang="ru">Choe JY, Combs AB, Folkers K. Potentiation of the toxicity of adriamicin by propranolol. Res Commun Chem Pathol Pharmacol. 1978;21:577-80.</mixed-citation><mixed-citation xml:lang="en">Choe JY, Combs AB, Folkers K. Potentiation of the toxicity of adriamicin by propranolol. Res Commun Chem Pathol Pharmacol. 1978;21:577-80.</mixed-citation></citation-alternatives></ref><ref id="cit252"><label>252</label><citation-alternatives><mixed-citation xml:lang="ru">Abd El-Aziz MA, Othman Al, Amer M, et al. Potential protective role of angiotensinconverting enzyme inhibitor captopril and enalapril against adriamicin-induced acute cardiac and hepatic toxicity in rats. J Appl Toxicol. 2001;21:469-743. doi:10.1002/jat.782.</mixed-citation><mixed-citation xml:lang="en">Abd El-Aziz MA, Othman Al, Amer M, et al. Potential protective role of angiotensinconverting enzyme inhibitor captopril and enalapril against adriamicin-induced acute cardiac and hepatic toxicity in rats. J Appl Toxicol. 2001;21:469-743. doi:10.1002/jat.782.</mixed-citation></citation-alternatives></ref><ref id="cit253"><label>253</label><citation-alternatives><mixed-citation xml:lang="ru">Okumura K, Jin D, Takai S, Miyazaki M. Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters. Jpn J Pharmacol. 2002;88(2):183-8. doi:10.1254/jjp.88.183.</mixed-citation><mixed-citation xml:lang="en">Okumura K, Jin D, Takai S, Miyazaki M. Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters. Jpn J Pharmacol. 2002;88(2):183-8. doi:10.1254/jjp.88.183.</mixed-citation></citation-alternatives></ref><ref id="cit254"><label>254</label><citation-alternatives><mixed-citation xml:lang="ru">Hiona A, Lee AS, Nagendran J, et al. Pretreatment with angiotensin-converting enzyme inhibitor improves doxorubicin-induced cardiomyopathy via preservation of mitochondrial function. J Thorac Cardiovasc Surg. 2011;142:396-403.e3. doi:10.1016/j.jtcvs.2010.07.097.</mixed-citation><mixed-citation xml:lang="en">Hiona A, Lee AS, Nagendran J, et al. Pretreatment with angiotensin-converting enzyme inhibitor improves doxorubicin-induced cardiomyopathy via preservation of mitochondrial function. J Thorac Cardiovasc Surg. 2011;142:396-403.e3. doi:10.1016/j.jtcvs.2010.07.097.</mixed-citation></citation-alternatives></ref><ref id="cit255"><label>255</label><citation-alternatives><mixed-citation xml:lang="ru">Lemmens K, Segers VF, Demolder M, et al. Role of neuregulin-1/ ErbB2 signaling in endothelium-cardiomiocite cross-talk. Biol Chem. 2006;281:19469-77. doi:10.1074/jbc.M600399200.</mixed-citation><mixed-citation xml:lang="en">Lemmens K, Segers VF, Demolder M, et al. Role of neuregulin-1/ ErbB2 signaling in endothelium-cardiomiocite cross-talk. Biol Chem. 2006;281:19469-77. doi:10.1074/jbc.M600399200.</mixed-citation></citation-alternatives></ref><ref id="cit256"><label>256</label><citation-alternatives><mixed-citation xml:lang="ru">Cernecka H, Ochodnicka-Mackovicova K, Kucerova D, et al. Enaprilat increases PPARbeta/ delta expression, without influence on PPRalpha and PPRgamma, and modulate cardiac function in sud-acute model of daunortubicini-induced cardiomyopathy. Eur J Pharmacol 2013;714:472-7. doi:10.1016/j.ejphar.2013.06.040.</mixed-citation><mixed-citation xml:lang="en">Cernecka H, Ochodnicka-Mackovicova K, Kucerova D, et al. Enaprilat increases PPARbeta/ delta expression, without influence on PPRalpha and PPRgamma, and modulate cardiac function in sud-acute model of daunortubicini-induced cardiomyopathy. Eur J Pharmacol 2013;714:472-7. doi:10.1016/j.ejphar.2013.06.040.</mixed-citation></citation-alternatives></ref><ref id="cit257"><label>257</label><citation-alternatives><mixed-citation xml:lang="ru">Tokudome T, Mizushige K, Noma T, et al. Prevention of doxorubicin (Adriamycin)-induced cardiomyophtaty by simultaneous administration of angiotensin–converting enzyme inhibition assessed by acoustic densitometry. J Cardiovasc Pharmacol. 2000;36:361-8. doi:10.1097/00005344-200009000-00012.</mixed-citation><mixed-citation xml:lang="en">Tokudome T, Mizushige K, Noma T, et al. Prevention of doxorubicin (Adriamycin)-induced cardiomyophtaty by simultaneous administration of angiotensin–converting enzyme inhibition assessed by acoustic densitometry. J Cardiovasc Pharmacol. 2000;36:361-8. doi:10.1097/00005344-200009000-00012.</mixed-citation></citation-alternatives></ref><ref id="cit258"><label>258</label><citation-alternatives><mixed-citation xml:lang="ru">Boucek RJ Jr, Steele A, Miracle A, Atkinson J. Effects of angiotensin-converting enzyme inhibitor on delayed-onset doxorubicin-induced cardiotoxicity. Cardiovasc Toxicol. 2003;3(4):319-29. doi:10.1385/ct:3:4:319.</mixed-citation><mixed-citation xml:lang="en">Boucek RJ Jr, Steele A, Miracle A, Atkinson J. Effects of angiotensin-converting enzyme inhibitor on delayed-onset doxorubicin-induced cardiotoxicity. Cardiovasc Toxicol. 2003;3(4):319-29. doi:10.1385/ct:3:4:319.</mixed-citation></citation-alternatives></ref><ref id="cit259"><label>259</label><citation-alternatives><mixed-citation xml:lang="ru">Subissi A, Evangelista, Giachetti A, Preclinical profile of zofenopril: an angiotensin converting enzyme inhibitor with peculiar cardioprotective properties. Cardiovasc. Drug Rev. 1999;2:115-33.</mixed-citation><mixed-citation xml:lang="en">Subissi A, Evangelista, Giachetti A, Preclinical profile of zofenopril: an angiotensin converting enzyme inhibitor with peculiar cardioprotective properties. Cardiovasc. Drug Rev. 1999;2:115-33.</mixed-citation></citation-alternatives></ref><ref id="cit260"><label>260</label><citation-alternatives><mixed-citation xml:lang="ru">Chopra M, Beswick H, Clapperton M, et al. Antioxidant effects of angiotensin-converting enzyme (ACE) inhibitors: free radical and oxidant scavenging are sulphydryl dependent, but lipid peroxidation is inhibited by both sulphydryl- and nonsulphydryl-containing ACE inhibitors. J. Cardiovasc. Pharmacol. 1992;19:330-40.</mixed-citation><mixed-citation xml:lang="en">Chopra M, Beswick H, Clapperton M, et al. Antioxidant effects of angiotensin-converting enzyme (ACE) inhibitors: free radical and oxidant scavenging are sulphydryl dependent, but lipid peroxidation is inhibited by both sulphydryl- and nonsulphydryl-containing ACE inhibitors. J. Cardiovasc. Pharmacol. 1992;19:330-40.</mixed-citation></citation-alternatives></ref><ref id="cit261"><label>261</label><citation-alternatives><mixed-citation xml:lang="ru">Napoli C, Cicala C, D’Armiento FP, et al. Beneficial effects of ACE-inhibition with zofenopril on plaque formation and low-density lipoprotein oxidation in watanabe heritable hyperlipidemic rabbits. Gen. Pharmacol. 1999;33:467-77.</mixed-citation><mixed-citation xml:lang="en">Napoli C, Cicala C, D’Armiento FP, et al. Beneficial effects of ACE-inhibition with zofenopril on plaque formation and low-density lipoprotein oxidation in watanabe heritable hyperlipidemic rabbits. Gen. Pharmacol. 1999;33:467-77.</mixed-citation></citation-alternatives></ref><ref id="cit262"><label>262</label><citation-alternatives><mixed-citation xml:lang="ru">Mak IT, Freedman AM, Dickens BF, Weglicki WB. Protective effects of sulphydrylcontaining enzyme inhibitors against free radical injury in endothelial cells. Biochem. Pharmacol. 1990;40:2169-75.</mixed-citation><mixed-citation xml:lang="en">Mak IT, Freedman AM, Dickens BF, Weglicki WB. Protective effects of sulphydrylcontaining enzyme inhibitors against free radical injury in endothelial cells. Biochem. Pharmacol. 1990;40:2169-75.</mixed-citation></citation-alternatives></ref><ref id="cit263"><label>263</label><citation-alternatives><mixed-citation xml:lang="ru">Li T, Danelisen I, Bello-Klein A, Singal PK. Effects of probucol on changes of antioxidant enzymes in adriamycin-induced cardiomyopathy in rats. Cardiovasc. Res. 2000;46:523- 30. doi:10.1016/s0008-6363(00)00039-0.</mixed-citation><mixed-citation xml:lang="en">Li T, Danelisen I, Bello-Klein A, Singal PK. Effects of probucol on changes of antioxidant enzymes in adriamycin-induced cardiomyopathy in rats. Cardiovasc. Res. 2000;46:523- 30. doi:10.1016/s0008-6363(00)00039-0.</mixed-citation></citation-alternatives></ref><ref id="cit264"><label>264</label><citation-alternatives><mixed-citation xml:lang="ru">Bosch X, Rovira M, Sitges M, et al. Enalapril and carvedilol for preventing chemotherapyinduced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial. J Am Coll Cardiol. 2013;61:2355-62. doi:10.1016/j.jacc.2013.02.072.</mixed-citation><mixed-citation xml:lang="en">Bosch X, Rovira M, Sitges M, et al. Enalapril and carvedilol for preventing chemotherapyinduced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial. J Am Coll Cardiol. 2013;61:2355-62. doi:10.1016/j.jacc.2013.02.072.</mixed-citation></citation-alternatives></ref><ref id="cit265"><label>265</label><citation-alternatives><mixed-citation xml:lang="ru">Akpek M, Ozdogru I, Sahin O, et al. Protective effects of spironolactone against anthracyclin-induced cardiomyopathy. Eur J Heart Fail. 2015;17:81-9. doi:10.1002/ejhf.196.</mixed-citation><mixed-citation xml:lang="en">Akpek M, Ozdogru I, Sahin O, et al. Protective effects of spironolactone against anthracyclin-induced cardiomyopathy. Eur J Heart Fail. 2015;17:81-9. doi:10.1002/ejhf.196.</mixed-citation></citation-alternatives></ref><ref id="cit266"><label>266</label><citation-alternatives><mixed-citation xml:lang="ru">Seicean S, Seiceаn A, Plana JC, et al. Effect of statin therapy on the risk for incident heart failure in patient with breast cancer receiving anthracycline chemotherapy: an observation clinical cohort study. J Am Coll Cardiol. 2012;60:2384-90. doi:10.1016/j.jacc.2012.07.067.</mixed-citation><mixed-citation xml:lang="en">Seicean S, Seiceаn A, Plana JC, et al. Effect of statin therapy on the risk for incident heart failure in patient with breast cancer receiving anthracycline chemotherapy: an observation clinical cohort study. J Am Coll Cardiol. 2012;60:2384-90. doi:10.1016/j.jacc.2012.07.067.</mixed-citation></citation-alternatives></ref><ref id="cit267"><label>267</label><citation-alternatives><mixed-citation xml:lang="ru">Acar Z, Kale A, Turgut M, et al. Efficiency of atorvastatin in the protection of anthracycline-induced cardiomyopathy. J Am Coll Cardiol. 2011;58:988-9. doi:10.1016/j.jacc.2011.05.025.</mixed-citation><mixed-citation xml:lang="en">Acar Z, Kale A, Turgut M, et al. Efficiency of atorvastatin in the protection of anthracycline-induced cardiomyopathy. J Am Coll Cardiol. 2011;58:988-9. doi:10.1016/j.jacc.2011.05.025.</mixed-citation></citation-alternatives></ref><ref id="cit268"><label>268</label><citation-alternatives><mixed-citation xml:lang="ru">Chotenimitkhun R, D’Agostino R, Lawrence JA, et al. Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Can J Cardiol. 2015;31:302-7. doi:10.1016/j.cjca.2014.11.020.</mixed-citation><mixed-citation xml:lang="en">Chotenimitkhun R, D’Agostino R, Lawrence JA, et al. Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Can J Cardiol. 2015;31:302-7. doi:10.1016/j.cjca.2014.11.020.</mixed-citation></citation-alternatives></ref><ref id="cit269"><label>269</label><citation-alternatives><mixed-citation xml:lang="ru">Colak MC, Parlakpinar H, Tasdemir S, et al. Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat. Hum Exp Toxicol. 2012;31(9):945-54. doi:10.1177/0960327112438288.</mixed-citation><mixed-citation xml:lang="en">Colak MC, Parlakpinar H, Tasdemir S, et al. Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat. Hum Exp Toxicol. 2012;31(9):945-54. doi:10.1177/0960327112438288.</mixed-citation></citation-alternatives></ref><ref id="cit270"><label>270</label><citation-alternatives><mixed-citation xml:lang="ru">Решина И.В., Калягин А. Н., Середа Н.Н. Применение ивабрадина с целью купирования кардиотоксических эффектов у больных онкологическими заболеваниями, получающих полихимиотерапию. Consilium Medicum. 2010;12(5):110-3.</mixed-citation><mixed-citation xml:lang="en">Reshina IV, Kalyagin AN, Sereda NN. The use of ivabradine for the purpose of relieving cardiotoxic effects in patients with oncological diseases receiving polychemotherapy. Consilium Medicum. 2010;12(5):110-3. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit271"><label>271</label><citation-alternatives><mixed-citation xml:lang="ru">Васюк Ю.А., Несветов В.В., Школьник Е.Л. и др. Возможности селективного ингибитора ионных f-каналов синусового узла ивабрадина в профилактике антрациклиновой кардиотоксичности у больных раком молочной железы. Рациональная фармакотерапия в кардиологии. 2017;13(2):184-90.</mixed-citation><mixed-citation xml:lang="en">Vasyuk YuA, Nesvetov VV, Shkolnik EL, et al. Possibilities of selective inhibitor of ion f-channels of the sinus node ivabradine in the prevention of anthracycline cardiotoxicity in breast cancer patients. Rational pharmacotherapy in cardiology. 2017;13(2):184-90. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit272"><label>272</label><citation-alternatives><mixed-citation xml:lang="ru">Amal Mohamed Moustafa Y, Shalahy Amany Abd Elrahman M. Impact of trimetazidine on doxorubicin induced acute cardiotoxicity in mice: a biochemical and electron microscopic study. Egyptian J Histology. 2006; 29(1):125-36.</mixed-citation><mixed-citation xml:lang="en">Amal Mohamed Moustafa Y, Shalahy Amany Abd Elrahman M. Impact of trimetazidine on doxorubicin induced acute cardiotoxicity in mice: a biochemical and electron microscopic study. Egyptian J Histology. 2006; 29(1):125-36.</mixed-citation></citation-alternatives></ref><ref id="cit273"><label>273</label><citation-alternatives><mixed-citation xml:lang="ru">Tallarico D, Rizzo V, Di Maio F. Myocardial cytoprotection by trimetazidine against anthracycline-nduced cardiotoxicity in anticancer chemotherapy. Angiology. 2003;54(2):219-27. doi:10.1177/000331970305400212.</mixed-citation><mixed-citation xml:lang="en">Tallarico D, Rizzo V, Di Maio F. Myocardial cytoprotection by trimetazidine against anthracycline-nduced cardiotoxicity in anticancer chemotherapy. Angiology. 2003;54(2):219-27. doi:10.1177/000331970305400212.</mixed-citation></citation-alternatives></ref><ref id="cit274"><label>274</label><citation-alternatives><mixed-citation xml:lang="ru">Васюк Ю.А., Школьник Е.Л., Несветов В.В. и др. Кардиоонкология: современные аспекты профилактики антрациклиновой кардиотоксичности Кардиология. 2016;56(12):72-9.</mixed-citation><mixed-citation xml:lang="en">Vasyuk YuA, Shkolnik EL, Nesvetov VV, et al. Cardioncology: modern aspects of prevention of anthracycline cardiotoxicity Kardiologija. 2016;56(12):72-9. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit275"><label>275</label><citation-alternatives><mixed-citation xml:lang="ru">Pascale C, Fornengo P, Epifani G, et al. Cardioprotection of trimetazidine and anthracycline- induced acute cardiotoxic effects. Lancet. 2002;359:1153-4. doi:10.1016/S0140-6736(02)08135-7.</mixed-citation><mixed-citation xml:lang="en">Pascale C, Fornengo P, Epifani G, et al. Cardioprotection of trimetazidine and anthracycline- induced acute cardiotoxic effects. Lancet. 2002;359:1153-4. doi:10.1016/S0140-6736(02)08135-7.</mixed-citation></citation-alternatives></ref><ref id="cit276"><label>276</label><citation-alternatives><mixed-citation xml:lang="ru">Калинкина Н.В. Влияние триметазидина на безболевую ишемию миокарда и диастолическую функцию левого желудочка у пациентов, получающих антрациклиновые антибиотики. Вестник неотложной и восстановительной медицины. 2006;2:195-8.</mixed-citation><mixed-citation xml:lang="en">Kalinkina NV. The effect of trimetazidine on pain-free myocardial ischemia and diastolic function of the left ventricle in patients receiving anthracycline antibiotics. Bulletin of Emergency and Restorative Medicine. 2006;2:195-8. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit277"><label>277</label><citation-alternatives><mixed-citation xml:lang="ru">Ватутин Н.Т., Калинкина Н.В., Риджок В.В., Столика О.И. Влияние триметазидина на вариабельность сердечного ритма и систолическую функцию левого желудочка у пациентов, получающих антрациклиновые антибиотики. Кровообращение, гемостаз. 2005;3- 4:141-5.</mixed-citation><mixed-citation xml:lang="en">Vatutin NT, Kalinkina NV, Rijok VV, Stolika OI. The effect of trimetazidine on heart rate variability and systolic function of the left ventricle in patients receiving anthracycline antibiotics. Blood circulation, hemostasis. 2005;3-4:141-5. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit278"><label>278</label><citation-alternatives><mixed-citation xml:lang="ru">Tase AG, Man MG, Tase A, Savoiu G. Trimetazidine added-on therapy could lower the risk of incidental left ventricular dysfunction with or without heart failure in epirubicinum recipients for breast cancer. JACC. 2017;69(11), Suppl.:917. doi:10.1016/S0735-1097(17)34306-1.</mixed-citation><mixed-citation xml:lang="en">Tase AG, Man MG, Tase A, Savoiu G. Trimetazidine added-on therapy could lower the risk of incidental left ventricular dysfunction with or without heart failure in epirubicinum recipients for breast cancer. JACC. 2017;69(11), Suppl.:917. doi:10.1016/S0735-1097(17)34306-1.</mixed-citation></citation-alternatives></ref><ref id="cit279"><label>279</label><citation-alternatives><mixed-citation xml:lang="ru">Strumia E. Creatine Phosphate: Pharmacological and Clinical Perspectives. Adv Ther. 2012;29(2):99-123. doi:10.1007/s12325-011-0091-4.</mixed-citation><mixed-citation xml:lang="en">Strumia E. Creatine Phosphate: Pharmacological and Clinical Perspectives. Adv Ther. 2012;29(2):99-123. doi:10.1007/s12325-011-0091-4.</mixed-citation></citation-alternatives></ref><ref id="cit280"><label>280</label><citation-alternatives><mixed-citation xml:lang="ru">Wang W, Zhaoqiang F, Bai J. Cardioprotective effects of creatine phosphate sodium in elderly breast cancer patients under epirubicin adjuvant chemotherapy. Int J Clin Exp Med. 2019;12(10):12418-25. http://www.ijcem.com/files/ijcem0094064.pdf</mixed-citation><mixed-citation xml:lang="en">Wang W, Zhaoqiang F, Bai J. Cardioprotective effects of creatine phosphate sodium in elderly breast cancer patients under epirubicin adjuvant chemotherapy. Int J Clin Exp Med. 2019;12(10):12418-25. http://www.ijcem.com/files/ijcem0094064.pdf</mixed-citation></citation-alternatives></ref><ref id="cit281"><label>281</label><citation-alternatives><mixed-citation xml:lang="ru">Дербугов В. Н., Потапов А. Л., Потиевская В. И., Хмелевский Я. М. Применение экзогенного фосфокреатина у пациентов пожилого и старческого возраста, оперируемых по поводу колоректального рака. Общая реаниматология. 2017;13(4):38-45. doi:10.15360/1813.9779.2017.4.38.</mixed-citation><mixed-citation xml:lang="en">Derbugov VN, Potapov AL, Potievskaya VI, Khmelevsky YaM. The use of exogenous phosphocreatin in elderly and senile patients operated on for colorectal cancer. General resuscitation. 2017;13(4):38-45. (In Russ.) doi:10.15360/1813.9779.2017.4.38.</mixed-citation></citation-alternatives></ref><ref id="cit282"><label>282</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu Jing, Yao Hong-mei. Influence of creatine phosphate sodium on the quality of life of patients undergoing cancer chemotherapy. Hainan Medical Journal. 2012;23(16):31-6.</mixed-citation><mixed-citation xml:lang="en">Zhu Jing, Yao Hong-mei. Influence of creatine phosphate sodium on the quality of life of patients undergoing cancer chemotherapy. Hainan Medical Journal. 2012;23(16):31-6.</mixed-citation></citation-alternatives></ref><ref id="cit283"><label>283</label><citation-alternatives><mixed-citation xml:lang="ru">Elli M, Sungur M, Genç G, et al. The late effects of anticancer therapy after childhood Wilm’s tumor: the role of diastolic function and ambulatory blood pressure monitoring. Jpn J Clin Oncol, 2013;43:1004-11. doi:10.1093/jjco/hyt105.</mixed-citation><mixed-citation xml:lang="en">Elli M, Sungur M, Genç G, et al. The late effects of anticancer therapy after childhood Wilm’s tumor: the role of diastolic function and ambulatory blood pressure monitoring. Jpn J Clin Oncol, 2013;43:1004-11. doi:10.1093/jjco/hyt105.</mixed-citation></citation-alternatives></ref><ref id="cit284"><label>284</label><citation-alternatives><mixed-citation xml:lang="ru">Minotti G. Pharmacology at work for cardio-oncology: ranolazine to treat early cardiotoxicity induced by antitumor drugs. J Pharmacol Exp Ther. 2013;346:343-9. doi:10.1124/jpet.113.204057.</mixed-citation><mixed-citation xml:lang="en">Minotti G. Pharmacology at work for cardio-oncology: ranolazine to treat early cardiotoxicity induced by antitumor drugs. J Pharmacol Exp Ther. 2013;346:343-9. doi:10.1124/jpet.113.204057.</mixed-citation></citation-alternatives></ref><ref id="cit285"><label>285</label><citation-alternatives><mixed-citation xml:lang="ru">Salvatorelli E, Menna P, Cantalupo E, et al. The concomitant management of cancer therapy and cardiac therapy. Biochim Biophys Acta. 2015;1848:2727-37. doi:10.1016/j.bbamem.2015.01.003.</mixed-citation><mixed-citation xml:lang="en">Salvatorelli E, Menna P, Cantalupo E, et al. The concomitant management of cancer therapy and cardiac therapy. Biochim Biophys Acta. 2015;1848:2727-37. doi:10.1016/j.bbamem.2015.01.003.</mixed-citation></citation-alternatives></ref><ref id="cit286"><label>286</label><citation-alternatives><mixed-citation xml:lang="ru">Cappetta D, Esposito G, Coppini R, et al. Effects of ranolazine in a model of doxorubicininduced left ventricle diastolic dysfunction. British Journal of Pharmacology. 2017;174:3696-712. doi:10.1111/bph.13791.</mixed-citation><mixed-citation xml:lang="en">Cappetta D, Esposito G, Coppini R, et al. Effects of ranolazine in a model of doxorubicininduced left ventricle diastolic dysfunction. British Journal of Pharmacology. 2017;174:3696-712. doi:10.1111/bph.13791.</mixed-citation></citation-alternatives></ref><ref id="cit287"><label>287</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang H, Arcidi JMJr, Hale SL, et al. Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts. Circulation. 2009;120:S16-S21. doi:10.1161/CIRCULATIONAHA.108.844167.</mixed-citation><mixed-citation xml:lang="en">Hwang H, Arcidi JMJr, Hale SL, et al. Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts. Circulation. 