<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2021-4618</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-4618</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Совершенствование возможностей оценки сердечно-сосудистого риска при помощи методов машинного обучения</article-title><trans-title-group xml:lang="en"><trans-title>Improvement of cardiovascular risk assessment using machine learning methods</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7380-8460</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gusev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гусев Александр Владимирович — кандидат технических наук, директор по развитию</p><p>Петрозаводск</p><p> </p></bio><bio xml:lang="en"><p>Petrozavodsk</p></bio><email xlink:type="simple">agusev@webiomed.ai</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8745-857X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаврилов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gavrilov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаврилов Денис Владимирович — эксперт по медицине</p><p>Петрозаводск</p><p> </p></bio><bio xml:lang="en"><p>Petrozavodsk</p></bio><email xlink:type="simple">dgavrilov@webiomed.ai</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2350-977X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новицкий</surname><given-names>Р. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Novitsky</surname><given-names>R. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новицкий Роман Эдвардович — генеральный директор</p><p>Петрозаводск</p></bio><bio xml:lang="en"><p>Petrozavodsk</p></bio><email xlink:type="simple">roman@webiomed.ai</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6654-1382</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>T. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузнецова Татьяна Юрьевна — доктор медицинских наук, доцент, заведующий кафедрой факультетской терапии, фтизиатрии, инфекционных болезней и эпидемиологии</p><p>Петрозаводск</p></bio><bio xml:lang="en"><p>Petrozavodsk</p></bio><email xlink:type="simple">eme@sampo.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6998-8406</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бойцов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Boytsov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бойцов Сергей Анатольевич — доктор медицинских наук, профессор, академик РАН, генеральный директор</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">prof-boytsov@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>К-Скай</institution><country>Россия</country></aff><aff xml:lang="en"><institution>K-Skai</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО ПетрГУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Petrozavodsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ НМИЦ Кардиологии Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Cardiology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>25</day><month>10</month><year>2021</year></pub-date><volume>26</volume><issue>12</issue><fpage>4618</fpage><lpage>4618</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гусев А.В., Гаврилов Д.В., Новицкий Р.Э., Кузнецова Т.Ю., Бойцов С.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Гусев А.В., Гаврилов Д.В., Новицкий Р.Э., Кузнецова Т.Ю., Бойцов С.А.</copyright-holder><copyright-holder xml:lang="en">Gusev A.V., Gavrilov D.V., Novitsky R.E., Kuznetsova T.Y., Boytsov S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/4618">https://russjcardiol.elpub.ru/jour/article/view/4618</self-uri><abstract><p>Рост распространенности сердечно-сосудистых заболеваний (ССЗ) определяет важность их прогноза, необходимость точной стратификации рисков, профилактических и лечебных воздействий. Большие базы медицинских данных и технологии их обработки в виде алгоритмов машинного обучения, появившиеся в последние годы, потенциально позволяют улучшить предсказательную точность и персонализировать терапевтические подходы к ССЗ. В обзоре исследуется применение машинного обучения в предсказании и определении клинических событий кардиологического профиля. Обсуждается роль данной технологии как в расчете общего сердечно-сосудистого риска, так и предсказании отдельных заболеваний и событий. Сравнивается предсказательная точность с принятыми шкалами расчета рисков и действие различных алгоритмов машинного обучения. Анализируются условия для применения машинного обучения и возможности разработки персонализированной тактики ведения больных с ССЗ.