russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2020-4005russjcardiol-4005Research ArticleСТАТЬИARTICLESФундаментальные и прикладные аспекты кальцификации коронарных артерийFundamental and practical aspects of coronary artery calcificationhttps://orcid.org/0000-0002-4642-3610БарбарашО. Л.BarbarashO. L.

директор, д.м.н., профессор, член-корр. РАН

SPIN-код: 5373-7620, AuthorID: 269011

Кемерово

M.D., Ph.D., Professor, Corresponding Member of the RAS, Director

Kemerovo

olb61@mail.ruhttps://orcid.org/0000-0003-3729-616XКашталапВ. В.KashtalapV. V.

заведующий отделом клинической кардиологии, д.м.н., доцент

SPIN-код: 8816-7409, AuthorID: 607714

Кемерово

M.D., Ph.D., Associate Professor, Head of the Department of Clinical Cardiology

Kemerovo

v_kash@mail.ruhttps://orcid.org/0000-0001-8418-8140ШибановаИ. А.ShibanovaI. A.

старший научный сотрудник лаборатоории реабилитации отдела клинической кардиологии, к.м.н.

SPIN-код: 8373-2908, AuthorID: 481109

Кемерово

M.D., Ph.D., Senior Research Associate of the Rehabilitation Laboratory of the Department of Clinical Cardiology

Kemerovo

shibia@kemcardio.ruhttps://orcid.org/0000-0002-7573-0636КоковА. Н.KokovA. N.

заведующий лаборатории лучевых методов диагногстики отдела клинической кардиологии, к.м.н.

SPIN-код: 8455-4271, AuthorID: 347050

Кемерово

M.D., Ph.D., Head of the Laboratory of Radiological Imaging of the Department of Clinical Cardiology

Kemerovo

radiology@bk.ruФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ)РоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian Federation202012072020253S3S40054005Copyright © Барбараш О.Л., Кашталап В.В., Шибанова И.А., Коков А.Н., 20202020Барбараш О.Л., Кашталап В.В., Шибанова И.А., Коков А.Н.Barbarash O.L., Kashtalap V.V., Shibanova I.A., Kokov A.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/4005

В обзорной статье обобщены результаты зарубежных и отечественных исследований, посвященных механизмам развития, а также клинико-прогностической роли коронарной кальцификации при ишемической болезни сердца. Представлены современные взгляды кардиологов, хирургов и врачей общей практики в отношении коморбидных заболеваний, проявлением которых может быть коронарная кальцификация. Обозначены современные аспекты формирования связи между атерогенезом, коронарной кальцификацией и резорбцией костной ткани; выделены группы информативных биологических маркеров, способных отражать тяжесть остео-коронарного континуума. Освещены современные диагностические возможности для выявления и характеристики коронарной кальцификации, обозначены их достоинства и ограничения. Обсуждены перспективы фармакологической коррекции атеросклероза с позиции влияния на коронарный кальциноз и остеопенический синдром. Представлены дальнейшие перспективы и направления исследований в этой области медицинской науки.

The review article summarizes the results of studies on the pathogenesis, as well as the clinical and prognostic role of coronary artery calcification (CAC) in coronary artery disease. The modern views of cardiologists, surgeons and general practitioners on the comorbidities manifested by CCA are presented. The modern ideas on the relationship between atherogenesis, CCA and bone resorption are described; groups of informative biological markers reflecting the severity of process are identified. Modern diagnostic methods for the detection and study of CCA are highlighted, their advantages and limitations are indicated. The effect of atherosclerosis treatment on coronary calcification and osteopenia are discussed. Further prospects and lines of research in this area are presented.

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The authors declare that there are no conflicts of interest present.