2009;120:S16-S21. doi:10.1161/CIRCULATIONAHA.108.844167.</mixed-citation></citation-alternatives></ref><ref id="cit288"><label>288</label><citation-alternatives><mixed-citation xml:lang="ru">Sossalla S, Kallmeyer B, Wagner S, et al. Altered Na (+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol. 2010;55:2330-42. doi:10.1016/j.jacc.2009.12.055.</mixed-citation><mixed-citation xml:lang="en">Sossalla S, Kallmeyer B, Wagner S, et al. Altered Na (+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol. 2010;55:2330-42. doi:10.1016/j.jacc.2009.12.055.</mixed-citation></citation-alternatives></ref><ref id="cit289"><label>289</label><citation-alternatives><mixed-citation xml:lang="ru">Figueredo VM, Pressman GS, Romero-Corral A, et al. Improvement in left ventricular systolic and diastolic performance during ranolazine treatment in patients with stable angina. J Cardiovasc Pharmacol Ther. 2011;16:168-72. doi:10.1177/1074248410382105.</mixed-citation><mixed-citation xml:lang="en">Figueredo VM, Pressman GS, Romero-Corral A, et al. Improvement in left ventricular systolic and diastolic performance during ranolazine treatment in patients with stable angina. J Cardiovasc Pharmacol Ther. 2011;16:168-72. doi:10.1177/1074248410382105.</mixed-citation></citation-alternatives></ref><ref id="cit290"><label>290</label><citation-alternatives><mixed-citation xml:lang="ru">Coppini R, Ferrantini C, Yao L, et al. Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy. Circulation. 2013;127:575-84. doi:10.1161/CIRCULATIONAHA.112.134932.</mixed-citation><mixed-citation xml:lang="en">Coppini R, Ferrantini C, Yao L, et al. Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy. Circulation. 2013;127:575-84. doi:10.1161/CIRCULATIONAHA.112.134932.</mixed-citation></citation-alternatives></ref><ref id="cit291"><label>291</label><citation-alternatives><mixed-citation xml:lang="ru">Williams S, Pourrier M, McAfee D, et al. Ranolazine improves diastolic function in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2014;306:H867-H881. doi:10.1152/ajpheart.00704.2013.</mixed-citation><mixed-citation xml:lang="en">Williams S, Pourrier M, McAfee D, et al. Ranolazine improves diastolic function in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2014;306:H867-H881. doi:10.1152/ajpheart.00704.2013.</mixed-citation></citation-alternatives></ref><ref id="cit292"><label>292</label><citation-alternatives><mixed-citation xml:lang="ru">De Angelis A, Cappetta D, Piegari E, et al. Long-term administration of ranolazine attenuates diastolic dysfunction and adverse myocardial remodeling in a model of heart failure with preserved ejection fraction. Int J Cardiol. 2016;217:69-79. doi:10.1016/j.ijcard.2016.04.168.</mixed-citation><mixed-citation xml:lang="en">De Angelis A, Cappetta D, Piegari E, et al. Long-term administration of ranolazine attenuates diastolic dysfunction and adverse myocardial remodeling in a model of heart failure with preserved ejection fraction. Int J Cardiol. 2016;217:69-79. doi:10.1016/j.ijcard.2016.04.168.</mixed-citation></citation-alternatives></ref><ref id="cit293"><label>293</label><citation-alternatives><mixed-citation xml:lang="ru">Tocchetti CG, Carpi A, Coppola C, et al. Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction. Eur J Heart Fail. 2014;16:358-66. doi:10.1002/ejhf.50.</mixed-citation><mixed-citation xml:lang="en">Tocchetti CG, Carpi A, Coppola C, et al. Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction. Eur J Heart Fail. 2014;16:358-66. doi:10.1002/ejhf.50.</mixed-citation></citation-alternatives></ref><ref id="cit294"><label>294</label><citation-alternatives><mixed-citation xml:lang="ru">Corradi F, Paolini L, De Caterina R. Ranolazine in the prevention of anthracycline cardiotoxicity. Pharmacol Res. 2014;79:88-102. doi:10.1016/j.phrs.2013.11.001.</mixed-citation><mixed-citation xml:lang="en">Corradi F, Paolini L, De Caterina R. Ranolazine in the prevention of anthracycline cardiotoxicity. Pharmacol Res. 2014;79:88-102. doi:10.1016/j.phrs.2013.11.001.</mixed-citation></citation-alternatives></ref><ref id="cit295"><label>295</label><citation-alternatives><mixed-citation xml:lang="ru">Negishi T, Thavendiranathan P, Negishi K, Marwick TH; SUCCOUR investigators. Rationale and design of the strain survelliance chemoteraphy for improving cardiovascular outcomes: The tial. JAAC Cardiovasc Imaging. 2018;11:1098-105.</mixed-citation><mixed-citation xml:lang="en">Negishi T, Thavendiranathan P, Negishi K, Marwick TH; SUCCOUR investigators. Rationale and design of the strain survelliance chemoteraphy for improving cardiovascular outcomes: The tial. JAAC Cardiovasc Imaging. 2018;11:1098-105.</mixed-citation></citation-alternatives></ref><ref id="cit296"><label>296</label><citation-alternatives><mixed-citation xml:lang="ru">Cardinale D, Colombo A, Bacchiani G, et al. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation. 2015;131:1981-8. doi:10.1161/CIRCULATIONAHA.114.013777.</mixed-citation><mixed-citation xml:lang="en">Cardinale D, Colombo A, Bacchiani G, et al. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation. 2015;131:1981-8. doi:10.1161/CIRCULATIONAHA.114.013777.</mixed-citation></citation-alternatives></ref><ref id="cit297"><label>297</label><citation-alternatives><mixed-citation xml:lang="ru">Tallaj JA, Franco V, Rayburn BK, et al. Response of doxorubicin-induced cardiomyopathy to the current management strategy of heart failure. J Heart Lung Transplant. 2005;24:2196- 201. doi:10.1016/j.healun.2004.12.108.</mixed-citation><mixed-citation xml:lang="en">Tallaj JA, Franco V, Rayburn BK, et al. Response of doxorubicin-induced cardiomyopathy to the current management strategy of heart failure. J Heart Lung Transplant. 2005;24:2196- 201. doi:10.1016/j.healun.2004.12.108.</mixed-citation></citation-alternatives></ref><ref id="cit298"><label>298</label><citation-alternatives><mixed-citation xml:lang="ru">Virani SA, Dent S, Brezden-Masley C, et al. Canadian Cardiovascular Society guidelines for evaluation and management of cardiovascular complications of cancer therapy. Can J Cardiol. 2016;32:831-41. doi:10.1016/j.cjca.2016.02.078.</mixed-citation><mixed-citation xml:lang="en">Virani SA, Dent S, Brezden-Masley C, et al. Canadian Cardiovascular Society guidelines for evaluation and management of cardiovascular complications of cancer therapy. Can J Cardiol. 2016;32:831-41. doi:10.1016/j.cjca.2016.02.078.</mixed-citation></citation-alternatives></ref><ref id="cit299"><label>299</label><citation-alternatives><mixed-citation xml:lang="ru">Мареев В.Ю., Фомин И.В., Агеев Ф.Т., и др. Клинические рекомендации ОССН-РКО-РНМОТ. Сердечная недостаточность: хроническая (ХСН) и острая декомпенсированная (ОДСН). Диагностика, профилактика и лечение. Кардиология. 2018;58(S6):8-158. doi:10.18087/cardio.2475.</mixed-citation><mixed-citation xml:lang="en">Mareev VYu, Fomin IV, Ageev FT, et al. Russian Heart Failure Society, Russian Society of Cardiology. Russian Scientific Medical Society of Internal Medicine Guidelines for Heart failure: chronic (CHF) and acute decompensated (ADHF). Diagnosis, prevention and treatment. Kardiologiia. 2018;58(6S):8-158. (In Russ.) doi:10.18087/cardio.2475.</mixed-citation></citation-alternatives></ref><ref id="cit300"><label>300</label><citation-alternatives><mixed-citation xml:lang="ru">Sacks FM, Pfeffer MA, Moye LA, et al.; for the Cholesterol and Recurrent Events Trial Investigators. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 1996;335:1001-9. doi:10.1056/NEJM199610033351401.</mixed-citation><mixed-citation xml:lang="en">Sacks FM, Pfeffer MA, Moye LA, et al.; for the Cholesterol and Recurrent Events Trial Investigators. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 1996;335:1001-9. doi:10.1056/NEJM199610033351401.</mixed-citation></citation-alternatives></ref><ref id="cit301"><label>301</label><citation-alternatives><mixed-citation xml:lang="ru">Cholesterol Treatment Trialists’ (CTT) Collaboration. Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy. PLoS One. 2012;7:e29849. doi:10.1371/journal.pone.0029849.</mixed-citation><mixed-citation xml:lang="en">Cholesterol Treatment Trialists’ (CTT) Collaboration. Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy. PLoS One. 2012;7:e29849. doi:10.1371/journal.pone.0029849.</mixed-citation></citation-alternatives></ref><ref id="cit302"><label>302</label><citation-alternatives><mixed-citation xml:lang="ru">Bonovas S, Filioussi K, Tsavaris N, Sitaras NM. Use of statins and breast cancer: a metaanalysis of seven randomized clinical trials and nine observational studies. J Clin Oncol. 2005;23:8606-12. doi:10.1200/JCO.2005.02.7045.</mixed-citation><mixed-citation xml:lang="en">Bonovas S, Filioussi K, Tsavaris N, Sitaras NM. Use of statins and breast cancer: a metaanalysis of seven randomized clinical trials and nine observational studies. J Clin Oncol. 2005;23:8606-12. doi:10.1200/JCO.2005.02.7045.</mixed-citation></citation-alternatives></ref><ref id="cit303"><label>303</label><citation-alternatives><mixed-citation xml:lang="ru">Undela K, Srikanth V, Bansal D. Statin use and risk of breast cancer: a meta-analysis of observational studies. Breast Cancer Res Treat. 2012;135:261-9. doi:10.1007/s10549-012-2154-x.</mixed-citation><mixed-citation xml:lang="en">Undela K, Srikanth V, Bansal D. Statin use and risk of breast cancer: a meta-analysis of observational studies. Breast Cancer Res Treat. 2012;135:261-9. doi:10.1007/s10549-012-2154-x.</mixed-citation></citation-alternatives></ref><ref id="cit304"><label>304</label><citation-alternatives><mixed-citation xml:lang="ru">Desai P, Chlebowski R, Cauley JA, et al. Prospective analysis of association between statin use and breast cancer risk in the women’s health initiative. Cancer Epidemiol Biomarkers Prev. 2013;22:1868-76. doi:10.1158/1055-9965.EPI-13-0562.</mixed-citation><mixed-citation xml:lang="en">Desai P, Chlebowski R, Cauley JA, et al. Prospective analysis of association between statin use and breast cancer risk in the women’s health initiative. Cancer Epidemiol Biomarkers Prev. 2013;22:1868-76. doi:10.1158/1055-9965.EPI-13-0562.</mixed-citation></citation-alternatives></ref><ref id="cit305"><label>305</label><citation-alternatives><mixed-citation xml:lang="ru">Preventing Anthracycline Cardiovascular Toxicity With Statins (PREVENT). https://clinicaltrials.gov/ct2/show/NCT01988571. Accessed June 26, 2017.</mixed-citation><mixed-citation xml:lang="en">Preventing Anthracycline Cardiovascular Toxicity With Statins (PREVENT). https://clinicaltrials.gov/ct2/show/NCT01988571. Accessed June 26, 2017.</mixed-citation></citation-alternatives></ref><ref id="cit306"><label>306</label><citation-alternatives><mixed-citation xml:lang="ru">Виценя М.В., Потехина А.В., Гаврюшина С.В. и др. Профилактика и лечение дисфункции левого желудочка и сердечной недостаточности, связанных с противоопухолевой терапией: возможности и перспективы. Эффективная фармакотерапия 2020;16(8):108-20. doi:10.33978/2307-3586-2020-16-18-108-120.</mixed-citation><mixed-citation xml:lang="en">Vitsenya MV Potekhina AV, Gavryushina SV, et al. Prevention and treatment of left ventricular dysfunction and heart failure associated with antitumor therapy: opportunities and prospects. Effective pharmacotherapy 2020;16(8):108-20. (In Russ.) doi:10.33978/2307-3586-2020-16-18-108-120.</mixed-citation></citation-alternatives></ref><ref id="cit307"><label>307</label><citation-alternatives><mixed-citation xml:lang="ru">Vitsenya M, Potekhina A, Gavryushina S, et al. Sacubitril/valsartan improves heart failure functional class, left ventricular systolic and diastolic function and neurohumoral status in patients with anthracycline-induced cardiomyopathy. Eur Heart Journal. 2020;41(Suppl 2):3265. doi:10.1093/ehjci/ehaa946.3265.</mixed-citation><mixed-citation xml:lang="en">Vitsenya M, Potekhina A, Gavryushina S, et al. Sacubitril/valsartan improves heart failure functional class, left ventricular systolic and diastolic function and neurohumoral status in patients with anthracycline-induced cardiomyopathy. Eur Heart Journal. 2020;41(Suppl 2):3265. doi:10.1093/ehjci/ehaa946.3265.</mixed-citation></citation-alternatives></ref><ref id="cit308"><label>308</label><citation-alternatives><mixed-citation xml:lang="ru">Rueckert S, Ruechl I, Kachlert S, et al. A monoclonal antibody as an effective therapeutic agent in breast cancer: trastuzumab. Expert Opinion on Biological Therapy. 2005;5(6):853- 66. doi:10.1517/14712598.5.6.853.</mixed-citation><mixed-citation xml:lang="en">Rueckert S, Ruechl I, Kachlert S, et al. A monoclonal antibody as an effective therapeutic agent in breast cancer: trastuzumab. Expert Opinion on Biological Therapy. 2005;5(6):853- 66. doi:10.1517/14712598.5.6.853.</mixed-citation></citation-alternatives></ref><ref id="cit309"><label>309</label><citation-alternatives><mixed-citation xml:lang="ru">Seisean S, Seisean A, Alan N, et al. Cardioprotective effects of β-adrenoreceptor blockade inpatients with breast cancer undergoing chemotherapy: follow-up study of heart failure. Circ Heart Fail. 2013;6:420-6. doi:10.1161/CIRCHEARTFAILURE.112.000055.</mixed-citation><mixed-citation xml:lang="en">Seisean S, Seisean A, Alan N, et al. Cardioprotective effects of β-adrenoreceptor blockade inpatients with breast cancer undergoing chemotherapy: follow-up study of heart failure. Circ Heart Fail. 2013;6:420-6. doi:10.1161/CIRCHEARTFAILURE.112.000055.</mixed-citation></citation-alternatives></ref><ref id="cit310"><label>310</label><citation-alternatives><mixed-citation xml:lang="ru">Slamon D, Eiermann W, Robert N, et al. Breast Cancer international Research Group. Adjuvant trastuzumab in HER2-positive breast cancer. N. Engl J Med. 2011;365:1273-83.</mixed-citation><mixed-citation xml:lang="en">Slamon D, Eiermann W, Robert N, et al. Breast Cancer international Research Group. Adjuvant trastuzumab in HER2-positive breast cancer. N. Engl J Med. 2011;365:1273-83.</mixed-citation></citation-alternatives></ref><ref id="cit311"><label>311</label><citation-alternatives><mixed-citation xml:lang="ru">Pituskin E, Mackey JR, Koshman S, et al. Multidisciplinary Approach to Novell Therapies in Cardio-oncology Research (MANTICORE 101-Breast). A randomized trial for the prevention of trastuzumab-assosiated cardiotoxicity. J Clin Oncol. 2017;35(8):870-7. doi:10.1200/JCO.2016.68.7830.</mixed-citation><mixed-citation xml:lang="en">Pituskin E, Mackey JR, Koshman S, et al. Multidisciplinary Approach to Novell Therapies in Cardio-oncology Research (MANTICORE 101-Breast). A randomized trial for the prevention of trastuzumab-assosiated cardiotoxicity. J Clin Oncol. 2017;35(8):870-7. doi:10.1200/JCO.2016.68.7830.</mixed-citation></citation-alternatives></ref><ref id="cit312"><label>312</label><citation-alternatives><mixed-citation xml:lang="ru">Oliva S, Cioffi G, Frattini S, et al.; on behalf of the Italian Cardio-Oncological Network. Administration of angiotensin-converting enzyme inhibitors and β-blockers during adjuvant trastuzumab chemotherapy for nonmetastatic breast cancer: marker of risk or cardioprotection in the real world? Oncologist. 2012;17:917-24. doi:10.1634/theoncologist.2011-0445.</mixed-citation><mixed-citation xml:lang="en">Oliva S, Cioffi G, Frattini S, et al.; on behalf of the Italian Cardio-Oncological Network. Administration of angiotensin-converting enzyme inhibitors and β-blockers during adjuvant trastuzumab chemotherapy for nonmetastatic breast cancer: marker of risk or cardioprotection in the real world? Oncologist. 2012;17:917-24. doi:10.1634/theoncologist.2011-0445.</mixed-citation></citation-alternatives></ref><ref id="cit313"><label>313</label><citation-alternatives><mixed-citation xml:lang="ru">Ewer MS, Vooletich MT, Durand JB, et al. Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol. 2005;23:7820-6. doi:10.1200/JCO.2005.13.300.</mixed-citation><mixed-citation xml:lang="en">Ewer MS, Vooletich MT, Durand JB, et al. Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol. 2005;23:7820-6. doi:10.1200/JCO.2005.13.300.</mixed-citation></citation-alternatives></ref><ref id="cit314"><label>314</label><citation-alternatives><mixed-citation xml:lang="ru">Mackey JR, Clemons M, Côté MA, et al. Cardiac management during adjuvant trastuzumab therapy: recommendations of the Canadian Trastuzumab Working Group. Curr Oncol. 2008;15:24-35.</mixed-citation><mixed-citation xml:lang="en">Mackey JR, Clemons M, Côté MA, et al. Cardiac management during adjuvant trastuzumab therapy: recommendations of the Canadian Trastuzumab Working Group. Curr Oncol. 2008;15:24-35.</mixed-citation></citation-alternatives></ref><ref id="cit315"><label>315</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt AC, Graf Ch, Brixius K, et al. Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus. The YESTONO Study. Clin Drug Invest. 2007;27(12):841-9.</mixed-citation><mixed-citation xml:lang="en">Schmidt AC, Graf Ch, Brixius K, et al. Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus. The YESTONO Study. Clin Drug Invest. 2007;27(12):841-9.</mixed-citation></citation-alternatives></ref><ref id="cit316"><label>316</label><citation-alternatives><mixed-citation xml:lang="ru">Un HH, Kim S, Kuh HJ, Lee JH. Downregulation of BIS sensitizes A549 cells for digoxinmediated inhibition of invasion and migration by the STAT3-dependent pathway. Biochem Biophys Res Commun. 2020;524(3):643-8. doi:10.1016/j.bbrc.2020.01.154.</mixed-citation><mixed-citation xml:lang="en">Un HH, Kim S, Kuh HJ, Lee JH. Downregulation of BIS sensitizes A549 cells for digoxinmediated inhibition of invasion and migration by the STAT3-dependent pathway. Biochem Biophys Res Commun. 2020;524(3):643-8. doi:10.1016/j.bbrc.2020.01.154.</mixed-citation></citation-alternatives></ref><ref id="cit317"><label>317</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y, Ma Q, Zhang S, et al. Digoxin Enhances the Anticancer Effect on Non-Small Cell Lung Cancer While Reducing the Cardiotoxicity of Adriamycin. Front Pharmacol. 2020;11:186. doi:10.3389/fphar.2020.00186.</mixed-citation><mixed-citation xml:lang="en">Wang Y, Ma Q, Zhang S, et al. Digoxin Enhances the Anticancer Effect on Non-Small Cell Lung Cancer While Reducing the Cardiotoxicity of Adriamycin. Front Pharmacol. 2020;11:186. doi:10.3389/fphar.2020.00186.</mixed-citation></citation-alternatives></ref><ref id="cit318"><label>318</label><citation-alternatives><mixed-citation xml:lang="ru">Yun HH, Kim S, Kuh HJ, Lee JH. Downregulation of BIS sensitizes A549 cells for digoxinmediated inhibition of invasion and migration by the STAT3-dependent pathway. Biochem Biophys Res Commun. 2020;524(3):643-8. doi:10.1016/j.bbrc.2020.01.154.</mixed-citation><mixed-citation xml:lang="en">Yun HH, Kim S, Kuh HJ, Lee JH. Downregulation of BIS sensitizes A549 cells for digoxinmediated inhibition of invasion and migration by the STAT3-dependent pathway. Biochem Biophys Res Commun. 2020;524(3):643-8. doi:10.1016/j.bbrc.2020.01.154.</mixed-citation></citation-alternatives></ref><ref id="cit319"><label>319</label><citation-alternatives><mixed-citation xml:lang="ru">Villani F, Comazzi R, Di Fronzo G, et al. Evaluation of doxorubicin cardiotoxicity in patients treated intermittently with beta-methyldigoxin. Tumori. 1982;68(4):349-53.</mixed-citation><mixed-citation xml:lang="en">Villani F, Comazzi R, Di Fronzo G, et al. Evaluation of doxorubicin cardiotoxicity in patients treated intermittently with beta-methyldigoxin. Tumori. 1982;68(4):349-53.</mixed-citation></citation-alternatives></ref><ref id="cit320"><label>320</label><citation-alternatives><mixed-citation xml:lang="ru">Shiga T, Im J, Kikuchi N, Arakawa Y. The Effective Use of Digoxin in a Patient with Metastatic Breast Cancer and Anthracycline-induced Cardiomyopathy. Intern Med. 2021;60(17):2819-23. doi:10.2169/internalmedicine.6787-20.</mixed-citation><mixed-citation xml:lang="en">Shiga T, Im J, Kikuchi N, Arakawa Y. The Effective Use of Digoxin in a Patient with Metastatic Breast Cancer and Anthracycline-induced Cardiomyopathy. Intern Med. 2021;60(17):2819-23. doi:10.2169/internalmedicine.6787-20.</mixed-citation></citation-alternatives></ref><ref id="cit321"><label>321</label><citation-alternatives><mixed-citation xml:lang="ru">Lenčová-Popelová O, Jirkovský E, Jansová H, et al. Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane. J Mol Cell Cardiol. 2016;91:92-103. doi:10.1016/j.yjmcc.2015.12.021.</mixed-citation><mixed-citation xml:lang="en">Lenčová-Popelová O, Jirkovský E, Jansová H, et al. Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane. J Mol Cell Cardiol. 2016;91:92-103. doi:10.1016/j.yjmcc.2015.12.021.</mixed-citation></citation-alternatives></ref><ref id="cit322"><label>322</label><citation-alternatives><mixed-citation xml:lang="ru">Xi L, Zhu SG, Das A, et al. Dietary Inorganic Nitrate Alleviates Doxorubicin Cardiotoxicity: echanisms and Implications. Nitric Oxide. 2012;26(4):274-84. doi:10.1016/j.niox.2012.03.006.</mixed-citation><mixed-citation xml:lang="en">Xi L, Zhu SG, Das A, et al. Dietary Inorganic Nitrate Alleviates Doxorubicin Cardiotoxicity: echanisms and Implications. Nitric Oxide. 2012;26(4):274-84. doi:10.1016/j.niox.2012.03.006.</mixed-citation></citation-alternatives></ref><ref id="cit323"><label>323</label><citation-alternatives><mixed-citation xml:lang="ru">Refaie MMM, Shehata S, El-Hussieny M, et al. Role of ATP-Sensitive Potassium Channel (KATP) and eNOS in Mediating the Protective Effect of Nicorandil in CyclophosphamideInduced Cardiotoxicity. Cardiovasc Toxicol. 2020;20(1):71-81. doi:10.1007/s12012-019-09535-8.</mixed-citation><mixed-citation xml:lang="en">Refaie MMM, Shehata S, El-Hussieny M, et al. Role of ATP-Sensitive Potassium Channel (KATP) and eNOS in Mediating the Protective Effect of Nicorandil in CyclophosphamideInduced Cardiotoxicity. Cardiovasc Toxicol. 2020;20(1):71-81. doi:10.1007/s12012-019-09535-8.</mixed-citation></citation-alternatives></ref><ref id="cit324"><label>324</label><citation-alternatives><mixed-citation xml:lang="ru">Piccirillo JF, Tierney RM, Costas I, et al. Prognostic importance of comorbidity in a hospital-based cancer registry. JAMA. 2004;291(20):2441-7.