</p></abstract><trans-abstract xml:lang="en"><p>The increase in the prevalence of cardiovascular diseases (CVDs) specifies the importance of their prediction, the need for accurate risk stratification, preventive and treatment interventions. Large medical databases and technologies for their processing in the form of machine learning algorithms that have appeared in recent years have the potential to improve predictive accuracy and personalize treatment approaches to CVDs. The review examines the application of machine learning in predicting and identifying cardiovascular events. The role of this technology both in the calculation of total cardiovascular risk and in the prediction of individual diseases and events is discussed. We compared the predictive accuracy of current risk scores and various machine learning algorithms. The conditions for using machine learning and developing personalized tactics for managing patients with CVDs are analyzed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>оценка риска</kwd><kwd>предсказание сердечно-сосудистых событий</kwd><kwd>машинное обучение</kwd><kwd>искусственный интеллект</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular diseases</kwd><kwd>risk assessment</kwd><kwd>prediction of cardiovascular events</kwd><kwd>machine learning</kwd><kwd>artificial intelligence</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке Министерства науки и высшего образования Российской Федерации в рамках Соглашения № 075-15-2021-665</funding-statement><funding-statement xml:lang="en">This research was financially supported by the Ministry of Science and Higher Education of the Russian Federation Theme No. 075-15- 2021-665</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шляхто Е.В., Баранова Е.И. Основные направления снижения сердечно-сосудистой смертности: что можно изменить уже сегодня? Российский кардиологический журнал. 2020;25(7):3983. doi:10.15829/1560-4071-2020-3983.</mixed-citation><mixed-citation xml:lang="en">Shlyakhto EV, Baranova EI. Central directions for reducing cardiovascular mortality: what can be changed today? Russian Journal of Cardiology. 2020;25(7):3983. (In Russ.) doi:10.15829/1560-4071-2020-3983.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Timmis A, Townsend N, Gale CP, et al. European Society of Cardiology: Cardiovascular Disease Statistics 2019. European Heart Journal. 2020;41(1):12-85. doi:10.1093/eurheartj/ehz859.</mixed-citation><mixed-citation xml:lang="en">Timmis A, Townsend N, Gale CP, et al. European Society of Cardiology: Cardiovascular Disease Statistics 2019. European Heart Journal. 2020;41(1):12-85. doi:10.1093/eurheartj/ehz859.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">ВОЗ. Глобальный план действий по профилактике неинфекционных заболеваний и борьбе с ними на 2013-2020 годы. Доступно на: https://apps.who.int/iris/bitstream/handle/10665/94384/9789244506233_rus.pdf.</mixed-citation><mixed-citation xml:lang="en">WHO. Global action plan for the prevention and control of noncommunicable diseases 2013-2020. (In Russ.) https://apps.who.int/iris/bitstream/handle/10665/94384/9789244506233_rus.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">ВОЗ. Доклад о ситуации в области неинфекционных заболеваний в мире, 2014. Доступно на: https://apps.who.int/iris/bitstream/handle/10665/148114/WHO_NMH_NVI_15.1_rus.pdf.</mixed-citation><mixed-citation xml:lang="en">WHO. Global Situation Report on Noncommunicable Disease, 2014. (In Russ.) https://apps.who.int/iris/bitstream/handle/10665/148114/WHO_NMH_NVI_15.1_rus.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Шляхто Е.В., Звартау Н.Э., Виллевальде С.В. и др. Система управления сердечно-сосудистыми рисками: предпосылки к созданию, принципы организации, таргетные группы. Российский кардиологический журнал. 2019;(11):69-82. doi:10.15829/1560-4071-2019-11-69-82.</mixed-citation><mixed-citation xml:lang="en">Shlyakhto EV, Zvartau NE, Villevalde SV, et al. Cardiovascular risk management system: prerequisites for developing, organization principles, target groups. Russian Journal of Cardiology. 2019;(11):69-82. (In Russ.) doi:10.15829/1560-4071-2019-11-69-82.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Damen JA, Hooft L, Schuit E, et al. Prediction models for cardiovascular disease risk in the general population: systematic review. BMJ. 2016;353:i2416. doi:10.1136/bmj.i2416.</mixed-citation><mixed-citation xml:lang="en">Damen JA, Hooft L, Schuit E, et al. Prediction models for cardiovascular disease risk in the general population: systematic review. BMJ. 2016;353:i2416. doi:10.1136/bmj.i2416.