russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2013-2-61-64russjcardiol-365Research ArticleКЛИНИКА И ФАРМАКОТЕРАПИЯGUIDELINES FOR THE PRACTITIONERСИМПАТИЧЕСКАЯ АКТИВНОСТЬ И АРТЕРИАЛЬНАЯ ГИПЕРТОНИЯ: ВОЗМОЖНОСТИ КОРРЕКЦИИSympathetic activity and arterial hypertension: potential for correctionШайдюкО. Ю.ShaydukO. Yu.

к. м.н., кардиолог, терапевт, доцент кафедры

ТаратухинЕ. О.TaratukhinE. O.

к. м.н., кардиолог, ассистент кафедры

cardio03@list.ruКафедра госпитальной терапии № 1 л/ф ГБОУ ВПО РНИМУ им. Н. И. Пирогова, Москва, РоссияРоссияHospital Therapy Department No. 1, Therapy Faculty, N. I. Pirogov National Medical Research University, Moscow, RussiaRussian Federation201328042013026164Copyright © Шайдюк О.Ю., Таратухин Е.О., 20132013Шайдюк О.Ю., Таратухин Е.О.Shayduk O.Y., Taratukhin E.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/365

Статья посвящена роли повышенной активности симпатической нервной системы в патогенезе артериальной гипертонии, её обострений – кризов и осложнений. Показано, что одним из эффективных путей, разрушающих порочные круги патогенеза этих состояний, является блокада периферических альфа-адренорецепторов.

Одним из препаратов выбора для неотложной терапии кризов и для постоянного амбулаторного лечения является урапидил, периферический симпатолитик со свойствами агониста серотониновых рецепторов центральной нервной системы.

The paper is focussed on the role of increased sympathetic activation in the pathogenesis of arterial hypertension (AH), its exacerbations (hypertensive crises), and complications. One of the effective methods of interrupting pathogenetic “vicious circles” in AH is the blockage of peripheral alpha-adrenoreceptors. One of the medications of choice for urgent treatment of hypertensive crises, as well as for long-term ambulatory treatment, is urapidil – a peripheral sympatholytic with characteristics of a central serotonin receptor agonist.

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The authors declare that there are no conflicts of interest present.