</mixed-citation><mixed-citation xml:lang="en">Piccirillo JF, Tierney RM, Costas I, et al. Prognostic importance of comorbidity in a hospital-based cancer registry. JAMA. 2004;291(20):2441-7.</mixed-citation></citation-alternatives></ref><ref id="cit325"><label>325</label><citation-alternatives><mixed-citation xml:lang="ru">Vaklavas C, Lenihan D, Kurzrock R, et al. Anti-vascular endothelial growth factor therapies and cardiovascular toxicity: what are the important clinical markers to target? Oncologist. 2010;15:130-41.</mixed-citation><mixed-citation xml:lang="en">Vaklavas C, Lenihan D, Kurzrock R, et al. Anti-vascular endothelial growth factor therapies and cardiovascular toxicity: what are the important clinical markers to target? Oncologist. 2010;15:130-41.</mixed-citation></citation-alternatives></ref><ref id="cit326"><label>326</label><citation-alternatives><mixed-citation xml:lang="ru">Lenihan DJ, Kowey PR. Overview and management of cardiac adverse events associated with tyrosine kinase inhibitors. Oncologist. 2013;18:900-8.</mixed-citation><mixed-citation xml:lang="en">Lenihan DJ, Kowey PR. Overview and management of cardiac adverse events associated with tyrosine kinase inhibitors. Oncologist. 2013;18:900-8.</mixed-citation></citation-alternatives></ref><ref id="cit327"><label>327</label><citation-alternatives><mixed-citation xml:lang="ru">Kerkela R, Woulfe KC, Durand JB, et al. Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci. 2009;2:15-25.</mixed-citation><mixed-citation xml:lang="en">Kerkela R, Woulfe KC, Durand JB, et al. Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci. 2009;2:15-25.</mixed-citation></citation-alternatives></ref><ref id="cit328"><label>328</label><citation-alternatives><mixed-citation xml:lang="ru">Khakoo AY Kassiotis CM,Tannir N, et al. Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor. Cancer. 2008;112:2500-8.</mixed-citation><mixed-citation xml:lang="en">Khakoo AY Kassiotis CM,Tannir N, et al. Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor. Cancer. 2008;112:2500-8.</mixed-citation></citation-alternatives></ref><ref id="cit329"><label>329</label><citation-alternatives><mixed-citation xml:lang="ru">Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356(2):125-34.</mixed-citation><mixed-citation xml:lang="en">Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356(2):125-34.</mixed-citation></citation-alternatives></ref><ref id="cit330"><label>330</label><citation-alternatives><mixed-citation xml:lang="ru">Meinardi MT, Gietema JA, van der Graaf WT, et al. Cardiovascular morbidity in long-term survivors of metastatic testicular cancer. J Clin Oncol. 2000;18(8):1725-32.</mixed-citation><mixed-citation xml:lang="en">Meinardi MT, Gietema JA, van der Graaf WT, et al. Cardiovascular morbidity in long-term survivors of metastatic testicular cancer. J Clin Oncol. 2000;18(8):1725-32.</mixed-citation></citation-alternatives></ref><ref id="cit331"><label>331</label><citation-alternatives><mixed-citation xml:lang="ru">Hassen LJ, Lenihan DJ, Baliga RR. Hypertension in the Cardio-Oncology Clinic. Heart Fail Clin. 2019;15:487-95. doi:10.1016/j.hfc.2019.06.010.</mixed-citation><mixed-citation xml:lang="en">Hassen LJ, Lenihan DJ, Baliga RR. Hypertension in the Cardio-Oncology Clinic. Heart Fail Clin. 2019;15:487-95. doi:10.1016/j.hfc.2019.06.010.</mixed-citation></citation-alternatives></ref><ref id="cit332"><label>332</label><citation-alternatives><mixed-citation xml:lang="ru">Maitland ML, Kasza KE, Karrison T, et al. Ambulatory monitoring detects sorafenibinduced blood pressure elevations on the first day of treatment.Clin Cancer Res. 2009;15:6250-7.</mixed-citation><mixed-citation xml:lang="en">Maitland ML, Kasza KE, Karrison T, et al. Ambulatory monitoring detects sorafenibinduced blood pressure elevations on the first day of treatment.Clin Cancer Res. 2009;15:6250-7.</mixed-citation></citation-alternatives></ref><ref id="cit333"><label>333</label><citation-alternatives><mixed-citation xml:lang="ru">Hamnvik OP, Choueiri TK,Turchin A, et al. Clinical risk factors for the development of hypertension in patients treated with inhibitors of the VEGF signaling pathway. Cancer. 2015;121:311-9. doi:10.1002/cncr.28972.</mixed-citation><mixed-citation xml:lang="en">Hamnvik OP, Choueiri TK,Turchin A, et al. Clinical risk factors for the development of hypertension in patients treated with inhibitors of the VEGF signaling pathway. Cancer. 2015;121:311-9. doi:10.1002/cncr.28972.</mixed-citation></citation-alternatives></ref><ref id="cit334"><label>334</label><citation-alternatives><mixed-citation xml:lang="ru">Abdel-Qadir H, Ethier JL, Lee DS, et al. Cardiovascular toxicity of angiogenesis inhibitors in treatment of malignancy: A systematic review and meta-analysis. Cancer Treat Rev. 2017;53:120-7. doi:10.1016/j.ctrv.2016.12.002.</mixed-citation><mixed-citation xml:lang="en">Abdel-Qadir H, Ethier JL, Lee DS, et al. Cardiovascular toxicity of angiogenesis inhibitors in treatment of malignancy: A systematic review and meta-analysis. Cancer Treat Rev. 2017;53:120-7. doi:10.1016/j.ctrv.2016.12.002.</mixed-citation></citation-alternatives></ref><ref id="cit335"><label>335</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж.Д., Конради А.О., Недогода С.В. и др. Артериальная гипертензия у взрослых. Клинические рекомендации 2020. Российский кардиологический журнал. 2020;25(3):3786. doi:10.15829/1560-4071-2020-3-3786.</mixed-citation><mixed-citation xml:lang="en">Kobalava ZhD, Konradi AO, Nedogoda SV, et al. Arterial hypertension in adults. Clinical guidelines 2020. Russian Journal of Cardiology. 2020;25(3):3786. (In Russ.) doi:10.15829/1560-4071-2020-3-3786.</mixed-citation></citation-alternatives></ref><ref id="cit336"><label>336</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen JB, Geara AS, Hogan JJ, Townsend RR. Hypertension in Cancer Patients and Survivors: Epidemiology, Diagnosis, and Management. JACC CardioOncol. 2019;1(2):238- 51. doi:10.1016/j.jaccao.2019.11.009.</mixed-citation><mixed-citation xml:lang="en">Cohen JB, Geara AS, Hogan JJ, Townsend RR. Hypertension in Cancer Patients and Survivors: Epidemiology, Diagnosis, and Management. JACC CardioOncol. 2019;1(2):238- 51. doi:10.1016/j.jaccao.2019.11.009.</mixed-citation></citation-alternatives></ref><ref id="cit337"><label>337</label><citation-alternatives><mixed-citation xml:lang="ru">Guglin M, Krischer J,Tamura R, et al. Randomized trial of lisinopril versus carvedilol to prevent trastuzumab cardiotoxicity in patients with breast cancer. J Am Coll Cardiol. 2019;73:2859-68.</mixed-citation><mixed-citation xml:lang="en">Guglin M, Krischer J,Tamura R, et al. Randomized trial of lisinopril versus carvedilol to prevent trastuzumab cardiotoxicity in patients with breast cancer. J Am Coll Cardiol. 2019;73:2859-68.</mixed-citation></citation-alternatives></ref><ref id="cit338"><label>338</label><citation-alternatives><mixed-citation xml:lang="ru">Bottinor WJ, Shuey MM, Manouchehri A, et al. Renin-Angiotensin-Aldosterone System Modulates Blood Pressure Response During Vascular Endothelial Growth Factor Receptor Inhibition. JACC CardioOncol. 2019;1(1):14-23. doi:10.1016/j.jaccao.2019.07.002.</mixed-citation><mixed-citation xml:lang="en">Bottinor WJ, Shuey MM, Manouchehri A, et al. Renin-Angiotensin-Aldosterone System Modulates Blood Pressure Response During Vascular Endothelial Growth Factor Receptor Inhibition. JACC CardioOncol. 2019;1(1):14-23. doi:10.1016/j.jaccao.2019.07.002.</mixed-citation></citation-alternatives></ref><ref id="cit339"><label>339</label><citation-alternatives><mixed-citation xml:lang="ru">Mouhayar E, Salahudeen A. Hypertension in cancer patients. Tex Heart Inst J. 2011;38(3):263-5.</mixed-citation><mixed-citation xml:lang="en">Mouhayar E, Salahudeen A. Hypertension in cancer patients. Tex Heart Inst J. 2011;38(3):263-5.</mixed-citation></citation-alternatives></ref><ref id="cit340"><label>340</label><citation-alternatives><mixed-citation xml:lang="ru">McKay RR, Rodriguez GE, Lin X, et al. Angiotensin system inhibitors and survival outcomes in patients with metastatic renal cell carcinoma. Clin Cancer Res. 2015;21:2471-9. doi:10.1158/1078-0432.CCR-14-2332.</mixed-citation><mixed-citation xml:lang="en">McKay RR, Rodriguez GE, Lin X, et al. Angiotensin system inhibitors and survival outcomes in patients with metastatic renal cell carcinoma. Clin Cancer Res. 2015;21:2471-9. doi:10.1158/1078-0432.CCR-14-2332.</mixed-citation></citation-alternatives></ref><ref id="cit341"><label>341</label><citation-alternatives><mixed-citation xml:lang="ru">Li XY, Sun JF, Hu SQ. The renin-angiotensin system blockers as adjunctive therapy for cancer: a meta-analysis of survival outcome. Eur Rev Med Pharmacol Sci. 2017;21:1375-83.</mixed-citation><mixed-citation xml:lang="en">Li XY, Sun JF, Hu SQ. The renin-angiotensin system blockers as adjunctive therapy for cancer: a meta-analysis of survival outcome. Eur Rev Med Pharmacol Sci. 2017;21:1375-83.</mixed-citation></citation-alternatives></ref><ref id="cit342"><label>342</label><citation-alternatives><mixed-citation xml:lang="ru">Catino AB, Hubbard RA,Chirinos JA, et al. Longitudinal assessment of vascular function with sunitinib in patients with metastatic renal cell carcinoma. Circ Heart Fail. 2018;11:e004408. doi:10.1161/CIRCHEARTFAILURE.117.004408.</mixed-citation><mixed-citation xml:lang="en">Catino AB, Hubbard RA,Chirinos JA, et al. Longitudinal assessment of vascular function with sunitinib in patients with metastatic renal cell carcinoma. Circ Heart Fail. 2018;11:e004408. doi:10.1161/CIRCHEARTFAILURE.117.004408.</mixed-citation></citation-alternatives></ref><ref id="cit343"><label>343</label><citation-alternatives><mixed-citation xml:lang="ru">Curwen JO, Musgrove HL, Kendrew J, et al. Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant, antihypertensive therapy. Clin Cancer Res. 2008;14:3124-31. doi:10.1158/1078-0432.CCR-07-4783.</mixed-citation><mixed-citation xml:lang="en">Curwen JO, Musgrove HL, Kendrew J, et al. Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant, antihypertensive therapy. Clin Cancer Res. 2008;14:3124-31. doi:10.1158/1078-0432.CCR-07-4783.</mixed-citation></citation-alternatives></ref><ref id="cit344"><label>344</label><citation-alternatives><mixed-citation xml:lang="ru">Marvel FA, Whelton SP, Blumenthal RS. A Cardio-Oncology Cardiovascular Prevention Framework. JACC CardioOncol. 2019;1(2):252-255. doi:10.1016/j.jaccao.2019.11.012.</mixed-citation><mixed-citation xml:lang="en">Marvel FA, Whelton SP, Blumenthal RS. A Cardio-Oncology Cardiovascular Prevention Framework. JACC CardioOncol. 2019;1(2):252-255. doi:10.1016/j.jaccao.2019.11.012.</mixed-citation></citation-alternatives></ref><ref id="cit345"><label>345</label><citation-alternatives><mixed-citation xml:lang="ru">Agarwal M, Thareja N, Benjamin M, et al. Tyrosine Kinase Inhibitor-Induced Hypertension. Curr Oncol Rep. 2018;20(8):65. doi:10.1007/s11912-018-0708-8.</mixed-citation><mixed-citation xml:lang="en">Agarwal M, Thareja N, Benjamin M, et al. Tyrosine Kinase Inhibitor-Induced Hypertension. Curr Oncol Rep. 2018;20(8):65. doi:10.1007/s11912-018-0708-8.</mixed-citation></citation-alternatives></ref><ref id="cit346"><label>346</label><citation-alternatives><mixed-citation xml:lang="ru">Cheung AK, Chang TI, Cushman WC, et al. Executive summary of the KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int. 2021;99(3):559-69. doi:10.1016/j.kint.2020.10.026.</mixed-citation><mixed-citation xml:lang="en">346 Cheung AK, Chang TI, Cushman WC, et al. Executive summary of the KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int. 2021;99(3):559-69. doi:10.1016/j.kint.2020.10.026.</mixed-citation></citation-alternatives></ref><ref id="cit347"><label>347</label><citation-alternatives><mixed-citation xml:lang="ru">Navi BB, Reiner AS, Kamel H, et al. Risk of arterial thromboembolism in patients with cancer. J Am Coll Cardiol. 2017;70(8):926-938. doi:10.1016/j.jacc.2017.06.047.</mixed-citation><mixed-citation xml:lang="en">Navi BB, Reiner AS, Kamel H, et al. Risk of arterial thromboembolism in patients with cancer. J Am Coll Cardiol. 2017;70(8):926-938. doi:10.1016/j.jacc.2017.06.047.</mixed-citation></citation-alternatives></ref><ref id="cit348"><label>348</label><citation-alternatives><mixed-citation xml:lang="ru">Berton G, Cordiano R, Cavuto F, et al. Neoplastic disease after acute coronary syndrome: incidence, duration, and features: the ABC-4* Study on Heart Disease. J Cardiovasc Med (Hagerstown). 2018;19(10):546-53. doi:10.2459/JCM.0000000000000701.</mixed-citation><mixed-citation xml:lang="en">Berton G, Cordiano R, Cavuto F, et al. Neoplastic disease after acute coronary syndrome: incidence, duration, and features: the ABC-4* Study on Heart Disease. J Cardiovasc Med (Hagerstown). 2018;19(10):546-53. doi:10.2459/JCM.0000000000000701.</mixed-citation></citation-alternatives></ref><ref id="cit349"><label>349</label><citation-alternatives><mixed-citation xml:lang="ru">Han XJ, Li JQ, Khannanova Z, Li Y. Optimal management of coronary artery disease in cancer patients. Chronic Dis Transl Med. 2020;5(4):221-33. doi:10.1016/j.cdtm.2019.12.007.</mixed-citation><mixed-citation xml:lang="en">Han XJ, Li JQ, Khannanova Z, Li Y. Optimal management of coronary artery disease in cancer patients. Chronic Dis Transl Med. 2020;5(4):221-33. doi:10.1016/j.cdtm.2019.12.007.</mixed-citation></citation-alternatives></ref><ref id="cit350"><label>350</label><citation-alternatives><mixed-citation xml:lang="ru">Herrmann J, Yang EH, Iliescu CA, et al. Vascular Toxicities of Cancer Therapies. The Old and the New — An Evolving Avenue. Circulation. 2016;133(13):1272-89. doi:10.1161/CIRCULATIONAHA.115.018347.</mixed-citation><mixed-citation xml:lang="en">Herrmann J, Yang EH, Iliescu CA, et al. Vascular Toxicities of Cancer Therapies. The Old and the New — An Evolving Avenue. Circulation. 2016;133(13):1272-89. doi:10.1161/CIRCULATIONAHA.115.018347.</mixed-citation></citation-alternatives></ref><ref id="cit351"><label>351</label><citation-alternatives><mixed-citation xml:lang="ru">Mohanty BD, Mohanty S, Hussain Y, et al. Management of ischemic coronary disease in patients receiving chemotherapy: an uncharted clinical challenge. Future Cardiol. 2017;13(3):247-57. doi:10.2217/fca-2017-0002.</mixed-citation><mixed-citation xml:lang="en">Mohanty BD, Mohanty S, Hussain Y, et al. Management of ischemic coronary disease in patients receiving chemotherapy: an uncharted clinical challenge. Future Cardiol. 2017;13(3):247-57. doi:10.2217/fca-2017-0002.</mixed-citation></citation-alternatives></ref><ref id="cit352"><label>352</label><citation-alternatives><mixed-citation xml:lang="ru">Gara E, Csikó KG, Ruzsa Z, et al. Anti-cancer drugs-induced arterial injury: risk stratification, prevention, and treatment. Med Oncol. 2019;36(8):72. doi:10.1007/s12032-019-1295-8.</mixed-citation><mixed-citation xml:lang="en">Gara E, Csikó KG, Ruzsa Z, et al. Anti-cancer drugs-induced arterial injury: risk stratification, prevention, and treatment. Med Oncol. 2019;36(8):72. doi:10.1007/s12032-019-1295-8.</mixed-citation></citation-alternatives></ref><ref id="cit353"><label>353</label><citation-alternatives><mixed-citation xml:lang="ru">Manouchehri A, Kanu E, Mauro MJ, et al. Tyrosine Kinase Inhibitors in Leukemia and Cardiovascular Events: From Mechanism to Patient Care. Arterioscler Thromb Vasc Biol. 2020;40(2):301-8. doi:10.1161/ATVBAHA.119.313353.</mixed-citation><mixed-citation xml:lang="en">Manouchehri A, Kanu E, Mauro MJ, et al. Tyrosine Kinase Inhibitors in Leukemia and Cardiovascular Events: From Mechanism to Patient Care. Arterioscler Thromb Vasc Biol. 2020;40(2):301-8. doi:10.1161/ATVBAHA.119.313353.</mixed-citation></citation-alternatives></ref><ref id="cit354"><label>354</label><citation-alternatives><mixed-citation xml:lang="ru">Boekholdt SM, Arsenault BJ, Mora S, et al. Association of LDL cholesterol, nonHDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA. 2012;307(12):1302-9. doi:10.1001/jama.2012.366. Erratum in: JAMA. 2012;307(16):1694. Erratum in: JAMA. 2012;307(18):1915.</mixed-citation><mixed-citation xml:lang="en">Boekholdt SM, Arsenault BJ, Mora S, et al. Association of LDL cholesterol, nonHDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA. 2012;307(12):1302-9. doi:10.1001/jama.2012.366. Erratum in: JAMA. 2012;307(16):1694. Erratum in: JAMA. 2012;307(18):1915.</mixed-citation></citation-alternatives></ref><ref id="cit355"><label>355</label><citation-alternatives><mixed-citation xml:lang="ru">Tall AR, Levine RL. Cardiovascular disease: commonality with cancer. Nature. 2017;543:45- 7. doi:10.1038/nature21505.</mixed-citation><mixed-citation xml:lang="en">Tall AR, Levine RL. Cardiovascular disease: commonality with cancer. Nature. 2017;543:45- 7. doi:10.1038/nature21505.</mixed-citation></citation-alternatives></ref><ref id="cit356"><label>356</label><citation-alternatives><mixed-citation xml:lang="ru">Shen Y, Wang C, Ren Y, Ye J. A comprehensive look at the role of hyperlipidemia in promoting colorectal cancer liver metastasis. J Cancer. 2018;9(16):2981-6. doi:10.7150/jca.25640.</mixed-citation><mixed-citation xml:lang="en">Shen Y, Wang C, Ren Y, Ye J. A comprehensive look at the role of hyperlipidemia in promoting colorectal cancer liver metastasis. J Cancer. 2018;9(16):2981-6. doi:10.7150/jca.25640.</mixed-citation></citation-alternatives></ref><ref id="cit357"><label>357</label><citation-alternatives><mixed-citation xml:lang="ru">Chimento A, Casaburi I, Avena P, et al. Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment. Front Endocrinol (Lausanne). 2019;9:807. doi:10.3389/fendo.2018.00807.</mixed-citation><mixed-citation xml:lang="en">Chimento A, Casaburi I, Avena P, et al. Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment. Front Endocrinol (Lausanne). 2019;9:807. doi:10.3389/fendo.2018.00807.</mixed-citation></citation-alternatives></ref><ref id="cit358"><label>358</label><citation-alternatives><mixed-citation xml:lang="ru">Fatehi Hassanabad A. Current perspectives on statins as potential anti-cancer therapeutics: clinical outcomes and underlying molecular mechanisms. Transl Lung Cancer Res. 2019;8(5):692-9. doi:10.21037/tlcr.2019.09.08.</mixed-citation><mixed-citation xml:lang="en">Fatehi Hassanabad A. Current perspectives on statins as potential anti-cancer therapeutics: clinical outcomes and underlying molecular mechanisms. Transl Lung Cancer Res. 2019;8(5):692-9. doi:10.21037/tlcr.2019.09.08.</mixed-citation></citation-alternatives></ref><ref id="cit359"><label>359</label><citation-alternatives><mixed-citation xml:lang="ru">Gazzerro P, Proto MC, Gangemi G, et al. Pharmacological actions of statins: a critical appraisal in the management of cancer. Pharmacol Rev. 2012;64:102-46. doi:10.1124/pr.111.004994.</mixed-citation><mixed-citation xml:lang="en">Gazzerro P, Proto MC, Gangemi G, et al. Pharmacological actions of statins: a critical appraisal in the management of cancer. Pharmacol Rev. 2012;64:102-46. doi:10.1124/pr.111.004994.</mixed-citation></citation-alternatives></ref><ref id="cit360"><label>360</label><citation-alternatives><mixed-citation xml:lang="ru">Farooqi MAM, Malhotra N, Mukherjee SD, et al Statin therapy in the treatment of active cancer: A systematic review and meta-analysis of randomized controlled trials. PLoS One. 2018;13(12):e0209486. doi:10.1371/journal.pone.0209486.</mixed-citation><mixed-citation xml:lang="en">Farooqi MAM, Malhotra N, Mukherjee SD, et al Statin therapy in the treatment of active cancer: A systematic review and meta-analysis of randomized controlled trials. PLoS One. 2018;13(12):e0209486. doi:10.1371/journal.pone.0209486.</mixed-citation></citation-alternatives></ref><ref id="cit361"><label>361</label><citation-alternatives><mixed-citation xml:lang="ru">Jang HJ, Kim HS, Kim JH, Lee J. The Effect of Statin Added to Systemic Anticancer Therapy: A Meta-Analysis of Randomized, Controlled Trials. J Clin Med. 2018;7:325. doi:10.3390/jcm7100325.</mixed-citation><mixed-citation xml:lang="en">Jang HJ, Kim HS, Kim JH, Lee J. The Effect of Statin Added to Systemic Anticancer Therapy: A Meta-Analysis of Randomized, Controlled Trials. J Clin Med. 2018;7:325. doi:10.3390/jcm7100325.</mixed-citation></citation-alternatives></ref><ref id="cit362"><label>362</label><citation-alternatives><mixed-citation xml:lang="ru">Jian-Yu E, Graber JM, Lu SE, et al. Effect of Metformin and Statin Use on Survival in Pancreatic Cancer Patients: a Systematic Literature Review and Meta-analysis. Curr Med Chem. 2018;25:2595-607. doi:10.2174/0929867324666170412145232.</mixed-citation><mixed-citation xml:lang="en">Jian-Yu E, Graber JM, Lu SE, et al. Effect of Metformin and Statin Use on Survival in Pancreatic Cancer Patients: a Systematic Literature Review and Meta-analysis. Curr Med Chem. 2018;25:2595-607. doi:10.2174/0929867324666170412145232.</mixed-citation></citation-alternatives></ref><ref id="cit363"><label>363</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y, Liang M, Sun C, et al. Statin Use and Risk of Pancreatic Cancer: An Updated Metaanalysis of 26 Studies. Pancreas. 2019;48:142-50. doi:10.1097/MPA.0000000000001226.</mixed-citation><mixed-citation xml:lang="en">Zhang Y, Liang M, Sun C, et al. Statin Use and Risk of Pancreatic Cancer: An Updated Metaanalysis of 26 Studies. Pancreas. 2019;48:142-50. doi:10.1097/MPA.0000000000001226.</mixed-citation></citation-alternatives></ref><ref id="cit364"><label>364</label><citation-alternatives><mixed-citation xml:lang="ru">Nayan M, Punjani N, Juurlink DN, et al. Statin use and kidney cancer survival outcomes: A systematic review and meta-analysis. Cancer Treat Rev. 2017;52:105-16. doi:10.1016/j.ctrv.2016.11.009.</mixed-citation><mixed-citation xml:lang="en">Nayan M, Punjani N, Juurlink DN, et al. Statin use and kidney cancer survival outcomes: A systematic review and meta-analysis. Cancer Treat Rev. 2017;52:105-16. doi:10.1016/j.ctrv.2016.11.009.</mixed-citation></citation-alternatives></ref><ref id="cit365"><label>365</label><citation-alternatives><mixed-citation xml:lang="ru">Xia DK, Hu ZG, Tian YF, Zeng FJ. Statin use and prognosis of lung cancer: a systematic review and meta-analysis of observational studies and randomized controlled trials Drug Des Devel Ther. 2019;13:405-22. doi:10.2147/DDDT.S187690.