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rossello X, Dorresteijn J AN, Janssen A, et al. Risk prediction tools in cardiovascular disease prevention: A report from the ESC Prevention of CVD Programme led by the European Association of Preventive Cardiology (EAPC) in collaboration with the Acute Cardiovascular Care Association (ACCA) and the Association of Cardiovascular Nursing and Allied Professions (ACNAP). European Journal of Preventive Cardiology. 2019;26(14):1534-44. doi:10.1177/2047487319846715.</mixed-citation><mixed-citation xml:lang="en">Rossello X, Dorresteijn J AN, Janssen A, et al. Risk prediction tools in cardiovascular disease prevention: A report from the ESC Prevention of CVD Programme led by the European Association of Preventive Cardiology (EAPC) in collaboration with the Acute Cardiovascular Care Association (ACCA) and the Association of Cardiovascular Nursing and Allied Professions (ACNAP). European Journal of Preventive Cardiology. 2019;26(14):1534-44. doi:10.1177/2047487319846715.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Benjamins JW, Hendriks T, Knuuti J, et al. A primer in artificial intelligence in cardiovascular medicine. Netherlands Heart Journal. 2019;27:392-402. doi:10.1007/s12471-019-1286-6.</mixed-citation><mixed-citation xml:lang="en">Benjamins JW, Hendriks T, Knuuti J, et al. A primer in artificial intelligence in cardiovascular medicine. Netherlands Heart Journal. 2019;27:392-402. doi:10.1007/s12471-019-1286-6.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hemingway H, Asselbergs FW, Danesh J, et al. Innovative Medicines Initiative 2nd programme, Big Data for Better Outcomes, BigData@Heart Consortium of 20 academic and industry partners including ESC. Big data from electronic health records for early and late translational cardiovascular research: challenges and potential. Eur Heart J. 2018;39(16):1481-95. doi:10.1093/eurheartj/ehx487.</mixed-citation><mixed-citation xml:lang="en">Hemingway H, Asselbergs FW, Danesh J, et al. Innovative Medicines Initiative 2nd programme, Big Data for Better Outcomes, BigData@Heart Consortium of 20 academic and industry partners including ESC. Big data from electronic health records for early and late translational cardiovascular research: challenges and potential. Eur Heart J. 2018;39(16):1481-95. doi:10.1093/eurheartj/ehx487.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Song X, Mitnitski A, Cox J, Rockwood K. Comparison of machine learning techniques with classical statistical models in predicting health outcomes. Stud Health Technol Inform. 2004;107(Pt 1):736-40. doi:10.3233/978-1-60750-949-3-736.</mixed-citation><mixed-citation xml:lang="en">Song X, Mitnitski A, Cox J, Rockwood K. Comparison of machine learning techniques with classical statistical models in predicting health outcomes. Stud Health Technol Inform. 2004;107(Pt 1):736-40. doi:10.3233/978-1-60750-949-3-736.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wu J, Roy J, Stewart WF. Prediction modeling using EHR data: challenges, strategies, and a comparison of machine learning approaches. Medical Care. 2010;48(6 Suppl):S106-13. doi:10.1097/MLR.0b013e3181de9e17.</mixed-citation><mixed-citation xml:lang="en">Wu J, Roy J, Stewart WF. Prediction modeling using EHR data: challenges, strategies, and a comparison of machine learning approaches. Medical Care. 2010;48(6 Suppl):S106-13. doi:10.1097/MLR.0b013e3181de9e17.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Weiss JC, Natarajan S, Peissig PL, et al. Machine Lea rning for Personalized Medicine: Predicting Primary Myocardial Infarction from Electronic Health Records. AI Magazin. 2012;33(4):33-45. doi:10.1609/aimag.v33i4.2438.</mixed-citation><mixed-citation xml:lang="en">Weiss JC, Natarajan S, Peissig PL, et al. Machine Lea rning for Personalized Medicine: Predicting Primary Myocardial Infarction from Electronic Health Records. AI Magazin. 2012;33(4):33-45. doi:10.1609/aimag.v33i4.2438.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">VanHouten JP, Starmer JM, Lorenzi NM, et al. Machine learning for risk prediction of acute coronary syndrome. AMIA Annu Symp Proc. 2014:1940-9. eCollection 2014.</mixed-citation><mixed-citation xml:lang="en">VanHouten JP, Starmer JM, Lorenzi NM, et al. Machine learning for risk prediction of acute coronary syndrome. AMIA Annu Symp Proc. 2014:1940-9. eCollection 2014.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Dai W, Brisimi TS, Adams WG, et al. Prediction of hospitalization due to heart diseases by supervised learning methods. Int J Med Inform. 2015;84(3):189-97. doi:10.1016/j.ijmedinf.2014.10.002.</mixed-citation><mixed-citation xml:lang="en">Dai W, Brisimi TS, Adams WG, et al. Prediction of hospitalization due to heart diseases by supervised learning methods. Int J Med Inform. 