russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2021-4492russjcardiol-4492Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWРоль катестатина в развитии и декомпенсации сердечной недостаточности: обзор литературыRole of catestatin in development and decompensation of heart failure: a literature reviewhttps://orcid.org/0000-0002-1650-1411МещеряковЮ. В.MeshcheryakovYu. V.

Мещеряков Юрий Владимирович — аспирант кафедры внутренних болезней ФГБОУ ВО «СамГМУ» Минздрава России; врач-ординатор кардиолог ФГБУ «НМИЦ ТПМ» Минздрава России; врач-терапевт, клинический фармаколог «GMS clinic»

Самара, Москва

Samara, Moscow

mesheryakov.yuri@gmail.comhttps://orcid.org/0000-0003-1881-024XГубареваИ. В.GubarevaI. V.

Губарева Ирина Валерьевна — доктор медицинских наук, заведующая кафедрой внутренних болезней

Самара

SPIN-код: 9960-6915

Samara

i.v.gubareva@samsmu.ruhttps://orcid.org/0000-0001-6824-3963ГубареваЕ. Ю.GubarevaE. Yu.

Губарева Екатерина Юрьевна — кандидат медицинских наук, ассистент кафедры факультетской терапии, врач отделения функциональной диагностики

Самара

Samara

ekaterina.ju.gubareva@gmail.comhttps://orcid.org/0000-0002-3361-9155АлексееваА. Ю.AlekseevaA. Yu.

Алексеева Анна Юрьевна — ординатор кафедры нервных болезней ИПО

Москва

Moscow

anna.yu.alekseeva@gmail.comФГБОУ ВО СамГМУ Минздрава России; ФГБУ НМИЦ ТПМ Минздрава России; GMS clinicРоссияSamara State Medical University; National Medical Research Center for Therapy and Preventive Medicine; GMS clinicRussian FederationФГБОУ ВО СамГМУ Минздрава РоссииРоссияSamara State Medical UniversityRussian FederationФГАОУ ВО Первый МГМУ им. И.М.Сеченова МЗ РФ (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation202120082021263SОбразование44924492Copyright © Мещеряков Ю.В., Губарева И.В., Губарева Е.Ю., Алексеева А.Ю., 20212021Мещеряков Ю.В., Губарева И.В., Губарева Е.Ю., Алексеева А.Ю.Meshcheryakov Y.V., Gubareva I.V., Gubareva E.Y., Alekseeva A.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/4492

Данная обзорная статья посвящена роли активации симпатической нервной системы (СНС) и значению определения концентрации нового биомаркера-производного хромогранина А катестатина (CST) для оценки прогноза больных с сердечной недостаточностью. В статье детально проанализированы работы, посвященные метаболизму маркера, его роли в клинических состояниях, сопровождающихся избыточной продукцией катехоламинов, в т.ч. способность компенсировать негативные последствия воздействия СНС на сердечно-сосудистую систему. Также в работе представлены основные положения исследований пациентов с сердечной недостаточностью, показана корреляционная зависимость уровня CST от функционального класса и стадии заболевания, возможности и потенциальные преимущества оценки маркера в дополнение к традиционным подходам у лиц, госпитализированных с острой декомпенсацией сердечной недостаточности.

The current literature review covers the role of sympathetic nervous system activation (SNS) and the significance of a new biomarker catestatin (CST), which is a chromogranin A-derived peptide, for assessing prognosis of patients with heart failure (HF). This review details the works devoted to CST metabolism and its role in clinical conditions with excessive catecholamine production, including the ability to counterbalance the adverse effects of SNS on cardiovascular system. The paper also presents the central results of studies on HF patients and shows the correlation of the CST level with HF functional class and stage. In addition, particular attention is paid on the possibilities and potential benefits of assessing the CST in addition to conventional management of patients hospitalized due to acute decompensated heart failure.

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The authors declare that there are no conflicts of interest present.