</mixed-citation><mixed-citation xml:lang="en">Xia DK, Hu ZG, Tian YF, Zeng FJ. Statin use and prognosis of lung cancer: a systematic review and meta-analysis of observational studies and randomized controlled trials Drug Des Devel Ther. 2019;13:405-22. doi:10.2147/DDDT.S187690.</mixed-citation></citation-alternatives></ref><ref id="cit366"><label>366</label><citation-alternatives><mixed-citation xml:lang="ru">Jeong GH, Lee KH, Kim JY, et al. Statin and Cancer Mortality and Survival: An Umbrella Systematic Review and Meta-Analysis. J Clin Med. 2020;9(2):326. doi:10.3390/jcm9020326.</mixed-citation><mixed-citation xml:lang="en">Jeong GH, Lee KH, Kim JY, et al. Statin and Cancer Mortality and Survival: An Umbrella Systematic Review and Meta-Analysis. J Clin Med. 2020;9(2):326. doi:10.3390/jcm9020326.</mixed-citation></citation-alternatives></ref><ref id="cit367"><label>367</label><citation-alternatives><mixed-citation xml:lang="ru">Sabatine MS, Giugliano RP, Keech AC, et al.; FOURIER Steering Committee and Investigators. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. 2017;376(18):1713-22. doi:10.1056/NEJMoa1615664.</mixed-citation><mixed-citation xml:lang="en">Sabatine MS, Giugliano RP, Keech AC, et al.; FOURIER Steering Committee and Investigators. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. 2017;376(18):1713-22. doi:10.1056/NEJMoa1615664.</mixed-citation></citation-alternatives></ref><ref id="cit368"><label>368</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz GG, Steg PG, Szarek M, et al.; ODYSSEY OUTCOMES Committees and Investigators. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. N Engl J Med. 2018;379(22):2097-107. doi:10.1056/NEJMoa1801174.</mixed-citation><mixed-citation xml:lang="en">Schwartz GG, Steg PG, Szarek M, et al.; ODYSSEY OUTCOMES Committees and Investigators. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. N Engl J Med. 2018;379(22):2097-107. doi:10.1056/NEJMoa1801174.</mixed-citation></citation-alternatives></ref><ref id="cit369"><label>369</label><citation-alternatives><mixed-citation xml:lang="ru">Asteggiano R, Norbiato C, Marengo S, Parrini I. Cancer and arrhythmias. e-Journal of Cardiology Practice. 2021;19:2020-1.</mixed-citation><mixed-citation xml:lang="en">Asteggiano R, Norbiato C, Marengo S, Parrini I. Cancer and arrhythmias. e-Journal of Cardiology Practice. 2021;19:2020-1.</mixed-citation></citation-alternatives></ref><ref id="cit370"><label>370</label><citation-alternatives><mixed-citation xml:lang="ru">Desai MY, Windecker S, Lancellotti P, et al. Prevention, Diagnosis, and Management of Radiation-Associated Cardiac Disease: JACC Scientific Expert Panel. J Am Coll Cardiol. 2019;74:905-27. doi:10.1016/j.jacc.2019.07.006.</mixed-citation><mixed-citation xml:lang="en">Desai MY, Windecker S, Lancellotti P, et al. Prevention, Diagnosis, and Management of Radiation-Associated Cardiac Disease: JACC Scientific Expert Panel. J Am Coll Cardiol. 2019;74:905-27. doi:10.1016/j.jacc.2019.07.006.</mixed-citation></citation-alternatives></ref><ref id="cit371"><label>371</label><citation-alternatives><mixed-citation xml:lang="ru">Hindricks G, Potpara T, Dagres N, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373-498. doi:10.1093/eurheartj/ehaa612. Erratum in: Eur Heart J. 2021;42(5):507. Erratum in: Eur Heart J. 2021;42(5):546-7. Erratum in: Eur Heart J. 2021 Sep 14.</mixed-citation><mixed-citation xml:lang="en">Hindricks G, Potpara T, Dagres N, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373-498. doi:10.1093/eurheartj/ehaa612. Erratum in: Eur Heart J. 2021;42(5):507. Erratum in: Eur Heart J. 2021;42(5):546-7. Erratum in: Eur Heart J. 2021 Sep 14.</mixed-citation></citation-alternatives></ref><ref id="cit372"><label>372</label><citation-alternatives><mixed-citation xml:lang="ru">Jakobsen C, Lamberts M, Carlson N, et al. Incidence of atrial fibrillation in different major cancer subtypes: a Nationwide population-based 12 year follow up study. BMC Cancer. 2019;19(1):1105. doi:10.1186/s12885-019-6314-9.</mixed-citation><mixed-citation xml:lang="en">Jakobsen C, Lamberts M, Carlson N, et al. Incidence of atrial fibrillation in different major cancer subtypes: a Nationwide population-based 12 year follow up study. BMC Cancer. 2019;19(1):1105. doi:10.1186/s12885-019-6314-9.</mixed-citation></citation-alternatives></ref><ref id="cit373"><label>373</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y, Tan D, Shi L, et al. Blueberry anthocyanins enriched extracts attenuate cyclophosphamide-induced cardiac injury. PLoS One. 2015;10(7):e0127813. doi:10.1371/journal. pone.0127813.</mixed-citation><mixed-citation xml:lang="en">Liu Y, Tan D, Shi L, et al. Blueberry anthocyanins enriched extracts attenuate cyclophosphamide-induced cardiac injury. PLoS One. 2015;10(7):e0127813. doi:10.1371/journal. pone.0127813.</mixed-citation></citation-alternatives></ref><ref id="cit374"><label>374</label><citation-alternatives><mixed-citation xml:lang="ru">Lara PN. The Cyclin-Dependent Kinase Inhibitor UCN-01 Plus Cisplatin in Advanced Solid Tumors: A California Cancer Consortium Phase I Pharmacokinetic and Molecular Correlative Trial. Clinical Cancer Research. 2005;11(12):4444-50. doi:10.1158/1078-0432.ccr-04-2602.</mixed-citation><mixed-citation xml:lang="en">Lara PN. The Cyclin-Dependent Kinase Inhibitor UCN-01 Plus Cisplatin in Advanced Solid Tumors: A California Cancer Consortium Phase I Pharmacokinetic and Molecular Correlative Trial. Clinical Cancer Research. 2005;11(12):4444-50. doi:10.1158/1078-0432.ccr-04-2602.</mixed-citation></citation-alternatives></ref><ref id="cit375"><label>375</label><citation-alternatives><mixed-citation xml:lang="ru">Tilleman TR, Richards WG, Zellos L, et al. Extrapleural pneumonectomy followed by intracavitary intraoperative hyperthermic cisplatin with pharmacologic cytoprotection for treatment of malignant pleural mesothelioma: a phase II prospective study. J Thorac Cardiovasc Surg. 2009;138(2):405-11. doi:10.1016/j.jtcvs.2009.02.046.</mixed-citation><mixed-citation xml:lang="en">Tilleman TR, Richards WG, Zellos L, et al. Extrapleural pneumonectomy followed by intracavitary intraoperative hyperthermic cisplatin with pharmacologic cytoprotection for treatment of malignant pleural mesothelioma: a phase II prospective study. J Thorac Cardiovasc Surg. 2009;138(2):405-11. doi:10.1016/j.jtcvs.2009.02.046.</mixed-citation></citation-alternatives></ref><ref id="cit376"><label>376</label><citation-alternatives><mixed-citation xml:lang="ru">Alexandre J, Molsehi J, Bersell K, et al. Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms. Pharmacology &amp; Therapeutics. 2018;189:89-103. doi:10.1016/j.pharmthera.2018.04.009.</mixed-citation><mixed-citation xml:lang="en">Alexandre J, Molsehi J, Bersell K, et al. Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms. Pharmacology &amp; Therapeutics. 2018;189:89-103. doi:10.1016/j.pharmthera.2018.04.009.</mixed-citation></citation-alternatives></ref><ref id="cit377"><label>377</label><citation-alternatives><mixed-citation xml:lang="ru">Ganatra S, Sharma A, Shah S, et al. Ibrutinib-associated atrial fibrillation. JACC. Clin. Electrophysiol. 2018;4(12):1491-500. doi:10.1016/j.jacep.2018.06.004.</mixed-citation><mixed-citation xml:lang="en">Ganatra S, Sharma A, Shah S, et al. Ibrutinib-associated atrial fibrillation. JACC. Clin. Electrophysiol. 2018;4(12):1491-500. doi:10.1016/j.jacep.2018.06.004.</mixed-citation></citation-alternatives></ref><ref id="cit378"><label>378</label><citation-alternatives><mixed-citation xml:lang="ru">Roselli E, Murthy S, Rice T, et al. Atrial fibrillation complicating lung cancer resection. The Journal of Thoracic and Cardiovascular Surgery. 2005;130(2):438.e1-438.e9. doi:10.1016/j.jtcvs.2005.02.010.</mixed-citation><mixed-citation xml:lang="en">Roselli E, Murthy S, Rice T, et al. Atrial fibrillation complicating lung cancer resection. The Journal of Thoracic and Cardiovascular Surgery. 2005;130(2):438.e1-438.e9. doi:10.1016/j.jtcvs.2005.02.010.</mixed-citation></citation-alternatives></ref><ref id="cit379"><label>379</label><citation-alternatives><mixed-citation xml:lang="ru">Siu C, Tung H, Chu K, et al. Prevalence and Predictors of New-Onset Atrial Fibrillation After Elective Surgery for Colorectal Cancer. Pacing and Clinical Electrophysiology. 2005;28(s1):S120-S123. doi:10.1111/j.1540-8159.2005.00024.</mixed-citation><mixed-citation xml:lang="en">Siu C, Tung H, Chu K, et al. Prevalence and Predictors of New-Onset Atrial Fibrillation After Elective Surgery for Colorectal Cancer. Pacing and Clinical Electrophysiology. 2005;28(s1):S120-S123. doi:10.1111/j.1540-8159.2005.00024.</mixed-citation></citation-alternatives></ref><ref id="cit380"><label>380</label><citation-alternatives><mixed-citation xml:lang="ru">Ojima T, Iwahashi M, Nakamori M, et al. Atrial fibrillation after esophageal cancer surgery: an analysis of 207 consecutive patients. Surgery Today. 2013;44(5):839-47. doi:10.1007/s00595-013-0616-3.</mixed-citation><mixed-citation xml:lang="en">Ojima T, Iwahashi M, Nakamori M, et al. Atrial fibrillation after esophageal cancer surgery: an analysis of 207 consecutive patients. Surgery Today. 2013;44(5):839-47. doi:10.1007/s00595-013-0616-3.</mixed-citation></citation-alternatives></ref><ref id="cit381"><label>381</label><citation-alternatives><mixed-citation xml:lang="ru">Васюк Ю.А., Шупенина Е.Ю., Новосел Е.О., Агапов И.С. Нарушения ритма и проводимости сердца как проявления кардиотоксичности противоопухолевого лечения — миф или реальность? Сибирский медицинский журнал. 2020;35(1):13-21. doi:10.29001/2073-8552-2020-35-1-13-21.</mixed-citation><mixed-citation xml:lang="en">Vasyuk YuA, Shupenina EYu, Novosel EO, Agapov IS. Heart rhythm and conduction disorders as manifestations of cardiotoxicity of anticancer treatment: myth or reality? The Siberian Journal of Clinical and Experimental Medicine. 2020;35(1):13-21. (In Russ.) doi:10.29001/2073-8552-2020-35-1-13-21.</mixed-citation></citation-alternatives></ref><ref id="cit382"><label>382</label><citation-alternatives><mixed-citation xml:lang="ru">Farmakis D, Parissis J, Filippatos G. Insights into oncocardiology: atrial fibrillation in cancer. JACC. 2014;63(10):945-53. doi:10.1016/j.jacc.2013.11.026.</mixed-citation><mixed-citation xml:lang="en">Farmakis D, Parissis J, Filippatos G. Insights into oncocardiology: atrial fibrillation in cancer. JACC. 2014;63(10):945-53. doi:10.1016/j.jacc.2013.11.026.</mixed-citation></citation-alternatives></ref><ref id="cit383"><label>383</label><citation-alternatives><mixed-citation xml:lang="ru">Lyman GH, Bohlke K, Khorana AA, et.al. Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update 2014. J Clin Oncol. 2015;33(6):654-6. doi:10.1200/JCO.2014.59.7351.</mixed-citation><mixed-citation xml:lang="en">Lyman GH, Bohlke K, Khorana AA, et.al. Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update 2014. J Clin Oncol. 2015;33(6):654-6. doi:10.1200/JCO.2014.59.7351.</mixed-citation></citation-alternatives></ref><ref id="cit384"><label>384</label><citation-alternatives><mixed-citation xml:lang="ru">Porta-Sanchez A, Gilbert C, Spears D, et al. Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review. J. Am. Heart Assoc. 2017;6(12):e07724. doi:10.1161/JAHA.117.007724.</mixed-citation><mixed-citation xml:lang="en">Porta-Sanchez A, Gilbert C, Spears D, et al. Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review. J. Am. Heart Assoc. 2017;6(12):e07724. doi:10.1161/JAHA.117.007724.</mixed-citation></citation-alternatives></ref><ref id="cit385"><label>385</label><citation-alternatives><mixed-citation xml:lang="ru">Tamargo J, Caballero R, Delpón E. Cancer chemotherapy and cardiac arrhythmias: a review. Drug Saf. 2015;38:129-52. doi:10.1007/s40264-014-0258-4.</mixed-citation><mixed-citation xml:lang="en">Tamargo J, Caballero R, Delpón E. Cancer chemotherapy and cardiac arrhythmias: a review. Drug Saf. 2015;38:129-52. doi:10.1007/s40264-014-0258-4.</mixed-citation></citation-alternatives></ref><ref id="cit386"><label>386</label><citation-alternatives><mixed-citation xml:lang="ru">Han J, Lee S, Lee G, et al. Phase I/II study of gefitinib (IressaR) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer. Cancer Chemother. Pharmacol. 2015;75(3):475-83. doi:10.1007/s00280-014-2664-9.</mixed-citation><mixed-citation xml:lang="en">Han J, Lee S, Lee G, et al. Phase I/II study of gefitinib (IressaR) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer. Cancer Chemother. Pharmacol. 2015;75(3):475-83. doi:10.1007/s00280-014-2664-9.</mixed-citation></citation-alternatives></ref><ref id="cit387"><label>387</label><citation-alternatives><mixed-citation xml:lang="ru">Fradley M, Viganego F, Kip K, et al. Rates and risk of arrhythmias in cancer survivors with chemotherapy induced cardiomyopathy compared with patients with other cardiomyopathies. Open Heart. 2017;4(2):e000701. doi:10.1136/openhrt-2017-000701.</mixed-citation><mixed-citation xml:lang="en">Fradley M, Viganego F, Kip K, et al. Rates and risk of arrhythmias in cancer survivors with chemotherapy induced cardiomyopathy compared with patients with other cardiomyopathies. Open Heart. 2017;4(2):e000701. doi:10.1136/openhrt-2017-000701.</mixed-citation></citation-alternatives></ref><ref id="cit388"><label>388</label><citation-alternatives><mixed-citation xml:lang="ru">Kim AS, Khorana AA, McCrae KR. Mechanisms and biomarkers of cancer-associated thrombosis. Transl Res. 2020;225:33-53. doi:10.1016/j.trsl.2020.06.012.</mixed-citation><mixed-citation xml:lang="en">Kim AS, Khorana AA, McCrae KR. Mechanisms and biomarkers of cancer-associated thrombosis. Transl Res. 2020;225:33-53. doi:10.1016/j.trsl.2020.06.012.</mixed-citation></citation-alternatives></ref><ref id="cit389"><label>389</label><citation-alternatives><mixed-citation xml:lang="ru">Eichinger S. Cancer associated thrombosis: Risk factors and outcomes. Thromb. Res. 2016;140:S12-S17. doi:10.1016/S0049-3848(16)30092-5.</mixed-citation><mixed-citation xml:lang="en">Eichinger S. Cancer associated thrombosis: Risk factors and outcomes. Thromb. Res. 2016;140:S12-S17. doi:10.1016/S0049-3848(16)30092-5.</mixed-citation></citation-alternatives></ref><ref id="cit390"><label>390</label><citation-alternatives><mixed-citation xml:lang="ru">Hamza MS, Mousa SA. Cancer-Associated Thrombosis: Risk Factors, Molecular Mechanisms, Future Management. Clin Appl Thromb Hemost. 2020;26: 1076029620954282. doi:10.1177/1076029620954282.</mixed-citation><mixed-citation xml:lang="en">Hamza MS, Mousa SA. Cancer-Associated Thrombosis: Risk Factors, Molecular Mechanisms, Future Management. Clin Appl Thromb Hemost. 2020;26: 1076029620954282. doi:10.1177/1076029620954282.</mixed-citation></citation-alternatives></ref><ref id="cit391"><label>391</label><citation-alternatives><mixed-citation xml:lang="ru">Razak NBA, Jones G, Bhandari M, et al. Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment Cancers (Basel) 2018;10(10):380. doi:10.3390/cancers10100380.</mixed-citation><mixed-citation xml:lang="en">Razak NBA, Jones G, Bhandari M, et al. Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment Cancers (Basel) 2018;10(10):380. doi:10.3390/cancers10100380.</mixed-citation></citation-alternatives></ref><ref id="cit392"><label>392</label><citation-alternatives><mixed-citation xml:lang="ru">Mukai M, Oka T. Mechanism and management of cancer-associated thrombosis. Journal of Cardiology. 2018;72(2):89-93. doi:10.1016/j.jjcc.2018.02.011.</mixed-citation><mixed-citation xml:lang="en">Mukai M, Oka T. Mechanism and management of cancer-associated thrombosis. Journal of Cardiology. 2018;72(2):89-93. doi:10.1016/j.jjcc.2018.02.011.</mixed-citation></citation-alternatives></ref><ref id="cit393"><label>393</label><citation-alternatives><mixed-citation xml:lang="ru">Donnellan E, Kevane B, Bird BR, Ainle FN. Cancer and venous thromboembolic disease: from molecular mechanisms to clinical management. Curr Oncol. 2014;21(3):134-43. doi:10.3747/co.21.1864.</mixed-citation><mixed-citation xml:lang="en">Donnellan E, Kevane B, Bird BR, Ainle FN. Cancer and venous thromboembolic disease: from molecular mechanisms to clinical management. Curr Oncol. 2014;21(3):134-43. doi:10.3747/co.21.1864.</mixed-citation></citation-alternatives></ref><ref id="cit394"><label>394</label><citation-alternatives><mixed-citation xml:lang="ru">Khorana AA, Carrier M, Garcia DA, Lee AY. Guidance for the prevention and treatment of cancer-associated venous thromboembolism. J Thromb Thrombolysis. 2016;41(1):81-91. doi:10.1007/s11239-015-1313-4.</mixed-citation><mixed-citation xml:lang="en">Khorana AA, Carrier M, Garcia DA, Lee AY. Guidance for the prevention and treatment of cancer-associated venous thromboembolism. J Thromb Thrombolysis. 2016;41(1):81-91. doi:10.1007/s11239-015-1313-4.</mixed-citation></citation-alternatives></ref><ref id="cit395"><label>395</label><citation-alternatives><mixed-citation xml:lang="ru">Mulder FI, Candeloro M, Kamphuisen PW, et al. The Khorana score for prediction of venous thromboembolism in cancer patients: a systematic review and meta-analysis. Haematologica. 2019;104(6):1277-87. doi:10.3324/haematol.2018.209114.</mixed-citation><mixed-citation xml:lang="en">Mulder FI, Candeloro M, Kamphuisen PW, et al. The Khorana score for prediction of venous thromboembolism in cancer patients: a systematic review and meta-analysis. Haematologica. 2019;104(6):1277-87. doi:10.3324/haematol.2018.209114.</mixed-citation></citation-alternatives></ref><ref id="cit396"><label>396</label><citation-alternatives><mixed-citation xml:lang="ru">Muñoz Martín AJ, Gallardo Díaz E, García Escobar I. et al. SEOM clinical guideline of venous thromboembolism (VTE) and cancer (2019). Clin Transl Oncol. 2020;22(2):171-86. doi:10.1007/s12094-019-02263-z.</mixed-citation><mixed-citation xml:lang="en">Muñoz Martín AJ, Gallardo Díaz E, García Escobar I. et al. SEOM clinical guideline of venous thromboembolism (VTE) and cancer (2019). Clin Transl Oncol. 2020;22(2):171-86. doi:10.1007/s12094-019-02263-z.</mixed-citation></citation-alternatives></ref><ref id="cit397"><label>397</label><citation-alternatives><mixed-citation xml:lang="ru">Федоткина Ю.А., Панченко Е.П. Тромбозы в онкологии. Часть 2. Атеротромбоз. 2017;(3):3-12.</mixed-citation><mixed-citation xml:lang="en">Fedotkina YuA, Panchenko EP. Thrombosis in oncology. Part 2. Atherothrombosis. 2017;(3):3-12. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit398"><label>398</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandes CJ, Morinaga LTK, Alves JL, et al. Cancer-associated thrombosis: the when, how and why. European Respiratory Review. 2019;28:180119. doi:10.1183/16000617.0119-2018.</mixed-citation><mixed-citation xml:lang="en">Fernandes CJ, Morinaga LTK, Alves JL, et al. Cancer-associated thrombosis: the when, how and why. European Respiratory Review. 2019;28:180119. doi:10.1183/16000617.0119-2018.</mixed-citation></citation-alternatives></ref><ref id="cit399"><label>399</label><citation-alternatives><mixed-citation xml:lang="ru">John AH. Epidemiology of venous thromboembolism. Nat. Rev. Cardiol. 2015;12:464-74. doi:10.1038/nrcardio.2015.83.</mixed-citation><mixed-citation xml:lang="en">John AH. Epidemiology of venous thromboembolism. Nat. Rev. Cardiol. 2015;12:464-74. doi:10.1038/nrcardio.2015.83.</mixed-citation></citation-alternatives></ref><ref id="cit400"><label>400</label><citation-alternatives><mixed-citation xml:lang="ru">Alahmari AK, Almalki ZS, Alahmari AK, Guo JJ. Thromboembolic Events Associated with Bevacizumab plus Chemotherapy for Patients with Colorectal Cancer: A Meta-Analysis of Randomized Controlled Trials. Am Health Drug Benefits. 2016;9(4):221-32.</mixed-citation><mixed-citation xml:lang="en">Alahmari AK, Almalki ZS, Alahmari AK, Guo JJ. Thromboembolic Events Associated with Bevacizumab plus Chemotherapy for Patients with Colorectal Cancer: A Meta-Analysis of Randomized Controlled Trials. Am Health Drug Benefits. 2016;9(4):221-32.</mixed-citation></citation-alternatives></ref><ref id="cit401"><label>401</label><citation-alternatives><mixed-citation xml:lang="ru">Российские клинические рекомендации по диагностике, лечению и профилактике венозных тромбоэмболических осложнений (ВТЭО). Флебология. 2015;4(2):1-51.</mixed-citation><mixed-citation xml:lang="en">Russian clinical guidelines for the diagnosis, treatment and prevention of venous thromboembolic complications (VTEO). Phlebology. 2015;4(2):1-51. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit402"><label>402</label><citation-alternatives><mixed-citation xml:lang="ru">Kahale LA, Hakoum MB, Tsolakian IG, et al. Anticoagulation for the long-term treatment of venous thromboembolism in people with cancer. Cochrane Database Syst Rev. 2018;6:CD006650. doi:10.1002/14651858.CD006650.pub5.</mixed-citation><mixed-citation xml:lang="en">Kahale LA, Hakoum MB, Tsolakian IG, et al. Anticoagulation for the long-term treatment of venous thromboembolism in people with cancer. Cochrane Database Syst Rev. 2018;6:CD006650. doi:10.1002/14651858.CD006650.pub5.</mixed-citation></citation-alternatives></ref><ref id="cit403"><label>403</label><citation-alternatives><mixed-citation xml:lang="ru">Farge D, Frere C, Connors JM, et al. 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer. Lancet Oncol. 2019;20:e566-e581. doi:10.1016/S1470-2045(19)30336-5.</mixed-citation><mixed-citation xml:lang="en">Farge D, Frere C, Connors JM, et al. 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer. Lancet Oncol. 2019;20:e566-e581. doi:10.1016/S1470-2045(19)30336-5.</mixed-citation></citation-alternatives></ref><ref id="cit404"><label>404</label><citation-alternatives><mixed-citation xml:lang="ru">Geddings JE, Hisada Y, Boulaftali Y, et al. Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice. J Thromb Haemost. 2016;14:153-66. doi:10.1111/jth.13181.</mixed-citation><mixed-citation xml:lang="en">Geddings JE, Hisada Y, Boulaftali Y, et al. Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice. J Thromb Haemost. 2016;14:153-66. doi:10.1111/jth.13181.</mixed-citation></citation-alternatives></ref><ref id="cit405"><label>405</label><citation-alternatives><mixed-citation xml:lang="ru">Key NS, Khorana AA, Kuderer NM, et al. Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update Journal of Clinical Oncology. 2020; 38(5):496-520. doi:10.1200/JCO.19.01461.</mixed-citation><mixed-citation xml:lang="en">Key NS, Khorana AA, Kuderer NM, et al. Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update Journal of Clinical Oncology. 2020; 38(5):496-520. doi:10.1200/JCO.19.01461.</mixed-citation></citation-alternatives></ref><ref id="cit406"><label>406</label><citation-alternatives><mixed-citation xml:lang="ru">Navi BB, Reiner AS, Kamel H, et al. Arterial thromboembolic events preceding the diagnosis of cancer in older persons. Blood. 2019;133:781-9. doi:10.1182/blood-2018-06-860874.</mixed-citation><mixed-citation xml:lang="en">Navi BB, Reiner AS, Kamel H, et al. Arterial thromboembolic events preceding the diagnosis of cancer in older persons. Blood. 2019;133:781-9. doi:10.1182/blood-2018-06-860874.</mixed-citation></citation-alternatives></ref><ref id="cit407"><label>407</label><citation-alternatives><mixed-citation xml:lang="ru">Javid M, Magee TR, Galland RB. Arterial thrombosis associated with malignant disease. Eur J Vasc Endovasc Surg. 2008;35(1):84-7. doi:10.1016/j.ejvs.2007.08.014.</mixed-citation><mixed-citation xml:lang="en">Javid M, Magee TR, Galland RB. Arterial thrombosis associated with malignant disease. Eur J Vasc Endovasc Surg. 2008;35(1):84-7. doi:10.1016/j.ejvs.2007.08.014.</mixed-citation></citation-alternatives></ref><ref id="cit408"><label>408</label><citation-alternatives><mixed-citation xml:lang="ru">Grilz E, Königsbrügge O, Posch F, et al. Frequency, risk factors, and impact on mortality of arterial thromboembolism in patients with cancer. Haematologica. 2018;103(9):1549-56. doi:10.3324/haematol.2018.192419.</mixed-citation><mixed-citation xml:lang="en">Grilz E, Königsbrügge O, Posch F, et al. Frequency, risk factors, and impact on mortality of arterial thromboembolism in patients with cancer. Haematologica. 2018;103(9):1549-56. doi:10.3324/haematol.2018.192419.</mixed-citation></citation-alternatives></ref><ref id="cit409"><label>409</label><citation-alternatives><mixed-citation xml:lang="ru">Mi Y, Yan S, Lu Y, et al. Venous thromboembolism has the same risk factors as atherosclerosis: A PRISMA-compliant systemic review and meta-analysis. Medicine (Baltimore) 2016;95:e4495. doi:10.1097/MD.0000000000004495.</mixed-citation><mixed-citation xml:lang="en">Mi Y, Yan S, Lu Y, et al. Venous thromboembolism has the same risk factors as atherosclerosis: A PRISMA-compliant systemic review and meta-analysis. Medicine (Baltimore) 2016;95:e4495. doi:10.1097/MD.0000000000004495.</mixed-citation></citation-alternatives></ref><ref id="cit410"><label>410</label><citation-alternatives><mixed-citation xml:lang="ru">Tuzovic M, Herrmann J, Iliescu C, et al. Arterial Thrombosis in Patients with Cancer. Curr. Treat. Options Cardiovasc. Med. 2018;20(5):40. doi:10.1007/s11936-018-0635-x.</mixed-citation><mixed-citation xml:lang="en">Tuzovic M, Herrmann J, Iliescu C, et al. Arterial Thrombosis in Patients with Cancer. Curr. Treat. Options Cardiovasc. Med. 2018;20(5):40. doi:10.1007/s11936-018-0635-x.</mixed-citation></citation-alternatives></ref><ref id="cit411"><label>411</label><citation-alternatives><mixed-citation xml:lang="ru">Rhea IB, Lyon AR, Fradley MG. Anticoagulation of Cardiovascular Conditions in the Cancer Patient: Review of Old and New Therapies. Curr Oncol Rep. 2019;21(5):45. doi:10.1007/s11912-019-0797-z.</mixed-citation><mixed-citation xml:lang="en">Rhea IB, Lyon AR, Fradley MG. Anticoagulation of Cardiovascular Conditions in the Cancer Patient: Review of Old and New Therapies. Curr Oncol Rep. 2019;21(5):45. doi:10.1007/s11912-019-0797-z.</mixed-citation></citation-alternatives></ref><ref id="cit412"><label>412</label><citation-alternatives><mixed-citation xml:lang="ru">Thachil J, Falanga A, Levi M, et al. Management of cancer-associated disseminated intravascular coagulation: guidance from the SSC of the ISTH. J Thromb Haemost. 2015;13:671-5. doi:10.1111/jth.12838.</mixed-citation><mixed-citation xml:lang="en">Thachil J, Falanga A, Levi M, et al. Management of cancer-associated disseminated intravascular coagulation: guidance from the SSC of the ISTH. J Thromb Haemost. 2015;13:671-5. doi:10.1111/jth.12838.</mixed-citation></citation-alternatives></ref><ref id="cit413"><label>413</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Л.А., Рагимов А.А. ДВС-синдром. 2-е изд., перераб. М.: ГЭОТАР-Медиа. 2020. 96 с. ISBN: 978-5-9704-5797-9.</mixed-citation><mixed-citation xml:lang="en">Alekseeva LA, Ragimov AA. DIC-syndrome. 2nd ed. M.: GEOTAR-Media. 2020. 96 p. (In Russ.) ISBN: 978-5-9704-5797-9.</mixed-citation></citation-alternatives></ref><ref id="cit414"><label>414</label><citation-alternatives><mixed-citation xml:lang="ru">Vitale FV, Longo-Sorbello GS, Rotondo S, Ferrau F. Understanding and treating solid tumorrelated disseminated intravascular coagulation in the “era” of targeted cancer therapies. SAGE Open Med. 2017;5:2050312117749133. doi:10.1177/2050312117749133.</mixed-citation><mixed-citation xml:lang="en">Vitale FV, Longo-Sorbello GS, Rotondo S, Ferrau F. Understanding and treating solid tumorrelated disseminated intravascular coagulation in the “era” of targeted cancer therapies. SAGE Open Med. 2017;5:2050312117749133. doi:10.1177/2050312117749133.</mixed-citation></citation-alternatives></ref><ref id="cit415"><label>415</label><citation-alternatives><mixed-citation xml:lang="ru">Govind Babu K, Bhat GR. Cancer-associated thrombotic microangiopathy. Ecancermedicalscience. 2016;10:649. doi:10.3332/ecancer.2016.649.</mixed-citation><mixed-citation xml:lang="en">Govind Babu K, Bhat GR. Cancer-associated thrombotic microangiopathy. Ecancermedicalscience. 2016;10:649. doi:10.3332/ecancer.2016.649.</mixed-citation></citation-alternatives></ref><ref id="cit416"><label>416</label><citation-alternatives><mixed-citation xml:lang="ru">Wada H, Matsumoto T, Suzuki K, et al. Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy. Thromb J. 2018;16:14. doi:10.1186/s12959-018-0168-2.</mixed-citation><mixed-citation xml:lang="en">Wada H, Matsumoto T, Suzuki K, et al. Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy. Thromb J. 2018;16:14. doi:10.1186/s12959-018-0168-2.</mixed-citation></citation-alternatives></ref><ref id="cit417"><label>417</label><citation-alternatives><mixed-citation xml:lang="ru">Кулиева А.А., Емелина Е.И., Гендлин Г.Е. и др. Сердечно-сосудистые осложнения терапии ингибиторами контрольных точек иммунитета. Качественная клиническая практика. 2019;(4):55-65. doi:10.1016/2588-0519-2019-4-55-65.</mixed-citation><mixed-citation xml:lang="en">Kulieva AA, Emelina EI, Gendlin GE, et al. Cardiovascular complications of therapy with immune checkpoint inhibitors. High-quality clinical practice. 2019;(4):55-65. (In Russ.) doi:10.1016/2588-0519-2019-4-55-65.</mixed-citation></citation-alternatives></ref><ref id="cit418"><label>418</label><citation-alternatives><mixed-citation xml:lang="ru">Postow MA, Sidlow R, Hellmann MD. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. N Engl J Med. 2018;378:158-68. doi:10.1056/NEJMra1703481.</mixed-citation><mixed-citation xml:lang="en">Postow MA, Sidlow R, Hellmann MD. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. N Engl J Med. 2018;378:158-68. doi:10.1056/NEJMra1703481.</mixed-citation></citation-alternatives></ref><ref id="cit419"><label>419</label><citation-alternatives><mixed-citation xml:lang="ru">D’Souza M, Nielsen D, Svane IM, et al. The risk of cardiac events in patients receiving immune checkpoint inhibitors: a nationwide Danish study. Eur Heart J. 2021;42:1621-31. doi:10.1093/eurheartj/ehaa884.</mixed-citation><mixed-citation xml:lang="en">D’Souza M, Nielsen D, Svane IM, et al. The risk of cardiac events in patients receiving immune checkpoint inhibitors: a nationwide Danish study. Eur Heart J. 2021;42:1621-31. doi:10.1093/eurheartj/ehaa884.</mixed-citation></citation-alternatives></ref><ref id="cit420"><label>420</label><citation-alternatives><mixed-citation xml:lang="ru">Esposito R, Fedele T, Orefice S, et al. An Emergent Form of Cardiotoxicity: Acute Myocarditis Induced by Immune Checkpoint Inhibitors. Biomolecules. 2021;11:785. doi:10.3390/biom11060785.</mixed-citation><mixed-citation xml:lang="en">Esposito R, Fedele T, Orefice S, et al. An Emergent Form of Cardiotoxicity: Acute Myocarditis Induced by Immune Checkpoint Inhibitors. Biomolecules. 2021;11:785. doi:10.3390/biom11060785.</mixed-citation></citation-alternatives></ref><ref id="cit421"><label>421</label><citation-alternatives><mixed-citation xml:lang="ru">Salem JE, Manouchehri A, Moey M, et al. Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study. Lancet Oncol. 2018;19:1579-89. doi:10.1016/S1470-2045(18)30608-9.</mixed-citation><mixed-citation xml:lang="en">Salem JE, Manouchehri A, Moey M, et al. Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study. Lancet Oncol. 2018;19:1579-89. doi:10.1016/S1470-2045(18)30608-9.</mixed-citation></citation-alternatives></ref><ref id="cit422"><label>422</label><citation-alternatives><mixed-citation xml:lang="ru">Xu S, Sharma UC, Tuttle C, Pokharel S. Immune Checkpoint Inhibitors: Cardiotoxicity in Pre-clinical Models and Clinical Studies. Front. Cardiovasc. Med. 2021;8:619650. doi:10.3389/fcvm.2021.619650.</mixed-citation><mixed-citation xml:lang="en">Xu S, Sharma UC, Tuttle C, Pokharel S. Immune Checkpoint Inhibitors: Cardiotoxicity in Pre-clinical Models and Clinical Studies. Front. Cardiovasc. Med. 2021;8:619650. doi:10.3389/fcvm.2021.619650.</mixed-citation></citation-alternatives></ref><ref id="cit423"><label>423</label><citation-alternatives><mixed-citation xml:lang="ru">Dolladille C, Ederhy S, Allouche S, et al. Late cardiac adverse events in patients with cancer treated with immune checkpoint inhibitors. J Immunother Cancer. 2020;8:e000261. doi:10.1136/jitc-2019-000261.</mixed-citation><mixed-citation xml:lang="en">Dolladille C, Ederhy S, Allouche S, et al. Late cardiac adverse events in patients with cancer treated with immune checkpoint inhibitors. J Immunother Cancer. 2020;8:e000261. doi:10.1136/jitc-2019-000261.</mixed-citation></citation-alternatives></ref><ref id="cit424"><label>424</label><citation-alternatives><mixed-citation xml:lang="ru">Кушнарева Е.А., Моисеева О.М. Миокардиты, ассоциированные с терапией ингибиторами контрольных точек: систематический анализ клинических случаев. Российский кардиологический журнал. 2020;25(11):3910. doi:10.15829/1560-4071-2020-3910.</mixed-citation><mixed-citation xml:lang="en">Kushnareva E.A., Moiseeva O.M. Immune checkpoint inhibitor myocarditis: a systematic case study. Russian Journal of Cardiology. 2020;25(11):3910. (In Russ.) doi:10.15829/1560-4071-2020-3910.</mixed-citation></citation-alternatives></ref><ref id="cit425"><label>425</label><citation-alternatives><mixed-citation xml:lang="ru">Michel L, Rassaf T, Totzeck M. Cardiotoxicity from immune checkpoint inhibitors. Int J Cardiol Heart Vasc. 2019;25:100420. doi:10.1016/j.ijcha.2019.100420.</mixed-citation><mixed-citation xml:lang="en">Michel L, Rassaf T, Totzeck M. Cardiotoxicity from immune checkpoint inhibitors. Int J Cardiol Heart Vasc. 2019;25:100420. doi:10.1016/j.ijcha.2019.100420.</mixed-citation></citation-alternatives></ref><ref id="cit426"><label>426</label><citation-alternatives><mixed-citation xml:lang="ru">Brahmer JR, Lacchetti C, Schneider BJ, et al. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2018;36(17):1714-68. doi:10.1200/JCO.2017.77.6385.</mixed-citation><mixed-citation xml:lang="en">Brahmer JR, Lacchetti C, Schneider BJ, et al. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2018;36(17):1714-68. doi:10.1200/JCO.2017.77.6385.</mixed-citation></citation-alternatives></ref><ref id="cit427"><label>427</label><citation-alternatives><mixed-citation xml:lang="ru">Imazio M, Colopi M, De Ferrari GM. Pericardial diseases in patients with cancer: Contemporary prevalence, management and outcomes. Heart. 2020;106:569-74. doi:10.1136/heartjnl-2019-315852.</mixed-citation><mixed-citation xml:lang="en">Imazio M, Colopi M, De Ferrari GM. Pericardial diseases in patients with cancer: Contemporary prevalence, management and outcomes. Heart. 2020;106:569-74. doi:10.1136/heartjnl-2019-315852.</mixed-citation></citation-alternatives></ref><ref id="cit428"><label>428</label><citation-alternatives><mixed-citation xml:lang="ru">Adler Y, Charron P, Imazio M, et al. 2015 ESC Guidelines for the diagnosis and management of pericardial diseases. Eur Heart J. 2015;36:2921-64. doi:10.1093/eurheartj/ehv318.</mixed-citation><mixed-citation xml:lang="en">Adler Y, Charron P, Imazio M, et al. 2015 ESC Guidelines for the diagnosis and management of pericardial diseases. Eur Heart J. 2015;36:2921-64. doi:10.1093/eurheartj/ehv318.</mixed-citation></citation-alternatives></ref><ref id="cit429"><label>429</label><citation-alternatives><mixed-citation xml:lang="ru">Sánchez-Enrique C, Nuñez-Gil IJ, Viana-Tejedor A, et al. Cause and Long-Term Outcome of Cardiac Tamponade. Am J Cardiol. 2016;117:664-9. doi:10.1016/j.amjcard.2015.11.023.</mixed-citation><mixed-citation xml:lang="en">Sánchez-Enrique C, Nuñez-Gil IJ, Viana-Tejedor A, et al. Cause and Long-Term Outcome of Cardiac Tamponade. Am J Cardiol. 2016;117:664-9. doi:10.1016/j.amjcard.2015.11.023.</mixed-citation></citation-alternatives></ref><ref id="cit430"><label>430</label><citation-alternatives><mixed-citation xml:lang="ru">Saab J, Hoda RS, Narula N, et al. Diagnostic yield of cytopathology in evaluating pericardial effusions: Clinicopathologic analysis of 419 specimens. Cancer Cytopathol. 2017;125:128-37. doi:10.1002/cncy.21790.</mixed-citation><mixed-citation xml:lang="en">Saab J, Hoda RS, Narula N, et al. Diagnostic yield of cytopathology in evaluating pericardial effusions: Clinicopathologic analysis of 419 specimens. Cancer Cytopathol. 2017;125:128-37. doi:10.1002/cncy.21790.</mixed-citation></citation-alternatives></ref><ref id="cit431"><label>431</label><citation-alternatives><mixed-citation xml:lang="ru">Patel N, Rafique AM, Eshaghian S, et al. Retrospective comparison of outcomes, diagnostic value, and complications of percutaneous prolonged drainage versus surgical pericardiotomy of pericardial effusion associated with malignancy. Am J Cardiol. 2013;112:1235-9. doi:10.1016/j.amjcard.2013.05.066.</mixed-citation><mixed-citation xml:lang="en">Patel N, Rafique AM, Eshaghian S, et al. Retrospective comparison of outcomes, diagnostic value, and complications of percutaneous prolonged drainage versus surgical pericardiotomy of pericardial effusion associated with malignancy. Am J Cardiol. 2013;112:1235-9. doi:10.1016/j.amjcard.2013.05.066.</mixed-citation></citation-alternatives></ref><ref id="cit432"><label>432</label><citation-alternatives><mixed-citation xml:lang="ru">van Nimwegen FA, Schaapveld M, Cutter DJ, et al. Radiation dose-response relationship for risk of coronary heart disease in survivors of Hodgkin lymphoma. J Clin Oncol 2016;34:235-43. doi:10.1200/JCO.2015.63.4444.</mixed-citation><mixed-citation xml:lang="en">van Nimwegen FA, Schaapveld M, Cutter DJ, et al. Radiation dose-response relationship for risk of coronary heart disease in survivors of Hodgkin lymphoma. J Clin Oncol 2016;34:235-43. doi:10.1200/JCO.2015.63.4444.</mixed-citation></citation-alternatives></ref><ref id="cit433"><label>433</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor C, Correa C, Duane FK, et al., Early Breast Cancer Trialists’ Collaborative Group Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials. J Clin Oncol. 2017;35:1641-9. doi:10.1200/JCO.2016.72.0722.</mixed-citation><mixed-citation xml:lang="en">Taylor C, Correa C, Duane FK, et al., Early Breast Cancer Trialists’ Collaborative Group Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials. J Clin Oncol. 2017;35:1641-9. doi:10.1200/JCO.2016.72.0722.</mixed-citation></citation-alternatives></ref><ref id="cit434"><label>434</label><citation-alternatives><mixed-citation xml:lang="ru">Armenian SH, Hudson MM, Mulder RL, et al. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2015;16:e123-36. doi:10.1016/S1470-2045(14)70409-7.</mixed-citation><mixed-citation xml:lang="en">Armenian SH, Hudson MM, Mulder RL, et al. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2015;16:e123-36. doi:10.1016/S1470-2045(14)70409-7.</mixed-citation></citation-alternatives></ref><ref id="cit435"><label>435</label><citation-alternatives><mixed-citation xml:lang="ru">Jacobse JN, Duane FK, Boekel NB, et al. Radiation dose-response for risk of myocardial infarction in breast cancer survivors. Int J Radiat Oncol Biol Phys. 2019;103:595-604. doi:10.1016/j.ijrobp.2018.10.025.</mixed-citation><mixed-citation xml:lang="en">Jacobse JN, Duane FK, Boekel NB, et al. Radiation dose-response for risk of myocardial infarction in breast cancer survivors. Int J Radiat Oncol Biol Phys. 2019;103:595-604. doi:10.1016/j.ijrobp.2018.10.025.</mixed-citation></citation-alternatives></ref><ref id="cit436"><label>436</label><citation-alternatives><mixed-citation xml:lang="ru">Rehammar JC, Jensen M-B, McGale P, et al. Risk of heart disease in relation to radiotherapy and chemotherapy with anthracyclines among 19,464 breast cancer patients in Denmark, 1977-2005. Radiother Oncol. 2017;123:299-305. doi:10.1016/j.radonc.2017.03.012.</mixed-citation><mixed-citation xml:lang="en">Rehammar JC, Jensen M-B, McGale P, et al. Risk of heart disease in relation to radiotherapy and chemotherapy with anthracyclines among 19,464 breast cancer patients in Denmark, 1977-2005. Radiother Oncol. 2017;123:299-305. doi:10.1016/j.radonc.2017.03.012.</mixed-citation></citation-alternatives></ref><ref id="cit437"><label>437</label><citation-alternatives><mixed-citation xml:lang="ru">Yavas G, Gultekin M, Yildiz O, et al. Assessment Of concomitant versus equential trastuzumab on radiation-induced cardiovascular toxicity. Hum Exp Toxicol. 2017;36:1121- 30. doi:10.1177/0960327116680276.</mixed-citation><mixed-citation xml:lang="en">Yavas G, Gultekin M, Yildiz O, et al. Assessment Of concomitant versus equential trastuzumab on radiation-induced cardiovascular toxicity. Hum Exp Toxicol. 2017;36:1121- 30. doi:10.1177/0960327116680276.</mixed-citation></citation-alternatives></ref><ref id="cit438"><label>438</label><citation-alternatives><mixed-citation xml:lang="ru">Sarfati D, Koczwara B, Jackson C. The impact of comorbidity on cancer and its treatment. CA Cancer J Clin. 2016;66:337-50. doi:10.3322/caac.21342.</mixed-citation><mixed-citation xml:lang="en">Sarfati D, Koczwara B, Jackson C. The impact of comorbidity on cancer and its treatment. CA Cancer J Clin. 2016;66:337-50. doi:10.3322/caac.21342.</mixed-citation></citation-alternatives></ref><ref id="cit439"><label>439</label><citation-alternatives><mixed-citation xml:lang="ru">Cuomo JR, Sharma GK, Conger PD, Weintraub NL. Novel concepts in radiation-induced cardiovascular disease. World J Cardiol 2016;8(9):504-19. doi:10.4330/wjc.v8.i9.504.</mixed-citation><mixed-citation xml:lang="en">Cuomo JR, Sharma GK, Conger PD, Weintraub NL. Novel concepts in radiation-induced cardiovascular disease. World J Cardiol 2016;8(9):504-19. doi:10.4330/wjc.v8.i9.504.</mixed-citation></citation-alternatives></ref><ref id="cit440"><label>440</label><citation-alternatives><mixed-citation xml:lang="ru">Sárközy M, Varga Z, Gáspár R. Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside. Clinical Research in Cardiology. Clin Res Cardiol. 2021;110(4):507-31. doi:10.1007/s00392-021-01809-y.</mixed-citation><mixed-citation xml:lang="en">Sárközy M, Varga Z, Gáspár R. Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside. Clinical Research in Cardiology. Clin Res Cardiol. 2021;110(4):507-31. doi:10.1007/s00392-021-01809-y.</mixed-citation></citation-alternatives></ref><ref id="cit441"><label>441</label><citation-alternatives><mixed-citation xml:lang="ru">Pudil R, Mueller C, Čelutkienė J, et al. Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology. European Journal of Heart Failure. 2020;22:1966-83. doi:10.1002/ejhf.2017.</mixed-citation><mixed-citation xml:lang="en">Pudil R, Mueller C, Čelutkienė J, et al. Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology. European Journal of Heart Failure. 2020;22:1966-83. doi:10.1002/ejhf.2017.</mixed-citation></citation-alternatives></ref><ref id="cit442"><label>442</label><citation-alternatives><mixed-citation xml:lang="ru">Walker V, Lairez O, Fondard O, et al. Myocardial deformation after radiotherapy: a layerspecific and territorial longitudinal strain analysis in a cohort of left-sided breast cancer patients (BACCARAT study). Radiat Oncol. 2020;15(1):201. doi:10.1186/s13014-020-01635-y.</mixed-citation><mixed-citation xml:lang="en">Walker V, Lairez O, Fondard O, et al. Myocardial deformation after radiotherapy: a layerspecific and territorial longitudinal strain analysis in a cohort of left-sided breast cancer patients (BACCARAT study). Radiat Oncol. 2020;15(1):201. doi:10.1186/s13014-020-01635-y.</mixed-citation></citation-alternatives></ref><ref id="cit443"><label>443</label><citation-alternatives><mixed-citation xml:lang="ru">van Nimwegen FA, Ntentas G, Darby SC, et al. Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines. Blood 2017;129:2257-65. doi:10.1182/blood-2016-09-740332.</mixed-citation><mixed-citation xml:lang="en">van Nimwegen FA, Ntentas G, Darby SC, et al. Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines. Blood 2017;129:2257-65. doi:10.1182/blood-2016-09-740332.</mixed-citation></citation-alternatives></ref><ref id="cit444"><label>444</label><citation-alternatives><mixed-citation xml:lang="ru">Saiki H, Petersen IA, Scott CG, et al. Risk of heart failure with preserved ejection fraction in older women after contemporary radiotherapy for breast cancer. Circulation. 2017;135:1388-96. doi:10.1161/CIRCULATIONAHA.116.025434.</mixed-citation><mixed-citation xml:lang="en">Saiki H, Petersen IA, Scott CG, et al. Risk of heart failure with preserved ejection fraction in older women after contemporary radiotherapy for breast cancer. Circulation. 2017;135:1388-96. doi:10.1161/CIRCULATIONAHA.116.025434.