2015;84(3):189-97. doi:10.1016/j.ijmedinf.2014.10.002.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tay D, Poh CL, Kitney RI. A novel neural-inspired learning algorithm with application to clinical risk prediction. Journal of Biomedical Informatics. 2015;54:305-14. doi:10.1016/j.jbi.2014.12.014.</mixed-citation><mixed-citation xml:lang="en">Tay D, Poh CL, Kitney RI. A novel neural-inspired learning algorithm with application to clinical risk prediction. Journal of Biomedical Informatics. 2015;54:305-14. doi:10.1016/j.jbi.2014.12.014.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Loghmanpour NA, Kanwar MK, Druzdzel MJ, et al. A new Bayesian network-based risk stratification model for prediction of short-term and long-term LVAD mortality. ASAIO J. 2015;61(3):313-23. doi:10.1097/MAT.0000000000000209.</mixed-citation><mixed-citation xml:lang="en">Loghmanpour NA, Kanwar MK, Druzdzel MJ, et al. A new Bayesian network-based risk stratification model for prediction of short-term and long-term LVAD mortality. ASAIO J. 2015;61(3):313-23. doi:10.1097/MAT.0000000000000209.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Churpek MM, Yuen TC, Winslow C, et al. Multicenter Comparison of Machine Learning Methods and Conventional Regression for Predicting Clinical Deterioration on the Wards. Crit Care Med. 2016;44(2):368-74. doi:10.1097/CCM.0000000000001571.</mixed-citation><mixed-citation xml:lang="en">Churpek MM, Yuen TC, Winslow C, et al. Multicenter Comparison of Machine Learning Methods and Conventional Regression for Predicting Clinical Deterioration on the Wards. Crit Care Med. 2016;44(2):368-74. doi:10.1097/CCM.0000000000001571.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Narain R, Saxena S, Goyal AK. Cardiovascular risk prediction: a comparative study of Framingham and quantum neural network based approach. Patient Preference and Adherence. 2016;10:1259-70. doi:10.2147/PPA.S108203.</mixed-citation><mixed-citation xml:lang="en">Narain R, Saxena S, Goyal AK. Cardiovascular risk prediction: a comparative study of Framingham and quantum neural network based approach. Patient Preference and Adherence. 2016;10:1259-70. doi:10.2147/PPA.S108203.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Motwani M, Dey D, Berman DS, et al. Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis. Eur Heart J. 2017;38(7):500-7. doi:10.1093/eurheartj/ehw188.</mixed-citation><mixed-citation xml:lang="en">Motwani M, Dey D, Berman DS, et al. Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis. Eur Heart J. 2017;38(7):500-7. doi:10.1093/eurheartj/ehw188.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Jae Kwon Kim, Sanggil Kang. Neural Network-Based Coronary Heart Disease Risk Prediction Using Feature Correlation Analysis. Journal of Healthcare Engineering. 2017:2780501. doi:10.1155/2017/2780501.</mixed-citation><mixed-citation xml:lang="en">Jae Kwon Kim, Sanggil Kang. Neural Network-Based Coronary Heart Disease Risk Prediction Using Feature Correlation Analysis. Journal of Healthcare Engineering. 2017:2780501. doi:10.1155/2017/2780501.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Shouval R, Hadanny A, Shlomo N, et al. Machine learning for prediction of 30-day mortality after ST elevation myocardial infraction: An Acute Coronary Syndrome Israeli Survey data mining study. Int J Cardiol. 2017;246:7-13. doi:10.1016/j.ijcard.2017.05.067.</mixed-citation><mixed-citation xml:lang="en">Shouval R, Hadanny A, Shlomo N, et al. Machine learning for prediction of 30-day mortality after ST elevation myocardial infraction: An Acute Coronary Syndrome Israeli Survey data mining study. Int J Cardiol. 2017;246:7-13. doi:10.1016/j.ijcard.2017.05.067.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Nanayakkara S, Fogarty S, Tremeer M, et al. Characterising risk of in-hospital mortality following cardiac arrest using machine learning: A retrospective international registry study. PLoS Med. 2018;15(11):e1002709. doi:10.1371/journal.pmed.1002709.</mixed-citation><mixed-citation xml:lang="en">Nanayakkara S, Fogarty S, Tremeer M, et al. Characterising risk of in-hospital mortality following cardiac arrest using machine learning: A retrospective international registry study. PLoS Med. 2018;15(11):e1002709. doi:10.1371/journal.pmed.1002709.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kakadiaris IA, Vrigkas M, Yen AA, et al. Machine Learning Outperforms ACC/AHA CVD Risk Calculator in MESA. Journal of the American Heart Association. 2018;7:e009476. doi:10.1161/JAHA.118.009476.