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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2020-3861</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-3861</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON THE ISSUE</subject></subj-group></article-categories><title-group><article-title>Ангиотензин II и COVID-19. Тайны взаимодействий</article-title><trans-title-group xml:lang="en"><trans-title>Angiotensin II and COVID-19. Secrets of interactions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8169-7812</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конради</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Konradi</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Конради Александра Олеговна — доктор медицинских наук, профессор, член-корреспондент РАН; заместитель генерального директора по научной работе; руководитель НИО артериальной гипертензии; директор Института трансляционной медицины, Университет ИТМО</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"/><email xlink:type="simple">konradi@almazovcenre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8892-6411</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Недошивин</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Nedoshivin</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Недошивин Александр Олегович — ученый секретарь, доктор медицинских наук, профессор</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"/><email xlink:type="simple">konradi@almazovcenre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ НМИЦ им. В.А. Алмазова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>26</day><month>04</month><year>2020</year></pub-date><volume>25</volume><issue>4</issue><fpage>3861</fpage><lpage>3861</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Конради А.О., Недошивин А.О., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Конради А.О., Недошивин А.О.</copyright-holder><copyright-holder xml:lang="en">Konradi A.O., Nedoshivin A.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/3861">https://russjcardiol.elpub.ru/jour/article/view/3861</self-uri><abstract><p>Статья посвящена актуальным данным о связи ренин-ангиотензиновой системы и применения препаратов, влияющих на ее активность с риском заражения и рисками исходов при COVID-19 инфекции. Приведен анализ последних данных литературы и сделан вывод об отсутствии связи приема ингибиторов ангиотензинпревращающего фермента и блокаторов рецепторов к ангиотензину II c каким-либо риском негативного исхода и отсутствии показаний к отмене этих групп препаратов.</p></abstract><trans-abstract xml:lang="en"><p>The article describes current data on the relationship of renin-angiotensin system and related drugs with the risk of COVID-19 infection and its outcomes. Analysis of the latest publications did not reveal association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with any risk of an unfavorable outcomes, and there was no data for withdrawal of these drugs.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>ингибиторы ангиотензинпревращающего фермента</kwd><kwd>ангиотензинпревращающий фермент 2 типа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>angiotensin converting enzyme inhibitors</kwd><kwd>angiotensin converting enzyme 2</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID19. https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-acc-ahastatement-addresses-concerns-re-using-raas-antagonists-in-covid-19.</mixed-citation><mixed-citation xml:lang="en">HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID19. https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-acc-ahastatement-addresses-concerns-re-using-raas-antagonists-in-covid-19.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. last updated on 21 April 2020, https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance</mixed-citation><mixed-citation xml:lang="en">ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. last updated on 21 April 2020, https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Шляхто Е.В. 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