</mixed-citation></citation-alternatives></ref><ref id="cit445"><label>445</label><citation-alternatives><mixed-citation xml:lang="ru">Armstrong GT, Joshi VM, Ness KK, et al. Comprehensive echocardiographic detection of treatment-related cardiac dysfunction in adult survivors of childhood cancer: results from the St. Jude Lifetime Cohort Study. J Am Coll Cardiol. 2015;65:2511-22. doi:10.1016/j.jacc.2015.04.013.</mixed-citation><mixed-citation xml:lang="en">Armstrong GT, Joshi VM, Ness KK, et al. Comprehensive echocardiographic detection of treatment-related cardiac dysfunction in adult survivors of childhood cancer: results from the St. Jude Lifetime Cohort Study. J Am Coll Cardiol. 2015;65:2511-22. doi:10.1016/j.jacc.2015.04.013.</mixed-citation></citation-alternatives></ref><ref id="cit446"><label>446</label><citation-alternatives><mixed-citation xml:lang="ru">Полтавская М.Г., Емелина Е.И., Авдеев Ю.В. и др. Поражения клапанов сердца вследствие лучевой терапии злокачественных новообразований. Кардиология. 2019;59(2S):56-68.</mixed-citation><mixed-citation xml:lang="en">Poltavskaya MG, Emelina EI, Avdeev YuV, et al. Lesions of the heart valves due to radiation therapy of malignant neoplasms. Kardiologija. 2019;59(2S):56-68. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit447"><label>447</label><citation-alternatives><mixed-citation xml:lang="ru">Trivedi SJ, Choudhary P, Lo Q, et al. Persistent reduction in global longitudinal strain in the longer term after radiation therapy in patients with breast cancer. Radiother Oncol. 2019;132:148-54. doi:10.1016/j.radonc.2018.10.023.</mixed-citation><mixed-citation xml:lang="en">Trivedi SJ, Choudhary P, Lo Q, et al. Persistent reduction in global longitudinal strain in the longer term after radiation therapy in patients with breast cancer. Radiother Oncol. 2019;132:148-54. doi:10.1016/j.radonc.2018.10.023.</mixed-citation></citation-alternatives></ref><ref id="cit448"><label>448</label><citation-alternatives><mixed-citation xml:lang="ru">Plana JC, Thavendiranathan P, Bucciarelli-Ducci C. Multi-Modality Imaging in the Assessment of Cardiovascular Toxicity in the Cancer Patient. J Am Coll Cardiol Img. 2018;11:1173-86. doi:10.1016/j.jcmg.2018.06.003.</mixed-citation><mixed-citation xml:lang="en">Plana JC, Thavendiranathan P, Bucciarelli-Ducci C. Multi-Modality Imaging in the Assessment of Cardiovascular Toxicity in the Cancer Patient. J Am Coll Cardiol Img. 2018;11:1173-86. doi:10.1016/j.jcmg.2018.06.003.</mixed-citation></citation-alternatives></ref><ref id="cit449"><label>449</label><citation-alternatives><mixed-citation xml:lang="ru">Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapyfor breast cancer. N Engl J Med. 2013;368:987-98. doi:10.1056/NEJMoa1209825.</mixed-citation><mixed-citation xml:lang="en">Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapyfor breast cancer. N Engl J Med. 2013;368:987-98. doi:10.1056/NEJMoa1209825.</mixed-citation></citation-alternatives></ref><ref id="cit450"><label>450</label><citation-alternatives><mixed-citation xml:lang="ru">Dess RT, Sun Y, Matuszak MM, et al. Cardiac events after radiation therapy: combined analysis of prospective multicenter trials for locally advanced non-small-cell lung cancer. J Clin Oncol. 2017;35:1395e1402. doi:10.1200/JCO.2016.71.6142.</mixed-citation><mixed-citation xml:lang="en">Dess RT, Sun Y, Matuszak MM, et al. Cardiac events after radiation therapy: combined analysis of prospective multicenter trials for locally advanced non-small-cell lung cancer. J Clin Oncol. 2017;35:1395e1402. doi:10.1200/JCO.2016.71.6142.</mixed-citation></citation-alternatives></ref><ref id="cit451"><label>451</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor C, McGale P, Brønnum D, et al. Cardiac structure injury after radiotherapy for breast cancer: cross-sectional study with individual patient data. J Clin Oncol. 2018;36:2288-96. doi:10.1200/JCO.2017.77.6351.</mixed-citation><mixed-citation xml:lang="en">Taylor C, McGale P, Brønnum D, et al. Cardiac structure injury after radiotherapy for breast cancer: cross-sectional study with individual patient data. J Clin Oncol. 2018;36:2288-96. doi:10.1200/JCO.2017.77.6351.</mixed-citation></citation-alternatives></ref><ref id="cit452"><label>452</label><citation-alternatives><mixed-citation xml:lang="ru">Reed GW, Masri A, Griffin BP, et al. Long-term mortality in patients with radiationassociated coronary artery disease treated with percutaneous coronary intervention. Circ Cardiovasc Interv. 2016;9:e003483. doi:10.1161/CIRCINTERVENTIONS.115.003483.</mixed-citation><mixed-citation xml:lang="en">Reed GW, Masri A, Griffin BP, et al. Long-term mortality in patients with radiationassociated coronary artery disease treated with percutaneous coronary intervention. Circ Cardiovasc Interv. 2016;9:e003483. doi:10.1161/CIRCINTERVENTIONS.115.003483.</mixed-citation></citation-alternatives></ref><ref id="cit453"><label>453</label><citation-alternatives><mixed-citation xml:lang="ru">Fender EA, Liang JJ, Sio TT, et al. Percutaneous revascularization in patients treated with thoracic radiation for cancer. Am Heart J. 2017;187:98-103. doi:10.1016/j.ahj.2017.02.014.</mixed-citation><mixed-citation xml:lang="en">Fender EA, Liang JJ, Sio TT, et al. Percutaneous revascularization in patients treated with thoracic radiation for cancer. Am Heart J. 2017;187:98-103. doi:10.1016/j.ahj.2017.02.014.</mixed-citation></citation-alternatives></ref><ref id="cit454"><label>454</label><citation-alternatives><mixed-citation xml:lang="ru">Bijl JM, Roos MM, van Leeuwen-Segarceanu EM, et al. Assessment of valvular disorders in survivors of Hodgkin’s lymphoma treated by mediastinal radiotherapy +/- chemotherapy. Am J Cardiol. 2016;117(4):691-6. doi:10.1016/j.amjcard.2015.11.027.</mixed-citation><mixed-citation xml:lang="en">Bijl JM, Roos MM, van Leeuwen-Segarceanu EM, et al. Assessment of valvular disorders in survivors of Hodgkin’s lymphoma treated by mediastinal radiotherapy +/- chemotherapy. Am J Cardiol. 2016;117(4):691-6. doi:10.1016/j.amjcard.2015.11.027.</mixed-citation></citation-alternatives></ref><ref id="cit455"><label>455</label><citation-alternatives><mixed-citation xml:lang="ru">van Nimwegen FA, Schaapveld M, Janus CP, et al. Cardiovascular disease after Hodgkin lymphoma treatment: 40-year disease risk. JAMA Intern Med. 2015;175:1007-17. doi:10.1001/jamainternmed.2015.1180.</mixed-citation><mixed-citation xml:lang="en">van Nimwegen FA, Schaapveld M, Janus CP, et al. Cardiovascular disease after Hodgkin lymphoma treatment: 40-year disease risk. JAMA Intern Med. 2015;175:1007-17. doi:10.1001/jamainternmed.2015.1180.</mixed-citation></citation-alternatives></ref><ref id="cit456"><label>456</label><citation-alternatives><mixed-citation xml:lang="ru">Donnellan E, Griffin BP, Johnston DR, et al. Rate of progression of aortic stenosis and its impact on outcomes in patients with radiation-associated cardiac disease: a matched cohort study. J Am Coll Cardiol Img. 2018;11:1072-80. doi:10.1016/j.jcmg.2018.04.019.</mixed-citation><mixed-citation xml:lang="en">Donnellan E, Griffin BP, Johnston DR, et al. Rate of progression of aortic stenosis and its impact on outcomes in patients with radiation-associated cardiac disease: a matched cohort study. J Am Coll Cardiol Img. 2018;11:1072-80. doi:10.1016/j.jcmg.2018.04.019.</mixed-citation></citation-alternatives></ref><ref id="cit457"><label>457</label><citation-alternatives><mixed-citation xml:lang="ru">Donnellan E, Masri A, Johnston DR, et al. Long-term outcomes of patients with mediastinal radiation-associated severe aortic stenosis and subsequent surgical aortic valve replacement: a matched cohort study. J Am Heart Assoc. 2017;6(5):e005396. doi:10.1161/JAHA.116.005396.</mixed-citation><mixed-citation xml:lang="en">Donnellan E, Masri A, Johnston DR, et al. Long-term outcomes of patients with mediastinal radiation-associated severe aortic stenosis and subsequent surgical aortic valve replacement: a matched cohort study. J Am Heart Assoc. 2017;6(5):e005396. doi:10.1161/JAHA.116.005396.</mixed-citation></citation-alternatives></ref><ref id="cit458"><label>458</label><citation-alternatives><mixed-citation xml:lang="ru">Desai MY, Cremer PC, Schoenhagen P. Thoracic aortic calcification: diagnostic, prognostic, and management considerations. J Am Coll Cardiol Img. 2018;11:1012-26.</mixed-citation><mixed-citation xml:lang="en">Desai MY, Cremer PC, Schoenhagen P. Thoracic aortic calcification: diagnostic, prognostic, and management considerations. J Am Coll Cardiol Img. 2018;11:1012-26.</mixed-citation></citation-alternatives></ref><ref id="cit459"><label>459</label><citation-alternatives><mixed-citation xml:lang="ru">Zafar MR, Mustafa SF, Miller TW, et al. Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis. Cardiooncology. 2020;14;6:8. doi:10.1186/s40959-020-00062-y</mixed-citation><mixed-citation xml:lang="en">Zafar MR, Mustafa SF, Miller TW, et al. Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis. Cardiooncology. 2020;14;6:8. doi:10.1186/s40959-020-00062-y</mixed-citation></citation-alternatives></ref><ref id="cit460"><label>460</label><citation-alternatives><mixed-citation xml:lang="ru">Groarke JD, Tanguturi VK, Hainer J, et al. Abnormal exercise response in long-term survivors of Hodgkin lymphoma treated with thoracic irradiation: evidence of cardiac autonomic dysfunction and impact on outcomes. J Am Coll Cardiol. 2015;65:573-83. doi:10.1016/j.jacc.2014.11.035.</mixed-citation><mixed-citation xml:lang="en">Groarke JD, Tanguturi VK, Hainer J, et al. Abnormal exercise response in long-term survivors of Hodgkin lymphoma treated with thoracic irradiation: evidence of cardiac autonomic dysfunction and impact on outcomes. J Am Coll Cardiol. 2015;65:573-83. doi:10.1016/j.jacc.2014.11.035.</mixed-citation></citation-alternatives></ref><ref id="cit461"><label>461</label><citation-alternatives><mixed-citation xml:lang="ru">Armanious MA, Mishra S, Fradley MG. Electrophysiologic toxicity of chemoradiation. Curr Oncol Rep. 2018;20:45. doi:10.1007/s11912-018-0691-0.</mixed-citation><mixed-citation xml:lang="en">Armanious MA, Mishra S, Fradley MG. Electrophysiologic toxicity of chemoradiation. Curr Oncol Rep. 2018;20:45. doi:10.1007/s11912-018-0691-0.</mixed-citation></citation-alternatives></ref><ref id="cit462"><label>462</label><citation-alternatives><mixed-citation xml:lang="ru">Cardinale D, Colombo A, Sandri MT, et al. Prevention of High-Dose Chemotherapy– Induced Cardiotoxicity in High-Risk Patients by Angiotensin-Converting Enzyme Inhibition. Circulation. 2006;114(23):2474-81. doi:10.1161/CIRCULATIONAHA.106.635144.</mixed-citation><mixed-citation xml:lang="en">Cardinale D, Colombo A, Sandri MT, et al. Prevention of High-Dose Chemotherapy– Induced Cardiotoxicity in High-Risk Patients by Angiotensin-Converting Enzyme Inhibition. Circulation. 2006;114(23):2474-81. doi:10.1161/CIRCULATIONAHA.106.635144.</mixed-citation></citation-alternatives></ref><ref id="cit463"><label>463</label><citation-alternatives><mixed-citation xml:lang="ru">Муратов Р.М., Бабенко С.И., Сачков А.С., Соболева Н.Н. Постлучевое поражение клапанов сердца. Принципы диагностики и результаты лечения. Кардиология. 2019;59(3):36-42. doi:10.18087/cardio.2019.3.10239.</mixed-citation><mixed-citation xml:lang="en">Muratov RM, Babenko SI, Sachkov AS, Soboleva NN. Post-radiation damage of heart valves. Principles of diagnosis and treatment results. Kardiologija. 2019;59(3):36-42. (In Russ.) doi:10.18087/cardio.2019.3.10239.</mixed-citation></citation-alternatives></ref><ref id="cit464"><label>464</label><citation-alternatives><mixed-citation xml:lang="ru">Common Terminology Criteria for Adverse Events (CTCAE) v5.0. U.S. department of health and human services, National Institutes of Health, National Cancer Institute. Publish Date: November 27, 2017. For further details on MedDRA refer to the MedDRA MSSO Web site (https://www.meddra.org/).</mixed-citation><mixed-citation xml:lang="en">Common Terminology Criteria for Adverse Events (CTCAE) v5.0. U.S. department of health and human services, National Institutes of Health, National Cancer Institute. Publish Date: November 27, 2017. For further details on MedDRA refer to the MedDRA MSSO Web site (https://www.meddra.org/).</mixed-citation></citation-alternatives></ref><ref id="cit465"><label>465</label><citation-alternatives><mixed-citation xml:lang="ru">Henriksen PA. Anthracycline cardiotoxicity: an update on mechanisms, monitoring and prevention. BMJ. 2018; 104(12):971-7. doi:10.1136/heartjnl-2017-312103.</mixed-citation><mixed-citation xml:lang="en">Henriksen PA. Anthracycline cardiotoxicity: an update on mechanisms, monitoring and prevention. BMJ. 2018; 104(12):971-7. doi:10.1136/heartjnl-2017-312103.</mixed-citation></citation-alternatives></ref><ref id="cit466"><label>466</label><citation-alternatives><mixed-citation xml:lang="ru">Buza V, Rajagopalan B, Curtis AB. Cancer Treatment-Induced Arrhythmias: Focus on Chemotherapy and Targeted Therapies. Circ Arrhythm Electrophysiol. 2017;10(8):e005443. doi:10.1161/CIRCEP.117.005443.</mixed-citation><mixed-citation xml:lang="en">Buza V, Rajagopalan B, Curtis AB. Cancer Treatment-Induced Arrhythmias: Focus on Chemotherapy and Targeted Therapies. Circ Arrhythm Electrophysiol. 2017;10(8):e005443. doi:10.1161/CIRCEP.117.005443.</mixed-citation></citation-alternatives></ref><ref id="cit467"><label>467</label><citation-alternatives><mixed-citation xml:lang="ru">Rhea PH, Burgos MG. Fradley. Arrhythmogenic Anticancer Drugs in Cardio-Oncology. Cardiol Clin. 2019;37:459-68. doi:10.1016/j.ccl.2019.07.011.</mixed-citation><mixed-citation xml:lang="en">Rhea PH, Burgos MG. Fradley. Arrhythmogenic Anticancer Drugs in Cardio-Oncology. Cardiol Clin. 2019;37:459-68. doi:10.1016/j.ccl.2019.07.011.</mixed-citation></citation-alternatives></ref><ref id="cit468"><label>468</label><citation-alternatives><mixed-citation xml:lang="ru">Емелина Е.И., Гендлин Г.Е., Никитин И.Г., и др. Нарушения ритма и проводимости у пациентов, получающих лечение ибрутинибом. Клиническая онкогематология. Фундаментальные исследования и клиническая практика. 2019;12(2):220-30. doi:10.21320/2500-2139-2019-12-2-220-230.</mixed-citation><mixed-citation xml:lang="en">Emelina EI, Gendlin GE, Nikitin IG, et al. Rhythm and conduction disorders in patients receiving treatment with ibrutinib. Clinical oncohematology. Basic research and clinical practice. 2019;12(2):220-30. (In Russ.) doi:10.21320/2500-2139-2019-12-2-220-230.</mixed-citation></citation-alternatives></ref><ref id="cit469"><label>469</label><citation-alternatives><mixed-citation xml:lang="ru">Емелина Е. И., Гендлин Г.Е., Никитин И. Г. Антитромботическая терапия у пациентов со злокачественными лимфопролиферативными заболеваниями, получающих ибрутиниб. Клиническая онкогематология. Фундаментальные исследования и клиническая практика. 2019;12(4):89-100. doi:10.21320/2500-2139-2019-12-4-449-460.</mixed-citation><mixed-citation xml:lang="en">Emelina EI, Gendlin GE, Nikitin IG. Antithrombotic therapy in patients with malignant lymphoproliferative diseases receiving ibrutinib. Clinical oncohematology. Basic research and clinical practice. 2019;12(4):89-100. (In Russ.) doi:10.21320/2500-2139-2019-12-4-449-460.</mixed-citation></citation-alternatives></ref><ref id="cit470"><label>470</label><citation-alternatives><mixed-citation xml:lang="ru">Российское кардиологическое общество (РКО). Хроническая сердечная недостаточность. Клинические рекомендации 2020. Российский кардиологический журнал. 2020;25(11):4083. doi:10.15829/1560-4071-2020-4083.</mixed-citation><mixed-citation xml:lang="en">Russian Society of Cardiology (RSC). 2020 Clinical practice guidelines for Chronic heart failure. Russian Journal of Cardiology. 2020;25(11):4083. (In Russ.) doi:10.15829/1560-4071-2020-4083.</mixed-citation></citation-alternatives></ref><ref id="cit471"><label>471</label><citation-alternatives><mixed-citation xml:lang="ru">Gregorietti V, Fernandez TL, Costa D, et al. Use of Sacubitril/valsartan in patients with cardio toxicity and heart failure due to chemotherapy. Cardiooncology. 2020;6(1):24. doi:10.1186/s40959-020-00078-4.</mixed-citation><mixed-citation xml:lang="en">Gregorietti V, Fernandez TL, Costa D, et al. Use of Sacubitril/valsartan in patients with cardio toxicity and heart failure due to chemotherapy. Cardiooncology. 2020;6(1):24. doi:10.1186/s40959-020-00078-4.</mixed-citation></citation-alternatives></ref><ref id="cit472"><label>472</label><citation-alternatives><mixed-citation xml:lang="ru">Singh JP, Solomon SD, Fradley MG, et al. Association of Cardiac Resynchronization Therapy With Change in Left Ventricular Ejection Fraction in Patients With ChemotherapyInduced Cardiomyopathy. JAMA. 2019;322(18):1799-805. doi:10.1001/jama.2019.16658.</mixed-citation><mixed-citation xml:lang="en">Singh JP, Solomon SD, Fradley MG, et al. Association of Cardiac Resynchronization Therapy With Change in Left Ventricular Ejection Fraction in Patients With ChemotherapyInduced Cardiomyopathy. JAMA. 2019;322(18):1799-805. doi:10.1001/jama.2019.16658.</mixed-citation></citation-alternatives></ref><ref id="cit473"><label>473</label><citation-alternatives><mixed-citation xml:lang="ru">Lenneman AJ, Wang L, Wigger M, et al. Heart transplant survival outcomes for adriamycin-dilated cardiomyopathy. Am J Cardiol. 2013;111(4):609-12. doi:10.1016/j.amjcard.2012.10.048.</mixed-citation><mixed-citation xml:lang="en">Lenneman AJ, Wang L, Wigger M, et al. Heart transplant survival outcomes for adriamycin-dilated cardiomyopathy. Am J Cardiol. 2013;111(4):609-12. doi:10.1016/j.amjcard.2012.10.048.</mixed-citation></citation-alternatives></ref><ref id="cit474"><label>474</label><citation-alternatives><mixed-citation xml:lang="ru">Gilchrist SC, Barac A, Ades PA, et al. Cardio-oncology rehabilitation to manage cardiovascular outcomes in cancer patients and survivors: a scientific statement from the American Heart Association. Circulation. 2019;139 (21):997-1012. doi:10.1161/CIR.0000000000000679.</mixed-citation><mixed-citation xml:lang="en">Gilchrist SC, Barac A, Ades PA, et al. Cardio-oncology rehabilitation to manage cardiovascular outcomes in cancer patients and survivors: a scientific statement from the American Heart Association. Circulation. 2019;139 (21):997-1012. doi:10.1161/CIR.0000000000000679.</mixed-citation></citation-alternatives></ref><ref id="cit475"><label>475</label><citation-alternatives><mixed-citation xml:lang="ru">Maia TN, Araujo GB, Teixeira JA, et al. Cardiotoxicity of Doxorubicin Treatment and Physical Activity: A Systematic Review. Int J Cardiovasc Sci. 2017;30(1):70-80. doi:10.5935/2359-4802.20170004.</mixed-citation><mixed-citation xml:lang="en">Maia TN, Araujo GB, Teixeira JA, et al. Cardiotoxicity of Doxorubicin Treatment and Physical Activity: A Systematic Review. Int J Cardiovasc Sci. 2017;30(1):70-80. doi:10.5935/2359-4802.20170004.</mixed-citation></citation-alternatives></ref><ref id="cit476"><label>476</label><citation-alternatives><mixed-citation xml:lang="ru">Fischetti F, Greco G, Cataldi S, et al. Effects of Physical Exercise Intervention on Psychological and Physical Fitness in Lymphoma Patients. Medicina 2019;55(7):379. doi:10.3390/medicina55070379.</mixed-citation><mixed-citation xml:lang="en">Fischetti F, Greco G, Cataldi S, et al. Effects of Physical Exercise Intervention on Psychological and Physical Fitness in Lymphoma Patients. Medicina 2019;55(7):379. doi:10.3390/medicina55070379.</mixed-citation></citation-alternatives></ref><ref id="cit477"><label>477</label><citation-alternatives><mixed-citation xml:lang="ru">Hooning MJ, Botma A, Aleman BM, et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst. 2007;99:365-75. doi:10.1093/jnci/djk064.</mixed-citation><mixed-citation xml:lang="en">Hooning MJ, Botma A, Aleman BM, et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst. 2007;99:365-75. doi:10.1093/jnci/djk064.</mixed-citation></citation-alternatives></ref><ref id="cit478"><label>478</label><citation-alternatives><mixed-citation xml:lang="ru">Chow EJ, Mueller BA, Baker KS, et al. Cardiovascular hospitalizations and mortality among recipients of hematopoietic stem cell transplantation. Ann Intern Med.2011;155:21-32. doi:10.7326/0003-4819-155-1-201107050-00004.</mixed-citation><mixed-citation xml:lang="en">Chow EJ, Mueller BA, Baker KS, et al. Cardiovascular hospitalizations and mortality among recipients of hematopoietic stem cell transplantation. Ann Intern Med.2011;155:21-32. doi:10.7326/0003-4819-155-1-201107050-00004.</mixed-citation></citation-alternatives></ref><ref id="cit479"><label>479</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С.А., Погосова Н.В., Бубнова М.Г. и др. Кардиоваскулярная профилактика 2017. Российские национальные рекомендации. Российский кардиологический журнал. 2018;23(6):7-122. doi:10.15829/1560-4071-2018-6-7-122.</mixed-citation><mixed-citation xml:lang="en">Boytsov SA, Pogosova NV, Bubnova MG, et al. Cardiovascular prevention 2017. Russian national recommendations. Russian Journal of Cardiology. 2018;23(6):7-122. (In Russ.) doi:10.15829/1560-4071-2018-6-7-122.</mixed-citation></citation-alternatives></ref><ref id="cit480"><label>480</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson L, Taylor RS. Cardiac rehabilitation for people with heart disease: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev. 2014;2014(12):CD011273. doi:10.1002/14651858.CD011273.pub2.</mixed-citation><mixed-citation xml:lang="en">Anderson L, Taylor RS. Cardiac rehabilitation for people with heart disease: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev. 2014;2014(12):CD011273. doi:10.1002/14651858.CD011273.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit481"><label>481</label><citation-alternatives><mixed-citation xml:lang="ru">Balady GJ, Williams MA, Ades PA, et al. Core components of cardiac rehabilitation/ secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation. Circulation. 2007;115:2675- 82. doi:10.1161/CIRCULATIONAHA.106.180945.</mixed-citation><mixed-citation xml:lang="en">Balady GJ, Williams MA, Ades PA, et al. Core components of cardiac rehabilitation/ secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation. Circulation. 2007;115:2675- 82. doi:10.1161/CIRCULATIONAHA.106.180945.