</mixed-citation><mixed-citation xml:lang="en">Kakadiaris IA, Vrigkas M, Yen AA, et al. Machine Learning Outperforms ACC/AHA CVD Risk Calculator in MESA. Journal of the American Heart Association. 2018;7:e009476. doi:10.1161/JAHA.118.009476.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Dimopoulos A, Nikolaidou M, Caballero FF, et al. Machine learning methodologies versus cardiovascular risk scores, in predicting disease risk. BMC Medical Research Methodology. 2018;18:179. doi:10.1186/s12874-018-0644-1.</mixed-citation><mixed-citation xml:lang="en">Dimopoulos A, Nikolaidou M, Caballero FF, et al. Machine learning methodologies versus cardiovascular risk scores, in predicting disease risk. BMC Medical Research Methodology. 2018;18:179. doi:10.1186/s12874-018-0644-1.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Quesada JA, Lopez‐Pineda A, Gil‐Guillén VF, et al. Machine learning to predict cardiovascular risk. The International Journal of Clinical Practice. 2019;73(10):e13389. doi:10.1111/ijcp.13389.</mixed-citation><mixed-citation xml:lang="en">Quesada JA, Lopez‐Pineda A, Gil‐Guillén VF, et al. Machine learning to predict cardiovascular risk. The International Journal of Clinical Practice. 2019;73(10):e13389. doi:10.1111/ijcp.13389.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ambale-Venkatesh B, Yang X, Wu CO, et al. Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis. Circ Res. 2017;121(9):1092-101. doi:10.1161/CIRCRESAHA.117.311312.</mixed-citation><mixed-citation xml:lang="en">Ambale-Venkatesh B, Yang X, Wu CO, et al. Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis. Circ Res. 2017;121(9):1092-101. doi:10.1161/CIRCRESAHA.117.311312.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ren Y, Fei H, Liang X, et al. A hybrid neural network model for predicting kidney disease in hypertension patients based on electronic health records. BMC Med Inform Decis Mak. 2019;19:51. doi:10.1186/s12911-019-0765-4.</mixed-citation><mixed-citation xml:lang="en">Ren Y, Fei H, Liang X, et al. A hybrid neural network model for predicting kidney disease in hypertension patients based on electronic health records. BMC Med Inform Decis Mak. 2019;19:51. doi:10.1186/s12911-019-0765-4.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Samad MD, Ulloa A, Wehner GJ, et al. Predicting Survival From Large Echocardiography and Electronic Health Record Datasets: Optimization With Machine Learning. JACC Cardiovasc Imaging. 2019;12(4):681-9. doi:10.1016/j.jcmg.2018.04.026.</mixed-citation><mixed-citation xml:lang="en">Samad MD, Ulloa A, Wehner GJ, et al. Predicting Survival From Large Echocardiography and Electronic Health Record Datasets: Optimization With Machine Learning. JACC Cardiovasc Imaging. 2019;12(4):681-9. doi:10.1016/j.jcmg.2018.04.026.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Zack CJ, Senecal C, Kinar Y, et al. Leveraging Machine Learning Techniques to Forecast Patient Prognosis After Percutaneous Coronary Intervention. JACC Cardiovasc Interv. 2019;12(14):1304-11. doi:10.1016/j.jcin.2019.02.035.</mixed-citation><mixed-citation xml:lang="en">Zack CJ, Senecal C, Kinar Y, et al. Leveraging Machine Learning Techniques to Forecast Patient Prognosis After Percutaneous Coronary Intervention. JACC Cardiovasc Interv. 2019;12(14):1304-11. doi:10.1016/j.jcin.2019.02.035.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Dinh A, Miertschin S, Young A, et al. A data-driven approach to predicting diabetes and cardiovascular disease with machine learning. BMC Med Inform Decis Mak. 2019;19(1):211. doi:10.1186/s12911-019-0918-5.</mixed-citation><mixed-citation xml:lang="en">Dinh A, Miertschin S, Young A, et al. A data-driven approach to predicting diabetes and cardiovascular disease with machine learning. BMC Med Inform Decis Mak. 2019;19(1):211. doi:10.1186/s12911-019-0918-5.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Steele AJ, Denaxas SC, Shah AD, et al. Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease. PLoS ONE. 2018;13(8):e0202344. doi:10.1371/journal.pone.0202344.</mixed-citation><mixed-citation xml:lang="en">Steele AJ, Denaxas SC, Shah AD, et al. Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease. PLoS ONE. 2018;13(8):e0202344. doi:10.1371/journal.pone.0202344.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Pieszko K, Hiczkiewicz J, Budzianowski P, et al. Machine-learned models using hematological inflammation markers in the prediction of short-term acute coronary syndrome outcomes. J Transl Med. 2018;16(1):334. doi:10.1186/s12967-018-1702-5.