<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2020-4011</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-4011</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Опыт использования донорского сердца с продленной холодовой ишемией</article-title><trans-title-group xml:lang="en"><trans-title>Experience of heart transplantation with an extended cold ischemic time of donor heart</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8576-9617</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомичев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomichev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>сердечно-сосудистый хирург кардиохирургического отделения аорты и коронарных артерий</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><email xlink:type="simple">a_fomichev@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5925-2275</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хван</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Khvan</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>сердечно-сосудистый хирург кардиохирургического отделения аорты и коронарных артерий</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><email xlink:type="simple">d_hvan@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1648-1529</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Агаева</surname><given-names>Х. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Agaeva</surname><given-names>H. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор кардиохирургического отделения аорты и коронарных артерий</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><email xlink:type="simple">agaeva_k@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7976-596X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жульков</surname><given-names>М. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhulkov</surname><given-names>M. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>сердечно-сосудистый хирург кардиохирургического отделения аорты и коронарных артерий</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><email xlink:type="simple">zhulkov_m@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3372-2889</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Доронин</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Doronin</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-кардиолог кардиохирургического отделения аорты и коронарных артерий</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><email xlink:type="simple">d_doronin@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9818-8678</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернявский</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernyavsky</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>директор Центра</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><email xlink:type="simple">amchern@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ Национальный медицинский исследовательский центр им. акад. Е. Н. Мешалкина Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Meshalkin National Medical Research Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>14</day><month>08</month><year>2020</year></pub-date><volume>25</volume><issue>8</issue><fpage>4011</fpage><lpage>4011</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фомичев А.В., Хван Д.С., Агаева Х.А., Жульков М.О., Доронин Д.В., Чернявский А.М., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Фомичев А.В., Хван Д.С., Агаева Х.А., Жульков М.О., Доронин Д.В., Чернявский А.М.</copyright-holder><copyright-holder xml:lang="en">Fomichev A.V., Khvan D.S., Agaeva H.A., Zhulkov M.O., Doronin D.V., Chernyavsky A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/4011">https://russjcardiol.elpub.ru/jour/article/view/4011</self-uri><abstract><sec><title>Цель</title><p>Цель. Ретроспективный анализ результатов трансплантации сердца (ТС) с продленной холодовой ишемией трансплантата (&gt;4 ч) по сравнению с ТС с короткой холодовой ишемией трансплантата (&lt;4 ч).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В ретроспективный анализ включены 52 реципиента, которым была выполнена ТС в период с 20 июля 2012г по 23 октября 2019г на базе ФГБУ “Национальный медицинский исследовательский центр им. акад. Е. Н. Мешалкина”. Пациенты разделены на две группы: в первую группу исследования включены 26 реципиентов, которым была произведена ортотопическая ТС с длительной холодовой ишемией трансплантата (&gt;240 мин), во вторую группу — 26 реципиентов с короткой холодовой ишемией трансплантата (&lt;240 мин). Выполнена оценка влияния времени холодовой ишемии трансплантата на госпитальную выживаемость, функцию донорского сердца, течение послеоперационного периода.