</mixed-citation></citation-alternatives></ref><ref id="cit482"><label>482</label><citation-alternatives><mixed-citation xml:lang="ru">Hamm LF, Sanderson BK, Ades PA, et al. Core competencies for cardiac rehabilitation/ secondary prevention professionals: 2010 update: position statement of the American Association of Cardiovascular and Pulmonary Rehabilitation. J Cardiopulm Rehabil Prev. 2011;31:2-10. doi:10.1097/HCR.0b013e318203999d.</mixed-citation><mixed-citation xml:lang="en">Hamm LF, Sanderson BK, Ades PA, et al. Core competencies for cardiac rehabilitation/ secondary prevention professionals: 2010 update: position statement of the American Association of Cardiovascular and Pulmonary Rehabilitation. J Cardiopulm Rehabil Prev. 2011;31:2-10. doi:10.1097/HCR.0b013e318203999d.</mixed-citation></citation-alternatives></ref><ref id="cit483"><label>483</label><citation-alternatives><mixed-citation xml:lang="ru">Бокерия Л. А., Аронов Д. М. Российские клинические рекомендации. Коронарное шунтирование больных ишемической болезнью сердца: реабилитация и вторичная профилактика. КардиоСоматика. 2016;7(3-4):5-71.</mixed-citation><mixed-citation xml:lang="en">Bokeria LA, Aronov DM. Russian clinical guidelines. Coronary bypass surgery in patients with coronary heart disease: rehabilitation and secondary prevention. Cardiosomatics. 2016;7(3-4):5-71. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit484"><label>484</label><citation-alternatives><mixed-citation xml:lang="ru">Арутюнов Г.П., Беграмбекова Ю.Л., Васюк Ю.А. и др. Рекомендации по назначению физических тренировок пациентам с хронической сердечной недостаточностью. Сердечная недостаточность. 2017;18(1):41-66.</mixed-citation><mixed-citation xml:lang="en">Arutyunov GP, Begrambekova YuL, Vasyuk YuA, et al. Recommendations for the appointment of physical training in patients with chronic heart failure. Heart failure. 2017;18(1):41-66. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit485"><label>485</label><citation-alternatives><mixed-citation xml:lang="ru">Российское кардиологическое общество (РКО). Острый инфаркт миокарда с подъемом сегмента ST электрокардиограммы. Клинические рекомендации 2020. Российский кардиологический журнал. 2020;25(11):4103. doi:10.15829/29/1560-4071-2020-4103.</mixed-citation><mixed-citation xml:lang="en">Russian Society of Cardiology (RSC). 2020 Clinical practice guidelines for Acute ST-segment elevation myocardial infarction. Russian Journal of Cardiology. 2020;25(11):4103. (In Russ.) doi:10.15829/29/1560-4071-2020-4103.</mixed-citation></citation-alternatives></ref><ref id="cit486"><label>486</label><citation-alternatives><mixed-citation xml:lang="ru">Knuuti J, Wijns W, Saraste A, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC) European Heart Journal. 2020;41(3):407-77. doi:10.1093/eurheartj/ehz425.</mixed-citation><mixed-citation xml:lang="en">Knuuti J, Wijns W, Saraste A, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC) European Heart Journal. 2020;41(3):407-77. doi:10.1093/eurheartj/ehz425.</mixed-citation></citation-alternatives></ref><ref id="cit487"><label>487</label><citation-alternatives><mixed-citation xml:lang="ru">Costanzo MR, Dipchand A, Starling R, et al. International Society of Heart and Lung Transplantation Guidelines. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29(8):914-56. doi:10.1016/j.healun.2010.05.034.</mixed-citation><mixed-citation xml:lang="en">Costanzo MR, Dipchand A, Starling R, et al. International Society of Heart and Lung Transplantation Guidelines. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29(8):914-56. doi:10.1016/j.healun.2010.05.034.</mixed-citation></citation-alternatives></ref><ref id="cit488"><label>488</label><citation-alternatives><mixed-citation xml:lang="ru">Piepoli MF, Corrà U, Adamopoulos S, et al. Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery: a policy statement from the cardiac rehabilitation section of the European Association for Cardiovascular Prevention &amp; Rehabilitation. Endorsed by the Committee for Practice Guidelines of the European Society of Cardiology. Eur J PrevCardiol. 2014;21(6):664-81. doi:10.1177/2047487312449597.</mixed-citation><mixed-citation xml:lang="en">Piepoli MF, Corrà U, Adamopoulos S, et al. Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery: a policy statement from the cardiac rehabilitation section of the European Association for Cardiovascular Prevention &amp; Rehabilitation. Endorsed by the Committee for Practice Guidelines of the European Society of Cardiology. Eur J PrevCardiol. 2014;21(6):664-81. doi:10.1177/2047487312449597.</mixed-citation></citation-alternatives></ref><ref id="cit489"><label>489</label><citation-alternatives><mixed-citation xml:lang="ru">Jones LW, Courneya KS, Mackey JR, et al. Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum. J Clin Oncol. 2012;30:2530-7. doi:10.1200/JCO.2011.39.9014.</mixed-citation><mixed-citation xml:lang="en">Jones LW, Courneya KS, Mackey JR, et al. Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum. J Clin Oncol. 2012;30:2530-7. doi:10.1200/JCO.2011.39.9014.</mixed-citation></citation-alternatives></ref><ref id="cit490"><label>490</label><citation-alternatives><mixed-citation xml:lang="ru">Peel AB, Barlow CE, Leonard D, et al. Cardiorespiratory fitness in survivors of cervical, endometrial, and ovarian cancers: the Cooper Center Longitudinal Study. Gynecol Oncol. 2015;138:394-7. doi:10.1016/j.ygyno.2015.05.027.</mixed-citation><mixed-citation xml:lang="en">Peel AB, Barlow CE, Leonard D, et al. Cardiorespiratory fitness in survivors of cervical, endometrial, and ovarian cancers: the Cooper Center Longitudinal Study. Gynecol Oncol. 2015;138:394-7. doi:10.1016/j.ygyno.2015.05.027.</mixed-citation></citation-alternatives></ref><ref id="cit491"><label>491</label><citation-alternatives><mixed-citation xml:lang="ru">Peel AB, Thomas SM, Dittus K, et al. Cardiorespiratory fitness in breast cancer patients: a call for normative values. J Am Heart Assoc. 2014;3:e000432. doi:10.1161/JAHA.113.000432.</mixed-citation><mixed-citation xml:lang="en">Peel AB, Thomas SM, Dittus K, et al. Cardiorespiratory fitness in breast cancer patients: a call for normative values. J Am Heart Assoc. 2014;3:e000432. doi:10.1161/JAHA.113.000432.</mixed-citation></citation-alternatives></ref><ref id="cit492"><label>492</label><citation-alternatives><mixed-citation xml:lang="ru">Miller AM, Lopez-Mitnik G, Somarriba G, et al. Exercise capacity in long-term survivors of pediatric cancer: an analysis from the Cardiac Risk Factors in Childhood Cancer Survivors Study. Pediatr Blood Cancer. 2013;60:663-8. doi:10.1002/pbc.24410.</mixed-citation><mixed-citation xml:lang="en">Miller AM, Lopez-Mitnik G, Somarriba G, et al. Exercise capacity in long-term survivors of pediatric cancer: an analysis from the Cardiac Risk Factors in Childhood Cancer Survivors Study. Pediatr Blood Cancer. 2013;60:663-8. doi:10.1002/pbc.24410.</mixed-citation></citation-alternatives></ref><ref id="cit493"><label>493</label><citation-alternatives><mixed-citation xml:lang="ru">De Caro E, Smeraldi A, Trocchio G, et al. Subclinical cardiac dysfunction and exercise performance in childhood cancer survivors. Pediatr Blood Cancer. 2011;56:122-6. doi:10.1002/pbc.22606.</mixed-citation><mixed-citation xml:lang="en">De Caro E, Smeraldi A, Trocchio G, et al. Subclinical cardiac dysfunction and exercise performance in childhood cancer survivors. Pediatr Blood Cancer. 2011;56:122-6. doi:10.1002/pbc.22606.</mixed-citation></citation-alternatives></ref><ref id="cit494"><label>494</label><citation-alternatives><mixed-citation xml:lang="ru">Mason С, Alfano СM, Smith AW, et al. Long-term physical activity trends in breast cancer survivors. Cancer Epidemiol Biomarkers Prev. 2013;22(6):1153-61. doi:10.1158/1055-9965.EPI-13-0141.</mixed-citation><mixed-citation xml:lang="en">Mason С, Alfano СM, Smith AW, et al. Long-term physical activity trends in breast cancer survivors. Cancer Epidemiol Biomarkers Prev. 2013;22(6):1153-61. doi:10.1158/1055-9965.EPI-13-0141.</mixed-citation></citation-alternatives></ref><ref id="cit495"><label>495</label><citation-alternatives><mixed-citation xml:lang="ru">Stevinson C, Lydon A, Amir Z. Adherence to physical activity guidelines among cancer support group participants. Eur J Cancer Care (Engl). 2014;23(2):199-205. doi:10.1111/ecc.12145.</mixed-citation><mixed-citation xml:lang="en">Stevinson C, Lydon A, Amir Z. Adherence to physical activity guidelines among cancer support group participants. Eur J Cancer Care (Engl). 2014;23(2):199-205. doi:10.1111/ecc.12145.</mixed-citation></citation-alternatives></ref><ref id="cit496"><label>496</label><citation-alternatives><mixed-citation xml:lang="ru">Courneya KS, Sellar CM, Stevinson C, et al. Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. J Clin Oncol. 2009;27:4605-12. doi:10.1200/JCO.2008.20.0634.</mixed-citation><mixed-citation xml:lang="en">Courneya KS, Sellar CM, Stevinson C, et al. Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. J Clin Oncol. 2009;27:4605-12. doi:10.1200/JCO.2008.20.0634.</mixed-citation></citation-alternatives></ref><ref id="cit497"><label>497</label><citation-alternatives><mixed-citation xml:lang="ru">Lakoski SG, Willis BL, Barlow CE, et al. Midlife cardiorespiratory fitness, incident cancer, and survival after cancer in men: the Cooper Center Longitudinal Study. JAMA Oncol. 2015;1:231-7. doi:10.1001/jamaoncol.2015.0226.</mixed-citation><mixed-citation xml:lang="en">Lakoski SG, Willis BL, Barlow CE, et al. Midlife cardiorespiratory fitness, incident cancer, and survival after cancer in men: the Cooper Center Longitudinal Study. JAMA Oncol. 2015;1:231-7. doi:10.1001/jamaoncol.2015.0226.</mixed-citation></citation-alternatives></ref><ref id="cit498"><label>498</label><citation-alternatives><mixed-citation xml:lang="ru">Okwuosa TM, Ray RM, Palomo A, et al. Pre-Diagnosis Exercise and Cardiovascular Events in Primary Breast Cancer: Women’s Health Initiative. J Am Coll Cardiol Cardio Onc. 2019;1(1):41-50. doi:10.1016/j.jaccao.2019.08.014.</mixed-citation><mixed-citation xml:lang="en">Okwuosa TM, Ray RM, Palomo A, et al. Pre-Diagnosis Exercise and Cardiovascular Events in Primary Breast Cancer: Women’s Health Initiative. J Am Coll Cardiol Cardio Onc. 2019;1(1):41-50. doi:10.1016/j.jaccao.2019.08.014.</mixed-citation></citation-alternatives></ref><ref id="cit499"><label>499</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson L, Oldridge N, Thompson DR, et al. Exercise-Based Cardiac Rehabilitation for Coronary Heart Disease: Cochrane Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2016;67(1):1-12. doi:10.1016/j.jacc.2015.10.044.</mixed-citation><mixed-citation xml:lang="en">Anderson L, Oldridge N, Thompson DR, et al. Exercise-Based Cardiac Rehabilitation for Coronary Heart Disease: Cochrane Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2016;67(1):1-12. doi:10.1016/j.jacc.2015.10.044.</mixed-citation></citation-alternatives></ref><ref id="cit500"><label>500</label><citation-alternatives><mixed-citation xml:lang="ru">Piepoli MF, Davos C, Francis DP, Coats AJ; ExTraMATCH Collaborative. Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ. 2004;328(7433):189. doi:10.1136/bmj.37938.645220.EE.</mixed-citation><mixed-citation xml:lang="en">Piepoli MF, Davos C, Francis DP, Coats AJ; ExTraMATCH Collaborative. Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ. 2004;328(7433):189. doi:10.1136/bmj.37938.645220.EE.</mixed-citation></citation-alternatives></ref><ref id="cit501"><label>501</label><citation-alternatives><mixed-citation xml:lang="ru">Scott JM, Nilsen TS, Gupta D, Jones LW. Exercise therapy and cardiovascular toxicity in cancer. Circulation. 2018;137:1176-91. doi:10.1161/CIRCULATIONAHA.117.024671.</mixed-citation><mixed-citation xml:lang="en">Scott JM, Nilsen TS, Gupta D, Jones LW. Exercise therapy and cardiovascular toxicity in cancer. Circulation. 2018;137:1176-91. doi:10.1161/CIRCULATIONAHA.117.024671.</mixed-citation></citation-alternatives></ref><ref id="cit502"><label>502</label><citation-alternatives><mixed-citation xml:lang="ru">Scott JM, Zabor EC, Schwitzer E, et al. Efficacy of exercise therapy on cardiorespiratory fitness in patients with cancer: a systematic review and meta-analysis. J Clin Oncol. 2018;36:2297-305. doi:10.1200/JCO.2017.77.5809.</mixed-citation><mixed-citation xml:lang="en">Scott JM, Zabor EC, Schwitzer E, et al. Efficacy of exercise therapy on cardiorespiratory fitness in patients with cancer: a systematic review and meta-analysis. J Clin Oncol. 2018;36:2297-305. doi:10.1200/JCO.2017.77.5809.</mixed-citation></citation-alternatives></ref><ref id="cit503"><label>503</label><citation-alternatives><mixed-citation xml:lang="ru">Dittus KL, Lakoski SG, Savage PD, et al. Exercise-based oncology rehabilitation: leveraging the cardiac rehabilitation model. J Cardiopulm Rehabil Prev. 2015;35:130-9. doi:10.1097/HCR.0000000000000091.</mixed-citation><mixed-citation xml:lang="en">Dittus KL, Lakoski SG, Savage PD, et al. Exercise-based oncology rehabilitation: leveraging the cardiac rehabilitation model. J Cardiopulm Rehabil Prev. 2015;35:130-9. doi:10.1097/HCR.0000000000000091.</mixed-citation></citation-alternatives></ref><ref id="cit504"><label>504</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt ME, Wiskemann J, Armbrust P, et al. Effects of resistance exercise on fatigue and quality of life in breast cancer patients undergoing adjuvant chemotherapy: A randomized controlled trial. Int J Cancer. 2015;137(2):471-80. doi:10.1002/ijc.29383.</mixed-citation><mixed-citation xml:lang="en">Schmidt ME, Wiskemann J, Armbrust P, et al. Effects of resistance exercise on fatigue and quality of life in breast cancer patients undergoing adjuvant chemotherapy: A randomized controlled trial. Int J Cancer. 2015;137(2):471-80. doi:10.1002/ijc.29383.</mixed-citation></citation-alternatives></ref><ref id="cit505"><label>505</label><citation-alternatives><mixed-citation xml:lang="ru">Qiang W, Dong F, Yan L, et al. Rehabilitation effect of systematic exercise on breast cancer patients after adjuvant chemotherapy. Clin. Oncol. Cancer Res. 2010;7:259-64. doi:10.1007/s11805-010-0528-6.</mixed-citation><mixed-citation xml:lang="en">Qiang W, Dong F, Yan L, et al. Rehabilitation effect of systematic exercise on breast cancer patients after adjuvant chemotherapy. Clin. Oncol. Cancer Res. 2010;7:259-64. doi:10.1007/s11805-010-0528-6.</mixed-citation></citation-alternatives></ref><ref id="cit506"><label>506</label><citation-alternatives><mixed-citation xml:lang="ru">Lipsetta A, Barretta S, Harunaa F, et al. The impact of exercise during adjuvant radiotherapy for breast cancer on fatigue and quality of life: A systematic review and metaanalysis. The Breast. 2017;32:144-55. doi:10.1016/j.breast.2017.02.002.</mixed-citation><mixed-citation xml:lang="en">Lipsetta A, Barretta S, Harunaa F, et al. The impact of exercise during adjuvant radiotherapy for breast cancer on fatigue and quality of life: A systematic review and metaanalysis. The Breast. 2017;32:144-55. doi:10.1016/j.breast.2017.02.002.</mixed-citation></citation-alternatives></ref><ref id="cit507"><label>507</label><citation-alternatives><mixed-citation xml:lang="ru">Lahart IM, Metsios GS, Nevill AM, Carmichael AR. Physical activity for women with breast cancer after adjuvant therapy. Cochrane Database Syst Rev. 2018;1(1):CD011292. doi:10.1002/14651858.CD011292.pub2.</mixed-citation><mixed-citation xml:lang="en">Lahart IM, Metsios GS, Nevill AM, Carmichael AR. Physical activity for women with breast cancer after adjuvant therapy. Cochrane Database Syst Rev. 2018;1(1):CD011292. doi:10.1002/14651858.CD011292.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit508"><label>508</label><citation-alternatives><mixed-citation xml:lang="ru">Jones LW, Liu Q, Armstrong GT, et al. Exercise and risk of major cardiovascular events in adult survivors of childhood Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2014;32:3643–50. doi:10.1200/JCO.2014.56.7511.</mixed-citation><mixed-citation xml:lang="en">Jones LW, Liu Q, Armstrong GT, et al. Exercise and risk of major cardiovascular events in adult survivors of childhood Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2014;32:3643–50. doi:10.1200/JCO.2014.56.7511.</mixed-citation></citation-alternatives></ref><ref id="cit509"><label>509</label><citation-alternatives><mixed-citation xml:lang="ru">Jones LW, Habel LA, Weltzien E, et al. Exercise and risk of cardiovascular events in women with nonmetastatic breast cancer. J Clin Oncol. 2016;34:2743-9. doi:10.1200/JCO.2015.65.6603.</mixed-citation><mixed-citation xml:lang="en">Jones LW, Habel LA, Weltzien E, et al. Exercise and risk of cardiovascular events in women with nonmetastatic breast cancer. J Clin Oncol. 2016;34:2743-9. doi:10.1200/JCO.2015.65.6603.</mixed-citation></citation-alternatives></ref><ref id="cit510"><label>510</label><citation-alternatives><mixed-citation xml:lang="ru">Lahart IM, Metsios GS, Nevill AM, Carmichael AR. Physical activity, risk of death and recurrence in breast cancer survivors: A systematic review and meta-analysis of epidemiological studies, Acta Oncologica. 2015;54(5):635-54. doi:10.3109/0284186X.2014.998275.</mixed-citation><mixed-citation xml:lang="en">Lahart IM, Metsios GS, Nevill AM, Carmichael AR. Physical activity, risk of death and recurrence in breast cancer survivors: A systematic review and meta-analysis of epidemiological studies, Acta Oncologica. 2015;54(5):635-54. doi:10.3109/0284186X.2014.998275.</mixed-citation></citation-alternatives></ref><ref id="cit511"><label>511</label><citation-alternatives><mixed-citation xml:lang="ru">Schmid D, Leitzmann MF. Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis. Ann Oncol. 2014;25(7):1293-311. doi:10.1093/annonc/mdu012.</mixed-citation><mixed-citation xml:lang="en">Schmid D, Leitzmann MF. Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis. Ann Oncol. 2014;25(7):1293-311. doi:10.1093/annonc/mdu012.</mixed-citation></citation-alternatives></ref><ref id="cit512"><label>512</label><citation-alternatives><mixed-citation xml:lang="ru">Koene RJ, Prizment AE, Blaes A, Konety SH. Shared risk factors in cardiovascular disease and cancer. Circulation. 2016;133:1104-14. doi:10.1161/CIRCULATIONAHA.115.020406.</mixed-citation><mixed-citation xml:lang="en">Koene RJ, Prizment AE, Blaes A, Konety SH. Shared risk factors in cardiovascular disease and cancer. Circulation. 2016;133:1104-14. doi:10.1161/CIRCULATIONAHA.115.020406.</mixed-citation></citation-alternatives></ref><ref id="cit513"><label>513</label><citation-alternatives><mixed-citation xml:lang="ru">Campia U, Moslehi JJ, Amiri-Kordestani A, et al. Cardio-Oncology: Vascular and Metabolic Perspectives: A Scientific Statement From the American Heart Association. Circulation. 2019;139(13):e579-e602. doi:10.1161/CIR.0000000000000641.</mixed-citation><mixed-citation xml:lang="en">Campia U, Moslehi JJ, Amiri-Kordestani A, et al. Cardio-Oncology: Vascular and Metabolic Perspectives: A Scientific Statement From the American Heart Association. Circulation. 2019;139(13):e579-e602. doi:10.1161/CIR.0000000000000641.</mixed-citation></citation-alternatives></ref><ref id="cit514"><label>514</label><citation-alternatives><mixed-citation xml:lang="ru">Doyle JJ, Neugut AI, Jacobson JS, et al. Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study. J Clin Oncol. 2005;23:8597-605. doi:10.1200/JCO.2005.02.5841.</mixed-citation><mixed-citation xml:lang="en">Doyle JJ, Neugut AI, Jacobson JS, et al. Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study. J Clin Oncol. 2005;23:8597-605. doi:10.1200/JCO.2005.02.5841.</mixed-citation></citation-alternatives></ref><ref id="cit515"><label>515</label><citation-alternatives><mixed-citation xml:lang="ru">Perez EA, Suman VJ, Davidson NE, et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol. 2008;26:1231- 8. doi:10.1200/JCO.2007.13.5467.</mixed-citation><mixed-citation xml:lang="en">Perez EA, Suman VJ, Davidson NE, et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol. 2008;26:1231- 8. doi:10.1200/JCO.2007.13.5467.</mixed-citation></citation-alternatives></ref><ref id="cit516"><label>516</label><citation-alternatives><mixed-citation xml:lang="ru">Armenian SH, Xu L, Ky B, et al. Cardiovascular disease among survivors of adult-onset cancer: a community-based retrospective cohort study. J Clin Oncol. 2016;34:1122-30. doi:10.1200/JCO.2015.64.0409.</mixed-citation><mixed-citation xml:lang="en">Armenian SH, Xu L, Ky B, et al. Cardiovascular disease among survivors of adult-onset cancer: a community-based retrospective cohort study. J Clin Oncol. 2016;34:1122-30. doi:10.1200/JCO.2015.64.0409.</mixed-citation></citation-alternatives></ref><ref id="cit517"><label>517</label><citation-alternatives><mixed-citation xml:lang="ru">Jefford M, Rowland J, Grunfeld E, et al. Implementing improved post-treatment care for cancer survivors in England, with reflections from Australia, Canada and the USA. Br J Cancer. 2013;108:14-20. doi:10.1038/bjc.2012.554.</mixed-citation><mixed-citation xml:lang="en">Jefford M, Rowland J, Grunfeld E, et al. Implementing improved post-treatment care for cancer survivors in England, with reflections from Australia, Canada and the USA. Br J Cancer. 2013;108:14-20. doi:10.1038/bjc.2012.554.</mixed-citation></citation-alternatives></ref><ref id="cit518"><label>518</label><citation-alternatives><mixed-citation xml:lang="ru">Schmitz KH, Ahmed RL, Troxel A, et al. Weight lifting in women with breast-cancer-related lymphedema. N Engl J Med. 2009;361:664-73. doi:10.1056/NEJMoa0810118.</mixed-citation><mixed-citation xml:lang="en">Schmitz KH, Ahmed RL, Troxel A, et al. Weight lifting in women with breast-cancer-related lymphedema. N Engl J Med. 2009;361:664-73. doi:10.1056/NEJMoa0810118.</mixed-citation></citation-alternatives></ref><ref id="cit519"><label>519</label><citation-alternatives><mixed-citation xml:lang="ru">Ehrman JK, Liguori G, Magal M, Riebe D. ACSM’s Guidelines for Graded Exercise Testing and Prescription. American College of Sports Medicine. 10th ed. Philadelphia: Wolters Kluwer. 2018:423-36.</mixed-citation><mixed-citation xml:lang="en">Ehrman JK, Liguori G, Magal M, Riebe D. ACSM’s Guidelines for Graded Exercise Testing and Prescription. American College of Sports Medicine. 