russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2015-11-98-103russjcardiol-463Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWАТОРВАСТАТИН У БОЛЬНЫХ С ОСТРОЙ И ХРОНИЧЕСКОЙ ФОРМОЙ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦАATORVASTATIN IN ACUTE AND CHRONIC KINDS OF ISCHEMIC HEART DISEASEОлейниковВ. Э.OleynikovV. E.

д. м.н., профессор, зав. кафедрой терапии

v.oleynikof@gmail.comХромоваА. А.KhromovaA. A.

ассистент  кафедры  терапии

ГусаковскаяЛ. И.GusakovskayaL. I.

доцент  кафедры  терапии

СергацкаяН. В.SergatskayaN. V.

ст. преподаватель кафедры терапии

РомановскаяЕ. М.RomanovskayaE. M.

ассистент кафедры терапии

ФГБОУ ВПО Пензенский государственный университет, медицинский институт, Пенза, РоссияRussian FederationФГБОУ ВПО Пензенский государственный университет, медицинский институт, Пенза, РоссияРоссияFSBEI HPE Penza State University, Medical Institute, Penza, RussiaRussian Federation20152811201501198103Copyright © Олейников В.Э., Хромова А.А., Гусаковская Л.И., Сергацкая Н.В., Романовская Е.М., 20152015Олейников В.Э., Хромова А.А., Гусаковская Л.И., Сергацкая Н.В., Романовская Е.М.Oleynikov V.E., Khromova A.A., Gusakovskaya L.I., Sergatskaya N.V., Romanovskaya E.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/463

В обзоре представлены данные клинических исследований, в которых продемонстрирована возможность эффективной терапии статинами острой и хронической форм ишемической болезни сердца. Анализируется применение максимальных доз аторвастатина, его раннее назначение, в первые 24-96 ч после острого сердечно-сосудистого события и при подготовке к реваскуляризации с целью снижения риска развития осложнений, смертности и улучшения прогноза. Рассматривается положительное действие аторвастатина, обусловленное не только гиполипидемическими свойствами, но и рядом плейотропных эффектов. Приведен анализ данных о частоте и тяжести побочных реакций у пациентов, получающих статины.

The review focuses on clinical trials data demonstrating a possibility of effective statin therapy of acute and chronic ischemic heart disease courses. The analysis of maximal dosages of atorvastatin application provided, its early prescription in first 24-96 hours after acute cardiovascular event and in preparing for revascularization with the aim to minimize the risk of adverse effects, death and to improve prognosis. The positive effect of atorvastatin is taken into consideration, mediated by not only its hypolipidemic effect, but a range of pleiotropic effects. The analysis is provided of the data on prevalence and severity of side effects in patients receiving statins.

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The authors declare that there are no conflicts of interest present.