</p></sec><sec><title>Результаты</title><p>Результаты. Ретроспективный анализ выявил более высокий показатель госпитальной выживаемости в группе реципиентов с длительной холодовой ишемией трансплантата (&gt;240 мин) — 88,5% по сравнению с 80,7% во второй группе. Не выявлено разницы между группами по частоте острого отторжения, потребности в инотропной поддержке, необходимости механической поддержки сердца, частоте послеоперационной почечной недостаточности, потребности в кардиостимуляции и инфекционных осложнений.</p></sec><sec><title>Заключение</title><p>Заключение. Наш опыт ТС с длительной ишемией трансплантата по причине малого количества пациентов не позволяет сделать глобальных выводов, но предварительный сравнительный анализ непосредственных результатов ТС с длительной и короткой ишемией не выявил значимых преимуществ в той или иной группе. Это дает основание для продолжения накопления опыта и дальнейшего исследования результатов использования сердец с длительной холодовой ишемией.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. A retrospective analysis of the outcomes of heart transplantation (HT) with extended cold ischemic time of donor heart (more than 4 hours) versus heart transplantation with short cold ischemia time (less than 4 hours).</p></sec><sec><title>Material and methods</title><p>Material and methods. The retrospective analysis included 52 recipients who underwent HT in the period from July 20, 2012 to October 23, 2019 in Meshalkin National Medical Research Center. The patients were divided into two groups: group 1 (n=26) — orthotopic HT with extended cold ischemic time (more than 240 minutes), group 2 (n=26) — short cold ischemia time (less than 240 minutes). The effect of cold ischemia duration on hospital survival, the function of donor heart, and the postoperative course was assessed.</p></sec><sec><title>Results</title><p>Results. A retrospective analysis revealed a higher rate of hospital survival in the group of recipients with extended cold ischemic time (more than 240 minutes) 88,5% compared to 80,7% in the second group. There was no difference between the groups in the acute rejection rate, the need for inotropic agents, mechanical circulatory support, and cardiac pacing, as well as the incidence of postoperative renal failure and infectious complications.</p></sec><sec><title>Conclusion</title><p>Conclusion. Due to the small number of patients, our experience in HT with extended cold ischemic time does not allow us to draw global conclusions, but a preliminary comparison of HT with extended and short cold ischemic time did not reveal significant advantages in one group or another. This provides a basis for further accumulation of experience and research.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трансплантация сердца</kwd><kwd>холодовая ишемия</kwd><kwd>сердечная недостаточность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart transplantation</kwd><kwd>cold ischemia</kwd><kwd>heart failure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">“Трансплантация сердца”. Национальные клинические рекомендации. http://transpl.ru/images/cms/data/pdf/nacional_nye_klinicheskie_rekomendacii_po_transplantacii_serdca.pdf.</mixed-citation><mixed-citation xml:lang="en">Heart transplantation. National clinical guidelines. 2013. (In Russ.) http://transpl.ru/images/cms/data/pdf/nacional_nye_klinicheskie_rekomendacii_po_transplantacii_serdca.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Que W, Hu X, Fujino M, et al. Prolonged cold ischemia time in mouse heart transplantation using supercooling preservation. Transplantation. 2019. doi:10.1097/TP.0000000000003089.</mixed-citation><mixed-citation xml:lang="en">Que W, Hu X, Fujino M, et al. Prolonged cold ischemia time in mouse heart transplantation using supercooling preservation. Transplantation. 2019. doi:10.1097/TP.0000000000003089.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">John MM, Shih W, Estevez D, et al. Interaction Between Ischemic Time and Donor Age on Adult Heart Transplant Outcomes in the Modern Era. Ann Thorac Surg. 2019;108(3):744-748. doi:10.1016/j.athoracsur.2019.03.042.</mixed-citation><mixed-citation xml:lang="en">John MM, Shih W, Estevez D, et al. Interaction Between Ischemic Time and Donor Age on Adult Heart Transplant Outcomes in the Modern Era. Ann Thorac Surg. 2019;108(3):744-748. doi:10.1016/j.athoracsur.2019.03.042.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kilic A, Weiss ES, Yuh DD, et al. Factors associated with 5-year survival in older heart transplant recipients. The Journal of Thoracic and Cardiovascular Surgery. 