10th ed. Philadelphia: Wolters Kluwer. 2018:423-36.</mixed-citation></citation-alternatives></ref><ref id="cit520"><label>520</label><citation-alternatives><mixed-citation xml:lang="ru">Bruce RA, Kusumi F, Hosmer D. Maximal oxygen intake and nomographicassessment of functional aerobic impairment in cardiovascular disease. Am Heart J. 1973;85:546-62.</mixed-citation><mixed-citation xml:lang="en">Bruce RA, Kusumi F, Hosmer D. Maximal oxygen intake and nomographicassessment of functional aerobic impairment in cardiovascular disease. Am Heart J. 1973;85:546-62.</mixed-citation></citation-alternatives></ref><ref id="cit521"><label>521</label><citation-alternatives><mixed-citation xml:lang="ru">Balke B, Ware RW. An experimental study of physical fitness of Air Force personnel. U S Armed Forces Med J. 1959;10:675-88.</mixed-citation><mixed-citation xml:lang="en">Balke B, Ware RW. An experimental study of physical fitness of Air Force personnel. U S Armed Forces Med J. 1959;10:675-88.</mixed-citation></citation-alternatives></ref><ref id="cit522"><label>522</label><citation-alternatives><mixed-citation xml:lang="ru">Naughton J, Balke B, Nagle F. Refinements in Method of Evaluation and Physical Conditioning Before and After Myocardial Infarction. Am J Cardiol.1964;14:837-43.</mixed-citation><mixed-citation xml:lang="en">Naughton J, Balke B, Nagle F. Refinements in Method of Evaluation and Physical Conditioning Before and After Myocardial Infarction. Am J Cardiol.1964;14:837-43.</mixed-citation></citation-alternatives></ref><ref id="cit523"><label>523</label><citation-alternatives><mixed-citation xml:lang="ru">Lakoski SG, Barlow CE, Koelwyn GJ, et al. The influence of adjuvant therapy on cardiorespiratory fitness in early-stage breast cancer seven years after diagnosis: the Cooper Center Longitudinal Study. Breast Cancer Res Treat. 2013;138:909-16. doi:10.1007/s10549-013-2478-1.</mixed-citation><mixed-citation xml:lang="en">Lakoski SG, Barlow CE, Koelwyn GJ, et al. The influence of adjuvant therapy on cardiorespiratory fitness in early-stage breast cancer seven years after diagnosis: the Cooper Center Longitudinal Study. Breast Cancer Res Treat. 2013;138:909-16. doi:10.1007/s10549-013-2478-1.</mixed-citation></citation-alternatives></ref><ref id="cit524"><label>524</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt K, Vogt L, Thiel C, et al. Validity of the six-minute walk test in cancer patients. Int J Sports Med. 2013;34:631-6. doi:10.1055/s-0032-1323746.</mixed-citation><mixed-citation xml:lang="en">Schmidt K, Vogt L, Thiel C, et al. Validity of the six-minute walk test in cancer patients. Int J Sports Med. 2013;34:631-6. doi:10.1055/s-0032-1323746.</mixed-citation></citation-alternatives></ref><ref id="cit525"><label>525</label><citation-alternatives><mixed-citation xml:lang="ru">Fletcher GF, Balady GJ, Amsterdam EA, et al. Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association.Circulation. 2001;104:1694-740. doi:10.1161/hc3901.095960.</mixed-citation><mixed-citation xml:lang="en">Fletcher GF, Balady GJ, Amsterdam EA, et al. Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association.Circulation. 2001;104:1694-740. doi:10.1161/hc3901.095960.</mixed-citation></citation-alternatives></ref><ref id="cit526"><label>526</label><citation-alternatives><mixed-citation xml:lang="ru">ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166:111-7. doi:10.1164/ajrccm.166.1.at1102.</mixed-citation><mixed-citation xml:lang="en">ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166:111-7. doi:10.1164/ajrccm.166.1.at1102.</mixed-citation></citation-alternatives></ref><ref id="cit527"><label>527</label><citation-alternatives><mixed-citation xml:lang="ru">Swedish National Institute of Public Health. Physical activity in the prevention and treatment of disease.2010.</mixed-citation><mixed-citation xml:lang="en">Swedish National Institute of Public Health. Physical activity in the prevention and treatment of disease. 2010.</mixed-citation></citation-alternatives></ref><ref id="cit528"><label>528</label><citation-alternatives><mixed-citation xml:lang="ru">Prado СМ, Purcell SA, Laviano A. Nutrition interventions to treat low muscle mass in cancer. Journal of Cachexia, Sarcopenia and Muscle. 2020;11:366-80. doi:10.1002/jcsm.12525.</mixed-citation><mixed-citation xml:lang="en">Prado СМ, Purcell SA, Laviano A. Nutrition interventions to treat low muscle mass in cancer. Journal of Cachexia, Sarcopenia and Muscle. 2020;11:366-80. doi:10.1002/jcsm.12525.</mixed-citation></citation-alternatives></ref><ref id="cit529"><label>529</label><citation-alternatives><mixed-citation xml:lang="ru">Maitland ML, Bakris GL, Black HR, et al. Cardiovascular Toxicities Panel, Convened by the Angiogenesis Task Force of the National Cancer Institute Investigational Drug Steering Committee. Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growthfactor signaling pathway inhibitors. J Natl Cancer Inst. 2010;102:596-604. doi:10.1093/jnci/djq091.</mixed-citation><mixed-citation xml:lang="en">Maitland ML, Bakris GL, Black HR, et al. Cardiovascular Toxicities Panel, Convened by the Angiogenesis Task Force of the National Cancer Institute Investigational Drug Steering Committee. Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growthfactor signaling pathway inhibitors. J Natl Cancer Inst. 2010;102:596-604. doi:10.1093/jnci/djq091.</mixed-citation></citation-alternatives></ref><ref id="cit530"><label>530</label><citation-alternatives><mixed-citation xml:lang="ru">Чазова И.Е., Тюляндин С.А., Виценя М.В. и др. Руководство по диагностике, профилактике и лечению сердечно-сосудистых осложнений противоопухолевой терапии. Часть II-V. Системные гипертензии. 2017;14(4):6-19. doi:10.26442/2075-082X_14.4.6-19.</mixed-citation><mixed-citation xml:lang="en">Chazova IE, Tyulyandin SA, Vitsenya MV, et al. Guidelines for the diagnosis, prevention and treatment of cardiovascular complications of antitumor therapy. Part II-V. Systemic hypertension. 2017;14(4):6-19. (In Russ.) doi:10.26442/2075-082X_14.4.6-19.</mixed-citation></citation-alternatives></ref><ref id="cit531"><label>531</label><citation-alternatives><mixed-citation xml:lang="ru">Кухарчук В.В., Ежов М.В., Сергиенко И.В. и др. Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза. Российские рекомендации, VII пересмотр. Атеросклероз и дислипидемии. 2020;1(38):7-42. doi:10.34687/2219-8202.JAD.2020.01.0002.</mixed-citation><mixed-citation xml:lang="en">Kukharchuk VV, Yezhov MV, Sergienko IV, etc. Diagnosis and correction of lipid metabolism disorders for the prevention and treatment of atherosclerosis. Russian recommendations, VII revision. Atherosclerosis and dyslipidemia. 2020;1(38):7-42. (In Russ.) doi:10.34687/2219-8202.JAD.2020.01.0002.</mixed-citation></citation-alternatives></ref><ref id="cit532"><label>532</label><citation-alternatives><mixed-citation xml:lang="ru">Swerdlow AJ, Higgins CD, Smith P, et al. Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst. 2007;99:206- 14. doi:10.1093/jnci/djk029.</mixed-citation><mixed-citation xml:lang="en">Swerdlow AJ, Higgins CD, Smith P, et al. Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst. 2007;99:206- 14. doi:10.1093/jnci/djk029.</mixed-citation></citation-alternatives></ref><ref id="cit533"><label>533</label><citation-alternatives><mixed-citation xml:lang="ru">CCSS | CCSS Cardiovascular Risk Calculator (stjude.org)</mixed-citation><mixed-citation xml:lang="en">CCSS | CCSS Cardiovascular Risk Calculator (stjude.org)</mixed-citation></citation-alternatives></ref><ref id="cit534"><label>534</label><citation-alternatives><mixed-citation xml:lang="ru">https://rae-org.ru/system/files/documents/pdf/saharnyy_diabet_2_tipa_u_vzroslyh.pdf</mixed-citation><mixed-citation xml:lang="en">https://rae-org.ru/system/files/documents/pdf/saharnyy_diabet_2_tipa_u_vzroslyh.pdf</mixed-citation></citation-alternatives></ref><ref id="cit535"><label>535</label><citation-alternatives><mixed-citation xml:lang="ru">Saylor PJ, Smith MR. Metabolic complications of androgen deprivation therapy for prostate cancer. J Urol. 2009;181:1998-2006. doi:10.1016/j.juro.2009.01.047.</mixed-citation><mixed-citation xml:lang="en">Saylor PJ, Smith MR. Metabolic complications of androgen deprivation therapy for prostate cancer. J Urol. 2009;181:1998-2006. doi:10.1016/j.juro.2009.01.047.</mixed-citation></citation-alternatives></ref><ref id="cit536"><label>536</label><citation-alternatives><mixed-citation xml:lang="ru">Meacham LR, Sklar CA, Li S, Liu Q, et al. Diabetes mellitus in long-term survivors of childhood cancer: increased risk associated with radiation therapy: a report for the Childhood Cancer Survivor Study. Arch Intern Med. 2009;169:1381-8. doi:10.1001/archinternmed.2009.209.</mixed-citation><mixed-citation xml:lang="en">Meacham LR, Sklar CA, Li S, Liu Q, et al. Diabetes mellitus in long-term survivors of childhood cancer: increased risk associated with radiation therapy: a report for the Childhood Cancer Survivor Study. Arch Intern Med. 2009;169:1381-8. doi:10.1001/archinternmed.2009.209.</mixed-citation></citation-alternatives></ref><ref id="cit537"><label>537</label><citation-alternatives><mixed-citation xml:lang="ru">Squires RW, Kaminsky LA, Porcari JP, et al. Progression of exercise training in early outpatient cardiac rehabilitation: An Official Statement From The American Association of Cardiovascular and Pulmonary Rehabilitation. J Cardiopulm Rehabil Prev. 2018;38:139- 46. doi:10.1097/HCR.0000000000000337.</mixed-citation><mixed-citation xml:lang="en">Squires RW, Kaminsky LA, Porcari JP, et al. Progression of exercise training in early outpatient cardiac rehabilitation: An Official Statement From The American Association of Cardiovascular and Pulmonary Rehabilitation. J Cardiopulm Rehabil Prev. 2018;38:139- 46. doi:10.1097/HCR.0000000000000337.</mixed-citation></citation-alternatives></ref><ref id="cit538"><label>538</label><citation-alternatives><mixed-citation xml:lang="ru">D’Ascenzi F, Anselmi F, Fiorentini C, et al. The benefits of exercise in cancer patients and the criteria for exercise prescription in cardio-oncology. European Journal of Preventive Cardiology. 2019;2047487319874900. doi:10.1177/2047487319874900.</mixed-citation><mixed-citation xml:lang="en">D’Ascenzi F, Anselmi F, Fiorentini C, et al. The benefits of exercise in cancer patients and the criteria for exercise prescription in cardio-oncology. European Journal of Preventive Cardiology. 2019;2047487319874900. doi:10.1177/2047487319874900.</mixed-citation></citation-alternatives></ref><ref id="cit539"><label>539</label><citation-alternatives><mixed-citation xml:lang="ru">Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81.</mixed-citation><mixed-citation xml:lang="en">Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81.</mixed-citation></citation-alternatives></ref><ref id="cit540"><label>540</label><citation-alternatives><mixed-citation xml:lang="ru">Lakoski SG, Jones LW, Krone RJ, et al. Autonomic dysfunction in early breast cancer: Incidence, clinical importance, and underlying mechanisms. Am Heart J. 2015;170:231- 41. doi:10.1016/j.ahj.2015.05.014.</mixed-citation><mixed-citation xml:lang="en">Lakoski SG, Jones LW, Krone RJ, et al. Autonomic dysfunction in early breast cancer: Incidence, clinical importance, and underlying mechanisms. Am Heart J. 2015;170:231- 41. doi:10.1016/j.ahj.2015.05.014.</mixed-citation></citation-alternatives></ref><ref id="cit541"><label>541</label><citation-alternatives><mixed-citation xml:lang="ru">Dolan LB, Campbell K, Gelmon K, et al. Interval versus continuous aerobic exercise training in breast cancer survivors a pilot RCT. Support Care Cancer. 2016;24:119-27. doi:10.1007/s00520-015-2749-y.</mixed-citation><mixed-citation xml:lang="en">Dolan LB, Campbell K, Gelmon K, et al. Interval versus continuous aerobic exercise training in breast cancer survivors a pilot RCT. Support Care Cancer. 2016;24:119-27. doi:10.1007/s00520-015-2749-y.</mixed-citation></citation-alternatives></ref><ref id="cit542"><label>542</label><citation-alternatives><mixed-citation xml:lang="ru">Toohey K, Pumpa KL, Arnolda L, et al. A pilot study examining the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular risk factors in cancer survivors. Peer J. 2016;4:e2613. doi:10.7717/peerj.2613.</mixed-citation><mixed-citation xml:lang="en">Toohey K, Pumpa KL, Arnolda L, et al. A pilot study examining the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular risk factors in cancer survivors. Peer J. 2016;4:e2613. doi:10.7717/peerj.2613.</mixed-citation></citation-alternatives></ref><ref id="cit543"><label>543</label><citation-alternatives><mixed-citation xml:lang="ru">Molassiotis A, Charalambous A, Taylor P, et al. The effect of resistance inspiratory muscle training in the management of breathlessness in patients with thoracic malignancies: A feasibility randomised trial. Support Care Cancer. 2015;23:1637-45. doi:10.1007/s00520-014-2511-x.</mixed-citation><mixed-citation xml:lang="en">Molassiotis A, Charalambous A, Taylor P, et al. The effect of resistance inspiratory muscle training in the management of breathlessness in patients with thoracic malignancies: A feasibility randomised trial. Support Care Cancer. 2015;23:1637-45. doi:10.1007/s00520-014-2511-x.</mixed-citation></citation-alternatives></ref><ref id="cit544"><label>544</label><citation-alternatives><mixed-citation xml:lang="ru">Jolly K, Taylor RS, Lip GYH, Stevens A. Home-based cardiac rehabilitation compared with centre-based rehabilitation and usual care: a systematic review and meta-analysis. Int J Cardiol. 2006;111(3):343-51. doi:10.1016/j.ijcard.2005.11.002.</mixed-citation><mixed-citation xml:lang="en">Jolly K, Taylor RS, Lip GYH, Stevens A. Home-based cardiac rehabilitation compared with centre-based rehabilitation and usual care: a systematic review and meta-analysis. Int J Cardiol. 2006;111(3):343-51. doi:10.1016/j.ijcard.2005.11.002.</mixed-citation></citation-alternatives></ref><ref id="cit545"><label>545</label><citation-alternatives><mixed-citation xml:lang="ru">Тaylor R, Dalal H, Jolly K, et al. Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev. 2010;1:CD007130. doi:10.1002/14651858.CD007130.pub2.</mixed-citation><mixed-citation xml:lang="en">Тaylor R, Dalal H, Jolly K, et al. Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev. 2010;1:CD007130. doi:10.1002/14651858.CD007130.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit546"><label>546</label><citation-alternatives><mixed-citation xml:lang="ru">Dalal HM, Zawada A, Jolly K, et al. Home based versus centre based cardiac rehabilitation: Cochrane systematic review and meta-analysis. BMJ. 2010;340:b5631. doi:10.1136/bmj.b5631.</mixed-citation><mixed-citation xml:lang="en">Dalal HM, Zawada A, Jolly K, et al. Home based versus centre based cardiac rehabilitation: Cochrane systematic review and meta-analysis. BMJ. 2010;340:b5631. doi:10.1136/bmj.b5631.</mixed-citation></citation-alternatives></ref><ref id="cit547"><label>547</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson L, Sharp GA, Norton RJ, et al. Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev. 2017;6(6):CD007130. doi:10.1002/14651858.CD007130.pub4.</mixed-citation><mixed-citation xml:lang="en">Anderson L, Sharp GA, Norton RJ, et al. Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev. 2017;6(6):CD007130. doi:10.1002/14651858.CD007130.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit548"><label>548</label><citation-alternatives><mixed-citation xml:lang="ru">Avila A, Claes J, Buys R, et al. Home-based exercise with telemonitoring guidance in patients with coronary artery disease: Does it improve long-term physical fitness? Eur J Prev Cardiol. 2020;27: 367-77. doi:10.1177/2047487319892201.</mixed-citation><mixed-citation xml:lang="en">Avila A, Claes J, Buys R, et al. Home-based exercise with telemonitoring guidance in patients with coronary artery disease: Does it improve long-term physical fitness? Eur J Prev Cardiol. 2020;27: 367-77. doi:10.1177/2047487319892201.</mixed-citation></citation-alternatives></ref><ref id="cit549"><label>549</label><citation-alternatives><mixed-citation xml:lang="ru">Magdy T, Burmeister BT, Burridge PW. Validating the pharmacogenomics of chemotherapyinduced cardiotoxicity: What is missing? Pharmacol Ther. 2016;168:113-25. doi:10.1016/j.pharmthera.2016.09.009.</mixed-citation><mixed-citation xml:lang="en">Magdy T, Burmeister BT, Burridge PW. Validating the pharmacogenomics of chemotherapyinduced cardiotoxicity: What is missing? Pharmacol Ther. 2016;168:113-25. doi:10.1016/j.pharmthera.2016.09.009.</mixed-citation></citation-alternatives></ref><ref id="cit550"><label>550</label><citation-alternatives><mixed-citation xml:lang="ru">Aminkeng F, Ross CJ, Rassekh SR, et al. Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity. Br J Clin Pharmacol. 2016;82(3):683-95.</mixed-citation><mixed-citation xml:lang="en">Aminkeng F, Ross CJ, Rassekh SR, et al. Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity. Br J Clin Pharmacol. 2016;82(3):683-95.</mixed-citation></citation-alternatives></ref><ref id="cit551"><label>551</label><citation-alternatives><mixed-citation xml:lang="ru">Christidi E, Huang H, Shafaattalab S, et al. Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cellderived cardiomyocytes. Scientific reports. 2020;10(1):10363. doi:10.1038/s41598-020-65979-x.</mixed-citation><mixed-citation xml:lang="en">Christidi E, Huang H, Shafaattalab S, et al. Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cellderived cardiomyocytes. Scientific reports. 2020;10(1):10363. doi:10.1038/s41598-020-65979-x.</mixed-citation></citation-alternatives></ref><ref id="cit552"><label>552</label><citation-alternatives><mixed-citation xml:lang="ru">Ware JS, Amor-Salamanca A, Tayal U, et al. Genetic Etiology for Alcohol-Induced Cardiac Toxicity. Journal of the American College of Cardiology. 2018;71(20):2293-302. doi:10.1016/j.jacc.2018.03.462.</mixed-citation><mixed-citation xml:lang="en">Ware JS, Amor-Salamanca A, Tayal U, et al. Genetic Etiology for Alcohol-Induced Cardiac Toxicity. Journal of the American College of Cardiology. 2018;71(20):2293-302. doi:10.1016/j.jacc.2018.03.462.</mixed-citation></citation-alternatives></ref><ref id="cit553"><label>553</label><citation-alternatives><mixed-citation xml:lang="ru">Linschoten M, Teske AJ, Baas AF, et al. Truncating Titin (TTN) Variants in ChemotherapyInduced Cardiomyopathy. Journal of cardiac failure. 2017;23(6):476-9.</mixed-citation><mixed-citation xml:lang="en">Linschoten M, Teske AJ, Baas AF, et al. Truncating Titin (TTN) Variants in ChemotherapyInduced Cardiomyopathy. Journal of cardiac failure. 2017;23(6):476-9.</mixed-citation></citation-alternatives></ref><ref id="cit554"><label>554</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Pavia P, Kim Y, Restrepo-Cordoba MA, et al. Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy. Circulation. 2019;140(1):31-41. doi:10.1161/CIRCULATIONAHA.118.037934.</mixed-citation><mixed-citation xml:lang="en">Garcia-Pavia P, Kim Y, Restrepo-Cordoba MA, et al. Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy. Circulation. 2019;140(1):31-41. doi:10.1161/CIRCULATIONAHA.118.037934.</mixed-citation></citation-alternatives></ref><ref id="cit555"><label>555</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X, Sun C-L, Quiñones-Lombraña A, et al. CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children’s Oncology Group Genome-Wide Association Study. Journal of Clinical Oncology. 2016;34(8):863-70. doi:10.1200/JCO.2015.63.4550.</mixed-citation><mixed-citation xml:lang="en">Wang X, Sun C-L, Quiñones-Lombraña A, et al. CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children’s Oncology Group Genome-Wide Association Study. Journal of Clinical Oncology. 2016;34(8):863-70. doi:10.1200/JCO.2015.63.4550.</mixed-citation></citation-alternatives></ref><ref id="cit556"><label>556</label><citation-alternatives><mixed-citation xml:lang="ru">Serie DJ, Crook JE, Necela BM, et al. Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial. Pharmacogenet Genomics. 2017;27(10):378-85. doi: 10.1097/FPC.0000000000000302.</mixed-citation><mixed-citation xml:lang="en">Serie DJ, Crook JE, Necela BM, et al. Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial. Pharmacogenet Genomics. 2017;27(10):378-85. doi: 10.1097/FPC.0000000000000302.</mixed-citation></citation-alternatives></ref><ref id="cit557"><label>557</label><citation-alternatives><mixed-citation xml:lang="ru">Serie DJ, Crook JE, Necela BM, et al. Breast Cancer Clinical Trial of Chemotherapy and Trastuzumab: Potential Tool to Identify Cardiac Modifying Variants of Dilated Cardiomyopathy. J Cardiovasc Dev Dis. 2017;4(2):6. doi:10.3390/jcdd4020006.</mixed-citation><mixed-citation xml:lang="en">Serie DJ, Crook JE, Necela BM, et al. Breast Cancer Clinical Trial of Chemotherapy and Trastuzumab: Potential Tool to Identify Cardiac Modifying Variants of Dilated Cardiomyopathy. J Cardiovasc Dev Dis. 2017;4(2):6. doi:10.3390/jcdd4020006.</mixed-citation></citation-alternatives></ref><ref id="cit558"><label>558</label><citation-alternatives><mixed-citation xml:lang="ru">Niemeijer MN, Van Den Berg ME, Eijgelsheim M, et al. Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update. Drug Safety. 2015;38(10):855-67. doi:10.1007/s40264-015-0316-6.</mixed-citation><mixed-citation xml:lang="en">Niemeijer MN, Van Den Berg ME, Eijgelsheim M, et al. Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update. Drug Safety. 2015;38(10):855-67. doi:10.1007/s40264-015-0316-6.</mixed-citation></citation-alternatives></ref><ref id="cit559"><label>559</label><citation-alternatives><mixed-citation xml:lang="ru">Adler A, Novelli V, Amin AS, et al. An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome. Circulation. 2020;141(6):418-28. doi:10.1161/CIRCULATIONAHA.119.043132.</mixed-citation><mixed-citation xml:lang="en">Adler A, Novelli V, Amin AS, et al. An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome. Circulation. 2020;141(6):418-28. doi:10.1161/CIRCULATIONAHA.119.043132.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