</mixed-citation><mixed-citation xml:lang="en">Pieszko K, Hiczkiewicz J, Budzianowski P, et al. Machine-learned models using hematological inflammation markers in the prediction of short-term acute coronary syndrome outcomes. J Transl Med. 2018;16(1):334. doi:10.1186/s12967-018-1702-5.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Angraal S, Mortazavi BJ, Gupta A, et al. Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction. JACC: Heart Failure. 2020;8(1):12-21. doi:10.1016/j.jchf.2019.06.013.</mixed-citation><mixed-citation xml:lang="en">Angraal S, Mortazavi BJ, Gupta A, et al. Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction. JACC: Heart Failure. 2020;8(1):12-21. doi:10.1016/j.jchf.2019.06.013.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Weng SF, Reps J, Kai J, et al. Can machine-learning improve cardiovascular risk prediction using routine clinical data? Plos One. 2017;12(4):e0174944. doi:10.1371/journal.pone.0174944.</mixed-citation><mixed-citation xml:lang="en">Weng SF, Reps J, Kai J, et al. Can machine-learning improve cardiovascular risk prediction using routine clinical data? Plos One. 2017;12(4):e0174944. doi:10.1371/journal.pone.0174944.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ye C, Fu T, Hao S, et al. Prediction of Incident Hypertension Within the Next Year: Prospective Study Using Statewide Electronic Health Records and Machine Learning. J Med Internet Res. 2018;20(1):e22. doi:10.2196/jmir.9268.</mixed-citation><mixed-citation xml:lang="en">Ye C, Fu T, Hao S, et al. Prediction of Incident Hypertension Within the Next Year: Prospective Study Using Statewide Electronic Health Records and Machine Learning. J Med Internet Res. 2018;20(1):e22. doi:10.2196/jmir.9268.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Mallya S, Srivastava N, Arai TJ, et al. Effectiveness of LSTMS in predicting congestive heart failure onset. 2019. Available from: https://arxiv.org/ftp/arxiv/papers/1902/1902.02443.pdf.</mixed-citation><mixed-citation xml:lang="en">Mallya S, Srivastava N, Arai TJ, et al. Effectiveness of LSTMS in predicting congestive heart failure onset. 2019. Available from: https://arxiv.org/ftp/arxiv/papers/1902/1902.02443.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Wallert J, Tomasoni M, Madison G, et al. Predicting two-year survival versus non-survival after first myocardial infarction using machine learning and Swedish national register data. BMC Medical Informatics and Decision Making. 2017;17(1):99. doi:10.1186/s12911-017-0500-y.</mixed-citation><mixed-citation xml:lang="en">Wallert J, Tomasoni M, Madison G, et al. Predicting two-year survival versus non-survival after first myocardial infarction using machine learning and Swedish national register data. BMC Medical Informatics and Decision Making. 2017;17(1):99. doi:10.1186/s12911-017-0500-y.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Golas SB, Shibahara T, Agboola S, et al. A machine learning model to predict the risk of 30-day readmissions in patients with heart failure: a retrospective analysis of electronic medical records data. BMC Medical Informatics and Decision Making. 2018;18(1):44. doi:10.1186/s12911-018-0620-z.</mixed-citation><mixed-citation xml:lang="en">Golas SB, Shibahara T, Agboola S, et al. A machine learning model to predict the risk of 30-day readmissions in patients with heart failure: a retrospective analysis of electronic medical records data. BMC Medical Informatics and Decision Making. 2018;18(1):44. doi:10.1186/s12911-018-0620-z.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Xia E, Du X, Mei J, et al. Outcome-Driven Clustering of Acute Coronary Syndrome Patients Using Multi-Task Neural Network with Attention. Stud Health Technol Inform. 2019;264:457-61. doi:10.3233/SHTI190263.</mixed-citation><mixed-citation xml:lang="en">Xia E, Du X, Mei J, et al. Outcome-Driven Clustering of Acute Coronary Syndrome Patients Using Multi-Task Neural Network with Attention. Stud Health Technol Inform. 2019;264:457-61. doi:10.3233/SHTI190263.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Sakr S, Elshawi R, Ahmed A, et al. (2018). Using machine learning on cardiorespiratory fitness data for predicting hypertension: The Henry Ford Exercise Testing (FIT) Project. PLoS ONE. 2018;13(4):e0195344. doi:10.1371/journal.pone.0195344.</mixed-citation><mixed-citation xml:lang="en">Sakr S, Elshawi R, Ahmed A, et al. (2018). Using machine learning on cardiorespiratory fitness data for predicting hypertension: The Henry Ford Exercise Testing (FIT) Project. PLoS ONE. 2018;13(4):e0195344. doi:10.1371/journal.pone.0195344.