2012;143(2):468-74. doi:10.1016/j.jtcvs.2011.10.036.</mixed-citation><mixed-citation xml:lang="en">Kilic A, Weiss ES, Yuh DD, et al. Factors associated with 5-year survival in older heart transplant recipients. The Journal of Thoracic and Cardiovascular Surgery. 2012;143(2):468-74. doi:10.1016/j.jtcvs.2011.10.036.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Nilsson J, Jernryd V, Qin G, et al. A nonrandomized open-label phase 2 trial of nonischemic heart preservation for human heart transplantation. Nat Commun. 2020;11(1):2976. doi:10.1038/s41467-020-16782-9.</mixed-citation><mixed-citation xml:lang="en">Nilsson J, Jernryd V, Qin G, et al. A nonrandomized open-label phase 2 trial of nonischemic heart preservation for human heart transplantation. Nat Commun. 2020;11(1):2976. doi:10.1038/s41467-020-16782-9.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ponikowski P, Voors AA, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129-200. doi:10.1093/eurheartj/ehw128.</mixed-citation><mixed-citation xml:lang="en">Ponikowski P, Voors AA, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129-200. doi:10.1093/eurheartj/ehw128.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Carter KT, Lirette ST, Baran DA, et al. The Effect of Cardiac Preservation Solutions on Heart Transplant Survival. J Surg Res. 2019;242:157-65. doi:10.1016/j.jss.2019.04.041.</mixed-citation><mixed-citation xml:lang="en">Carter KT, Lirette ST, Baran DA, et al. The Effect of Cardiac Preservation Solutions on Heart Transplant Survival. J Surg Res. 2019;242:157-65. doi:10.1016/j.jss.2019.04.041.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kiamanesh O, Khosla A, Johansson E, et al. Transplant Proc. Transplantation Proceedings. 2019;51(10):3409-11. doi:10.1016/j.transproceed.2019.08.032.</mixed-citation><mixed-citation xml:lang="en">Kiamanesh O, Khosla A, Johansson E, et al. Transplant Proc. Transplantation Proceedings. 2019;51(10):3409-11. doi:10.1016/j.transproceed.2019.08.032.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Reich HJ, Kobashigawa J, Aintablian TL, et al. Effects of Older Donor Age and Cold Ischemic Time on Long-Term Outcomes of Heart Transplantation. Tex Heart Inst J. 2018;45(1):17-22. doi:10.14503/THIJ-16-6178.</mixed-citation><mixed-citation xml:lang="en">Reich HJ, Kobashigawa J, Aintablian TL, et al. Effects of Older Donor Age and Cold Ischemic Time on Long-Term Outcomes of Heart Transplantation. Tex Heart Inst J. 2018;45(1):17-22. doi:10.14503/THIJ-16-6178.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Shafiq F, Wang Y, Li G, et al. Clinical outcome of donor heart with prolonged cold ischemic time: A single‐center study. J Card Surg. 2019;35(2):397-404. doi:10.1111/jocs.14404.</mixed-citation><mixed-citation xml:lang="en">Shafiq F, Wang Y, Li G, et al. Clinical outcome of donor heart with prolonged cold ischemic time: A single‐center study. J Card Surg. 2019;35(2):397-404. doi:10.1111/jocs.14404.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Buendía-Fuentes F, Almenar-Bonet L, Martínez-Dolz L, et al. Ischemic time as a predictor of physical recovery in the first months after heart transplantation. ISRN Cardiol. 2012;2012:907102. doi:10.5402/2012/907102.</mixed-citation><mixed-citation xml:lang="en">Buendía-Fuentes F, Almenar-Bonet L, Martínez-Dolz L, et al. Ischemic time as a predictor of physical recovery in the first months after heart transplantation. ISRN Cardiol. 2012;2012:907102. doi:10.5402/2012/907102.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Gaffey AC, Chen CW, Chung JJ, et al. Extended distance cardiac allograft can successfully be utilized without impacting long-term survival. J Heart Lung Transplant. 2017;36(9):968-72. doi:10.1016/j.healun.2017.04.002.</mixed-citation><mixed-citation xml:lang="en">Gaffey AC, Chen CW, Chung JJ, et al. Extended distance cardiac allograft can successfully be utilized without impacting long-term survival. J Heart Lung Transplant. 2017;36(9):968-72. doi:10.1016/j.healun.2017.04.002.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Minasian SM, Galagudza MM, Dmitriev YV, et al. Preservation of the donor heart: from basic science to clinical studies. Interact CardioVasc Thorac Surg. 2015;20:510-19. doi:10.1093/icvts/ivu432.</mixed-citation><mixed-citation xml:lang="en">Minasian SM, Galagudza MM, Dmitriev YV, et al. Preservation of the donor heart: from basic science to clinical studies. Interact CardioVasc Thorac Surg. 2015;20:510-19. doi:10.1093/icvts/ivu432.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