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Daghistani TA, Elshawi R, Sakr S, et al. Predictors of in-hospital length of stay among cardiac patients: A machine learning approach. Int J Cardiol. 2019;288:140-7. doi:10.1016/j.ijcard.2019.01.046.</mixed-citation><mixed-citation xml:lang="en">Daghistani TA, Elshawi R, Sakr S, et al. Predictors of in-hospital length of stay among cardiac patients: A machine learning approach. Int J Cardiol. 2019;288:140-7. doi:10.1016/j.ijcard.2019.01.046.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kendale S, Kulkarni P, Rosenberg AD, Wang J. Supervised Machine-learning Predictive Analytics for Prediction of Postinduction Hypotension. Anesthesiology. 2018;129(4):675-88. doi:10.1097/ALN.0000000000002374.</mixed-citation><mixed-citation xml:lang="en">Kendale S, Kulkarni P, Rosenberg AD, Wang J. Supervised Machine-learning Predictive Analytics for Prediction of Postinduction Hypotension. Anesthesiology. 2018;129(4):675-88. doi:10.1097/ALN.0000000000002374.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Meyer A, Zverinski D, Pfahringer B, et al. Machine learning for real-time prediction of complications in critical care: a retrospective study. Lancet Respir Med. 2018;6(12):905- 14. doi:10.1016/S2213-2600(18)30300-X.</mixed-citation><mixed-citation xml:lang="en">Meyer A, Zverinski D, Pfahringer B, et al. Machine learning for real-time prediction of complications in critical care: a retrospective study. Lancet Respir Med. 2018;6(12):905- 14. doi:10.1016/S2213-2600(18)30300-X.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Xu F, Zhu J, Sun N, et al. Development and validation of prediction models for hypertension risks in rural Chinese populations. J Glob Health. 2019;9(2):020601. doi:10.7189/jogh.09.020601.</mixed-citation><mixed-citation xml:lang="en">Xu F, Zhu J, Sun N, et al. Development and validation of prediction models for hypertension risks in rural Chinese populations. J Glob Health. 2019;9(2):020601. doi:10.7189/jogh.09.020601.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Chen Y, Qi B. Representation learning in intraoperative vital signs for heart failure risk prediction. BMC Med Inform Decis Mak. 2019;19(1):260. doi:10.1186/s12911-019-0978-6.</mixed-citation><mixed-citation xml:lang="en">Chen Y, Qi B. Representation learning in intraoperative vital signs for heart failure risk prediction. BMC Med Inform Decis Mak. 2019;19(1):260. doi:10.1186/s12911-019-0978-6.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Barrett LA, Payrovnaziri SN, Bian J, He Z. Building Computational Models to Predict One-Year Mortality in ICU Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome. Available from: https://arxiv.org/pdf/1812.05072.pdf.</mixed-citation><mixed-citation xml:lang="en">Barrett LA, Payrovnaziri SN, Bian J, He Z. Building Computational Models to Predict One-Year Mortality in ICU Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome. Available from: https://arxiv.org/pdf/1812.05072.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Payrovnaziri SN, Barrett LA, Bis D, et al. Enhancing Prediction Models for One-Year Mortality in Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome. Stud Health Technol Inform. 2019;264:273-7. doi:10.3233/SHTI190226.</mixed-citation><mixed-citation xml:lang="en">Payrovnaziri SN, Barrett LA, Bis D, et al. Enhancing Prediction Models for One-Year Mortality in Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome. Stud Health Technol Inform. 2019;264:273-7. doi:10.3233/SHTI190226.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Cheon S, Kim J, Lim J. The Use of Deep Learning to Predict Stroke Patient Mortality. Int J Environ Res Public Health. 2019;16(11):e1876. doi:10.3390/ijerph16111876.</mixed-citation><mixed-citation xml:lang="en">Cheon S, Kim J, Lim J. The Use of Deep Learning to Predict Stroke Patient Mortality. Int J Environ Res Public Health. 2019;16(11):e1876. doi:10.3390/ijerph16111876.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Alaa AM, Bolton T, Di Angelantonio E, et al. Cardiovascular disease risk prediction using automated machine learning: A prospective study of 423,604 UK Biobank participants. PLoS ONE. 2019;14(5):e0213653. doi:10.1371/journal.pone.0213653.</mixed-citation><mixed-citation xml:lang="en">Alaa AM, Bolton T, Di Angelantonio E, et al. Cardiovascular disease risk prediction using automated machine learning: A prospective study of 423,604 UK Biobank participants. PLoS ONE. 2019;14(5):e0213653. doi:10.1371/journal.pone.0213653.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Padmanabhan M, Yuan P, Chada G, Nguyen HV. Physician-Friendly Machine Learning: A Case Study with Cardiovascular Disease Risk Prediction. J Clin Med. 2019;8(7):e1050, doi:10.3390/jcm8071050.</mixed-citation><mixed-citation xml:lang="en">Padmanabhan M, Yuan P, Chada G, Nguyen HV. Physician-Friendly Machine Learning: A Case Study with Cardiovascular Disease Risk Prediction. J Clin Med. 2019;8(7):e1050, doi:10.3390/jcm8071050.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Choi E, Bahadori MT, Kulas JA, et al. RETAIN: an interpretable predictive model for healthcare using reverse time attention mechanism. Adv. Neural Inf. Process. Syst. 2016;3504-12. Available from: https://arxiv.org/pdf/1608.05745.pdf.</mixed-citation><mixed-citation xml:lang="en">Choi E, Bahadori MT, Kulas JA, et al. RETAIN: an interpretable predictive model for healthcare using reverse time attention mechanism. Adv. Neural Inf. Process. Syst. 2016;3504-12. Available from: https://arxiv.org/pdf/1608.05745.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Choi E, Schuetz A, Stewart WF, Sun J. Using recurrent neural network models for early detection of heart failure onset. J Am Med Inform Assoc. 2017;24(2):361-70. doi:10.1093/jamia/ocw112.</mixed-citation><mixed-citation xml:lang="en">Choi E, Schuetz A, Stewart WF, Sun J. Using recurrent neural network models for early detection of heart failure onset. J Am Med Inform Assoc. 2017;24(2):361-70. doi:10.1093/jamia/ocw112.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Rasmy L, Wu Y, Wang N, et al. A study of generalizability of recurrent neural networkbased predictive models for heart failure onset risk using a large and heterogeneous EHR data set. J Biomed Inform. 2018;84:11-6. doi:10.1016/j.jbi.2018.06.011.</mixed-citation><mixed-citation xml:lang="en">Rasmy L, Wu Y, Wang N, et al. A study of generalizability of recurrent neural networkbased predictive models for heart failure onset risk using a large and heterogeneous EHR data set. J Biomed Inform. 2018;84:11-6. doi:10.1016/j.jbi.2018.06.011.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Park J, Kim JW, Ryu B, et al. Patient-Level Prediction of Cardio-Cerebrovascular Events in Hypertension Using Nationwide Claims Data. J Med Internet Res. 2019;21(2):e11757. doi:10.2196/11757.</mixed-citation><mixed-citation xml:lang="en">Park J, Kim JW, Ryu B, et al. Patient-Level Prediction of Cardio-Cerebrovascular Events in Hypertension Using Nationwide Claims Data. J Med Internet Res. 2019;21(2):e11757. doi:10.2196/11757.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Mezzatesta S, Torino C, Meo P, et al. A machine learning-based approach for predicting the outbreak of cardiovascular diseases in patients on dialysis. Comput Methods Programs Biomed. 2019;177:9-15. doi:10.1016/j.cmpb.2019.05.005.</mixed-citation><mixed-citation xml:lang="en">Mezzatesta S, Torino C, Meo P, et al. A machine learning-based approach for predicting the outbreak of cardiovascular diseases in patients on dialysis. Comput Methods Programs Biomed. 2019;177:9-15. doi:10.1016/j.cmpb.2019.05.005.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Mansoor H, Elgendy IY, Segal R, et al. Risk prediction model for in-hospital mortality in women with ST-elevation myocardial infarction: A machine learning approach. Heart Lung. 2017;46(6):405-11. doi:10.1016/j.hrtlng.2017.09.003.</mixed-citation><mixed-citation xml:lang="en">Mansoor H, Elgendy IY, Segal R, et al. Risk prediction model for in-hospital mortality in women with ST-elevation myocardial infarction: A machine learning approach. Heart Lung. 2017;46(6):405-11. doi:10.1016/j.hrtlng.2017.09.003.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Sung JM, Cho IJ, Sung D, et al. Development and verification of prediction models for preventing cardiovascular diseases. PLoS One. 2019;14(9):e0222809. doi:10.1371/journal.pone.0222809.</mixed-citation><mixed-citation xml:lang="en">Sung JM, Cho IJ, Sung D, et al. Development and verification of prediction models for preventing cardiovascular diseases. PLoS One. 2019;14(9):e0222809. doi:10.1371/journal.pone.0222809.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Segar MW, Vaduganathan M, Patel KV, et al. Machine Learning to Predict the Risk of Incident Heart Failure Hospitalization Among Patients With Diabetes: The WATCH-DM Risk Score. Diabetes Care 2019;42(12):2298-306. doi:10.2337/dc19-0587</mixed-citation><mixed-citation xml:lang="en">Segar MW, Vaduganathan M, Patel KV, et al. Machine Learning to Predict the Risk of Incident Heart Failure Hospitalization Among Patients With Diabetes: The WATCH-DM Risk Score. Diabetes Care 2019;42(12):2298-306. doi:10.2337/dc19-0587</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
